CA2523786A1 - Gene de ?-12 desaturase approprie pour differents niveaux de degradation d'acides gras polyinsatures dans des levures oleagineuses - Google Patents

Gene de ?-12 desaturase approprie pour differents niveaux de degradation d'acides gras polyinsatures dans des levures oleagineuses Download PDF

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Publication number
CA2523786A1
CA2523786A1 CA002523786A CA2523786A CA2523786A1 CA 2523786 A1 CA2523786 A1 CA 2523786A1 CA 002523786 A CA002523786 A CA 002523786A CA 2523786 A CA2523786 A CA 2523786A CA 2523786 A1 CA2523786 A1 CA 2523786A1
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CA
Canada
Prior art keywords
desaturase
ala
leu
gene
val
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002523786A
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English (en)
Inventor
Narendra S. Yadav
Hongxiang Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
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Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2523786A1 publication Critical patent/CA2523786A1/fr
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
CA002523786A 2003-05-07 2004-05-07 Gene de ?-12 desaturase approprie pour differents niveaux de degradation d'acides gras polyinsatures dans des levures oleagineuses Abandoned CA2523786A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US46867703P 2003-05-07 2003-05-07
US60/468,677 2003-05-07
US48420903P 2003-06-30 2003-06-30
US60/484,209 2003-06-30
PCT/US2004/014542 WO2004104167A2 (fr) 2003-05-07 2004-05-07 Gene de ?-12 desaturase approprie pour differents niveaux de degradation d'acides gras polyinsatures dans des levures oleagineuses

Publications (1)

Publication Number Publication Date
CA2523786A1 true CA2523786A1 (fr) 2004-12-02

Family

ID=33479252

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002523786A Abandoned CA2523786A1 (fr) 2003-05-07 2004-05-07 Gene de ?-12 desaturase approprie pour differents niveaux de degradation d'acides gras polyinsatures dans des levures oleagineuses

Country Status (7)

Country Link
US (3) US7214491B2 (fr)
EP (1) EP1620561A4 (fr)
AU (1) AU2004242095A1 (fr)
BR (1) BRPI0410681A (fr)
CA (1) CA2523786A1 (fr)
NO (1) NO20055777L (fr)
WO (1) WO2004104167A2 (fr)

Families Citing this family (37)

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US7238482B2 (en) * 2003-05-07 2007-07-03 E. I. Du Pont De Nemours And Company Production of polyunsaturated fatty acids in oleaginous yeasts
KR101187081B1 (ko) * 2003-08-22 2012-09-27 산토리 홀딩스 가부시키가이샤 지질생산균의 취득방법
BRPI0511236A (pt) * 2004-06-04 2007-11-27 Fluxome Sciences As método para a produção de ácidos graxos poliinsaturados com quatro ou mais ligações duplas, saccharomyces cerevisiae geneticamente modificado que tem capacidade de produzir ácidos graxos poliinsaturados com quatro ou mais ligações duplas quando desenvolvido em um substrato que não de ácido graxo, composição, uso da composição e uso de um saccharomyces cervisiae geneticamente modificado
CA2568624C (fr) 2004-06-25 2014-03-25 E. I. Du Pont De Nemours And Company Desaturase delta-8 et son utilisation dans la fabrication d'acides gras polyinsatures
US7550286B2 (en) 2004-11-04 2009-06-23 E. I. Du Pont De Nemours And Company Docosahexaenoic acid producing strains of Yarrowia lipolytica
BRPI0609040B1 (pt) * 2005-03-18 2018-07-31 Microbia, Inc. Fungo recombinante do gênero yarrowia, método de produção de um carotenóide e método de preparo de um aditivo alimentício ou ração contendo um carotenóide
US7943823B2 (en) 2006-04-28 2011-05-17 E.I. Du Pont De Nemours And Company Delta-8 desaturase and its use in making polyunsaturated fatty acids
US8691555B2 (en) 2006-09-28 2014-04-08 Dsm Ip Assests B.V. Production of carotenoids in oleaginous yeast and fungi
AU2007322223B2 (en) 2006-10-23 2012-12-13 Corteva Agriscience Llc Delta-8 desaturases and their use in making polyunsaturated fatty acids
US7709239B2 (en) * 2006-12-07 2010-05-04 E.I. Du Pont De Nemours And Company Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids
US8846374B2 (en) * 2006-12-12 2014-09-30 E I Du Pont De Nemours And Company Carotenoid production in a recombinant oleaginous yeast
UA103595C2 (uk) * 2007-04-03 2013-11-11 Е. І. Дю Пон Де Немур Енд Компані Мультизими і їх застосування в отриманні поліненасичених жирних кислот
US7943365B2 (en) 2007-05-03 2011-05-17 E.I. Du Pont De Nemours And Company Δ-5 desaturases and their use in making polyunsaturated fatty acids
US20090117253A1 (en) * 2007-10-03 2009-05-07 E. I. Du Pont De Nemours And Company Peroxisome biogenesis factor protein (pex) disruptions for altering polyunsaturated fatty acids and total lipid content in oleaginous eukaryotic organisms
CA2701130A1 (fr) * 2007-10-03 2009-04-09 E.I. Du Pont De Nemours And Company Perturbations des proteines des facteurs de biogenese du peroxysome (pex) pour modifier la teneur en acides gras polyinsatures et la teneur en lipides totaux dans des organismes eucaryotes oleagineux
US20090264520A1 (en) * 2008-04-21 2009-10-22 Asha Lipid Sciences, Inc. Lipid-containing compositions and methods of use thereof
US7892792B2 (en) 2008-06-27 2011-02-22 Indian Institute Of Science Cells expressing Pichia cytochrome C
WO2010064146A2 (fr) 2008-12-02 2010-06-10 Chiralgen, Ltd. Procédé pour la synthèse d’acides nucléiques modifiés par des atomes de phosphore
JP5620402B2 (ja) 2008-12-18 2014-11-05 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ 発酵プロセスにおけるマロン酸副産物生成の低下
KR101885383B1 (ko) 2009-07-06 2018-08-03 웨이브 라이프 사이언시스 리미티드 신규한 핵산 프로드러그 및 그의 사용 방법
EP2542671A2 (fr) * 2010-03-02 2013-01-09 Massachusetts Institute Of Technology Ingénierie microbienne pour la production d'acides gras et de dérivés d'acides gras
JP2013525549A (ja) * 2010-04-22 2013-06-20 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 微生物バイオマスから多価不飽和脂肪酸含有組成物を得る方法
EP2620428B1 (fr) 2010-09-24 2019-05-22 Wave Life Sciences Ltd. Groupe auxiliaire asymétrique
JP6168700B2 (ja) 2011-03-07 2017-07-26 ディーエスエム ニュートリショナル プロダクツ アーゲーＤＳＭ Ｎｕｔｒｉｔｉｏｎａｌ Ｐｒｏｄｕｃｔｓ ＡＧ スラウストキトリド微生物の操作
JP6128529B2 (ja) 2011-07-19 2017-05-17 ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． 官能化核酸の合成のための方法
JP6453212B2 (ja) 2012-07-13 2019-01-16 ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． キラル制御
CA2879066C (fr) 2012-07-13 2019-08-13 Shin Nippon Biomedical Laboratories, Ltd. Adjuvant d'acide nucleique chiral
DK2872485T3 (da) 2012-07-13 2021-03-08 Wave Life Sciences Ltd Asymmetrisk hjælpegruppe
CN102787128A (zh) * 2012-08-28 2012-11-21 江南大学 一种用于多不饱和脂肪酸生物合成的脱饱和酶Δ9 Des
US9005940B2 (en) 2012-12-21 2015-04-14 E I Du Pont De Nemours And Company Down-regulation of a polynucleotide encoding a Sou2 sorbitol utilization protein to modify lipid production in microbial cells
WO2014141098A1 (fr) 2013-03-13 2014-09-18 Dsm Nutritional Products Ag Modification génétique de micro-organismes
WO2015108047A1 (fr) 2014-01-15 2015-07-23 株式会社新日本科学 Adjuvant d'acide nucléique chiral possédant une activité d'induction d'immunité, et activateur d'induction d'immunité
WO2015108046A1 (fr) 2014-01-15 2015-07-23 株式会社新日本科学 Adjuvant d'acide nucléique chiral ayant une activité anti-allergique, et agent anti-allergique
EP3095459A4 (fr) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Adjuvant d'acide nucléique chiral ayant un effet antitumoral et agent antitumoral
SG10201912897UA (en) 2014-01-16 2020-02-27 Wave Life Sciences Ltd Chiral design
CN103834672B (zh) * 2014-03-17 2015-12-09 昆明理工大学 一种δ12-脂肪酸脱氢酶基因及其应用
CN110229832A (zh) * 2019-06-16 2019-09-13 山东理工大学 一种提高耶式解脂酵母生物量和细胞壁产量的菌株和方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ190194A (en) 1978-05-08 1982-02-23 Cpc International Inc Production of oil by fermenting yeast in fatty acids
GB8507058D0 (en) * 1985-03-19 1985-04-24 Efamol Ltd Pharmaceutical & dietary compositions
GB8524275D0 (en) * 1985-10-02 1985-11-06 Efamol Ltd Pharmaceutical & dietary compositions
GB8524276D0 (en) * 1985-10-02 1985-11-06 Efamol Ltd Pharmaceutical & dietary compositions
IE63225B1 (en) * 1988-09-13 1995-04-05 Efamol Holdings Use of fatty acids in the treatment of myalgic encephalomyelitis
CA2083259C (fr) * 1990-05-25 2007-05-15 William D. Hitz Sequence des nucleotides du gene de la stearoyle-acp-desaturase du soja
ZA92452B (en) * 1991-01-24 1992-10-28 Martek Corp Microbial oil mixtures and uses thereof
US6872872B1 (en) * 1992-11-17 2005-03-29 E. I. Du Pont De Nemours And Company Genes for microsomal delta-12 fatty acid desaturases and related enzymes from plants
US6372965B1 (en) * 1992-11-17 2002-04-16 E.I. Du Pont De Nemours And Company Genes for microsomal delta-12 fatty acid desaturases and hydroxylases from plants
EP0668919B1 (fr) 1992-11-17 2003-06-04 E.I. Du Pont De Nemours And Company Genes pour des desaturases d'acides gras en position delta-12 microsomales et enzymes apparentees provenant de plantes
US5968809A (en) * 1997-04-11 1999-10-19 Abbot Laboratories Methods and compositions for synthesis of long chain poly-unsaturated fatty acids
US6372966B1 (en) * 2000-06-07 2002-04-16 Pure Seed Testing Inc. Kentucky bluegrass variety known as ‘Brilliant’
US7211656B2 (en) * 2002-01-30 2007-05-01 Abbott Laboratories Desaturase genes, enzymes encoded thereby, and uses thereof
ES2542420T3 (es) 2002-05-22 2015-08-05 Monsanto Technology Llc Desaturasas de ácidos grasos de hongos
US7364883B2 (en) * 2004-05-07 2008-04-29 Yeastern Biotech Co., Ltd. Process for producing poly-unsaturated fatty acids by oleaginous yeasts

Also Published As

Publication number Publication date
AU2004242095A1 (en) 2004-12-02
WO2004104167A3 (fr) 2005-04-28
NO20055777D0 (no) 2005-12-06
US7749703B2 (en) 2010-07-06
US20060263867A1 (en) 2006-11-23
BRPI0410681A (pt) 2006-06-20
US20050043527A1 (en) 2005-02-24
EP1620561A2 (fr) 2006-02-01
US20060263866A1 (en) 2006-11-23
US7214491B2 (en) 2007-05-08
WO2004104167A2 (fr) 2004-12-02
NO20055777L (no) 2006-02-07
EP1620561A4 (fr) 2006-08-23

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US7125672B2 (en) Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts
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