CA2561281C - Pharmaceutical composition comprising a salt of mirtazapine - Google Patents

Pharmaceutical composition comprising a salt of mirtazapine Download PDF

Info

Publication number
CA2561281C
CA2561281C CA2561281A CA2561281A CA2561281C CA 2561281 C CA2561281 C CA 2561281C CA 2561281 A CA2561281 A CA 2561281A CA 2561281 A CA2561281 A CA 2561281A CA 2561281 C CA2561281 C CA 2561281C
Authority
CA
Canada
Prior art keywords
mirtazapine
salt
formulation
acid
maleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2561281A
Other languages
English (en)
French (fr)
Other versions
CA2561281A1 (en
Inventor
Sytske Hyke Moolenaar
Gerardus Johannes Kemperman
Kees Van Der Voort Maarschalk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme BV
Original Assignee
MSD Oss BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MSD Oss BV filed Critical MSD Oss BV
Publication of CA2561281A1 publication Critical patent/CA2561281A1/en
Application granted granted Critical
Publication of CA2561281C publication Critical patent/CA2561281C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2561281A 2004-04-21 2005-04-19 Pharmaceutical composition comprising a salt of mirtazapine Expired - Fee Related CA2561281C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04101664 2004-04-21
EP04101664.3 2004-04-21
PCT/EP2005/051714 WO2005102352A1 (en) 2004-04-21 2005-04-19 Pharmaceutical composition comprising a salt of mirtazapine

Publications (2)

Publication Number Publication Date
CA2561281A1 CA2561281A1 (en) 2005-11-03
CA2561281C true CA2561281C (en) 2013-04-02

Family

ID=34928990

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2561281A Expired - Fee Related CA2561281C (en) 2004-04-21 2005-04-19 Pharmaceutical composition comprising a salt of mirtazapine

Country Status (31)

Country Link
US (1) US20070111993A1 (https=)
EP (1) EP1729777B1 (https=)
JP (2) JP5260959B2 (https=)
CN (2) CN1942191B (https=)
AR (1) AR049028A1 (https=)
AT (1) ATE424210T1 (https=)
AU (1) AU2005235383B2 (https=)
BR (1) BRPI0509953A (https=)
CA (1) CA2561281C (https=)
CY (1) CY1109018T1 (https=)
DE (1) DE602005013066D1 (https=)
DK (1) DK1729777T3 (https=)
EC (1) ECSP066938A (https=)
ES (1) ES2321961T3 (https=)
HR (1) HRP20090190T1 (https=)
IL (1) IL178201A (https=)
LV (1) LV13556B (https=)
MX (1) MXPA06011830A (https=)
MY (1) MY144899A (https=)
NO (1) NO20065077L (https=)
NZ (1) NZ550052A (https=)
PE (1) PE20060400A1 (https=)
PL (1) PL1729777T3 (https=)
PT (1) PT1729777E (https=)
RS (1) RS50764B (https=)
RU (1) RU2375362C2 (https=)
SI (1) SI1729777T1 (https=)
TW (1) TW200538100A (https=)
UA (1) UA89773C2 (https=)
WO (1) WO2005102352A1 (https=)
ZA (1) ZA200608305B (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA83666C2 (ru) * 2003-07-10 2008-08-11 Н.В. Органон Способ получения энантиомерно чистого миртазапина
EP1792618A1 (en) * 2005-11-30 2007-06-06 Rainer Freynhagen R-mirtazapine for the treatment of pain
TW200808804A (en) * 2006-05-22 2008-02-16 Organon Nv Mirtazapine for the treatment of neuropathic pain
CN104095824B (zh) * 2013-04-09 2016-08-31 上海信谊万象药业股份有限公司 一种米氮平缓释片及其制备方法
PL3261645T3 (pl) 2015-02-27 2021-12-06 Dechra Limited Pobudzanie apetytu, zarządzanie utratą masy ciała, i leczenie anoreksji u psów i kotów
CN111053735A (zh) * 2020-02-25 2020-04-24 上海阶平医院管理有限公司 一种治疗失眠的冷敷凝胶

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL189199C (nl) * 1975-04-05 1993-02-01 Akzo Nv Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.
US4193828A (en) * 1976-07-27 1980-03-18 Fiber Materials, Inc. Method of forming carbon composites
US4515792A (en) * 1982-09-30 1985-05-07 Ciba-Geigy Corporation Tetracyclic heterocycles and antidepressant compositions thereof
EP0813873B1 (en) * 1996-06-19 2002-02-13 Akzo Nobel N.V. Pharmaceutical composition comprising mirtazapine and one or more selective serotonin reuptake inhibitors
IL121076A (en) * 1996-06-19 2000-10-31 Akzo Nobel Nv Pharmaceutical combinations comprising mirtazapine and one or more selective serotonin reuptake inhibitors
WO1999051237A1 (en) * 1998-04-02 1999-10-14 Akzo Nobel N.V. Oral liquid antidepressant solution
WO2001000196A2 (en) * 1999-06-25 2001-01-04 University Of South Florida Mirtazapine for weight gain in wasting diseases
US6281207B1 (en) * 1999-09-15 2001-08-28 Reed Richter Treatment of movement disorders by administration of mirtazapine
WO2001042239A1 (en) * 1999-12-13 2001-06-14 Sumika Fine Chemicals Co., Ltd. Process for the preparation of a pyridinemethanol compound
SK14162002A3 (sk) * 2000-04-05 2003-03-04 Akzo Nobel N.V. Kombinácia obsahujúca paracetamol alebo nesteroidné protizápalové liečivo, použitie mirtazapínu, paracetamolu a pacientský balíček

Also Published As

Publication number Publication date
EP1729777B1 (en) 2009-03-04
CN1942191A (zh) 2007-04-04
EP1729777A1 (en) 2006-12-13
PL1729777T3 (pl) 2009-07-31
TW200538100A (en) 2005-12-01
ZA200608305B (en) 2008-08-27
BRPI0509953A (pt) 2007-09-25
CN1942191B (zh) 2011-02-02
US20070111993A1 (en) 2007-05-17
AU2005235383A1 (en) 2005-11-03
NO20065077L (no) 2006-11-14
CN101824035A (zh) 2010-09-08
SI1729777T1 (sl) 2009-08-31
CA2561281A1 (en) 2005-11-03
CY1109018T1 (el) 2014-07-02
IL178201A (en) 2010-06-30
PE20060400A1 (es) 2006-05-27
WO2005102352A1 (en) 2005-11-03
UA89773C2 (ru) 2010-03-10
IL178201A0 (en) 2006-12-31
LV13556B (en) 2007-07-20
AR049028A1 (es) 2006-06-21
RS50764B (sr) 2010-08-31
MY144899A (en) 2011-11-30
ECSP066938A (es) 2006-12-20
JP5260959B2 (ja) 2013-08-14
JP2007533705A (ja) 2007-11-22
HRP20090190T1 (en) 2009-05-31
DK1729777T3 (da) 2009-06-08
NZ550052A (en) 2010-02-26
ATE424210T1 (de) 2009-03-15
MXPA06011830A (es) 2007-03-23
ES2321961T3 (es) 2009-06-15
AU2005235383B2 (en) 2010-05-27
RU2006140988A (ru) 2008-05-27
JP2013136626A (ja) 2013-07-11
DE602005013066D1 (de) 2009-04-16
RU2375362C2 (ru) 2009-12-10
PT1729777E (pt) 2009-04-27

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