CA2540342A1 - 4-amino (aza) quinoline derivatives as capsaicin receptor agonists - Google Patents
4-amino (aza) quinoline derivatives as capsaicin receptor agonists Download PDFInfo
- Publication number
- CA2540342A1 CA2540342A1 CA002540342A CA2540342A CA2540342A1 CA 2540342 A1 CA2540342 A1 CA 2540342A1 CA 002540342 A CA002540342 A CA 002540342A CA 2540342 A CA2540342 A CA 2540342A CA 2540342 A1 CA2540342 A1 CA 2540342A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- amine
- trifluoromethyl
- salt according
- ylmethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 102000011040 TRPV Cation Channels Human genes 0.000 title claims abstract description 174
- 229940044601 receptor agonist Drugs 0.000 title claims abstract description 116
- 239000000018 receptor agonist Substances 0.000 title claims abstract description 116
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title claims description 4
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- FEMVRMTZUODENK-UHFFFAOYSA-N 3-fluoro-n-[5-(trifluoromethyl)thiophen-2-yl]pyrido[2,3-b]pyrazin-8-amine Chemical compound C=1C=NC2=NC(F)=CN=C2C=1NC1=CC=C(C(F)(F)F)S1 FEMVRMTZUODENK-UHFFFAOYSA-N 0.000 claims description 2
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- JQEVLWMZLHMXTQ-UHFFFAOYSA-N n-(7-chloro-1,8-naphthyridin-4-yl)-2-methyl-1,3-thiazol-5-amine Chemical compound S1C(C)=NC=C1NC1=CC=NC2=NC(Cl)=CC=C12 JQEVLWMZLHMXTQ-UHFFFAOYSA-N 0.000 claims description 2
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- TVBBAECERWQUKW-UHFFFAOYSA-N n-[2-methyl-7-(trifluoromethyl)quinazolin-4-yl]-2-(trifluoromethyl)-1,3-thiazol-5-amine Chemical compound C=12C=CC(C(F)(F)F)=CC2=NC(C)=NC=1NC1=CN=C(C(F)(F)F)S1 TVBBAECERWQUKW-UHFFFAOYSA-N 0.000 claims description 2
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- SOIVVERMMKARJC-UHFFFAOYSA-N 1-(2,4-dichlorophenyl)-n-[(2-ethoxynaphthalen-1-yl)methyl]-n-[(6-fluoro-1-propylbenzimidazol-2-yl)methyl]methanamine Chemical compound N=1C2=CC=C(F)C=C2N(CCC)C=1CN(CC=1C2=CC=CC=C2C=CC=1OCC)CC1=CC=C(Cl)C=C1Cl SOIVVERMMKARJC-UHFFFAOYSA-N 0.000 claims 1
- HVRLYJRVWOJWNF-UHFFFAOYSA-N 1-(2,4-dichlorophenyl)-n-[(2-ethoxynaphthalen-1-yl)methyl]-n-[[1-(2-methoxyethyl)benzimidazol-2-yl]methyl]methanamine Chemical compound CCOC1=CC=C2C=CC=CC2=C1CN(CC=1N(C2=CC=CC=C2N=1)CCOC)CC1=CC=C(Cl)C=C1Cl HVRLYJRVWOJWNF-UHFFFAOYSA-N 0.000 claims 1
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- VSZAVNCUXDQZQE-UHFFFAOYSA-N 2-(3-chlorophenyl)-n-[(3-methoxyphenyl)methyl]pyridine-4-carboxamide Chemical compound COC1=CC=CC(CNC(=O)C=2C=C(N=CC=2)C=2C=C(Cl)C=CC=2)=C1 VSZAVNCUXDQZQE-UHFFFAOYSA-N 0.000 claims 1
- YSOHFFXSRTZDBS-UHFFFAOYSA-N 2-(3-chlorophenyl)-n-[[3-(difluoromethoxy)phenyl]methyl]-1,6-naphthyridine-4-carboxamide Chemical compound FC(F)OC1=CC=CC(CNC(=O)C=2C3=CN=CC=C3N=C(C=2)C=2C=C(Cl)C=CC=2)=C1 YSOHFFXSRTZDBS-UHFFFAOYSA-N 0.000 claims 1
- HNOOCWMFLUSLIP-UHFFFAOYSA-N 2-(3-chlorophenyl)-n-[[3-(trifluoromethyl)phenyl]methyl]-1,6-naphthyridine-4-carboxamide Chemical compound FC(F)(F)C1=CC=CC(CNC(=O)C=2C3=CN=CC=C3N=C(C=2)C=2C=C(Cl)C=CC=2)=C1 HNOOCWMFLUSLIP-UHFFFAOYSA-N 0.000 claims 1
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- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Manufacturing & Machinery (AREA)
- Pulmonology (AREA)
- Ceramic Engineering (AREA)
- Urology & Nephrology (AREA)
- Inorganic Chemistry (AREA)
- Structural Engineering (AREA)
- Materials Engineering (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51624603P | 2003-10-31 | 2003-10-31 | |
| US60/516,246 | 2003-10-31 | ||
| PCT/US2004/036295 WO2005042498A2 (en) | 2003-10-31 | 2004-10-28 | 4-amino (aza) quinoline derivatives as capsaicin receptor agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2540342A1 true CA2540342A1 (en) | 2005-05-12 |
Family
ID=34549510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002540342A Abandoned CA2540342A1 (en) | 2003-10-31 | 2004-10-28 | 4-amino (aza) quinoline derivatives as capsaicin receptor agonists |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20060194805A1 (cg-RX-API-DMAC10.html) |
| EP (1) | EP1678149A2 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2007509985A (cg-RX-API-DMAC10.html) |
| CN (1) | CN1890223A (cg-RX-API-DMAC10.html) |
| AU (1) | AU2004285052A1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2540342A1 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2005042498A2 (cg-RX-API-DMAC10.html) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003296984A1 (en) * | 2002-12-13 | 2004-07-09 | Neurogen Corporation | 2-substituted quinazolin-4-ylamine analogues as capsaicin receptor modulators |
| CN1964717A (zh) * | 2004-04-08 | 2007-05-16 | 神经能质公司 | 经取代∴啉－4－基胺 |
| WO2007081517A2 (en) | 2005-12-21 | 2007-07-19 | Abbott Laboratories | Anti-viral compounds |
| ATE541844T1 (de) * | 2005-12-21 | 2012-02-15 | Abbott Lab | Antivirale verbindungen |
| US9757476B2 (en) | 2006-06-08 | 2017-09-12 | Warsaw Orthopedic, Inc. | Compositions and methods for diagnosis of axial pain with or without radiculopathy |
| CN101479269A (zh) * | 2006-06-23 | 2009-07-08 | 阿斯利康(瑞典)有限公司 | 蝶啶衍生物及其作为组织蛋白酶抑制剂的用途 |
| US7943666B2 (en) * | 2006-07-24 | 2011-05-17 | Trinity Laboratories, Inc. | Esters of capsaicin for treating pain |
| JP2010501593A (ja) * | 2006-08-24 | 2010-01-21 | セレネックス， インコーポレイテッド | イソキノリン、キナゾリンおよびフタラジン誘導体 |
| US7645767B2 (en) | 2006-08-31 | 2010-01-12 | Trinity Laboratories, Inc. | Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy |
| WO2008076752A1 (en) * | 2006-12-15 | 2008-06-26 | Janssen Pharmaceutica N.V. | Benzimidazole trpv1 inhibitors |
| EP2094276A4 (en) | 2006-12-20 | 2011-01-05 | Abbott Lab | ANTIVIRAL COMPOUNDS |
| ES2569660T3 (es) | 2007-06-08 | 2016-05-12 | Mannkind Corporation | Inhibidores de la IRE-1alfa |
| AU2008343932B2 (en) | 2007-12-19 | 2013-08-15 | Amgen Inc. | Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors |
| BRPI0905715A2 (pt) * | 2008-02-15 | 2015-07-14 | Bone Therapeutics | Composição farmacêutica e kit de componentes |
| US20100285134A1 (en) | 2008-02-15 | 2010-11-11 | Bone Therepeutics | Pharmaceutical composition for use in the treatment and/or the prevention of osteoarticular diseases |
| ATE531372T1 (de) * | 2008-04-07 | 2011-11-15 | Amgen Inc | Gem-disubstituierte und spirocyclische aminopyridine/pyrimidine als zellcyclus- inhibitoren |
| BRPI0916576A2 (pt) | 2008-08-04 | 2017-06-27 | Chdi Inc | pelo menos uma entidade química, composição farmacêutica, e, método para tratar uma condição ou distúrbio. |
| CA2752885A1 (en) | 2009-02-27 | 2010-09-02 | Ambit Biosciences Corporation | Jak kinase modulating quinazoline derivatives and methods of use thereof |
| EP2427056A4 (en) * | 2009-05-07 | 2012-08-22 | Univ Cincinnati | METHODS FOR PREVENTING ISCHEMIC LESION BY STIMULATION OF PERIPHERAL NICE PERIPHERAL |
| NZ601547A (en) | 2010-01-25 | 2014-04-30 | Chdi Foundation Inc | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| EP2611789A1 (en) | 2010-09-01 | 2013-07-10 | Ambit Biosciences Corporation | Quinazoline compounds and methods of use thereof |
| WO2012060845A1 (en) * | 2010-11-05 | 2012-05-10 | University Of Cincinnati | Methods of preventing ischemic injury using peripheral nociceptive stimulation |
| CN102091061B (zh) * | 2010-11-12 | 2012-07-04 | 河北医科大学 | 1,2-二苯乙烯衍生物在制药中的应用 |
| ES2542647T3 (es) | 2011-03-09 | 2015-08-07 | Merck Patent Gmbh | Derivados de pirido[2,3 b]pirazina y sus usos terapéuticos |
| KR101606250B1 (ko) | 2011-03-23 | 2016-03-24 | 암젠 인크 | Cdk 4/6 및 flt3의 융합된 트리사이클릭 이중 저해제 |
| WO2013033068A1 (en) | 2011-08-30 | 2013-03-07 | Stephen Martin Courtney | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| SG2014012926A (en) | 2011-08-30 | 2014-06-27 | Chdi Foundation Inc | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| AU2014209107B2 (en) * | 2013-01-28 | 2018-04-12 | Viamet Pharmaceuticals (NC), Inc. | Metalloenzyme inhibitor compounds |
| US10092528B2 (en) | 2013-03-13 | 2018-10-09 | Altria Client Services Llc | Application of encapsulated capsaicin and analogues thereof for controlling calorie intake |
| MX372995B (es) | 2014-07-17 | 2020-04-13 | Chdi Foundation Inc | Metodos y composiciones para el tratamiento de trastornos relacionados con vih. |
| JP6899323B2 (ja) | 2014-10-14 | 2021-07-07 | ラ ホーヤ インスティテュート オブ アレルギー アンド イミュノロジー | 低分子量タンパク質チロシンホスファターゼの阻害剤、及びその使用 |
| US11066420B2 (en) * | 2017-05-01 | 2021-07-20 | Sanford Burnham Prebys Medical Discovery Institute | Inhibitors of low molecular weight protein tyrosine phosphatase (LMPTP) and uses thereof |
| EP3735408B1 (en) | 2018-01-05 | 2023-11-29 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Substituted halo-quinoline derivatives, method of preparation and applications thereof |
| CN108863949B (zh) * | 2018-07-09 | 2021-01-15 | 湖南博隽生物医药有限公司 | 一种用于治疗慢性炎性痛的辣椒素受体拮抗剂及合成方法 |
| EP3959197A4 (en) * | 2019-04-24 | 2022-10-12 | Children's Medical Center Corporation | PAPD5 INHIBITORS AND METHODS OF USE THEREOF |
| WO2023081800A1 (en) * | 2021-11-05 | 2023-05-11 | The Regents Of The University Of California | Alpha-2a adrenergic receptor modulators and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5538325A (en) * | 1978-09-11 | 1980-03-17 | Sankyo Co Ltd | 4-anilinoquinazoline derivative and its preparation |
| US5034393A (en) * | 1989-07-27 | 1991-07-23 | Dowelanco | Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives |
| GB9922171D0 (en) * | 1999-09-21 | 1999-11-17 | Zeneca Ltd | Chemical compounds |
| HK1046688A1 (zh) * | 1999-09-21 | 2003-01-24 | Astrazeneca Ab | 喹唑啉化合物和含有喹唑啉化合物的藥物組合物 |
| BR0111754A (pt) * | 2000-06-28 | 2003-04-29 | Astrazeneca Ab | Uso de um composto, método para inibir aurora 2 quinase em um animal de sangue quente, composto, e, composição farmacêutica |
| RS63204A (sr) * | 2002-01-17 | 2006-10-27 | Neurogen Corporation | Supstituisani analozi hinazolin-4-ilamina kao modulatori kapsaicina |
-
2004
- 2004-10-28 EP EP04796879A patent/EP1678149A2/en not_active Withdrawn
- 2004-10-28 AU AU2004285052A patent/AU2004285052A1/en not_active Abandoned
- 2004-10-28 JP JP2006538401A patent/JP2007509985A/ja not_active Withdrawn
- 2004-10-28 WO PCT/US2004/036295 patent/WO2005042498A2/en not_active Ceased
- 2004-10-28 CA CA002540342A patent/CA2540342A1/en not_active Abandoned
- 2004-10-28 CN CNA2004800367091A patent/CN1890223A/zh active Pending
-
2006
- 2006-04-26 US US11/412,526 patent/US20060194805A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005042498A3 (en) | 2005-07-07 |
| US20060194805A1 (en) | 2006-08-31 |
| WO2005042498A2 (en) | 2005-05-12 |
| CN1890223A (zh) | 2007-01-03 |
| JP2007509985A (ja) | 2007-04-19 |
| AU2004285052A1 (en) | 2005-05-12 |
| EP1678149A2 (en) | 2006-07-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |