CA2555812A1 - 3-3-di-substituted-oxindoles as inhibitors of translation initiation - Google Patents
3-3-di-substituted-oxindoles as inhibitors of translation initiation Download PDFInfo
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- CA2555812A1 CA2555812A1 CA002555812A CA2555812A CA2555812A1 CA 2555812 A1 CA2555812 A1 CA 2555812A1 CA 002555812 A CA002555812 A CA 002555812A CA 2555812 A CA2555812 A CA 2555812A CA 2555812 A1 CA2555812 A1 CA 2555812A1
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- C07D209/04—Indoles; Hydrogenated indoles
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- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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| US60/544,384 | 2004-02-13 | ||
| PCT/US2005/004373 WO2005080335A1 (en) | 2004-02-13 | 2005-02-11 | 3-3-di-substituted-oxindoles as inhibitors of translation initiation |
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| CA2555812A1 true CA2555812A1 (en) | 2005-09-01 |
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| US6777217B1 (en) | 1996-03-26 | 2004-08-17 | President And Fellows Of Harvard College | Histone deacetylases, and uses related thereto |
| US20030129724A1 (en) | 2000-03-03 | 2003-07-10 | Grozinger Christina M. | Class II human histone deacetylases, and uses related thereto |
| US7244853B2 (en) | 2001-05-09 | 2007-07-17 | President And Fellows Of Harvard College | Dioxanes and uses thereof |
| EA013209B1 (ru) * | 2004-04-08 | 2010-04-30 | Топотаргет А/С | Производные дифенилоксиндол-2-она и их применение для лечения рака |
| JP2007537275A (ja) * | 2004-05-12 | 2007-12-20 | ケモセントリックス， インコーポレイテッド | アリールスルホンアミド |
| US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| EP1861126A4 (en) | 2005-03-22 | 2009-11-18 | Harvard College | TREATMENT OF PROTEIN REMOVAL TROUBLES |
| US8222423B2 (en) | 2006-02-14 | 2012-07-17 | Dana-Farber Cancer Institute, Inc. | Bifunctional histone deacetylase inhibitors |
| CN103739515B (zh) * | 2006-02-14 | 2015-11-25 | 哈佛大学的校长及成员们 | 组蛋白去乙酰化酶抑制剂 |
| JP5497431B2 (ja) | 2006-05-03 | 2014-05-21 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ヒストンデアセチラーゼおよびチューブリンデアセチラーゼ阻害剤 |
| AU2008240599A1 (en) * | 2007-04-24 | 2008-10-30 | Topotarget A/S | Substituted 3-(4-hydroxyphenyl)-indolin-2-one-compounds |
| JP5665740B2 (ja) | 2008-07-23 | 2015-02-04 | プレジデント アンド フェローズ オブ ハーバード カレッジ | デアセチラーゼ阻害剤およびその使用 |
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| US9421211B2 (en) | 2009-05-28 | 2016-08-23 | President And Fellows Of Harvard College | N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation |
| WO2011019393A2 (en) | 2009-08-11 | 2011-02-17 | President And Fellows Of Harvard College | Class- and isoform-specific hdac inhibitors and uses thereof |
| CN102127002B (zh) * | 2011-01-20 | 2012-06-27 | 华东师范大学 | 一种制备3,3-二芳基取代和3-烷基-3-芳基取代氧化吲哚衍生物的方法 |
| US20160106711A1 (en) * | 2012-09-20 | 2016-04-21 | President And Fellows Of Harvard College | 3-3-Di-Substituted-Oxindoles as Inhibitors of Translation Initiation |
| WO2014113820A1 (en) * | 2013-01-18 | 2014-07-24 | Shapiro David J | Estrogen receptor inhibitors |
| WO2014145386A2 (en) | 2013-03-15 | 2014-09-18 | University Of Florida Research Foundation Incorporated | Novel allosteric inhibitors of thymidylate synthase |
| US9718775B2 (en) | 2014-03-14 | 2017-08-01 | Milliken & Company | Oxindole compounds and compositions comprising the same |
| EA201790317A1 (ru) * | 2014-09-10 | 2018-07-31 | Эпизим, Инк. | Ингибиторы smyd |
| US10076267B2 (en) | 2014-10-03 | 2018-09-18 | General Electric Company | Methods and systems for improved navigation |
| AR105025A1 (es) * | 2015-06-19 | 2017-08-30 | Astellas Pharma Inc | Compuesto de imidazodiazepina |
| US10835524B2 (en) | 2015-06-24 | 2020-11-17 | University Of Florida Research Foundation, Incorporated | Compositions for the treatment of pancreatic cancer and uses thereof |
| WO2020009958A1 (en) * | 2018-07-03 | 2020-01-09 | The Board Of Trustees Of The University Of Illinois | Activators of the unfolded protein response |
| AU2020372895A1 (en) * | 2019-11-01 | 2022-05-26 | Fmc Agro Singapore Pte. Ltd. | An efficient new process for synthesis of 2-amino-5-chloro-N-,3-dimethylbenzamide |
| CN113548999B (zh) * | 2020-04-24 | 2023-04-28 | 复旦大学 | 消旋和手性3-(2,3-丁二烯基)氧化吲哚酮类化合物及制备方法及应用 |
| WO2021222738A1 (en) * | 2020-05-01 | 2021-11-04 | The Board Of Trustees Of The University Of Illinois | Compounds for estrogen receptor positive cancers |
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| CA3189839A1 (en) * | 2020-08-31 | 2023-03-03 | Laura E. BROWN | Novel fungal modulators |
| CN114057624B (zh) * | 2021-12-10 | 2023-09-12 | 贵州大学 | 一种茶香酮拼接氧化吲哚类化合物及其制备方法及应用 |
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| ES426436A1 (es) | 1974-05-18 | 1976-07-01 | Andreu Sa Dr | Procedimiento para la obtencion de derivados de la 3,3-bis (4-hidroxifenil)-2-indolinona. |
| JPS55129284A (en) * | 1979-03-27 | 1980-10-06 | Shionogi & Co Ltd | 3-(1-imipazolyl)indolin-2-one |
| US4522811A (en) * | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
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| US5849780A (en) * | 1992-01-30 | 1998-12-15 | Sanofi | 1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
| JPH07301916A (ja) | 1994-04-28 | 1995-11-14 | Nippon Zeon Co Ltd | ポジ型レジスト組成物 |
| JPH08183853A (ja) | 1994-12-28 | 1996-07-16 | Nippon G Ii Plast Kk | ポリカーボネート、ポリカーボネート組成物およびこれらの製造方法 |
| DE19638888A1 (de) | 1996-09-23 | 1998-03-26 | Bayer Ag | Cokatalysatoren für die Bisphenolsynthese |
| JP4035287B2 (ja) | 2000-12-11 | 2008-01-16 | 本州化学工業株式会社 | イサチンビス（ｏ−クレゾール）の製造方法 |
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| DE10202874A1 (de) | 2002-01-25 | 2003-08-07 | Basf Ag | Verfahren zur Herstellung von 3,3-Bis-(4-hydroxyaryl)- oxindolen |
| AU2003230581A1 (en) * | 2002-03-15 | 2003-09-29 | Eli Lilly And Company | Dihydroindol-2-one derivatives as steroid hormone nuclear receptor modulators |
| EA013209B1 (ru) * | 2004-04-08 | 2010-04-30 | Топотаргет А/С | Производные дифенилоксиндол-2-она и их применение для лечения рака |
| EP2305246B1 (en) | 2005-01-31 | 2015-08-26 | The Trustees of the University of Pennsylvania | Tumor necrosis factor inhibitors |
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| US8044089B2 (en) | 2011-10-25 |
| US20090299058A1 (en) | 2009-12-03 |
| US20100249201A1 (en) | 2010-09-30 |
| WO2005080335A1 (en) | 2005-09-01 |
| US20100256388A1 (en) | 2010-10-07 |
| JP4989976B2 (ja) | 2012-08-01 |
| US7737172B2 (en) | 2010-06-15 |
| EP1718611A1 (en) | 2006-11-08 |
| JP2007522234A (ja) | 2007-08-09 |
| EP1718611A4 (en) | 2009-09-23 |
| AU2005214338A1 (en) | 2005-09-01 |
| US8088816B2 (en) | 2012-01-03 |
| AU2005214338B2 (en) | 2011-11-10 |
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