CA2506127C - Methods of generating high-production of antibodies from hybridomas created by in vitro immunization - Google Patents
Methods of generating high-production of antibodies from hybridomas created by in vitro immunization Download PDFInfo
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- CA2506127C CA2506127C CA2506127A CA2506127A CA2506127C CA 2506127 C CA2506127 C CA 2506127C CA 2506127 A CA2506127 A CA 2506127A CA 2506127 A CA2506127 A CA 2506127A CA 2506127 C CA2506127 C CA 2506127C
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/243—Colony Stimulating Factors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
- C12N15/1024—In vivo mutagenesis using high mutation rate "mutator" host strains by inserting genetic material, e.g. encoding an error prone polymerase, disrupting a gene for mismatch repair
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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| US50165003P | 2003-09-10 | 2003-09-10 | |
| US60/501,650 | 2003-09-10 | ||
| PCT/US2003/036702 WO2004046330A2 (en) | 2002-11-15 | 2003-11-14 | Methods of generating high-production of antibodies from hybridomas created by in vitro immunization |
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| CA2506127A1 CA2506127A1 (en) | 2004-06-03 |
| CA2506127C true CA2506127C (en) | 2013-07-09 |
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| US6982169B2 (en) * | 2001-01-15 | 2006-01-03 | Morphotek, Inc. | Chemical inhibitors of mismatch repair |
| WO2004046330A2 (en) | 2002-11-15 | 2004-06-03 | Morphotek, Inc. | Methods of generating high-production of antibodies from hybridomas created by in vitro immunization |
| AU2006249062B2 (en) | 2005-05-18 | 2012-12-20 | Morphosys Ag | Anti-GM-CSF antibodies and uses therefor |
| KR101486183B1 (ko) | 2006-02-08 | 2015-01-28 | 모르포테크, 인크. | 항원성 ｇｍ-ｃｓｆ 펩티드 및 ｇｍ-ｃｓｆ에 대한 항체 |
| AU2013201228B2 (en) * | 2006-02-08 | 2016-01-21 | Eisai, Inc. | Antigenic gm-csf peptides and antibodies to gm-csf |
| EP2013620A2 (en) * | 2006-04-17 | 2009-01-14 | Morphotek, Inc. | Whole genome evolution technology applied to improve protein and antibody yields by cells |
| US8603950B2 (en) | 2007-02-20 | 2013-12-10 | Anaptysbio, Inc. | Methods of generating libraries and uses thereof |
| EP2221384A4 (en) * | 2007-12-03 | 2011-04-06 | Advance Kk | METHOD FOR MANUFACTURING ANTIBODY |
| EP2289937A1 (en) * | 2009-08-24 | 2011-03-02 | Wilfried Stücker | Production of monoclonal antibodies in vitro |
| EP2582862B1 (en) * | 2010-06-16 | 2016-04-13 | CDI Laboratories Inc. | Methods and systems for generating, validating and using monoclonal antibodies |
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2003
- 2003-11-14 WO PCT/US2003/036702 patent/WO2004046330A2/en active Search and Examination
- 2003-11-14 JP JP2004570421A patent/JP4555089B2/ja not_active Expired - Lifetime
- 2003-11-14 US US10/714,228 patent/US7754450B2/en active Active
- 2003-11-14 CA CA2506127A patent/CA2506127C/en not_active Expired - Lifetime
- 2003-11-14 AT AT03786774T patent/ATE444359T1/de not_active IP Right Cessation
- 2003-11-14 EP EP20030786774 patent/EP1572971B1/en not_active Expired - Lifetime
- 2003-11-14 DE DE60329526T patent/DE60329526D1/de not_active Expired - Lifetime
- 2003-11-14 AU AU2003295576A patent/AU2003295576B2/en not_active Expired
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2010
- 2010-05-25 US US12/786,530 patent/US8445229B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ATE444359T1 (de) | 2009-10-15 |
| WO2004046330A2 (en) | 2004-06-03 |
| US7754450B2 (en) | 2010-07-13 |
| AU2003295576B2 (en) | 2011-03-17 |
| US20040214288A1 (en) | 2004-10-28 |
| JP2006526983A (ja) | 2006-11-30 |
| DE60329526D1 (de) | 2009-11-12 |
| JP4555089B2 (ja) | 2010-09-29 |
| US20100311169A1 (en) | 2010-12-09 |
| EP1572971B1 (en) | 2009-09-30 |
| WO2004046330A3 (en) | 2006-09-28 |
| EP1572971A4 (en) | 2007-07-04 |
| EP1572971A2 (en) | 2005-09-14 |
| US8445229B2 (en) | 2013-05-21 |
| CA2506127A1 (en) | 2004-06-03 |
| AU2003295576A1 (en) | 2004-06-15 |
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