CA2537034C - Mass spectrometry methods for simultaneous detection of metabolic enzyme activity and metabolite levels - Google Patents

Mass spectrometry methods for simultaneous detection of metabolic enzyme activity and metabolite levels Download PDF

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Publication number
CA2537034C
CA2537034C CA2537034A CA2537034A CA2537034C CA 2537034 C CA2537034 C CA 2537034C CA 2537034 A CA2537034 A CA 2537034A CA 2537034 A CA2537034 A CA 2537034A CA 2537034 C CA2537034 C CA 2537034C
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CA
Canada
Prior art keywords
disease
metabolic
deficiency
sample
disorder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2537034A
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English (en)
French (fr)
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CA2537034A1 (en
Inventor
Blas Cerda
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Revvity Health Sciences Inc
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PerkinElmer LAS Inc
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Publication of CA2537034A1 publication Critical patent/CA2537034A1/en
Application granted granted Critical
Publication of CA2537034C publication Critical patent/CA2537034C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/04Endocrine or metabolic disorders

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CA2537034A 2003-08-29 2004-08-30 Mass spectrometry methods for simultaneous detection of metabolic enzyme activity and metabolite levels Expired - Lifetime CA2537034C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/652,732 US20050048499A1 (en) 2003-08-29 2003-08-29 Tandem mass spectrometry method for the genetic screening of inborn errors of metabolism in newborns
US10/652,732 2003-08-29
PCT/US2004/028238 WO2005021779A1 (en) 2003-08-29 2004-08-30 Mass spectrometry methods for simultaneous detection of metabolic enzyme activity and metabolite levels

Publications (2)

Publication Number Publication Date
CA2537034A1 CA2537034A1 (en) 2005-03-10
CA2537034C true CA2537034C (en) 2015-11-17

Family

ID=34217718

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2537034A Expired - Lifetime CA2537034C (en) 2003-08-29 2004-08-30 Mass spectrometry methods for simultaneous detection of metabolic enzyme activity and metabolite levels

Country Status (7)

Country Link
US (4) US20050048499A1 (enExample)
EP (1) EP1664325B1 (enExample)
JP (2) JP4838129B2 (enExample)
AU (1) AU2004269410B2 (enExample)
CA (1) CA2537034C (enExample)
ES (1) ES2527306T3 (enExample)
WO (1) WO2005021779A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050048499A1 (en) * 2003-08-29 2005-03-03 Perkin Elmer Life Sciences, Inc. Tandem mass spectrometry method for the genetic screening of inborn errors of metabolism in newborns
US7485435B2 (en) * 2004-08-30 2009-02-03 Perkinelmer Las, Inc. Simultaneous detection of metabolic enzyme activity and metabolite levels
JP5009784B2 (ja) * 2004-04-30 2012-08-22 マイクロマス ユーケー リミテッド 質量分析計
GB0409676D0 (en) * 2004-04-30 2004-06-02 Micromass Ltd Mass spectrometer
DE602005016899D1 (de) * 2005-05-20 2009-11-12 Germediq Forsch & Entw Ges Mbh Verfahren zur Bestimmung von kardiovaskulären Risikofaktoren
JP5005955B2 (ja) * 2006-05-24 2012-08-22 田辺三菱製薬株式会社 被験物質の脂質代謝異常症誘発可能性を予測する方法
EP2061899B1 (en) * 2006-09-19 2012-08-29 Metabolon Inc. Biomarkers for prostate cancer and methods using the same
US7923257B2 (en) * 2007-05-04 2011-04-12 Perkinelmer Health Sciences, Inc. Detecting isomers using differential derivatization mass spectrometry
CN101796408B (zh) * 2007-06-29 2014-05-07 奎斯特诊断投资公司 用液相层析-质谱法分析体液内的氨基酸
AU2008332886B2 (en) * 2007-12-05 2014-10-09 Spoton Clinical Diagnostics Limited Methods and compositions
FI20090100A0 (fi) * 2009-03-16 2009-03-16 Wallac Oy Biotinidaasimääritys
DE112015001169T5 (de) 2014-03-10 2016-12-22 Micromass Uk Limited Bestätigung unter Verwendung einer Mehrzahl von Kollisionsquerschnitts-("CCS")-Messungen
WO2015152234A1 (ja) 2014-03-31 2015-10-08 積水メディカル株式会社 アシルカルニチン組成物
JP6101385B2 (ja) * 2015-04-24 2017-03-22 株式会社 資生堂 分析方法
WO2016171182A1 (ja) * 2015-04-24 2016-10-27 株式会社資生堂 分析方法及び内部標準物質
CN105510583A (zh) * 2015-11-25 2016-04-20 北京中科非凡生物技术有限公司 检测生物素酶酶活性的试剂盒
EP3443497A1 (en) * 2016-04-11 2019-02-20 DiscernDx, Inc. Mass spectrometric data analysis workflow
WO2018174858A1 (en) * 2017-03-21 2018-09-27 Mprobe Inc. Clinical method for the population screening of adult metabolic disorder associated with chronic human disease
CN111272888A (zh) * 2020-01-10 2020-06-12 山东英盛生物技术有限公司 一种新生儿血片中氨基酸及肉碱筛查预处理方法
US20220395767A1 (en) * 2021-06-15 2022-12-15 Perkinelmer Health Sciences, Inc. Enhancing lcms analyte signals
CN114121275B (zh) * 2021-11-02 2024-09-27 浙江大学 一种基于大数据遗传代谢病筛查效率提升的智能分析方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5096812A (en) * 1989-06-08 1992-03-17 Osborn Laboratories, Inc. Assay method for gamma glutamyltransferase (GGT) in liquid blood and dried blood
US5538857A (en) * 1994-06-01 1996-07-23 Isolab, Inc. Assay for enzyme activity from a red blood sample using a direct microfluorometric assay
US5629210A (en) * 1995-06-02 1997-05-13 University Of Pittsburgh Of The Commonwealth System Of Higher Education Rapid screening test for smith-lemli-opitz syndrome
ATE253126T1 (de) * 1998-08-25 2003-11-15 Univ Washington Schnelle quantitative analyse von proteinen oder proteinfunktionen in komplexen gemischen
WO2000026677A1 (en) 1998-10-30 2000-05-11 Burstein Laboratories, Inc. Trackable optical discs with concurrently readable analyte material
US6455321B1 (en) * 1999-01-30 2002-09-24 Neo Gen Screening, Inc. Method for interpreting tandem mass spectrometry data for clinical diagnosis
US6258605B1 (en) * 1999-03-26 2001-07-10 Neo Gen Screening, Inc. Clinical method for the genetic screening of newborns using tandem mass spectrometry
DE60031357T2 (de) * 1999-12-29 2007-08-30 PerkinElmer Life Sciences, Inc., Norton Geräte, Kits und Verfahren zum Testen von Körperflüssigkeiten zum Screening vonNeugeborenen durch Tandem-Massenspektrometrie-Kits
US20050048499A1 (en) * 2003-08-29 2005-03-03 Perkin Elmer Life Sciences, Inc. Tandem mass spectrometry method for the genetic screening of inborn errors of metabolism in newborns

Also Published As

Publication number Publication date
US20090111137A1 (en) 2009-04-30
JP2007503818A (ja) 2007-03-01
EP1664325A4 (en) 2008-04-30
US20050048499A1 (en) 2005-03-03
EP1664325A1 (en) 2006-06-07
AU2004269410A1 (en) 2005-03-10
AU2004269410B2 (en) 2008-12-18
US8318417B2 (en) 2012-11-27
WO2005021779A1 (en) 2005-03-10
ES2527306T3 (es) 2015-01-22
US20120122131A1 (en) 2012-05-17
CA2537034A1 (en) 2005-03-10
EP1664325B1 (en) 2014-10-08
JP2011167208A (ja) 2011-09-01
US20060234326A1 (en) 2006-10-19
US8399186B2 (en) 2013-03-19
JP4838129B2 (ja) 2011-12-14

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