CA2495875C - Process for producing metered dose inhaler formulations - Google Patents

Process for producing metered dose inhaler formulations Download PDF

Info

Publication number
CA2495875C
CA2495875C CA2495875A CA2495875A CA2495875C CA 2495875 C CA2495875 C CA 2495875C CA 2495875 A CA2495875 A CA 2495875A CA 2495875 A CA2495875 A CA 2495875A CA 2495875 C CA2495875 C CA 2495875C
Authority
CA
Canada
Prior art keywords
metered dose
dose inhaler
container
suspension
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2495875A
Other languages
English (en)
French (fr)
Other versions
CA2495875A1 (en
Inventor
Saeed Chaudhry
Stefan A. Sharpe
Julianne Berry
Joel A. Sequeira
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp & Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CA2495875A1 publication Critical patent/CA2495875A1/en
Application granted granted Critical
Publication of CA2495875C publication Critical patent/CA2495875C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B31/00—Packaging articles or materials under special atmospheric or gaseous conditions; Adding propellants to aerosol containers
    • B65B31/003—Adding propellants in fluid form to aerosol containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
    • B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Mechanical Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
CA2495875A 2002-08-27 2003-08-26 Process for producing metered dose inhaler formulations Expired - Fee Related CA2495875C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US40612702P 2002-08-27 2002-08-27
US60/406,127 2002-08-27
US42243602P 2002-10-30 2002-10-30
US60/422,436 2002-10-30
PCT/US2003/026512 WO2004020289A1 (en) 2002-08-27 2003-08-26 Process for producing metered dose inhaler formulations

Publications (2)

Publication Number Publication Date
CA2495875A1 CA2495875A1 (en) 2004-03-11
CA2495875C true CA2495875C (en) 2010-06-22

Family

ID=31981380

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2495875A Expired - Fee Related CA2495875C (en) 2002-08-27 2003-08-26 Process for producing metered dose inhaler formulations

Country Status (14)

Country Link
US (3) US20040042973A1 (enExample)
EP (2) EP1542904B1 (enExample)
JP (3) JP4679901B2 (enExample)
AT (2) ATE503687T1 (enExample)
AU (1) AU2003265639A1 (enExample)
CA (1) CA2495875C (enExample)
CY (1) CY1107376T1 (enExample)
DE (2) DE60318727T2 (enExample)
DK (1) DK1542904T3 (enExample)
ES (1) ES2297262T3 (enExample)
MX (1) MXPA05002248A (enExample)
PT (1) PT1542904E (enExample)
SI (1) SI1542904T1 (enExample)
WO (1) WO2004020289A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0207906D0 (en) 2002-04-05 2002-05-15 3M Innovative Properties Co Formoterol and mometasone aerosol formulations
ES2388537T3 (es) * 2002-08-23 2012-10-16 Merck Sharp & Dohme Corp. Inhalador dosificador que contiene una formulación en suspensión de aerosol
JP2007509147A (ja) * 2003-10-20 2007-04-12 シェーリング　コーポレイション 薬学的エアロゾル組成物
SE0401408D0 (sv) * 2004-06-02 2004-06-02 Astrazeneca Ab Diameter measuring device
WO2006040598A2 (en) * 2004-10-12 2006-04-20 Generics (Uk) Limited Process for the preparation of suspension aerosol formulations, wherein the particles are formed by precipitation inside an aerosol canister
US20070099883A1 (en) * 2005-10-07 2007-05-03 Cheryl Lynn Calis Anhydrous mometasone furoate formulation
EP2083798A1 (en) * 2006-10-19 2009-08-05 Cipla Limited Pharmaceutical compositions and nasal spray incorporating anhydrous mometasone furoate
KR20100004993A (ko) 2007-02-09 2010-01-13 쉐링 코포레이션 안정한 약제학적 약물 에어로졸
US20080253970A1 (en) * 2007-02-09 2008-10-16 Schering Corporation Stable Pharmaceutical Drug Products
DK2429510T3 (en) 2009-05-12 2015-09-28 Galenica Ab The oil-in-water emulsion mometasone and propylene glycol
PL2429490T3 (pl) * 2009-05-12 2017-06-30 Galenica Ab Emulsja mometazonu typu olej-w-wodzie
MX2012008906A (es) * 2010-02-10 2012-08-15 Astrazeneca Uk Ltd Proceso para proporcionar un cartucho relleno para un inhalador.
AU2015200276B2 (en) * 2010-02-10 2016-01-21 Astrazeneca Uk Limited A filled canister for an inhaler
CN107626019A (zh) * 2016-07-18 2018-01-26 卓效医疗有限公司 手持式喷雾器
CN107951893B (zh) * 2016-10-18 2022-04-26 天津金耀集团有限公司 一种糠酸莫米松粉吸入剂组合物

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3592319A (en) * 1968-10-28 1971-07-13 Roy S Rousseau Article feed control
US3835898A (en) * 1972-11-13 1974-09-17 Kartridg Pak Co Remotely adjustable filling head
US4793461A (en) * 1987-02-26 1988-12-27 The Kartridg Pak Co. Container feed apparatus
US5143260A (en) * 1990-06-05 1992-09-01 Nozone Dispenser Systems, Inc. Aerosol adapter clamp and power system
US5182097A (en) * 1991-02-14 1993-01-26 Virginia Commonwealth University Formulations for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
PT656206E (pt) * 1991-06-10 2001-11-30 Schering Corp Formulacoes de aerossois sem clorofluorocarbonetos
US6503482B1 (en) * 1991-06-10 2003-01-07 Schering Corporation Non-chlorofluorocarbon aerosol formulations
US5275212A (en) * 1993-02-24 1994-01-04 Minnesota Mining And Manufacturing Company Aerosol filling method
GB9612297D0 (en) * 1996-06-11 1996-08-14 Minnesota Mining & Mfg Medicinal aerosol formulations
US5698161A (en) 1996-08-26 1997-12-16 Michigan Critical Care Consultants, Inc. Hollow, multi-dimensional array membrane
CO4900027A1 (es) * 1996-08-29 2000-03-27 Schering Corp Formulaciones en aerosol de furoato de mometasona sin cloro- fluorocarburos .
US6068832A (en) * 1996-08-29 2000-05-30 Schering Corporation Chlorofluorocarbon-free mometasone furoate aerosol formulations
US20060165606A1 (en) * 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6004537A (en) * 1998-12-18 1999-12-21 Baker Norton Pharmaceuticals, Inc. Pharmaceutical solution aerosol formulations containing fluoroalkanes, budesonide and formoterol
GB9904919D0 (en) * 1999-03-03 1999-04-28 Novartis Ag Organic compounds
US20030032632A1 (en) * 1999-12-24 2003-02-13 Crispps Leslie Alan Pharmaceutical aerosol formulation of salmeterol and fluticasone propionate
AU2001278115A1 (en) * 2000-08-04 2002-02-18 Longwood Pharmaceutical Research, Inc. Formulations of mometasone and a bronchodilator for pulmonary administration
ITMI20010428A1 (it) * 2001-03-02 2002-09-02 Chemo Breath S A Composizioni ad uso inalatorio a base di formoterolo
AR036358A1 (es) * 2001-08-28 2004-09-01 Schering Corp Un inhalador de dosis medidas que contiene una formulacion de suspension en aerosol para inhalacion, un proceso para la produccion de la formulacion, el producto y el uso de una formulacion para la manufactura de un medicamento de asma
GB0207906D0 (en) * 2002-04-05 2002-05-15 3M Innovative Properties Co Formoterol and mometasone aerosol formulations
ES2388537T3 (es) * 2002-08-23 2012-10-16 Merck Sharp & Dohme Corp. Inhalador dosificador que contiene una formulación en suspensión de aerosol
JP2007509147A (ja) * 2003-10-20 2007-04-12 シェーリング　コーポレイション 薬学的エアロゾル組成物
CA2641616A1 (en) * 2006-02-09 2007-08-23 Schering Corporation Pharmaceutical formulations
US20080253970A1 (en) * 2007-02-09 2008-10-16 Schering Corporation Stable Pharmaceutical Drug Products

Also Published As

Publication number Publication date
EP1878664B1 (en) 2011-03-30
EP1542904B1 (en) 2008-01-16
ATE384001T1 (de) 2008-02-15
JP2011046726A (ja) 2011-03-10
DE60318727T2 (de) 2009-01-08
DE60318727D1 (de) 2008-03-06
US20040042973A1 (en) 2004-03-04
DE60336602D1 (de) 2011-05-12
WO2004020289A1 (en) 2004-03-11
AU2003265639A1 (en) 2004-03-19
PT1542904E (pt) 2008-03-24
CA2495875A1 (en) 2004-03-11
US20130068218A1 (en) 2013-03-21
CY1107376T1 (el) 2012-12-19
JP2005537095A (ja) 2005-12-08
EP1542904A1 (en) 2005-06-22
MXPA05002248A (es) 2005-06-08
ATE503687T1 (de) 2011-04-15
JP2006305390A (ja) 2006-11-09
EP1878664A1 (en) 2008-01-16
SI1542904T1 (sl) 2008-06-30
DK1542904T3 (da) 2008-04-21
US20080066744A1 (en) 2008-03-20
JP4679901B2 (ja) 2011-05-11
ES2297262T3 (es) 2008-05-01

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20150826