CA2535255A1 - Improved halohydrin dehalogenases and related polynucleotides - Google Patents
Improved halohydrin dehalogenases and related polynucleotides Download PDFInfo
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- CA2535255A1 CA2535255A1 CA002535255A CA2535255A CA2535255A1 CA 2535255 A1 CA2535255 A1 CA 2535255A1 CA 002535255 A CA002535255 A CA 002535255A CA 2535255 A CA2535255 A CA 2535255A CA 2535255 A1 CA2535255 A1 CA 2535255A1
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- C12N15/09—Recombinant DNA-technology
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- C12N15/52—Genes encoding for enzymes or proenzymes
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| JP5191399B2 (ja) | 2006-03-03 | 2013-05-08 | ビーエーエスエフ ソシエタス・ヨーロピア | ハロヒドリンデハロゲナーゼを用いたラセミ体のエポキシドおよびシアン酸からの光学活性５−置換２−オキサゾリジノンの製造方法 |
| CN101528917B (zh) | 2006-10-02 | 2015-07-29 | 科德克希思公司 | 用于制备立体异构纯的他汀类及其合成中间体的组合物和方法 |
| EP2130922A4 (en) * | 2007-03-07 | 2010-03-31 | Mitsubishi Rayon Co | IMPROVED HALOHYDRIN EPOXIDASE |
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| DK3023494T3 (en) | 2008-06-13 | 2019-02-25 | Codexis Inc | PROCEDURE FOR SYNTHESIS OF POLYNUCLEOTIDE VARIETIES |
| US20090312196A1 (en) | 2008-06-13 | 2009-12-17 | Codexis, Inc. | Method of synthesizing polynucleotide variants |
| US8288131B2 (en) * | 2008-08-27 | 2012-10-16 | Codexis, Inc. | Ketoreductase polypeptides and uses thereof |
| EP2329013B1 (en) | 2008-08-27 | 2015-10-28 | Codexis, Inc. | Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| SG172231A1 (en) * | 2008-12-18 | 2011-07-28 | Codexis Inc | Recombinant halohydrin dehalogenase polypeptides |
| SG173815A1 (en) | 2009-02-26 | 2011-09-29 | Codexis Inc | Transaminase biocatalysts |
| EP2446026B1 (en) | 2009-06-22 | 2017-08-09 | Codexis, Inc. | Transaminase reactions |
| EP3409765B1 (en) | 2009-06-22 | 2021-08-04 | Codexis, Inc. | Ketoreductase-mediated stereoselective route to alpha chloroalcohols |
| EP2478137B1 (en) | 2009-09-18 | 2017-09-13 | Codexis, Inc. | Reduced codon mutagenesis |
| US20110082055A1 (en) * | 2009-09-18 | 2011-04-07 | Codexis, Inc. | Reduced codon mutagenesis |
| EP2510089B1 (en) | 2009-12-08 | 2015-10-21 | Codexis, Inc. | Synthesis of prazole compounds |
| WO2011140219A1 (en) | 2010-05-04 | 2011-11-10 | Codexis, Inc. | Biocatalysts for ezetimibe synthesis |
| EP2606139B1 (en) | 2010-08-16 | 2015-07-15 | Codexis, Inc. | Biocatalysts and methods for the synthesis of (1r,2r)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine |
| US9267159B2 (en) | 2010-12-08 | 2016-02-23 | Codexis, Inc. | Biocatalysts and methods for the synthesis of armodafinil |
| HUE038800T2 (hu) | 2011-04-13 | 2018-11-28 | Codexis Inc | Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására |
| US9139819B2 (en) | 2011-11-18 | 2015-09-22 | Codexis, Inc. | Biocatalysts for the preparation of hydroxy substituted carbamates |
| HUE036947T2 (hu) | 2012-05-11 | 2018-08-28 | Codexis Inc | Átalakított iminreduktázok és eljárások keton- és aminvegyületek reduktív aminálására |
| CN104372038A (zh) * | 2013-08-12 | 2015-02-25 | 南京朗恩生物科技有限公司 | 两步催化制备(r)-4-氰基-3-羟基丁酸乙酯的方法 |
| JP6643987B2 (ja) | 2013-11-13 | 2020-02-12 | コデクシス， インコーポレイテッド | ケトン化合物およびアミン化合物の還元的アミノ化のための操作されたイミンレダクターゼおよび方法 |
| US10370648B2 (en) | 2014-11-25 | 2019-08-06 | Codexis, Inc. | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
| US10696953B2 (en) | 2015-02-10 | 2020-06-30 | Codexis, Inc. | Ketoreductase polypeptides for the synthesis of chiral compounds |
| CN104745557B (zh) * | 2015-03-05 | 2017-09-22 | 浙江工业大学 | 来源于嗜清洁细小杆菌卤醇脱卤酶突变体及其应用 |
| EP3093337A3 (en) | 2015-05-13 | 2017-03-15 | Samsung Electronics Co., Ltd. | Microorganism including gene encoding protein having hydroxylase activity and method of reducing concentration of fluorinated methane in sample using the same |
| EP3178922B1 (en) | 2015-12-07 | 2019-05-22 | Samsung Electronics Co., Ltd. | Bacterial cytochrome p450 protein variant and method of reducing concentration of fluorinated methane in sample using the same |
| ES2975412T3 (es) | 2018-06-21 | 2024-07-05 | Fis Fabbrica Italiana Sintetici Spa | Proceso enzimático para la preparación de droxidopa |
| CN109295044A (zh) * | 2018-10-26 | 2019-02-01 | 浙江大学 | 一种卤醇脱卤酶突变体及其应用 |
| BR112021008642A2 (pt) * | 2018-11-07 | 2021-08-10 | The Royal Institution For The Advancement Of Learning/ Mcgill University | compostos peptídicos indutores de testosterona e combinações associadas |
| EP4649143A1 (en) | 2023-01-12 | 2025-11-19 | Novartis AG | Engineered ketoreductase polypeptides |
| CN119530210B (zh) * | 2024-11-12 | 2025-10-03 | 南京师范大学 | 卤醇脱卤酶突变体及编码基因、重组载体、重组菌株、酶制剂和应用 |
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| EP0879890A1 (en) | 1997-05-21 | 1998-11-25 | Rijksuniversiteit te Groningen | Enantioselective epoxide hydrolases and genes encoding these |
| WO1999032434A1 (en) * | 1997-12-19 | 1999-07-01 | Warner-Lambert Export Limited | Process for the synthesis of 1,3-diols |
| HUP0103659A3 (en) * | 1998-04-30 | 2003-01-28 | Kaneka Corp | Process for producing 6-cyanomethyl-1,3-dioxane-4-acetic acid derivatives |
| CA2305564C (en) * | 1998-08-05 | 2008-06-17 | Kaneka Corporation | Process for the preparation of optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives |
| EP1194582A1 (de) * | 1999-07-09 | 2002-04-10 | Forschungszentrum Jülich Gmbh | Verfahren zur reduktion von keto-carbonsäuren und deren estern |
| KR100512080B1 (ko) * | 1999-12-03 | 2005-09-02 | 카네카 코포레이션 | 신규 카르보닐 환원효소, 그의 유전자, 및 그의 이용 방법 |
| EP1158054A1 (en) | 2000-05-25 | 2001-11-28 | Rijksuniversiteit te Groningen | Enzymatic conversion of epoxides |
| AU2003258187A1 (en) | 2002-08-09 | 2004-02-25 | Codexis, Inc. | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives |
| JP2007502123A (ja) | 2003-08-11 | 2007-02-08 | コデクシス， インコーポレイテッド | 改善されたハロヒドリンデハロゲナーゼおよび関連するポリヌクレオチド |
| US7588928B2 (en) | 2003-08-11 | 2009-09-15 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
| US7541171B2 (en) * | 2003-08-11 | 2009-06-02 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
| EP1660669A4 (en) * | 2003-08-11 | 2008-10-01 | Codexis Inc | ENZYMATIC PROCEDURES FOR THE PREPARATION OF 4-SUBSTITUTED 3-HYDROXYBUTYLIC ACID DERIVATIVES AND OF VICINAL CYANO, HYDROXY-SUBSTITUTED CARBOXYLIC ACID ESTERS |
-
2004
- 2004-08-11 JP JP2006523447A patent/JP2007502123A/ja active Pending
- 2004-08-11 EP EP04781364A patent/EP1654356A1/en not_active Withdrawn
- 2004-08-11 MX MXPA06001725A patent/MXPA06001725A/es unknown
- 2004-08-11 CA CA002535255A patent/CA2535255A1/en not_active Abandoned
- 2004-08-11 BR BRPI0413501-6A patent/BRPI0413501A/pt not_active IP Right Cessation
- 2004-08-11 SG SG200808477-4A patent/SG148180A1/en unknown
- 2004-08-11 KR KR1020067002876A patent/KR20060064617A/ko not_active Ceased
- 2004-08-11 US US10/917,179 patent/US7824898B2/en active Active
- 2004-08-11 WO PCT/US2004/026654 patent/WO2005017141A1/en not_active Ceased
- 2004-08-11 AU AU2004265693A patent/AU2004265693A1/en not_active Abandoned
-
2006
- 2006-01-19 IL IL173261A patent/IL173261A0/en unknown
- 2006-01-25 NO NO20060405A patent/NO20060405L/no not_active Application Discontinuation
-
2009
- 2009-10-05 US US12/573,824 patent/US8101395B2/en not_active Expired - Lifetime
-
2012
- 2012-01-12 US US13/349,514 patent/US8535910B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1654356A1 (en) | 2006-05-10 |
| NO20060405L (no) | 2006-03-10 |
| JP2007502123A (ja) | 2007-02-08 |
| US20050153417A1 (en) | 2005-07-14 |
| BRPI0413501A (pt) | 2006-10-10 |
| IL173261A0 (en) | 2006-06-11 |
| SG148180A1 (en) | 2008-12-31 |
| US8101395B2 (en) | 2012-01-24 |
| MXPA06001725A (es) | 2006-04-27 |
| KR20060064617A (ko) | 2006-06-13 |
| US8535910B2 (en) | 2013-09-17 |
| AU2004265693A1 (en) | 2005-02-24 |
| US20100167345A1 (en) | 2010-07-01 |
| US20120208259A1 (en) | 2012-08-16 |
| US7824898B2 (en) | 2010-11-02 |
| WO2005017141A1 (en) | 2005-02-24 |
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