CA2511189A1 - Inhibiteurs benzamidiques du recepteur p2x<sb>7</sb> - Google Patents

Inhibiteurs benzamidiques du recepteur p2x<sb>7</sb> Download PDF

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Publication number
CA2511189A1
CA2511189A1 CA002511189A CA2511189A CA2511189A1 CA 2511189 A1 CA2511189 A1 CA 2511189A1 CA 002511189 A CA002511189 A CA 002511189A CA 2511189 A CA2511189 A CA 2511189A CA 2511189 A1 CA2511189 A1 CA 2511189A1
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Canada
Prior art keywords
alkyl
hydroxy
methyl
cycloalkyl
formula
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Abandoned
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CA002511189A
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English (en)
Inventor
Allen J. Duplantier
Chakrapani Subramanyam
Mark A. Dombroski
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Pfizer Products Inc
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Individual
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Publication of CA2511189A1 publication Critical patent/CA2511189A1/fr
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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    • C07D233/70—One oxygen atom

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  • Orthopedic Medicine & Surgery (AREA)
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  • Heart & Thoracic Surgery (AREA)
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Abstract

La présente invention concerne des inhibiteurs benzamidiques du récepteur P2X¿7? de formule (I), dans laquelle R?1¿ à R?3¿ sont tels que définis dans la description. Les composés de l'invention sont utiles dans le traitement de troubles médiés par l'IL-1, y compris, entre autres, les maladies inflammatoires telles que l'ostéoarthrite et l'arthrite rhumatoïde, les allergies, l'asthme, la BPCO, le cancer, la reperfusion ou l'ischémie lors d'un AVC ou d'une crise cardiaque, les maladies auto-immunes et d'autres pathologies.
CA002511189A 2002-12-31 2003-12-30 Inhibiteurs benzamidiques du recepteur p2x<sb>7</sb> Abandoned CA2511189A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43722802P 2002-12-31 2002-12-31
US60/437,228 2002-12-31
PCT/IB2003/006232 WO2004058731A1 (fr) 2002-12-31 2003-12-30 Inhibiteurs benzamidiques du recepteur p2x7

Publications (1)

Publication Number Publication Date
CA2511189A1 true CA2511189A1 (fr) 2004-07-15

Family

ID=32682421

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002511189A Abandoned CA2511189A1 (fr) 2002-12-31 2003-12-30 Inhibiteurs benzamidiques du recepteur p2x<sb>7</sb>

Country Status (7)

Country Link
EP (1) EP1581507A1 (fr)
JP (1) JP2006513205A (fr)
AU (1) AU2003288640A1 (fr)
BR (1) BR0317844A (fr)
CA (1) CA2511189A1 (fr)
MX (1) MXPA05007130A (fr)
WO (1) WO2004058731A1 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7071223B1 (en) 2002-12-31 2006-07-04 Pfizer, Inc. Benzamide inhibitors of the P2X7 receptor
EP1626962B1 (fr) 2003-05-12 2007-02-28 Pfizer Products Inc. Inhibiteurs benzamidiques du recepteur p2x7
EP1837330B1 (fr) * 2003-05-12 2012-10-24 Pfizer Products Inc. Inhibiteurs benzamidiques du recepteur P2X7
MXPA06014022A (es) 2004-06-29 2007-02-08 Pfizer Prod Inc Prcedimientos para preparar inhibidores de p2x7.
RU2410430C2 (ru) * 2004-08-31 2011-01-27 Силентис С.А.У. Способы и композиции для ингибирования экспрессии рецептора p2х7
EP1951689A1 (fr) * 2005-11-07 2008-08-06 Abbott Laboratories Antagonistes des recepteurs p2x7 et methodes d'utilisation
BRPI0910034B1 (pt) 2008-03-25 2022-02-08 Affectis Pharmaceuticals Ag Antagonistas do p2x7r e composições farmacêuticas que os compreendem
EP2243772B1 (fr) 2009-04-14 2012-01-18 Affectis Pharmaceuticals AG Nouveaux antagonistes P2X7R et leur utilisation
US20130195919A1 (en) 2010-03-05 2013-08-01 President And Fellows Of Harvard College Induced dendritic cell compositions and uses thereof
AU2011252351A1 (en) 2010-05-14 2012-10-11 Affectis Pharmaceuticals Ag Novel methods for the preparation of P2X7R antagonists
NZ608729A (en) * 2010-10-01 2014-08-29 Taisho Pharmaceutical Co Ltd 1,2,4-triazolone derivative
WO2012110190A1 (fr) 2011-02-17 2012-08-23 Affectis Pharmaceuticals Ag Nouveaux antagonistes p2x7r et leur utilisation
JP2014513671A (ja) 2011-02-22 2014-06-05 アクテリオン ファーマシューティカルズ リミテッド Ｐ２ｘ７受容体アンタゴニストとしてのベンズアミド誘導体
WO2012163456A1 (fr) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Nouveaux antagonistes de p2x7r et leur utilisation
WO2012163792A1 (fr) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Nouveaux antagonistes de p2x7r et leur utilisation
AR087274A1 (es) 2011-07-22 2014-03-12 Actelion Pharmaceuticals Ltd Derivados de amidas heterociclicas como antagonistas de receptores p2x7
SG11201403933UA (en) 2012-01-20 2014-08-28 Actelion Pharmaceuticals Ltd Heterocyclic amide derivatives as p2x7 receptor antagonists
TWI568722B (zh) 2012-06-15 2017-02-01 葛蘭馬克製藥公司 作爲ｍＰＧＥＳ－１抑制劑之三唑酮化合物
CA2890886C (fr) 2012-12-12 2020-10-27 Actelion Pharmaceuticals Ltd Derives d'indole carboxamide utilises en tant qu'antagonistes du recepteur p2x7
WO2014097140A1 (fr) 2012-12-18 2014-06-26 Actelion Pharmaceuticals Ltd Dérivés d'indole carboxamide utilisés en tant qu'antagonistes du récepteur p2x7
JP6282016B2 (ja) 2013-01-22 2018-02-21 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Ｐ２ｘ７受容体アンタゴニストとしての複素環アミド誘導体
EP2956457B1 (fr) 2013-01-22 2016-11-23 Actelion Pharmaceuticals Ltd Dérivés d'amides hétérocycliques utilisés comme antagonistes du récepteur p2x7
WO2015099107A1 (fr) 2013-12-26 2015-07-02 塩野義製薬株式会社 Dérivé cyclique à six chaînons contenant de l'azote et composition pharmaceutique le contenant
PL3287443T3 (pl) 2015-04-24 2022-02-21 Shionogi & Co., Ltd 6-członowa pochodna heterocykliczna i kompozycja farmaceutyczna ją zawierająca
MX2019004107A (es) 2016-10-17 2019-08-05 Shionogi & Co Derivado heterociclico nitrogenado biciclico y composicion farmaceutica que lo contiene.
WO2020036133A1 (fr) * 2018-08-17 2020-02-20 クミアイ化学工業株式会社 Dérivé d'amide d'acide 3-(1h-1,2,4-triazole-1-yl) benzoïque et agent de lutte contre des organismes nuisibles

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4405614A1 (de) * 1994-02-22 1995-08-24 Bayer Ag Substituierte Triazolinone
CZ225699A3 (cs) * 1996-12-23 2000-09-13 Du Pont Pharmaceuticals Company Dusíkaté heteroaromatické sloučeniny jako inhibitory faktoru Xa
PA8557501A1 (es) * 2001-11-12 2003-06-30 Pfizer Prod Inc Benzamida, heteroarilamida y amidas inversas

Also Published As

Publication number Publication date
AU2003288640A1 (en) 2004-07-22
BR0317844A (pt) 2005-12-06
EP1581507A1 (fr) 2005-10-05
JP2006513205A (ja) 2006-04-20
MXPA05007130A (es) 2005-08-26
WO2004058731A1 (fr) 2004-07-15

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