CA2540977A1 - Methods and compositions for the oral administration of prodrugs of proton pump inhibitors - Google Patents

Methods and compositions for the oral administration of prodrugs of proton pump inhibitors Download PDF

Info

Publication number
CA2540977A1
CA2540977A1 CA002540977A CA2540977A CA2540977A1 CA 2540977 A1 CA2540977 A1 CA 2540977A1 CA 002540977 A CA002540977 A CA 002540977A CA 2540977 A CA2540977 A CA 2540977A CA 2540977 A1 CA2540977 A1 CA 2540977A1
Authority
CA
Canada
Prior art keywords
prodrug
dosage form
membrane permeability
proton pump
pump inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002540977A
Other languages
English (en)
French (fr)
Inventor
Jie Shen
Devin F. Welty
Diane D. Tang-Liu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan, Inc.
Jie Shen
Devin F. Welty
Diane D. Tang-Liu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan, Inc., Jie Shen, Devin F. Welty, Diane D. Tang-Liu filed Critical Allergan, Inc.
Publication of CA2540977A1 publication Critical patent/CA2540977A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002540977A 2003-10-03 2004-10-01 Methods and compositions for the oral administration of prodrugs of proton pump inhibitors Abandoned CA2540977A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US50835603P 2003-10-03 2003-10-03
US60/508,356 2003-10-03
US51388003P 2003-10-22 2003-10-22
US60/513,880 2003-10-22
PCT/US2004/032099 WO2005034951A1 (en) 2003-10-03 2004-10-01 Methods and compositions for the oral administration of prodrugs of proton pump inhibitors

Publications (1)

Publication Number Publication Date
CA2540977A1 true CA2540977A1 (en) 2005-04-21

Family

ID=34437281

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002540977A Abandoned CA2540977A1 (en) 2003-10-03 2004-10-01 Methods and compositions for the oral administration of prodrugs of proton pump inhibitors

Country Status (13)

Country Link
US (1) US20050075371A1 (zh)
EP (1) EP1670467A1 (zh)
JP (1) JP2007518700A (zh)
KR (1) KR20060082082A (zh)
AR (1) AR045857A1 (zh)
AU (1) AU2004279378A1 (zh)
BR (1) BRPI0415044A (zh)
CA (1) CA2540977A1 (zh)
IL (1) IL174265A0 (zh)
MX (1) MXPA06003461A (zh)
NO (1) NO20061354L (zh)
TW (1) TW200522956A (zh)
WO (1) WO2005034951A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070060621A1 (en) * 2004-02-18 2007-03-15 Hughes Patrick M Methods and compositions for the administration of prodrugs of proton pump inhibitors
BRPI0507837A (pt) * 2004-02-18 2007-07-10 Allergan Inc métodos e composições para a administração intravenosa de compostos relacionados a inibidores de bomba de prótons
WO2007081871A1 (en) * 2006-01-10 2007-07-19 Allergan, Inc. Therapeutic salt compositions of sulfonyl ester prodrugs of proton pump inhibitors and methods for their preparation

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE416649B (sv) * 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
IL75400A (en) * 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
FI90544C (fi) * 1986-11-13 1994-02-25 Eisai Co Ltd Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi
US4965269A (en) * 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles
ATE184602T1 (de) * 1990-06-20 1999-10-15 Astra Ab Dialkoxypyridinylbenzimidazolderivate, verfahren zur herstellung und ihre pharmazeutische verwendung
SE9301830D0 (sv) * 1993-05-28 1993-05-28 Ab Astra New compounds
US5708017A (en) * 1995-04-04 1998-01-13 Merck & Co., Inc. Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors
SE510650C2 (sv) * 1997-05-30 1999-06-14 Astra Ab Ny förening
US6093734A (en) * 1998-08-10 2000-07-25 Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin Prodrugs of proton pump inhibitors
CA2338311C (en) * 1998-08-10 2007-01-23 Michael E. Garst Prodrugs of the pyridyl methyl sulfinyl benzimidazoles
EP1556371B1 (en) * 2002-07-19 2006-04-19 Winston Pharmaceuticals LLC Benzimidazole derivatives and their use as prodrugs of proton pump inhibitor
MXPA06000410A (es) * 2003-07-15 2006-03-17 Allergan Inc Procedimiento para preparar profarmacos isomericamente puros de inhibidores de la bomba de protones.

Also Published As

Publication number Publication date
IL174265A0 (en) 2006-08-01
AU2004279378A1 (en) 2005-04-21
JP2007518700A (ja) 2007-07-12
TW200522956A (en) 2005-07-16
WO2005034951A1 (en) 2005-04-21
KR20060082082A (ko) 2006-07-14
AR045857A1 (es) 2005-11-16
NO20061354L (no) 2006-05-03
US20050075371A1 (en) 2005-04-07
BRPI0415044A (pt) 2006-12-12
MXPA06003461A (es) 2006-06-05
EP1670467A1 (en) 2006-06-21

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Legal Events

Date Code Title Description
FZDE Discontinued