AU2004269410B2 - Mass spectrometry methods for simultaneous detection of metabolic enzyme activity and metabolite levels - Google Patents

Mass spectrometry methods for simultaneous detection of metabolic enzyme activity and metabolite levels Download PDF

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Publication number
AU2004269410B2
AU2004269410B2 AU2004269410A AU2004269410A AU2004269410B2 AU 2004269410 B2 AU2004269410 B2 AU 2004269410B2 AU 2004269410 A AU2004269410 A AU 2004269410A AU 2004269410 A AU2004269410 A AU 2004269410A AU 2004269410 B2 AU2004269410 B2 AU 2004269410B2
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AU
Australia
Prior art keywords
metabolic
sample
product
analytes
enzymes
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Expired
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AU2004269410A
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English (en)
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AU2004269410A1 (en
Inventor
Blas Cerda
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Revvity Health Sciences Inc
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PerkinElmer Health Sciences Inc
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Publication of AU2004269410A1 publication Critical patent/AU2004269410A1/en
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Assigned to PERKINELMER HEALTH SCIENCES, INC. reassignment PERKINELMER HEALTH SCIENCES, INC. Request to Amend Deed and Register Assignors: PERKINELMER LAS, INC.
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AU2004269410A 2003-08-29 2004-08-30 Mass spectrometry methods for simultaneous detection of metabolic enzyme activity and metabolite levels Expired AU2004269410B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/652,732 2003-08-29
US10/652,732 US20050048499A1 (en) 2003-08-29 2003-08-29 Tandem mass spectrometry method for the genetic screening of inborn errors of metabolism in newborns
PCT/US2004/028238 WO2005021779A1 (en) 2003-08-29 2004-08-30 Mass spectrometry methods for simultaneous detection of metabolic enzyme activity and metabolite levels

Publications (2)

Publication Number Publication Date
AU2004269410A1 AU2004269410A1 (en) 2005-03-10
AU2004269410B2 true AU2004269410B2 (en) 2008-12-18

Family

ID=34217718

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2004269410A Expired AU2004269410B2 (en) 2003-08-29 2004-08-30 Mass spectrometry methods for simultaneous detection of metabolic enzyme activity and metabolite levels

Country Status (7)

Country Link
US (4) US20050048499A1 (enExample)
EP (1) EP1664325B1 (enExample)
JP (2) JP4838129B2 (enExample)
AU (1) AU2004269410B2 (enExample)
CA (1) CA2537034C (enExample)
ES (1) ES2527306T3 (enExample)
WO (1) WO2005021779A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7485435B2 (en) * 2004-08-30 2009-02-03 Perkinelmer Las, Inc. Simultaneous detection of metabolic enzyme activity and metabolite levels
US20050048499A1 (en) * 2003-08-29 2005-03-03 Perkin Elmer Life Sciences, Inc. Tandem mass spectrometry method for the genetic screening of inborn errors of metabolism in newborns
GB0409676D0 (en) * 2004-04-30 2004-06-02 Micromass Ltd Mass spectrometer
WO2005106453A2 (en) * 2004-04-30 2005-11-10 Micromass Uk Limited Mass spectrometer
ATE444491T1 (de) * 2005-05-20 2009-10-15 Germediq Forsch & Entw Ges Mbh Verfahren zur bestimmung von kardiovaskulären risikofaktoren
JP5005955B2 (ja) * 2006-05-24 2012-08-22 田辺三菱製薬株式会社 被験物質の脂質代謝異常症誘発可能性を予測する方法
EP2560006A3 (en) 2006-09-19 2013-06-12 Metabolon Inc. Biomarkers for prostate cancer and methods using the same
US7923257B2 (en) * 2007-05-04 2011-04-12 Perkinelmer Health Sciences, Inc. Detecting isomers using differential derivatization mass spectrometry
CA2691974C (en) * 2007-06-29 2016-08-30 Quest Diagnostics Investments Incorporated Analysis of amino acids in body fluid by liquid chromatography-mass spectrometry
US8628936B2 (en) 2007-12-05 2014-01-14 King's College London Methods and compositions for multiplexed screening of disease
FI20090100A0 (fi) * 2009-03-16 2009-03-16 Wallac Oy Biotinidaasimääritys
DE112015001188B4 (de) * 2014-03-10 2026-01-08 Micromass Uk Limited Identifikation von Unbekannten unter Heranziehung eines theoretischen Kollisionsquerschnitts
WO2015152234A1 (ja) 2014-03-31 2015-10-08 積水メディカル株式会社 アシルカルニチン組成物
JP6101385B2 (ja) * 2015-04-24 2017-03-22 株式会社 資生堂 分析方法
WO2016171182A1 (ja) * 2015-04-24 2016-10-27 株式会社資生堂 分析方法及び内部標準物質
CN105510583A (zh) * 2015-11-25 2016-04-20 北京中科非凡生物技术有限公司 检测生物素酶酶活性的试剂盒
US20190130994A1 (en) * 2016-04-11 2019-05-02 Discerndx, Inc. Mass Spectrometric Data Analysis Workflow
WO2018174858A1 (en) * 2017-03-21 2018-09-27 Mprobe Inc. Clinical method for the population screening of adult metabolic disorder associated with chronic human disease
CN111272888A (zh) * 2020-01-10 2020-06-12 山东英盛生物技术有限公司 一种新生儿血片中氨基酸及肉碱筛查预处理方法
US20220395767A1 (en) * 2021-06-15 2022-12-15 Perkinelmer Health Sciences, Inc. Enhancing lcms analyte signals
CN114121275B (zh) * 2021-11-02 2024-09-27 浙江大学 一种基于大数据遗传代谢病筛查效率提升的智能分析方法
EP4679082A1 (en) 2024-07-10 2026-01-14 Masdiag Sp. z o.o. Method for improved determination of the acylcarnitine profile in biological material

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5096812A (en) * 1989-06-08 1992-03-17 Osborn Laboratories, Inc. Assay method for gamma glutamyltransferase (GGT) in liquid blood and dried blood
US5538857A (en) * 1994-06-01 1996-07-23 Isolab, Inc. Assay for enzyme activity from a red blood sample using a direct microfluorometric assay
US5629210A (en) * 1995-06-02 1997-05-13 University Of Pittsburgh Of The Commonwealth System Of Higher Education Rapid screening test for smith-lemli-opitz syndrome
EP1329513B1 (en) * 1998-08-25 2011-12-07 University of Washington Rapid quantitative analysis of proteins or protein function in complex mixtures
CN1332850A (zh) 1998-10-30 2002-01-23 伯斯坦技术公司 具有同时可读分析物材料的可跟踪光盘
US6258605B1 (en) * 1999-03-26 2001-07-10 Neo Gen Screening, Inc. Clinical method for the genetic screening of newborns using tandem mass spectrometry
US6455321B1 (en) * 1999-01-30 2002-09-24 Neo Gen Screening, Inc. Method for interpreting tandem mass spectrometry data for clinical diagnosis
EP1113269B1 (en) 1999-12-29 2006-10-18 PerkinElmer Life Sciences, Inc. Test tray, kit and methods for screening body fluids of newborns by tandem mass spectrometry
US20050048499A1 (en) 2003-08-29 2005-03-03 Perkin Elmer Life Sciences, Inc. Tandem mass spectrometry method for the genetic screening of inborn errors of metabolism in newborns

Also Published As

Publication number Publication date
JP4838129B2 (ja) 2011-12-14
CA2537034C (en) 2015-11-17
AU2004269410A1 (en) 2005-03-10
US20050048499A1 (en) 2005-03-03
WO2005021779A1 (en) 2005-03-10
JP2007503818A (ja) 2007-03-01
US20120122131A1 (en) 2012-05-17
US8399186B2 (en) 2013-03-19
EP1664325B1 (en) 2014-10-08
US8318417B2 (en) 2012-11-27
CA2537034A1 (en) 2005-03-10
EP1664325A1 (en) 2006-06-07
US20060234326A1 (en) 2006-10-19
ES2527306T3 (es) 2015-01-22
US20090111137A1 (en) 2009-04-30
EP1664325A4 (en) 2008-04-30
JP2011167208A (ja) 2011-09-01

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired