CA2502209A1 - Methylene-bridged selective androgen receptor modulators and methods of use thereof - Google Patents
Methylene-bridged selective androgen receptor modulators and methods of use thereof Download PDFInfo
- Publication number
- CA2502209A1 CA2502209A1 CA002502209A CA2502209A CA2502209A1 CA 2502209 A1 CA2502209 A1 CA 2502209A1 CA 002502209 A CA002502209 A CA 002502209A CA 2502209 A CA2502209 A CA 2502209A CA 2502209 A1 CA2502209 A1 CA 2502209A1
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- Prior art keywords
- androgen receptor
- compound
- receptor modulator
- selective androgen
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- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US41816602P | 2002-10-15 | 2002-10-15 | |
| US60/418,166 | 2002-10-15 | ||
| PCT/US2003/032511 WO2004035738A2 (en) | 2002-10-15 | 2003-10-14 | Methylene-bridged selective androgen receptor modulators and methods of use thereof |
Publications (1)
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| CA2502209A1 true CA2502209A1 (en) | 2004-04-29 |
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| CA002502209A Abandoned CA2502209A1 (en) | 2002-10-15 | 2003-10-14 | Methylene-bridged selective androgen receptor modulators and methods of use thereof |
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| Country | Link |
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| US (2) | US7253210B2 (enExample) |
| EP (1) | EP1562594A4 (enExample) |
| JP (1) | JP2006506369A (enExample) |
| CN (1) | CN1726034A (enExample) |
| AU (1) | AU2003287077B2 (enExample) |
| CA (1) | CA2502209A1 (enExample) |
| TW (1) | TW200503711A (enExample) |
| WO (1) | WO2004035738A2 (enExample) |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7622503B2 (en) | 2000-08-24 | 2009-11-24 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US7645898B2 (en) | 2000-08-24 | 2010-01-12 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and method of use thereof |
| US7855229B2 (en) | 2000-08-24 | 2010-12-21 | University Of Tennessee Research Foundation | Treating wasting disorders with selective androgen receptor modulators |
| US7919647B2 (en) | 2000-08-24 | 2011-04-05 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US8853266B2 (en) | 2001-12-06 | 2014-10-07 | University Of Tennessee Research Foundation | Selective androgen receptor modulators for treating diabetes |
| US9150501B2 (en) | 2007-09-11 | 2015-10-06 | Gtx, Inc. | Solid forms of selective androgen receptor modulators |
| US9604916B2 (en) | 2012-07-13 | 2017-03-28 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| US9622992B2 (en) | 2012-07-13 | 2017-04-18 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| US9744149B2 (en) | 2012-07-13 | 2017-08-29 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| US9884038B2 (en) | 2004-06-07 | 2018-02-06 | University Of Tennessee Research Foundation | Selective androgen receptor modulator and methods of use thereof |
| US9889110B2 (en) | 2004-06-07 | 2018-02-13 | University Of Tennessee Research Foundation | Selective androgen receptor modulator for treating hormone-related conditions |
| US9969683B2 (en) | 2012-07-13 | 2018-05-15 | Gtx, Inc. | Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS) |
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- 2003-10-14 CA CA002502209A patent/CA2502209A1/en not_active Abandoned
- 2003-10-14 AU AU2003287077A patent/AU2003287077B2/en not_active Ceased
- 2003-10-14 EP EP03777598A patent/EP1562594A4/en not_active Withdrawn
- 2003-10-14 WO PCT/US2003/032511 patent/WO2004035738A2/en not_active Ceased
- 2003-10-14 JP JP2004544890A patent/JP2006506369A/ja active Pending
- 2003-10-14 CN CNA2003801061426A patent/CN1726034A/zh active Pending
- 2003-10-14 US US10/683,157 patent/US7253210B2/en not_active Expired - Lifetime
- 2003-10-15 TW TW092128551A patent/TW200503711A/zh unknown
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2007
- 2007-07-30 US US11/882,073 patent/US20080319009A1/en not_active Abandoned
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| US7622503B2 (en) | 2000-08-24 | 2009-11-24 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and methods of use thereof |
| US7645898B2 (en) | 2000-08-24 | 2010-01-12 | University Of Tennessee Research Foundation | Selective androgen receptor modulators and method of use thereof |
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| US8853266B2 (en) | 2001-12-06 | 2014-10-07 | University Of Tennessee Research Foundation | Selective androgen receptor modulators for treating diabetes |
| US10662148B2 (en) | 2004-06-07 | 2020-05-26 | University Of Tennessee Research Foundation | Selective androgen receptor modulator and methods of use thereof |
| US10053418B2 (en) | 2004-06-07 | 2018-08-21 | University Of Tennessee Research Foundation | Selective androgen receptor modulator and methods of use thereof |
| US9889110B2 (en) | 2004-06-07 | 2018-02-13 | University Of Tennessee Research Foundation | Selective androgen receptor modulator for treating hormone-related conditions |
| US9884038B2 (en) | 2004-06-07 | 2018-02-06 | University Of Tennessee Research Foundation | Selective androgen receptor modulator and methods of use thereof |
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| US11090283B2 (en) | 2007-09-11 | 2021-08-17 | University Of Tennessee Research Foundation | Solid forms of selective androgen receptor modulators |
| US12053448B2 (en) | 2007-09-11 | 2024-08-06 | University Of Tennessee Research Foundation | Solid forms of selective androgen receptor modulators |
| US9744149B2 (en) | 2012-07-13 | 2017-08-29 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| US9622992B2 (en) | 2012-07-13 | 2017-04-18 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| US9969683B2 (en) | 2012-07-13 | 2018-05-15 | Gtx, Inc. | Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS) |
| US9604916B2 (en) | 2012-07-13 | 2017-03-28 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
| US10258596B2 (en) | 2012-07-13 | 2019-04-16 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| US10314807B2 (en) | 2012-07-13 | 2019-06-11 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
| US10849873B2 (en) | 2012-07-13 | 2020-12-01 | Oncternal Therapeutics, Inc | Non-invasive method of evaluating breast cancers for selective androgen receptor modulator (SARM) therapy |
| US10987334B2 (en) | 2012-07-13 | 2021-04-27 | University Of Tennessee Research Foundation | Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs) |
| US12115146B2 (en) | 2012-07-13 | 2024-10-15 | University Of Tennessee Research Foundation | Treatment of skeletal-related events for breast cancer patients |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004035738A3 (en) | 2004-07-15 |
| US20080319009A1 (en) | 2008-12-25 |
| WO2004035738A2 (en) | 2004-04-29 |
| EP1562594A2 (en) | 2005-08-17 |
| US7253210B2 (en) | 2007-08-07 |
| US20040147550A1 (en) | 2004-07-29 |
| EP1562594A4 (en) | 2008-12-17 |
| CN1726034A (zh) | 2006-01-25 |
| AU2003287077B2 (en) | 2007-09-20 |
| JP2006506369A (ja) | 2006-02-23 |
| TW200503711A (en) | 2005-02-01 |
| AU2003287077A1 (en) | 2004-05-04 |
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