CA2519568C - 6"-amino-6"-deoxygalactosylceramides - Google Patents

6"-amino-6"-deoxygalactosylceramides Download PDF

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Publication number
CA2519568C
CA2519568C CA2519568A CA2519568A CA2519568C CA 2519568 C CA2519568 C CA 2519568C CA 2519568 A CA2519568 A CA 2519568A CA 2519568 A CA2519568 A CA 2519568A CA 2519568 C CA2519568 C CA 2519568C
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CA
Canada
Prior art keywords
compound
subject
alkyl
mammal
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2519568A
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English (en)
Other versions
CA2519568A1 (fr
Inventor
Paul B. Savage
Albert Bendelac
Luc Teyton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Chicago
Brigham Young University
Scripps Research Institute
Original Assignee
University of Chicago
Brigham Young University
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by University of Chicago, Brigham Young University, Scripps Research Institute filed Critical University of Chicago
Publication of CA2519568A1 publication Critical patent/CA2519568A1/fr
Application granted granted Critical
Publication of CA2519568C publication Critical patent/CA2519568C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des composés de galactosylcéramide.
CA2519568A 2003-03-20 2003-03-20 6"-amino-6"-deoxygalactosylceramides Expired - Lifetime CA2519568C (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2003/008530 WO2004094444A1 (fr) 2003-03-20 2003-03-20 6'-amino-6'-deoxygalactosylceramides

Publications (2)

Publication Number Publication Date
CA2519568A1 CA2519568A1 (fr) 2004-11-04
CA2519568C true CA2519568C (fr) 2012-01-03

Family

ID=33308974

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2519568A Expired - Lifetime CA2519568C (fr) 2003-03-20 2003-03-20 6"-amino-6"-deoxygalactosylceramides

Country Status (4)

Country Link
EP (1) EP1611147A4 (fr)
AU (1) AU2003225891A1 (fr)
CA (1) CA2519568C (fr)
WO (1) WO2004094444A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7419958B2 (en) 2001-03-26 2008-09-02 Dana-Farber Cancer Institute, Inc. Method of attenuating reactions to skin irritants
US7645873B2 (en) 2003-03-20 2010-01-12 The Scripps Research Institute 6″-amino-6″-deoxygalactosylceramides
WO2006060117A2 (fr) 2004-11-02 2006-06-08 The Board Of Trustees Of The Leland Stanford Junior University Methodes d'inhibition des cellules nkt
DK1848813T3 (da) 2005-01-28 2013-07-15 Univ Brigham Young Aktivering af bakterielt glycolipid fra CD1D-begrænsede NKT-celler
US8227581B2 (en) * 2006-04-07 2012-07-24 The Scripps Research Institute Modified α-galactosyl ceramides for staining and stimulating natural killer T cells
WO2008005824A1 (fr) 2006-06-30 2008-01-10 The Scripps Research Institute Adjuvants et procédés d'utilisation
US8916164B2 (en) 2007-08-29 2014-12-23 Abivax Methods of enhancing adjuvaticity of vaccine compositions
EP2058011A1 (fr) * 2007-11-07 2009-05-13 Wittycell Cellule Nkt activant des antigènes et/ou médicaments à liaison gycolipids covalentyl
EP2060252A1 (fr) 2007-11-19 2009-05-20 Wittycell Nouvelle formulation de dérivés de galactosylcéramide
US9220767B2 (en) 2008-10-08 2015-12-29 Abivax Vaccine composition for use against influenza
EP2842961B1 (fr) 2012-04-26 2016-12-14 Riken Nouveau glycolipide de carbamate et son utilisation
US9321796B2 (en) 2012-06-28 2016-04-26 Universiteit Gent Galactopyranosyl derivatives useful as medicaments
KR102162619B1 (ko) 2012-07-26 2020-10-08 빅토리아 링크 엘티디 유기 화합물
CN105008380B (zh) * 2012-12-06 2018-01-23 维多利亚联结有限公司 缀合化合物
WO2015187040A1 (fr) * 2014-06-05 2015-12-10 Regan James Anderson Analogues d'amino-sphingoglycolipide

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5936076A (en) * 1991-08-29 1999-08-10 Kirin Beer Kabushiki Kaisha αgalactosylceramide derivatives
TW261533B (fr) * 1992-07-16 1995-11-01 Kirin Brewery

Also Published As

Publication number Publication date
CA2519568A1 (fr) 2004-11-04
EP1611147A1 (fr) 2006-01-04
WO2004094444A1 (fr) 2004-11-04
AU2003225891A1 (en) 2004-11-19
EP1611147A4 (fr) 2007-10-17

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Effective date: 20230320