CA2519711C - Implantable medical device with beneficial agent concentration gradient - Google Patents
Implantable medical device with beneficial agent concentration gradient Download PDFInfo
- Publication number
- CA2519711C CA2519711C CA2519711A CA2519711A CA2519711C CA 2519711 C CA2519711 C CA 2519711C CA 2519711 A CA2519711 A CA 2519711A CA 2519711 A CA2519711 A CA 2519711A CA 2519711 C CA2519711 C CA 2519711C
- Authority
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- Prior art keywords
- matrix
- agent
- therapeutic agent
- implantable medical
- medical device
- Prior art date
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- Expired - Fee Related
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- FQCQGOZEWWPOKI-UHFFFAOYSA-K trisalicylate-choline Chemical compound [Mg+2].C[N+](C)(C)CCO.OC1=CC=CC=C1C([O-])=O.OC1=CC=CC=C1C([O-])=O.OC1=CC=CC=C1C([O-])=O FQCQGOZEWWPOKI-UHFFFAOYSA-K 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 229960003726 vasopressin Drugs 0.000 description 1
- 229960001722 verapamil Drugs 0.000 description 1
- 229940087652 vioxx Drugs 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000012711 vitamin K3 Nutrition 0.000 description 1
- 239000011652 vitamin K3 Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 229940041603 vitamin k 3 Drugs 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- FUTVBRXUIKZACV-UHFFFAOYSA-L zinc;3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,23-diid-2-yl]propanoic acid Chemical compound [Zn+2].[N-]1C(C=C2C(=C(C=C)C(C=C3C(=C(C=C)C(=C4)[N-]3)C)=N2)C)=C(C)C(CCC(O)=O)=C1C=C1C(CCC(O)=O)=C(C)C4=N1 FUTVBRXUIKZACV-UHFFFAOYSA-L 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/041—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
- A61L2300/604—Biodegradation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Prostheses (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/402,893 US7056338B2 (en) | 2003-03-28 | 2003-03-28 | Therapeutic agent delivery device with controlled therapeutic agent release rates |
| US10/402,893 | 2003-03-28 | ||
| US10/777,283 | 2004-02-11 | ||
| US10/777,283 US20050010170A1 (en) | 2004-02-11 | 2004-02-11 | Implantable medical device with beneficial agent concentration gradient |
| PCT/US2004/009602 WO2004087214A1 (en) | 2003-03-28 | 2004-03-29 | Implantable medical device with beneficial agent concentration gradient |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2519711A1 CA2519711A1 (en) | 2004-10-14 |
| CA2519711C true CA2519711C (en) | 2012-01-17 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2519711A Expired - Fee Related CA2519711C (en) | 2003-03-28 | 2004-03-29 | Implantable medical device with beneficial agent concentration gradient |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8449901B2 (https=) |
| EP (3) | EP1610823B1 (https=) |
| JP (1) | JP5596896B2 (https=) |
| AT (1) | ATE526038T1 (https=) |
| AU (1) | AU2004226327A1 (https=) |
| CA (1) | CA2519711C (https=) |
| WO (1) | WO2004087214A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7169178B1 (en) * | 2002-11-12 | 2007-01-30 | Advanced Cardiovascular Systems, Inc. | Stent with drug coating |
| US7959659B2 (en) | 2004-01-02 | 2011-06-14 | Advanced Cardiovascular Systems, Inc. | High-density lipoprotein coated medical devices |
| US20060246109A1 (en) * | 2005-04-29 | 2006-11-02 | Hossainy Syed F | Concentration gradient profiles for control of agent release rates from polymer matrices |
| US8568764B2 (en) | 2006-05-31 | 2013-10-29 | Advanced Cardiovascular Systems, Inc. | Methods of forming coating layers for medical devices utilizing flash vaporization |
| US8246973B2 (en) | 2006-06-21 | 2012-08-21 | Advanced Cardiovascular Systems, Inc. | Freeze-thaw method for modifying stent coating |
| WO2008008845A2 (en) * | 2006-07-11 | 2008-01-17 | Microchips, Inc. | Multi-reservoir pump device for dialysis, biosensing, or delivery of substances |
| US7682388B2 (en) * | 2007-01-30 | 2010-03-23 | Medtronic Vascular, Inc. | Stent with longitudinal groove |
| EP2111818B1 (en) * | 2007-02-14 | 2016-11-02 | Shandong Rientech Medical Technology Co., Ltd. | Intracoronary stent with asymmetric drug releasing controlled coating |
| JP2008245699A (ja) * | 2007-03-29 | 2008-10-16 | Yamaguchi Univ | 薬剤徐放ステント |
| US8852620B2 (en) * | 2007-07-20 | 2014-10-07 | Medtronic Vascular, Inc. | Medical devices comprising polymeric drug delivery systems with drug solubility gradients |
| JP2009247506A (ja) * | 2008-04-03 | 2009-10-29 | Kaneka Corp | ステント |
| US8652506B2 (en) * | 2008-06-05 | 2014-02-18 | Boston Scientific Scimed, Inc. | Bio-degradable block co-polymers for controlled release |
| US20100249944A1 (en) * | 2009-03-31 | 2010-09-30 | Thomas Jonathan D | Multizone Implants |
| US20100249854A1 (en) * | 2009-03-31 | 2010-09-30 | Thomas Jonathan D | Multizone Implants |
| US20100249832A1 (en) * | 2009-03-31 | 2010-09-30 | Joshua Stopek | Multizone Implants |
| US9592043B2 (en) * | 2009-03-31 | 2017-03-14 | Covidien Lp | Multizone implants |
| US20100292777A1 (en) * | 2009-05-13 | 2010-11-18 | Boston Scientific Scimed, Inc. | Stent |
| US9283305B2 (en) | 2009-07-09 | 2016-03-15 | Medtronic Vascular, Inc. | Hollow tubular drug eluting medical devices |
| US20110070358A1 (en) * | 2009-09-20 | 2011-03-24 | Medtronic Vascular, Inc. | Method of forming hollow tubular drug eluting medical devices |
| US8460745B2 (en) * | 2009-09-20 | 2013-06-11 | Medtronic Vascular, Inc. | Apparatus and methods for loading a drug eluting medical device |
| US8678046B2 (en) | 2009-09-20 | 2014-03-25 | Medtronic Vascular, Inc. | Apparatus and methods for loading a drug eluting medical device |
| US8828474B2 (en) | 2009-09-20 | 2014-09-09 | Medtronic Vascular, Inc. | Apparatus and methods for loading a drug eluting medical device |
| US8616040B2 (en) | 2010-09-17 | 2013-12-31 | Medtronic Vascular, Inc. | Method of forming a drug-eluting medical device |
| US8333801B2 (en) | 2010-09-17 | 2012-12-18 | Medtronic Vascular, Inc. | Method of Forming a Drug-Eluting Medical Device |
| US8632846B2 (en) | 2010-09-17 | 2014-01-21 | Medtronic Vascular, Inc. | Apparatus and methods for loading a drug eluting medical device |
| DE102011107109A1 (de) * | 2011-07-12 | 2013-01-17 | Translumina Gmbh | Implantierbare Gefäßstütze |
| US20130103162A1 (en) * | 2011-10-25 | 2013-04-25 | Kieran Costello | Coated stent |
| US9220759B2 (en) | 2012-02-23 | 2015-12-29 | Abbott Cardiovascular Systems Inc. | Treatment of diabetic patients with a drug eluting stent and adjunctive therapy |
| US9220584B2 (en) | 2012-03-30 | 2015-12-29 | Abbott Cardiovascular Systems Inc. | Treatment of diabetic patients with a stent and locally administered adjunctive therapy |
| US20130259921A1 (en) * | 2012-03-30 | 2013-10-03 | Abbott Cardiovascular Systems Inc. | Treatment Of Diabetic Patients With A Stent And An Adjunctive Drug Formulation |
| US20140099351A1 (en) | 2012-10-04 | 2014-04-10 | Axxia Pharmaceuticals, Llc | Process for making controlled release medical implant products |
| US20140121750A1 (en) * | 2012-10-31 | 2014-05-01 | Cook Medical Technologies Llc | Fixation Process For Nesting Stents |
| EP2967938B1 (en) | 2013-03-14 | 2017-03-01 | Medtronic Vascular Inc. | Method for manufacturing a stent and stent manufactured thereby |
| EP2994174A1 (en) | 2013-05-06 | 2016-03-16 | Abbott Cardiovascular Systems Inc. | A hollow stent filled with a therapeutic agent formulation |
| EP3060174B1 (en) * | 2013-10-22 | 2020-05-27 | Concievalve LLC | Methods for inhibiting stenosis, obstruction, or calcification of a stented heart valve or bioprosthesis |
| US20160022570A1 (en) | 2014-07-25 | 2016-01-28 | Robert W. Adams | Medical implant |
Family Cites Families (430)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3657744A (en) | 1970-05-08 | 1972-04-25 | Univ Minnesota | Method for fixing prosthetic implants in a living body |
| US5643314A (en) | 1995-11-13 | 1997-07-01 | Navius Corporation | Self-expanding stent |
| US5876419A (en) * | 1976-10-02 | 1999-03-02 | Navius Corporation | Stent and method for making a stent |
| JPS6037735B2 (ja) * | 1978-10-18 | 1985-08-28 | 住友電気工業株式会社 | 人工血管 |
| US4300244A (en) | 1979-09-19 | 1981-11-17 | Carbomedics, Inc. | Cardiovascular grafts |
| US4531936A (en) | 1981-01-29 | 1985-07-30 | Gordon Robert T | Device and method for the selective delivery of drugs to the myocardium |
| US5441745A (en) | 1982-03-30 | 1995-08-15 | Vestar, Inc. | Method of delivering micellular particles encapsulating chemotherapeutic agents to tumors in a body |
| US4542025A (en) | 1982-07-29 | 1985-09-17 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
| US4834755A (en) | 1983-04-04 | 1989-05-30 | Pfizer Hospital Products Group, Inc. | Triaxially-braided fabric prosthesis |
| US4580568A (en) | 1984-10-01 | 1986-04-08 | Cook, Incorporated | Percutaneous endovascular stent and method for insertion thereof |
| US4824436A (en) | 1985-04-09 | 1989-04-25 | Harvey Wolinsky | Method for the prevention of restenosis |
| US4650466A (en) * | 1985-11-01 | 1987-03-17 | Angiobrade Partners | Angioplasty device |
| US5102417A (en) | 1985-11-07 | 1992-04-07 | Expandable Grafts Partnership | Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft |
| US4733665C2 (en) * | 1985-11-07 | 2002-01-29 | Expandable Grafts Partnership | Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft |
| US4955878A (en) | 1986-04-04 | 1990-09-11 | Biotechnology, Inc. | Kit for preventing or treating arterial dysfunction resulting from angioplasty procedures |
| JPH0763489B2 (ja) | 1986-10-31 | 1995-07-12 | 宇部興産株式会社 | 医療用チユ−ブ |
| US4800882A (en) * | 1987-03-13 | 1989-01-31 | Cook Incorporated | Endovascular stent and delivery system |
| US5059211A (en) | 1987-06-25 | 1991-10-22 | Duke University | Absorbable vascular stent |
| US4969458A (en) | 1987-07-06 | 1990-11-13 | Medtronic, Inc. | Intracoronary stent and method of simultaneous angioplasty and stent implant |
| US5460817A (en) | 1988-01-19 | 1995-10-24 | Allied Colloids Ltd. | Particulate composition comprising a core of matrix polymer with active ingredient distributed therein |
| US5157049A (en) | 1988-03-07 | 1992-10-20 | The United States Of America As Represented By The Department Of Health & Human Services | Method of treating cancers sensitive to treatment with water soluble derivatives of taxol |
| JP3038339B2 (ja) | 1988-05-02 | 2000-05-08 | ザイナクシス・テクノロジーズ・インコーポレーテッド | バイオ粒子の表面膜に対してバイオアフェクティング物質を結合する化合物 |
| US4989601A (en) * | 1988-05-02 | 1991-02-05 | Medical Engineering & Development Institute, Inc. | Method, apparatus, and substance for treating tissue having neoplastic cells |
| US5213580A (en) | 1988-08-24 | 1993-05-25 | Endoluminal Therapeutics, Inc. | Biodegradable polymeric endoluminal sealing process |
| US5019090A (en) | 1988-09-01 | 1991-05-28 | Corvita Corporation | Radially expandable endoprosthesis and the like |
| US5053048A (en) | 1988-09-22 | 1991-10-01 | Cordis Corporation | Thromboresistant coating |
| CA1322628C (en) * | 1988-10-04 | 1993-10-05 | Richard A. Schatz | Expandable intraluminal graft |
| LU87410A1 (fr) * | 1988-12-20 | 1990-07-10 | Cird | Composition cosmetique ou pharmaceutique contenant des microspheres de polymeres ou de corps gras chargees d'au moins un produit actif |
| CH678393A5 (https=) | 1989-01-26 | 1991-09-13 | Ulrich Prof Dr Med Sigwart | |
| US5078726A (en) * | 1989-02-01 | 1992-01-07 | Kreamer Jeffry W | Graft stent and method of repairing blood vessels |
| JPH02207940A (ja) | 1989-02-06 | 1990-08-17 | Olympus Optical Co Ltd | リン酸塩系鋳型材 |
| US4960790A (en) | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
| US4990155A (en) * | 1989-05-19 | 1991-02-05 | Wilkoff Howard M | Surgical stent method and apparatus |
| US4994071A (en) * | 1989-05-22 | 1991-02-19 | Cordis Corporation | Bifurcating stent apparatus and method |
| US5171262A (en) | 1989-06-15 | 1992-12-15 | Cordis Corporation | Non-woven endoprosthesis |
| US5674278A (en) | 1989-08-24 | 1997-10-07 | Arterial Vascular Engineering, Inc. | Endovascular support device |
| US5059166A (en) | 1989-12-11 | 1991-10-22 | Medical Innovative Technologies R & D Limited Partnership | Intra-arterial stent with the capability to inhibit intimal hyperplasia |
| US5176617A (en) | 1989-12-11 | 1993-01-05 | Medical Innovative Technologies R & D Limited Partnership | Use of a stent with the capability to inhibit malignant growth in a vessel such as a biliary duct |
| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| US5843089A (en) | 1990-12-28 | 1998-12-01 | Boston Scientific Corporation | Stent lining |
| US5439446A (en) | 1994-06-30 | 1995-08-08 | Boston Scientific Corporation | Stent and therapeutic delivery system |
| US5049132A (en) | 1990-01-08 | 1991-09-17 | Cordis Corporation | Balloon catheter for delivering therapeutic agents |
| US5192744A (en) | 1990-01-12 | 1993-03-09 | Northwestern University | Method of inhibiting angiogenesis of tumors |
| EP0512071B1 (en) | 1990-01-25 | 1996-10-30 | Children's Hospital | Method and compositions for inhibiting angiogenesis |
| DE69108423T2 (de) | 1990-02-08 | 1995-07-27 | Howmedica | Aufblasbarer Dilatator. |
| US5545208A (en) | 1990-02-28 | 1996-08-13 | Medtronic, Inc. | Intralumenal drug eluting prosthesis |
| CA2049973C (en) | 1990-02-28 | 2002-12-24 | Rodney G. Wolff | Intralumenal drug eluting prosthesis |
| US5242399A (en) | 1990-04-25 | 1993-09-07 | Advanced Cardiovascular Systems, Inc. | Method and system for stent delivery |
| US5344426A (en) | 1990-04-25 | 1994-09-06 | Advanced Cardiovascular Systems, Inc. | Method and system for stent delivery |
| US5290271A (en) * | 1990-05-14 | 1994-03-01 | Jernberg Gary R | Surgical implant and method for controlled release of chemotherapeutic agents |
| WO1991017724A1 (en) | 1990-05-17 | 1991-11-28 | Harbor Medical Devices, Inc. | Medical device polymer |
| US5092841A (en) * | 1990-05-17 | 1992-03-03 | Wayne State University | Method for treating an arterial wall injured during angioplasty |
| US5407683A (en) | 1990-06-01 | 1995-04-18 | Research Corporation Technologies, Inc. | Pharmaceutical solutions and emulsions containing taxol |
| EP0533816B1 (en) * | 1990-06-15 | 1995-06-14 | Cortrak Medical, Inc. | Drug delivery apparatus |
| AU1411992A (en) | 1991-01-15 | 1992-08-27 | Robert A Bok | A composition containing a tetracycline and use for inhibiting angiogenesis |
| WO1992015286A1 (en) | 1991-02-27 | 1992-09-17 | Nova Pharmaceutical Corporation | Anti-infective and anti-inflammatory releasing systems for medical devices |
| US5171217A (en) | 1991-02-28 | 1992-12-15 | Indiana University Foundation | Method for delivery of smooth muscle cell inhibitors |
| US5197978B1 (en) * | 1991-04-26 | 1996-05-28 | Advanced Coronary Tech | Removable heat-recoverable tissue supporting device |
| FR2678833B1 (fr) | 1991-07-08 | 1995-04-07 | Rhone Poulenc Rorer Sa | Nouvelles compositions pharmaceutiques a base de derives de la classe des taxanes. |
| US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US5500013A (en) * | 1991-10-04 | 1996-03-19 | Scimed Life Systems, Inc. | Biodegradable drug delivery vascular stent |
| US5464450A (en) | 1991-10-04 | 1995-11-07 | Scimed Lifesystems Inc. | Biodegradable drug delivery vascular stent |
| WO1993006792A1 (en) | 1991-10-04 | 1993-04-15 | Scimed Life Systems, Inc. | Biodegradable drug delivery vascular stent |
| CA2079417C (en) * | 1991-10-28 | 2003-01-07 | Lilip Lau | Expandable stents and method of making same |
| FR2683449A1 (fr) * | 1991-11-08 | 1993-05-14 | Cardon Alain | Endoprothese pour implantation transluminale. |
| US5270047A (en) | 1991-11-21 | 1993-12-14 | Kauffman Raymond F | Local delivery of dipyridamole for the treatment of proliferative diseases |
| US5260002A (en) | 1991-12-23 | 1993-11-09 | Vanderbilt University | Method and apparatus for producing uniform polymeric spheres |
| US5516781A (en) | 1992-01-09 | 1996-05-14 | American Home Products Corporation | Method of treating restenosis with rapamycin |
| CA2087132A1 (en) * | 1992-01-31 | 1993-08-01 | Michael S. Williams | Stent capable of attachment within a body lumen |
| DE69326631T2 (de) | 1992-03-19 | 2000-06-08 | Medtronic, Inc. | Intraluminales Erweiterungsgerät |
| US5282823A (en) | 1992-03-19 | 1994-02-01 | Medtronic, Inc. | Intravascular radially expandable stent |
| EP0633907A1 (en) | 1992-03-30 | 1995-01-18 | Alza Corporation | Additives for bioerodible polymers to regulate degradation |
| US5383928A (en) * | 1992-06-10 | 1995-01-24 | Emory University | Stent sheath for local drug delivery |
| GB9213077D0 (en) | 1992-06-19 | 1992-08-05 | Erba Carlo Spa | Polymerbound taxol derivatives |
| DE4222380A1 (de) * | 1992-07-08 | 1994-01-13 | Ernst Peter Prof Dr M Strecker | In den Körper eines Patienten perkutan implantierbare Endoprothese |
| KR940003548U (ko) | 1992-08-14 | 1994-02-21 | 김형술 | 세탁물 건조기 |
| US5650447A (en) | 1992-08-24 | 1997-07-22 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitric oxide-releasing polymers to treat restenosis and related disorders |
| US5525357A (en) * | 1992-08-24 | 1996-06-11 | The United States Of America As Represented By The Department Of Health And Human Services | Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
| US5342621A (en) | 1992-09-15 | 1994-08-30 | Advanced Cardiovascular Systems, Inc. | Antithrombogenic surface |
| US6306421B1 (en) | 1992-09-25 | 2001-10-23 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US5770609A (en) | 1993-01-28 | 1998-06-23 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies |
| US5578075B1 (en) | 1992-11-04 | 2000-02-08 | Daynke Res Inc | Minimally invasive bioactivated endoprosthesis for vessel repair |
| US5342348A (en) | 1992-12-04 | 1994-08-30 | Kaplan Aaron V | Method and device for treating and enlarging body lumens |
| US5419760A (en) | 1993-01-08 | 1995-05-30 | Pdt Systems, Inc. | Medicament dispensing stent for prevention of restenosis of a blood vessel |
| JP2746755B2 (ja) | 1993-01-19 | 1998-05-06 | シュナイダー(ユーエスエー)インク | クラッド複合ステント |
| US5981568A (en) * | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US5595722A (en) * | 1993-01-28 | 1997-01-21 | Neorx Corporation | Method for identifying an agent which increases TGF-beta levels |
| US6491938B2 (en) | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6663881B2 (en) | 1993-01-28 | 2003-12-16 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US5439686A (en) | 1993-02-22 | 1995-08-08 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor |
| US5523092A (en) | 1993-04-14 | 1996-06-04 | Emory University | Device for local drug delivery and methods for using the same |
| ES2114964T3 (es) | 1993-04-23 | 1998-06-16 | Schneider Europ Ag | Endoprotesis con una capa de recubrimiento de material elastico y metodo para aplicar la capa sobre la endoprotesis. |
| US5441515A (en) | 1993-04-23 | 1995-08-15 | Advanced Cardiovascular Systems, Inc. | Ratcheting stent |
| US5464650A (en) | 1993-04-26 | 1995-11-07 | Medtronic, Inc. | Intravascular stent and method |
| CA2162586C (en) | 1993-05-13 | 2006-01-03 | David J. Grainger | Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells |
| EP1155689B1 (en) | 1993-07-19 | 2006-09-20 | Angiotech Pharmaceuticals, Inc. | Anti-angiogenic stents and methods of their preparation |
| US5886026A (en) * | 1993-07-19 | 1999-03-23 | Angiotech Pharmaceuticals Inc. | Anti-angiogenic compositions and methods of use |
| US20030203976A1 (en) * | 1993-07-19 | 2003-10-30 | William L. Hunter | Anti-angiogenic compositions and methods of use |
| AU7476894A (en) | 1993-07-29 | 1995-02-28 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Method of treating atherosclerosis or restenosis using microtubule stabilizing agent |
| US5380299A (en) * | 1993-08-30 | 1995-01-10 | Med Institute, Inc. | Thrombolytic treated intravascular medical device |
| US6087479A (en) * | 1993-09-17 | 2000-07-11 | Nitromed, Inc. | Localized use of nitric oxide-adducts to prevent internal tissue damage |
| US5457113A (en) | 1993-10-15 | 1995-10-10 | Eli Lilly And Company | Methods for inhibiting vascular smooth muscle cell proliferation and restinosis |
| US5415869A (en) | 1993-11-12 | 1995-05-16 | The Research Foundation Of State University Of New York | Taxol formulation |
| US5443497A (en) | 1993-11-22 | 1995-08-22 | The Johns Hopkins University | Percutaneous prosthetic by-pass graft and method of use |
| US5554147A (en) * | 1994-02-01 | 1996-09-10 | Caphco, Inc. | Compositions and devices for controlled release of active ingredients |
| US5556413A (en) | 1994-03-11 | 1996-09-17 | Advanced Cardiovascular Systems, Inc. | Coiled stent with locking ends |
| US5733303A (en) | 1994-03-17 | 1998-03-31 | Medinol Ltd. | Flexible expandable stent |
| US5843120A (en) | 1994-03-17 | 1998-12-01 | Medinol Ltd. | Flexible-expandable stent |
| US5449373A (en) | 1994-03-17 | 1995-09-12 | Medinol Ltd. | Articulated stent |
| US5636641A (en) | 1994-07-25 | 1997-06-10 | Advanced Cardiovascular Systems, Inc. | High strength member for intracorporeal use |
| US5843741A (en) | 1994-08-01 | 1998-12-01 | Massachusetts Insitute Of Technology | Method for altering the differentiation of anchorage dependent cells on an electrically conducting polymer |
| US5660873A (en) | 1994-09-09 | 1997-08-26 | Bioseal, Limited Liability Corporaton | Coating intraluminal stents |
| US5891108A (en) * | 1994-09-12 | 1999-04-06 | Cordis Corporation | Drug delivery stent |
| US5545210A (en) | 1994-09-22 | 1996-08-13 | Advanced Coronary Technology, Inc. | Method of implanting a permanent shape memory alloy stent |
| US5817152A (en) | 1994-10-19 | 1998-10-06 | Birdsall; Matthew | Connected stent apparatus |
| US5707385A (en) * | 1994-11-16 | 1998-01-13 | Advanced Cardiovascular Systems, Inc. | Drug loaded elastic membrane and method for delivery |
| AU3783295A (en) | 1994-11-16 | 1996-05-23 | Advanced Cardiovascular Systems Inc. | Shape memory locking mechanism for intravascular stent |
| CA2301351C (en) | 1994-11-28 | 2002-01-22 | Advanced Cardiovascular Systems, Inc. | Method and apparatus for direct laser cutting of metal stents |
| US5665591A (en) | 1994-12-06 | 1997-09-09 | Trustees Of Boston University | Regulation of smooth muscle cell proliferation |
| US5637113A (en) | 1994-12-13 | 1997-06-10 | Advanced Cardiovascular Systems, Inc. | Polymer film for wrapping a stent structure |
| US6231600B1 (en) | 1995-02-22 | 2001-05-15 | Scimed Life Systems, Inc. | Stents with hybrid coating for medical devices |
| CA2213403C (en) | 1995-02-22 | 2007-01-16 | Menlo Care, Inc. | Covered expanding mesh stent |
| GB9505721D0 (en) | 1995-03-21 | 1995-05-10 | Univ London | Expandable surgical stent |
| US5605696A (en) * | 1995-03-30 | 1997-02-25 | Advanced Cardiovascular Systems, Inc. | Drug loaded polymeric material and method of manufacture |
| US5837313A (en) | 1995-04-19 | 1998-11-17 | Schneider (Usa) Inc | Drug release stent coating process |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| US6120536A (en) | 1995-04-19 | 2000-09-19 | Schneider (Usa) Inc. | Medical devices with long term non-thrombogenic coatings |
| DE69623455T2 (de) | 1995-04-19 | 2003-01-16 | Schneider (Usa) Inc., Plymouth | Beschichteter dilatator zur abgabe eines arzneistoffs |
| US5575771A (en) | 1995-04-24 | 1996-11-19 | Walinsky; Paul | Balloon catheter with external guidewire |
| US5766584A (en) | 1995-06-02 | 1998-06-16 | Massachusetts Institute Of Technology | Inhibition of vascular smooth muscle cell proliferation with implanted matrix containing vascular endothelial cells |
| US6774278B1 (en) * | 1995-06-07 | 2004-08-10 | Cook Incorporated | Coated implantable medical device |
| US5609629A (en) * | 1995-06-07 | 1997-03-11 | Med Institute, Inc. | Coated implantable medical device |
| US7611533B2 (en) * | 1995-06-07 | 2009-11-03 | Cook Incorporated | Coated implantable medical device |
| US7550005B2 (en) * | 1995-06-07 | 2009-06-23 | Cook Incorporated | Coated implantable medical device |
| AU716005B2 (en) * | 1995-06-07 | 2000-02-17 | Cook Medical Technologies Llc | Implantable medical device |
| US5992769A (en) | 1995-06-09 | 1999-11-30 | The Regents Of The University Of Michigan | Microchannel system for fluid delivery |
| JPH11509754A (ja) | 1995-07-25 | 1999-08-31 | メドステント・インコーポレーテッド | 膨張型ステント |
| DE19539449A1 (de) | 1995-10-24 | 1997-04-30 | Biotronik Mess & Therapieg | Verfahren zur Herstellung intraluminaler Stents aus bioresorbierbarem Polymermaterial |
| US5607442A (en) * | 1995-11-13 | 1997-03-04 | Isostent, Inc. | Stent with improved radiopacity and appearance characteristics |
| US5741293A (en) | 1995-11-28 | 1998-04-21 | Wijay; Bandula | Locking stent |
| US6017363A (en) * | 1997-09-22 | 2000-01-25 | Cordis Corporation | Bifurcated axially flexible stent |
| US5843117A (en) | 1996-02-14 | 1998-12-01 | Inflow Dynamics Inc. | Implantable vascular and endoluminal stents and process of fabricating the same |
| US6441025B2 (en) | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
| US6334871B1 (en) * | 1996-03-13 | 2002-01-01 | Medtronic, Inc. | Radiopaque stent markers |
| US5725548A (en) * | 1996-04-08 | 1998-03-10 | Iowa India Investments Company Limited | Self-locking stent and method for its production |
| US5713949A (en) * | 1996-08-06 | 1998-02-03 | Jayaraman; Swaminathan | Microporous covered stents and method of coating |
| US5928916A (en) | 1996-04-25 | 1999-07-27 | Medtronic, Inc. | Ionic attachment of biomolecules with a guanidino moiety to medical device surfaces |
| US5922021A (en) | 1996-04-26 | 1999-07-13 | Jang; G. David | Intravascular stent |
| US6783543B2 (en) * | 2000-06-05 | 2004-08-31 | Scimed Life Systems, Inc. | Intravascular stent with increasing coating retaining capacity |
| US20040106985A1 (en) | 1996-04-26 | 2004-06-03 | Jang G. David | Intravascular stent |
| US5617878A (en) | 1996-05-31 | 1997-04-08 | Taheri; Syde A. | Stent and method for treatment of aortic occlusive disease |
| US5697971A (en) | 1996-06-11 | 1997-12-16 | Fischell; Robert E. | Multi-cell stent with cells having differing characteristics |
| US7070590B1 (en) | 1996-07-02 | 2006-07-04 | Massachusetts Institute Of Technology | Microchip drug delivery devices |
| US5797898A (en) | 1996-07-02 | 1998-08-25 | Massachusetts Institute Of Technology | Microchip drug delivery devices |
| US6120535A (en) | 1996-07-29 | 2000-09-19 | Radiance Medical Systems, Inc. | Microporous tubular prosthesis |
| US5922020A (en) | 1996-08-02 | 1999-07-13 | Localmed, Inc. | Tubular prosthesis having improved expansion and imaging characteristics |
| US6007517A (en) | 1996-08-19 | 1999-12-28 | Anderson; R. David | Rapid exchange/perfusion angioplasty catheter |
| US5797887A (en) | 1996-08-27 | 1998-08-25 | Novovasc Llc | Medical device with a surface adapted for exposure to a blood stream which is coated with a polymer containing a nitrosyl-containing organo-metallic compound which releases nitric oxide from the coating to mediate platelet aggregation |
| US6057367A (en) | 1996-08-30 | 2000-05-02 | Duke University | Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses |
| US5807404A (en) | 1996-09-19 | 1998-09-15 | Medinol Ltd. | Stent with variable features to optimize support and method of making such stent |
| US6174326B1 (en) * | 1996-09-25 | 2001-01-16 | Terumo Kabushiki Kaisha | Radiopaque, antithrombogenic stent and method for its production |
| US5824045A (en) | 1996-10-21 | 1998-10-20 | Inflow Dynamics Inc. | Vascular and endoluminal stents |
| US6099561A (en) | 1996-10-21 | 2000-08-08 | Inflow Dynamics, Inc. | Vascular and endoluminal stents with improved coatings |
| US5868781A (en) * | 1996-10-22 | 1999-02-09 | Scimed Life Systems, Inc. | Locking stent |
| WO1998018407A1 (de) | 1996-10-28 | 1998-05-07 | BIOTRONIK MESS- UND THERAPIEGERäTE GMBH & CO. INGENIEURBüRO BERLIN | Stent |
| AU4896797A (en) | 1996-11-04 | 1998-05-29 | Davidson, Charles | Extendible stent apparatus and method for deploying the same |
| ZA9710342B (en) | 1996-11-25 | 1998-06-10 | Alza Corp | Directional drug delivery stent and method of use. |
| US5980972A (en) | 1996-12-20 | 1999-11-09 | Schneider (Usa) Inc | Method of applying drug-release coatings |
| US5906759A (en) | 1996-12-26 | 1999-05-25 | Medinol Ltd. | Stent forming apparatus with stent deforming blades |
| IT1289815B1 (it) | 1996-12-30 | 1998-10-16 | Sorin Biomedica Cardio Spa | Stent per angioplastica e relativo procedimento di produzione |
| US5733330A (en) * | 1997-01-13 | 1998-03-31 | Advanced Cardiovascular Systems, Inc. | Balloon-expandable, crush-resistant locking stent |
| JPH10204700A (ja) | 1997-01-16 | 1998-08-04 | Nec Corp | ヘリックス用電解研磨装置 |
| US5980551A (en) | 1997-02-07 | 1999-11-09 | Endovasc Ltd., Inc. | Composition and method for making a biodegradable drug delivery stent |
| US5853419A (en) | 1997-03-17 | 1998-12-29 | Surface Genesis, Inc. | Stent |
| US5843172A (en) | 1997-04-15 | 1998-12-01 | Advanced Cardiovascular Systems, Inc. | Porous medicated stent |
| US6240616B1 (en) | 1997-04-15 | 2001-06-05 | Advanced Cardiovascular Systems, Inc. | Method of manufacturing a medicated porous metal prosthesis |
| US6273913B1 (en) | 1997-04-18 | 2001-08-14 | Cordis Corporation | Modified stent useful for delivery of drugs along stent strut |
| US6033433A (en) * | 1997-04-25 | 2000-03-07 | Scimed Life Systems, Inc. | Stent configurations including spirals |
| US5843175A (en) | 1997-06-13 | 1998-12-01 | Global Therapeutics, Inc. | Enhanced flexibility surgical stent |
| FR2764794B1 (fr) | 1997-06-20 | 1999-11-12 | Nycomed Lab Sa | Dispositif tubulaire expanse a epaisseur variable |
| US5855600A (en) * | 1997-08-01 | 1999-01-05 | Inflow Dynamics Inc. | Flexible implantable stent with composite design |
| US5899935A (en) | 1997-08-04 | 1999-05-04 | Schneider (Usa) Inc. | Balloon expandable braided stent with restraint |
| US5984957A (en) | 1997-08-12 | 1999-11-16 | Schneider (Usa) Inc | Radially expanded prostheses with axial diameter control |
| US6306166B1 (en) | 1997-08-13 | 2001-10-23 | Scimed Life Systems, Inc. | Loading and release of water-insoluble drugs |
| US6159488A (en) | 1997-08-14 | 2000-12-12 | Agricultural Research Org. Ministry Of Agriculture (Gov.) | Intracoronary stents containing quinazolinone derivatives |
| US6121027A (en) | 1997-08-15 | 2000-09-19 | Surmodics, Inc. | Polybifunctional reagent having a polymeric backbone and photoreactive moieties and bioactive groups |
| US6569688B2 (en) | 1997-08-26 | 2003-05-27 | Technion Research & Development Foundation Ltd. | Intravascular apparatus method |
| US6056722A (en) | 1997-09-18 | 2000-05-02 | Iowa-India Investments Company Limited Of Douglas | Delivery mechanism for balloons, drugs, stents and other physical/mechanical agents and methods of use |
| KR20010082497A (ko) | 1997-09-24 | 2001-08-30 | 메드 인스티튜트, 인코포레이티드 | 반경방향으로 팽창가능한 스텐트 |
| US6042606A (en) * | 1997-09-29 | 2000-03-28 | Cook Incorporated | Radially expandable non-axially contracting surgical stent |
| US5972027A (en) * | 1997-09-30 | 1999-10-26 | Scimed Life Systems, Inc | Porous stent drug delivery system |
| US5976182A (en) | 1997-10-03 | 1999-11-02 | Advanced Cardiovascular Systems, Inc. | Balloon-expandable, crush-resistant locking stent and method of loading the same |
| KR100232852B1 (ko) | 1997-10-15 | 1999-12-01 | 윤종용 | 잉크젯 프린터 헤드 및 이의 제조방법 |
| US5992000A (en) | 1997-10-16 | 1999-11-30 | Scimed Life Systems, Inc. | Stent crimper |
| US6273908B1 (en) | 1997-10-24 | 2001-08-14 | Robert Ndondo-Lay | Stents |
| US6309414B1 (en) | 1997-11-04 | 2001-10-30 | Sorin Biomedica Cardio S.P.A. | Angioplasty stents |
| US6190404B1 (en) | 1997-11-07 | 2001-02-20 | Advanced Bio Prosthetic Surfaces, Ltd. | Intravascular stent and method for manufacturing an intravascular stent |
| US6030414A (en) * | 1997-11-13 | 2000-02-29 | Taheri; Syde A. | Variable stent and method for treatment of arterial disease |
| US6156062A (en) | 1997-12-03 | 2000-12-05 | Ave Connaught | Helically wrapped interlocking stent |
| IT1296619B1 (it) | 1997-12-10 | 1999-07-14 | Sorin Biomedica Cardio Spa | Procedimento per il trattamento di protesi a struttura aperturata e relativi dispositivi. |
| US5964798A (en) | 1997-12-16 | 1999-10-12 | Cardiovasc, Inc. | Stent having high radial strength |
| US6533807B2 (en) | 1998-02-05 | 2003-03-18 | Medtronic, Inc. | Radially-expandable stent and delivery system |
| US6140127A (en) | 1998-02-18 | 2000-10-31 | Cordis Corporation | Method of coating an intravascular stent with an endothelial cell adhesive five amino acid peptide |
| US6077296A (en) | 1998-03-04 | 2000-06-20 | Endologix, Inc. | Endoluminal vascular prosthesis |
| EP1222941B2 (en) | 1998-03-30 | 2009-04-22 | Conor Medsystems, Inc. | Flexible medical device |
| US20040127977A1 (en) | 2002-09-20 | 2004-07-01 | Conor Medsystems, Inc. | Expandable medical device with openings for delivery of multiple beneficial agents |
| US7208011B2 (en) * | 2001-08-20 | 2007-04-24 | Conor Medsystems, Inc. | Implantable medical device with drug filled holes |
| US7208010B2 (en) | 2000-10-16 | 2007-04-24 | Conor Medsystems, Inc. | Expandable medical device for delivery of beneficial agent |
| US7179289B2 (en) | 1998-03-30 | 2007-02-20 | Conor Medsystems, Inc. | Expandable medical device for delivery of beneficial agent |
| US6241762B1 (en) | 1998-03-30 | 2001-06-05 | Conor Medsystems, Inc. | Expandable medical device with ductile hinges |
| US6019789A (en) * | 1998-04-01 | 2000-02-01 | Quanam Medical Corporation | Expandable unit cell and intraluminal stent |
| US6206916B1 (en) * | 1998-04-15 | 2001-03-27 | Joseph G. Furst | Coated intraluminal graft |
| US20010029351A1 (en) | 1998-04-16 | 2001-10-11 | Robert Falotico | Drug combinations and delivery devices for the prevention and treatment of vascular disease |
| US6013099A (en) | 1998-04-29 | 2000-01-11 | Medtronic, Inc. | Medical device for delivering a water-insoluble therapeutic salt or substance |
| US6423345B2 (en) * | 1998-04-30 | 2002-07-23 | Acusphere, Inc. | Matrices formed of polymer and hydrophobic compounds for use in drug delivery |
| US6206914B1 (en) | 1998-04-30 | 2001-03-27 | Medtronic, Inc. | Implantable system with drug-eluting cells for on-demand local drug delivery |
| US6280411B1 (en) | 1998-05-18 | 2001-08-28 | Scimed Life Systems, Inc. | Localized delivery of drug agents |
| US6083258A (en) | 1998-05-28 | 2000-07-04 | Yadav; Jay S. | Locking stent |
| US6153252A (en) | 1998-06-30 | 2000-11-28 | Ethicon, Inc. | Process for coating stents |
| WO2000004999A1 (en) | 1998-07-21 | 2000-02-03 | Biocompatibles Limited | Coating |
| US20020038146A1 (en) * | 1998-07-29 | 2002-03-28 | Ulf Harry | Expandable stent with relief cuts for carrying medicines and other materials |
| CA2340652C (en) | 1998-08-20 | 2013-09-24 | Cook Incorporated | Coated implantable medical device comprising paclitaxel |
| US6203991B1 (en) | 1998-08-21 | 2001-03-20 | The Regents Of The University Of Michigan | Inhibition of smooth muscle cell migration by heme oxygenase I |
| JP2002523136A (ja) | 1998-08-21 | 2002-07-30 | プロビデンス ヘルス システム−オレゴン | 挿入可能なステント及び該ステントの製造及び使用方法 |
| US7662409B2 (en) * | 1998-09-25 | 2010-02-16 | Gel-Del Technologies, Inc. | Protein matrix materials, devices and methods of making and using thereof |
| US6206915B1 (en) * | 1998-09-29 | 2001-03-27 | Medtronic Ave, Inc. | Drug storing and metering stent |
| US6293967B1 (en) | 1998-10-29 | 2001-09-25 | Conor Medsystems, Inc. | Expandable medical device with ductile hinges |
| US6528121B2 (en) * | 1998-11-19 | 2003-03-04 | Dow Corning Toray Silicone Co., Ltd. | Aqueous treatment agent for wiping paper |
| US6063101A (en) | 1998-11-20 | 2000-05-16 | Precision Vascular Systems, Inc. | Stent apparatus and method |
| DE59907401D1 (de) | 1998-12-21 | 2003-11-20 | Lonza Ag | Verfahren zur Herstellung von 2,5-Diamino-4,6-dihalogenpyrimidinen |
| US6120847A (en) | 1999-01-08 | 2000-09-19 | Scimed Life Systems, Inc. | Surface treatment method for stent coating |
| US6530950B1 (en) * | 1999-01-12 | 2003-03-11 | Quanam Medical Corporation | Intraluminal stent having coaxial polymer member |
| US6273910B1 (en) | 1999-03-11 | 2001-08-14 | Advanced Cardiovascular Systems, Inc. | Stent with varying strut geometry |
| US6730116B1 (en) | 1999-04-16 | 2004-05-04 | Medtronic, Inc. | Medical device for intraluminal endovascular stenting |
| US6287335B1 (en) | 1999-04-26 | 2001-09-11 | William J. Drasler | Intravascular folded tubular endoprosthesis |
| US6334807B1 (en) * | 1999-04-30 | 2002-01-01 | International Business Machines Corporation | Chemical mechanical polishing in-situ end point system |
| US6245101B1 (en) * | 1999-05-03 | 2001-06-12 | William J. Drasler | Intravascular hinge stent |
| US6375676B1 (en) | 1999-05-17 | 2002-04-23 | Advanced Cardiovascular Systems, Inc. | Self-expanding stent with enhanced delivery precision and stent delivery system |
| US6290673B1 (en) | 1999-05-20 | 2001-09-18 | Conor Medsystems, Inc. | Expandable medical device delivery system and method |
| WO2001001957A1 (en) | 1999-05-27 | 2001-01-11 | Biocompatibles Limited | Local drug delivery |
| CN1378445B (zh) * | 1999-08-06 | 2013-02-06 | 得克萨斯系统大学评议会 | 药物释放生物可降解纤维植入物 |
| US6759054B2 (en) | 1999-09-03 | 2004-07-06 | Advanced Cardiovascular Systems, Inc. | Ethylene vinyl alcohol composition and coating |
| WO2001017577A1 (en) * | 1999-09-03 | 2001-03-15 | Advanced Cardiovascular Systems, Inc. | A porous prosthesis and a method of depositing substances into the pores |
| US6790228B2 (en) | 1999-12-23 | 2004-09-14 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
| US6379381B1 (en) | 1999-09-03 | 2002-04-30 | Advanced Cardiovascular Systems, Inc. | Porous prosthesis and a method of depositing substances into the pores |
| US7807211B2 (en) | 1999-09-03 | 2010-10-05 | Advanced Cardiovascular Systems, Inc. | Thermal treatment of an implantable medical device |
| US7682647B2 (en) | 1999-09-03 | 2010-03-23 | Advanced Cardiovascular Systems, Inc. | Thermal treatment of a drug eluting implantable medical device |
| US6713119B2 (en) | 1999-09-03 | 2004-03-30 | Advanced Cardiovascular Systems, Inc. | Biocompatible coating for a prosthesis and a method of forming the same |
| US6503954B1 (en) * | 2000-03-31 | 2003-01-07 | Advanced Cardiovascular Systems, Inc. | Biocompatible carrier containing actinomycin D and a method of forming the same |
| US6239118B1 (en) | 1999-10-05 | 2001-05-29 | Richard A. Schatz | Method for preventing restenosis using a substituted adenine derivative |
| US6682545B1 (en) * | 1999-10-06 | 2004-01-27 | The Penn State Research Foundation | System and device for preventing restenosis in body vessels |
| AU1084101A (en) | 1999-10-14 | 2001-04-23 | United Stenting, Inc. | Stents with multilayered struts |
| US6331189B1 (en) | 1999-10-18 | 2001-12-18 | Medtronic, Inc. | Flexible medical stent |
| US6428569B1 (en) * | 1999-11-09 | 2002-08-06 | Scimed Life Systems Inc. | Micro structure stent configurations |
| US6461631B1 (en) | 1999-11-16 | 2002-10-08 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
| AU770395B2 (en) | 1999-11-17 | 2004-02-19 | Boston Scientific Limited | Microfabricated devices for the delivery of molecules into a carrier fluid |
| US6338739B1 (en) | 1999-12-22 | 2002-01-15 | Ethicon, Inc. | Biodegradable stent |
| US6613432B2 (en) | 1999-12-22 | 2003-09-02 | Biosurface Engineering Technologies, Inc. | Plasma-deposited coatings, devices and methods |
| US6908624B2 (en) | 1999-12-23 | 2005-06-21 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
| US6471979B2 (en) * | 1999-12-29 | 2002-10-29 | Estrogen Vascular Technology, Llc | Apparatus and method for delivering compounds to a living organism |
| US6491617B1 (en) | 1999-12-30 | 2002-12-10 | St. Jude Medical, Inc. | Medical devices that resist restenosis |
| US6899731B2 (en) | 1999-12-30 | 2005-05-31 | Boston Scientific Scimed, Inc. | Controlled delivery of therapeutic agents by insertable medical devices |
| US6746686B2 (en) | 2000-01-24 | 2004-06-08 | Biocompatibles Uk Limited | Coated implants |
| US6375826B1 (en) | 2000-02-14 | 2002-04-23 | Advanced Cardiovascular Systems, Inc. | Electro-polishing fixture and electrolyte solution for polishing stents and method |
| US7828835B2 (en) * | 2000-03-01 | 2010-11-09 | Medinol Ltd. | Longitudinally flexible stent |
| US6551838B2 (en) | 2000-03-02 | 2003-04-22 | Microchips, Inc. | Microfabricated devices for the storage and selective exposure of chemicals and devices |
| EP1132058A1 (en) * | 2000-03-06 | 2001-09-12 | Advanced Laser Applications Holding S.A. | Intravascular prothesis |
| US6379382B1 (en) | 2000-03-13 | 2002-04-30 | Jun Yang | Stent having cover with drug delivery capability |
| US7300662B2 (en) | 2000-05-12 | 2007-11-27 | Cordis Corporation | Drug/drug delivery systems for the prevention and treatment of vascular disease |
| US20040243097A1 (en) | 2000-05-12 | 2004-12-02 | Robert Falotico | Antiproliferative drug and delivery device |
| US6776796B2 (en) * | 2000-05-12 | 2004-08-17 | Cordis Corportation | Antiinflammatory drug and delivery device |
| US7419678B2 (en) | 2000-05-12 | 2008-09-02 | Cordis Corporation | Coated medical devices for the prevention and treatment of vascular disease |
| US20020007213A1 (en) * | 2000-05-19 | 2002-01-17 | Robert Falotico | Drug/drug delivery systems for the prevention and treatment of vascular disease |
| US20050002986A1 (en) | 2000-05-12 | 2005-01-06 | Robert Falotico | Drug/drug delivery systems for the prevention and treatment of vascular disease |
| US20020005206A1 (en) * | 2000-05-19 | 2002-01-17 | Robert Falotico | Antiproliferative drug and delivery device |
| US20020007215A1 (en) * | 2000-05-19 | 2002-01-17 | Robert Falotico | Drug/drug delivery systems for the prevention and treatment of vascular disease |
| US20020007214A1 (en) * | 2000-05-19 | 2002-01-17 | Robert Falotico | Drug/drug delivery systems for the prevention and treatment of vascular disease |
| EP1301221B1 (en) | 2000-05-16 | 2006-02-15 | Ortho-McNeil Pharmaceutical, Inc. | Process for coating medical devices using super-critical carbon dioxide |
| US6395326B1 (en) | 2000-05-31 | 2002-05-28 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for depositing a coating onto a surface of a prosthesis |
| US6673385B1 (en) * | 2000-05-31 | 2004-01-06 | Advanced Cardiovascular Systems, Inc. | Methods for polymeric coatings stents |
| US6723373B1 (en) | 2000-06-16 | 2004-04-20 | Cordis Corporation | Device and process for coating stents |
| US6585765B1 (en) | 2000-06-29 | 2003-07-01 | Advanced Cardiovascular Systems, Inc. | Implantable device having substances impregnated therein and a method of impregnating the same |
| US20020077693A1 (en) | 2000-12-19 | 2002-06-20 | Barclay Bruce J. | Covered, coiled drug delivery stent and method |
| US6709451B1 (en) | 2000-07-14 | 2004-03-23 | Norman Noble, Inc. | Channeled vascular stent apparatus and method |
| US6555157B1 (en) | 2000-07-25 | 2003-04-29 | Advanced Cardiovascular Systems, Inc. | Method for coating an implantable device and system for performing the method |
| US6548308B2 (en) | 2000-09-25 | 2003-04-15 | Picoliter Inc. | Focused acoustic energy method and device for generating droplets of immiscible fluids |
| US6254632B1 (en) | 2000-09-28 | 2001-07-03 | Advanced Cardiovascular Systems, Inc. | Implantable medical device having protruding surface structures for drug delivery and cover attachment |
| US6716444B1 (en) | 2000-09-28 | 2004-04-06 | Advanced Cardiovascular Systems, Inc. | Barriers for polymer-coated implantable medical devices and methods for making the same |
| US6953560B1 (en) | 2000-09-28 | 2005-10-11 | Advanced Cardiovascular Systems, Inc. | Barriers for polymer-coated implantable medical devices and methods for making the same |
| US6805898B1 (en) | 2000-09-28 | 2004-10-19 | Advanced Cardiovascular Systems, Inc. | Surface features of an implantable medical device |
| US6746773B2 (en) | 2000-09-29 | 2004-06-08 | Ethicon, Inc. | Coatings for medical devices |
| US6764507B2 (en) | 2000-10-16 | 2004-07-20 | Conor Medsystems, Inc. | Expandable medical device with improved spatial distribution |
| ES2243556T3 (es) | 2000-10-16 | 2005-12-01 | Conor Medsystems, Inc. | Dispositivo medico expandible para proporcionar un agente beneficioso. |
| US6506437B1 (en) * | 2000-10-17 | 2003-01-14 | Advanced Cardiovascular Systems, Inc. | Methods of coating an implantable device having depots formed in a surface thereof |
| US6558733B1 (en) | 2000-10-26 | 2003-05-06 | Advanced Cardiovascular Systems, Inc. | Method for etching a micropatterned microdepot prosthesis |
| US6783793B1 (en) | 2000-10-26 | 2004-08-31 | Advanced Cardiovascular Systems, Inc. | Selective coating of medical devices |
| US6758859B1 (en) | 2000-10-30 | 2004-07-06 | Kenny L. Dang | Increased drug-loading and reduced stress drug delivery device |
| US10398830B2 (en) * | 2000-11-17 | 2019-09-03 | Vactronix Scientific, Llc | Device for in vivo delivery of bioactive agents and method of manufacture thereof |
| WO2002041931A2 (en) | 2000-11-27 | 2002-05-30 | Medtronic, Inc. | Stents and methods for preparing stents |
| US6517888B1 (en) | 2000-11-28 | 2003-02-11 | Scimed Life Systems, Inc. | Method for manufacturing a medical device having a coated portion by laser ablation |
| EP1343548B1 (en) * | 2000-11-28 | 2012-03-28 | Boston Scientific Limited | Method and apparatus for delivery of therapeutic from a delivery matrix |
| AU2002246570A1 (en) | 2000-12-07 | 2002-08-06 | The Medstar Research Institute | Inhibition of restenosis using a dna-coated stent |
| US6545097B2 (en) * | 2000-12-12 | 2003-04-08 | Scimed Life Systems, Inc. | Drug delivery compositions and medical devices containing block copolymer |
| US6929660B1 (en) | 2000-12-22 | 2005-08-16 | Advanced Cardiovascular Systems, Inc. | Intravascular stent |
| US20020082679A1 (en) | 2000-12-22 | 2002-06-27 | Avantec Vascular Corporation | Delivery or therapeutic capable agents |
| US7077859B2 (en) | 2000-12-22 | 2006-07-18 | Avantec Vascular Corporation | Apparatus and methods for variably controlled substance delivery from implanted prostheses |
| US20030033007A1 (en) * | 2000-12-22 | 2003-02-13 | Avantec Vascular Corporation | Methods and devices for delivery of therapeutic capable agents with variable release profile |
| US6663662B2 (en) | 2000-12-28 | 2003-12-16 | Advanced Cardiovascular Systems, Inc. | Diffusion barrier layer for implantable devices |
| US6635082B1 (en) | 2000-12-29 | 2003-10-21 | Advanced Cardiovascular Systems Inc. | Radiopaque stent |
| GB0100761D0 (en) * | 2001-01-11 | 2001-02-21 | Biocompatibles Ltd | Drug delivery from stents |
| GB0100760D0 (en) * | 2001-01-11 | 2001-02-21 | Biocompatibles Ltd | Drug delivery from stents |
| EP1223305B1 (en) | 2001-01-16 | 2008-04-23 | Services Petroliers Schlumberger | Bi-stable expandable device and method for expanding such a device |
| US6706274B2 (en) | 2001-01-18 | 2004-03-16 | Scimed Life Systems, Inc. | Differential delivery of nitric oxide |
| US6752829B2 (en) * | 2001-01-30 | 2004-06-22 | Scimed Life Systems, Inc. | Stent with channel(s) for containing and delivering a biologically active material and method for manufacturing the same |
| US20040204756A1 (en) | 2004-02-11 | 2004-10-14 | Diaz Stephen Hunter | Absorbent article with improved liquid acquisition capacity |
| US20040073294A1 (en) * | 2002-09-20 | 2004-04-15 | Conor Medsystems, Inc. | Method and apparatus for loading a beneficial agent into an expandable medical device |
| US20040220660A1 (en) | 2001-02-05 | 2004-11-04 | Shanley John F. | Bioresorbable stent with beneficial agent reservoirs |
| US6964680B2 (en) | 2001-02-05 | 2005-11-15 | Conor Medsystems, Inc. | Expandable medical device with tapered hinge |
| US20020127263A1 (en) | 2001-02-27 | 2002-09-12 | Wenda Carlyle | Peroxisome proliferator-acitvated receptor gamma ligand eluting medical device |
| US20050278014A9 (en) | 2001-03-07 | 2005-12-15 | Wolfgang Daum | Stent and method for drug delivery from stents |
| WO2002072014A2 (en) * | 2001-03-08 | 2002-09-19 | Volcano Therapeutics, Inc. | Medical devices, compositions and methods for treating vulnerable plaque |
| US6378988B1 (en) | 2001-03-19 | 2002-04-30 | Microfab Technologies, Inc. | Cartridge element for micro jet dispensing |
| US20020138136A1 (en) | 2001-03-23 | 2002-09-26 | Scimed Life Systems, Inc. | Medical device having radio-opacification and barrier layers |
| US6780424B2 (en) | 2001-03-30 | 2004-08-24 | Charles David Claude | Controlled morphologies in polymer drug for release of drugs from polymer films |
| US6712845B2 (en) | 2001-04-24 | 2004-03-30 | Advanced Cardiovascular Systems, Inc. | Coating for a stent and a method of forming the same |
| US6599415B1 (en) | 2001-04-30 | 2003-07-29 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for electropolishing surfaces |
| US6660034B1 (en) | 2001-04-30 | 2003-12-09 | Advanced Cardiovascular Systems, Inc. | Stent for increasing blood flow to ischemic tissues and a method of using the same |
| US6605154B1 (en) | 2001-05-31 | 2003-08-12 | Advanced Cardiovascular Systems, Inc. | Stent mounting device |
| US6679980B1 (en) * | 2001-06-13 | 2004-01-20 | Advanced Cardiovascular Systems, Inc. | Apparatus for electropolishing a stent |
| US7493162B2 (en) | 2001-06-15 | 2009-02-17 | Cardiac Pacemakers, Inc. | Pulmonary vein stent for treating atrial fibrillation |
| US7247313B2 (en) | 2001-06-27 | 2007-07-24 | Advanced Cardiovascular Systems, Inc. | Polyacrylates coatings for implantable medical devices |
| US6695920B1 (en) | 2001-06-27 | 2004-02-24 | Advanced Cardiovascular Systems, Inc. | Mandrel for supporting a stent and a method of using the mandrel to coat a stent |
| US6656216B1 (en) | 2001-06-29 | 2003-12-02 | Advanced Cardiovascular Systems, Inc. | Composite stent with regioselective material |
| US6676987B2 (en) * | 2001-07-02 | 2004-01-13 | Scimed Life Systems, Inc. | Coating a medical appliance with a bubble jet printing head |
| US6682771B2 (en) * | 2001-07-02 | 2004-01-27 | Scimed Life Systems, Inc. | Coating dispensing system and method using a solenoid head for coating medical devices |
| US20030050687A1 (en) * | 2001-07-03 | 2003-03-13 | Schwade Nathan D. | Biocompatible stents and method of deployment |
| DE60120955T3 (de) | 2001-07-20 | 2015-06-25 | Cid S.P.A. | Stent |
| JP2003036944A (ja) * | 2001-07-25 | 2003-02-07 | Sumitomo Wiring Syst Ltd | コネクタ |
| US7056338B2 (en) | 2003-03-28 | 2006-06-06 | Conor Medsystems, Inc. | Therapeutic agent delivery device with controlled therapeutic agent release rates |
| US20040249443A1 (en) | 2001-08-20 | 2004-12-09 | Shanley John F. | Expandable medical device for treating cardiac arrhythmias |
| US6908622B2 (en) | 2001-09-24 | 2005-06-21 | Boston Scientific Scimed, Inc. | Optimized dosing for drug coated stents |
| US20050025808A1 (en) | 2001-09-24 | 2005-02-03 | Herrmann Robert A. | Medical devices and methods for inhibiting smooth muscle cell proliferation |
| US7195640B2 (en) * | 2001-09-25 | 2007-03-27 | Cordis Corporation | Coated medical devices for the treatment of vulnerable plaque |
| US6753071B1 (en) | 2001-09-27 | 2004-06-22 | Advanced Cardiovascular Systems, Inc. | Rate-reducing membrane for release of an agent |
| DE10150995A1 (de) * | 2001-10-08 | 2003-04-10 | Biotronik Mess & Therapieg | Implantat mit proliferationshemmender Substanz |
| US20030077312A1 (en) | 2001-10-22 | 2003-04-24 | Ascher Schmulewicz | Coated intraluminal stents and reduction of restenosis using same |
| US20030088307A1 (en) | 2001-11-05 | 2003-05-08 | Shulze John E. | Potent coatings for stents |
| US6939376B2 (en) * | 2001-11-05 | 2005-09-06 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
| EP1310242A1 (en) | 2001-11-13 | 2003-05-14 | SORIN BIOMEDICA CARDIO S.p.A. | Carrier and kit for endoluminal delivery of active principles |
| US7014654B2 (en) | 2001-11-30 | 2006-03-21 | Scimed Life Systems, Inc. | Stent designed for the delivery of therapeutic substance or other agents |
| US6939374B2 (en) | 2001-12-21 | 2005-09-06 | Scimed Life Systems, Inc. | Stents, stenting systems, and related methods for agent delivery |
| DE20200220U1 (de) * | 2002-01-08 | 2002-03-21 | Translumina Gmbh | Stent |
| US6911040B2 (en) | 2002-01-24 | 2005-06-28 | Cordis Corporation | Covered segmented stent |
| US7445629B2 (en) | 2002-01-31 | 2008-11-04 | Boston Scientific Scimed, Inc. | Medical device for delivering biologically active material |
| US20030181973A1 (en) | 2002-03-20 | 2003-09-25 | Harvinder Sahota | Reduced restenosis drug containing stents |
| US6743463B2 (en) | 2002-03-28 | 2004-06-01 | Scimed Life Systems, Inc. | Method for spray-coating a medical device having a tubular wall such as a stent |
| US20030204239A1 (en) | 2002-04-26 | 2003-10-30 | Wenda Carlyle | Endovascular stent with a preservative coating |
| US6645547B1 (en) | 2002-05-02 | 2003-11-11 | Labcoat Ltd. | Stent coating device |
| US6670612B1 (en) * | 2002-07-01 | 2003-12-30 | Kla-Tencor Technologies Corporation | Undercut measurement using SEM |
| US20040127976A1 (en) | 2002-09-20 | 2004-07-01 | Conor Medsystems, Inc. | Method and apparatus for loading a beneficial agent into an expandable medical device |
| US6818063B1 (en) | 2002-09-24 | 2004-11-16 | Advanced Cardiovascular Systems, Inc. | Stent mandrel fixture and method for minimizing coating defects |
| US6702850B1 (en) | 2002-09-30 | 2004-03-09 | Mediplex Corporation Korea | Multi-coated drug-eluting stent for antithrombosis and antirestenosis |
| WO2004043509A1 (en) | 2002-11-08 | 2004-05-27 | Conor Medsystems, Inc. | Expandable medical device and method for treating chronic total occlusions with local delivery of an angiogenic factor |
| US20040142014A1 (en) | 2002-11-08 | 2004-07-22 | Conor Medsystems, Inc. | Method and apparatus for reducing tissue damage after ischemic injury |
| AU2003287633A1 (en) | 2002-11-08 | 2004-06-03 | Innovational Holdings, Llc | Method and apparatus for reducing tissue damage after ischemic injury |
| US6896965B1 (en) | 2002-11-12 | 2005-05-24 | Advanced Cardiovascular Systems, Inc. | Rate limiting barriers for implantable devices |
| PL376169A1 (en) | 2002-11-15 | 2005-12-27 | Novartis Ag | Drug delivery system |
| US6982004B1 (en) | 2002-11-26 | 2006-01-03 | Advanced Cardiovascular Systems, Inc. | Electrostatic loading of drugs on implantable medical devices |
| US20050079199A1 (en) | 2003-02-18 | 2005-04-14 | Medtronic, Inc. | Porous coatings for drug release from medical devices |
| US6926919B1 (en) | 2003-02-26 | 2005-08-09 | Advanced Cardiovascular Systems, Inc. | Method for fabricating a coating for a medical device |
| WO2005016396A1 (en) | 2003-08-13 | 2005-02-24 | Poly-Med, Inc. | Biocompatible controlled release coatings for medical devices and related methods |
| US8088404B2 (en) | 2003-03-20 | 2012-01-03 | Medtronic Vasular, Inc. | Biocompatible controlled release coatings for medical devices and related methods |
| US20040202692A1 (en) | 2003-03-28 | 2004-10-14 | Conor Medsystems, Inc. | Implantable medical device and method for in situ selective modulation of agent delivery |
| US7482034B2 (en) | 2003-04-24 | 2009-01-27 | Boston Scientific Scimed, Inc. | Expandable mask stent coating method |
| DE602004031011D1 (de) | 2003-04-25 | 2011-02-24 | Boston Scient Scimed Inc | Feste arzneimittelformulierung und vorrichtung zu ihrer aufbewahrung und kontrollierten abgabe |
| US8518097B2 (en) | 2003-04-25 | 2013-08-27 | Medtronic Vascular, Inc. | Plasticized stent coatings |
| US20040215311A1 (en) | 2003-04-28 | 2004-10-28 | Kantor John D. | Method and system for improving stent retention using stent openings |
| US6923996B2 (en) | 2003-05-06 | 2005-08-02 | Scimed Life Systems, Inc. | Processes for producing polymer coatings for release of therapeutic agent |
| US7279174B2 (en) | 2003-05-08 | 2007-10-09 | Advanced Cardiovascular Systems, Inc. | Stent coatings comprising hydrophilic additives |
| US7524527B2 (en) | 2003-05-19 | 2009-04-28 | Boston Scientific Scimed, Inc. | Electrostatic coating of a device |
| AU2004247027A1 (en) | 2003-05-28 | 2004-12-23 | Innovational Holdings, Llc | Methods of delivering anti-restenotic agents from a stent |
| US7169179B2 (en) | 2003-06-05 | 2007-01-30 | Conor Medsystems, Inc. | Drug delivery device and method for bi-directional drug delivery |
| US7186789B2 (en) | 2003-06-11 | 2007-03-06 | Advanced Cardiovascular Systems, Inc. | Bioabsorbable, biobeneficial polyester polymers for use in drug eluting stent coatings |
| US20050118344A1 (en) | 2003-12-01 | 2005-06-02 | Pacetti Stephen D. | Temperature controlled crimping |
| JP2005046611A (ja) | 2003-07-01 | 2005-02-24 | Medtronic Vascular Inc | 薬剤含有ポリマーが塗布されたステント用のエネルギーで活性化された接着剤層 |
| WO2005007035A1 (en) | 2003-07-07 | 2005-01-27 | Medtronic Vascular | Coated stent with timed release of multiple therapeutic agents to inhibit restenosis adjacent to the stent ends |
| US7318945B2 (en) | 2003-07-09 | 2008-01-15 | Medtronic Vascular, Inc. | Laminated drug-polymer coated stent having dipped layers |
| US20050033417A1 (en) | 2003-07-31 | 2005-02-10 | John Borges | Coating for controlled release of a therapeutic agent |
| US7357940B2 (en) | 2003-07-31 | 2008-04-15 | Boston Scientific Scimed, Inc. | Implantable or insertable medical devices containing graft copolymer for controlled delivery of therapeutic agents |
| US8870814B2 (en) | 2003-07-31 | 2014-10-28 | Boston Scientific Scimed, Inc. | Implantable or insertable medical devices containing silicone copolymer for controlled delivery of therapeutic agent |
| US20050037047A1 (en) | 2003-08-11 | 2005-02-17 | Young-Ho Song | Medical devices comprising spray dried microparticles |
| US20050049693A1 (en) | 2003-08-25 | 2005-03-03 | Medtronic Vascular Inc. | Medical devices and compositions for delivering biophosphonates to anatomical sites at risk for vascular disease |
| US20050055078A1 (en) | 2003-09-04 | 2005-03-10 | Medtronic Vascular, Inc. | Stent with outer slough coating |
| US20050060020A1 (en) | 2003-09-17 | 2005-03-17 | Scimed Life Systems, Inc. | Covered stent with biologically active material |
| US7785653B2 (en) | 2003-09-22 | 2010-08-31 | Innovational Holdings Llc | Method and apparatus for loading a beneficial agent into an expandable medical device |
| US8801692B2 (en) | 2003-09-24 | 2014-08-12 | Medtronic Vascular, Inc. | Gradient coated stent and method of fabrication |
| US7060319B2 (en) | 2003-09-24 | 2006-06-13 | Boston Scientific Scimed, Inc. | method for using an ultrasonic nozzle to coat a medical appliance |
| US7055237B2 (en) | 2003-09-29 | 2006-06-06 | Medtronic Vascular, Inc. | Method of forming a drug eluting stent |
| US7744645B2 (en) | 2003-09-29 | 2010-06-29 | Medtronic Vascular, Inc. | Laminated drug-polymer coated stent with dipped and cured layers |
| US7198675B2 (en) | 2003-09-30 | 2007-04-03 | Advanced Cardiovascular Systems | Stent mandrel fixture and method for selectively coating surfaces of a stent |
| CA2541138A1 (en) | 2003-10-06 | 2005-05-06 | Novartis Ag | Use of genetic polymorphisms that associate with efficacy of treatment of inflammatory disease |
| US7704544B2 (en) | 2003-10-07 | 2010-04-27 | Advanced Cardiovascular Systems, Inc. | System and method for coating a tubular implantable medical device |
| US6984411B2 (en) | 2003-10-14 | 2006-01-10 | Boston Scientific Scimed, Inc. | Method for roll coating multiple stents |
| US20050087520A1 (en) | 2003-10-28 | 2005-04-28 | Lixiao Wang | Method and apparatus for selective ablation of coatings from medical devices |
| US20050100577A1 (en) | 2003-11-10 | 2005-05-12 | Parker Theodore L. | Expandable medical device with beneficial agent matrix formed by a multi solvent system |
| US20050112170A1 (en) | 2003-11-20 | 2005-05-26 | Hossainy Syed F. | Coatings for implantable devices comprising polymers of lactic acid and methods for fabricating the same |
| WO2005053937A1 (en) | 2003-12-01 | 2005-06-16 | Advanced Cardiovascular Systems, Inc. | Temperature controlled crimping |
| US7303758B2 (en) | 2004-01-20 | 2007-12-04 | Cordis Corporation | Local vascular delivery of mycophenolic acid in combination with rapamycin to prevent restenosis following vascular injury |
| ITTO20040056A1 (it) | 2004-02-05 | 2004-05-05 | Sorin Biomedica Cardio Spa | Stent per l'erogazione endoliminale di principi o agenti attivi |
| US7806924B2 (en) | 2004-02-18 | 2010-10-05 | Cordis Corporation | Implantable structures for local vascular delivery of cladribine in combination with rapamycin for restenosis |
| US20050197691A1 (en) | 2004-02-18 | 2005-09-08 | Medtronic Vascular, Inc. | Medical devices to treat or inhibit restenosis |
| US7294145B2 (en) | 2004-02-26 | 2007-11-13 | Boston Scientific Scimed, Inc. | Stent with differently coated inside and outside surfaces |
| US8137397B2 (en) | 2004-02-26 | 2012-03-20 | Boston Scientific Scimed, Inc. | Medical devices |
| US8828416B2 (en) | 2004-03-09 | 2014-09-09 | Cordis Corporation | Local vascular delivery of topotecan in combination with rapamycin to prevent restenosis following vascular injury |
| US6979473B2 (en) | 2004-03-15 | 2005-12-27 | Boston Scientific Scimed, Inc. | Method for fine bore orifice spray coating of medical devices and pre-filming atomization |
| US20050208093A1 (en) | 2004-03-22 | 2005-09-22 | Thierry Glauser | Phosphoryl choline coating compositions |
| US7875282B2 (en) | 2004-03-22 | 2011-01-25 | Cordis Corporation | Coated medical device for local vascular delivery of Panzem® in combination with rapamycin to prevent restenosis following vascular injury |
| EP1727583A1 (en) | 2004-03-23 | 2006-12-06 | Boston Scientific Limited | Agent eluting stent and catheter |
| US20050214339A1 (en) | 2004-03-29 | 2005-09-29 | Yiwen Tang | Biologically degradable compositions for medical applications |
| US20050220836A1 (en) | 2004-03-31 | 2005-10-06 | Robert Falotico | Drug delivery device |
| US8007737B2 (en) | 2004-04-14 | 2011-08-30 | Wyeth | Use of antioxidants to prevent oxidation and reduce drug degradation in drug eluting medical devices |
| CA2502018A1 (en) | 2004-04-16 | 2005-10-16 | Conor Medsystems, Inc. | Bioresorbable stent delivery system |
| US8048149B2 (en) | 2004-05-13 | 2011-11-01 | Medtronic Vascular, Inc. | Intraluminal stent including therapeutic agent delivery pads, and method of manufacturing the same |
| US20050261762A1 (en) | 2004-05-21 | 2005-11-24 | Medtronic Vascular, Inc. | Medical devices to prevent or inhibit restenosis |
| US20050261757A1 (en) | 2004-05-21 | 2005-11-24 | Conor Medsystems, Inc. | Stent with contoured bridging element |
| US20060020329A1 (en) | 2004-05-26 | 2006-01-26 | Medtronic Vascular, Inc. | Semi-directional drug delivering stents |
| EP1753451A4 (en) | 2004-06-07 | 2008-11-12 | Conor Medsystems Inc | LOCAL DELIVERY OF GROWTH FACTORS FOR STRAIN CELL TRANSPLANTATION |
| US7365007B2 (en) * | 2004-06-30 | 2008-04-29 | Intel Corporation | Interconnects with direct metalization and conductive polymer |
| JP4888914B2 (ja) | 2004-12-08 | 2012-02-29 | イノベーショナル・ホールディングス・エルエルシー | 異なるヒンジ性能を有する拡張可能な医療装置 |
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2004
- 2004-03-29 AU AU2004226327A patent/AU2004226327A1/en not_active Abandoned
- 2004-03-29 AT AT04758550T patent/ATE526038T1/de not_active IP Right Cessation
- 2004-03-29 WO PCT/US2004/009602 patent/WO2004087214A1/en not_active Ceased
- 2004-03-29 JP JP2006509440A patent/JP5596896B2/ja not_active Expired - Fee Related
- 2004-03-29 EP EP04758550A patent/EP1610823B1/en not_active Expired - Lifetime
- 2004-03-29 EP EP10010593A patent/EP2272544A1/en not_active Withdrawn
- 2004-03-29 CA CA2519711A patent/CA2519711C/en not_active Expired - Fee Related
- 2004-03-29 EP EP10010594.9A patent/EP2289571B1/en not_active Expired - Lifetime
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2006
- 2006-03-07 US US11/369,592 patent/US8449901B2/en not_active Expired - Fee Related
-
2013
- 2013-03-26 US US13/850,605 patent/US20130209663A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006523501A (ja) | 2006-10-19 |
| ATE526038T1 (de) | 2011-10-15 |
| US8449901B2 (en) | 2013-05-28 |
| EP2289571A1 (en) | 2011-03-02 |
| EP1610823A1 (en) | 2006-01-04 |
| AU2004226327A1 (en) | 2004-10-14 |
| WO2004087214A1 (en) | 2004-10-14 |
| CA2519711A1 (en) | 2004-10-14 |
| EP1610823B1 (en) | 2011-09-28 |
| EP2289571B1 (en) | 2016-08-03 |
| EP2272544A1 (en) | 2011-01-12 |
| US20060147489A1 (en) | 2006-07-06 |
| JP5596896B2 (ja) | 2014-09-24 |
| US20130209663A1 (en) | 2013-08-15 |
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|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20190329 |