CA2495350C - Use of lck inhibitor for treatment of immunologic diseases - Google Patents
Use of lck inhibitor for treatment of immunologic diseases Download PDFInfo
- Publication number
- CA2495350C CA2495350C CA2495350A CA2495350A CA2495350C CA 2495350 C CA2495350 C CA 2495350C CA 2495350 A CA2495350 A CA 2495350A CA 2495350 A CA2495350 A CA 2495350A CA 2495350 C CA2495350 C CA 2495350C
- Authority
- CA
- Canada
- Prior art keywords
- phenyl
- methyl
- phenylamino
- treatment
- indolinone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
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Landscapes
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- Animal Behavior & Ethology (AREA)
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- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10237423.6 | 2002-08-16 | ||
| DE10237423A DE10237423A1 (de) | 2002-08-16 | 2002-08-16 | Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen |
| PCT/EP2003/008890 WO2004017948A2 (en) | 2002-08-16 | 2003-08-11 | Use of lck inhibitor for treatment of immunologic diseases |
Publications (2)
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| CA2495350A1 CA2495350A1 (en) | 2004-03-04 |
| CA2495350C true CA2495350C (en) | 2012-05-29 |
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| EP (2) | EP1530466B1 (enExample) |
| JP (1) | JP2006514611A (enExample) |
| AU (1) | AU2003255413A1 (enExample) |
| CA (1) | CA2495350C (enExample) |
| CY (1) | CY1116093T1 (enExample) |
| DE (1) | DE10237423A1 (enExample) |
| DK (1) | DK1530466T3 (enExample) |
| ES (1) | ES2530392T3 (enExample) |
| PT (1) | PT1530466E (enExample) |
| SI (1) | SI1530466T1 (enExample) |
| WO (1) | WO2004017948A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
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| PE20060777A1 (es) * | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| US20060154939A1 (en) * | 2004-12-24 | 2006-07-13 | Boehringer Ingelheim International Gmbh | Medicaments for the Treatment or Prevention of Fibrotic Diseases |
| WO2007057399A2 (en) * | 2005-11-15 | 2007-05-24 | Boehringer Ingelheim International Gmbh | Treatment of cancer with indole derivatives |
| WO2007057397A1 (en) * | 2005-11-15 | 2007-05-24 | Boehringer Ingelheim International Gmbh | Treatment of cancer |
| FR2909876A1 (fr) * | 2006-12-19 | 2008-06-20 | Galderma Res & Dev S N C Snc | Utilisation du nepafenac ou ses derives pour le traitement de desordres dermatologiques |
| MX2009008408A (es) | 2007-02-12 | 2009-11-02 | Stefan Hansson | Diagnosis y tratamiento de preeclampsia. |
| EP2985025B1 (en) | 2008-06-06 | 2018-01-17 | Boehringer Ingelheim International Gmbh | Pharmaceutical combination |
| HUE030274T2 (en) * | 2008-07-18 | 2017-05-29 | A1M Pharma Ab | The therapeutic use of the root binding and antioxidant alpha-1 microglobulin |
| US8802384B2 (en) | 2009-03-12 | 2014-08-12 | Boehringer Ingelheim International Gmbh | Method or system using biomarkers for the monitoring of a treatment |
| JP2012526766A (ja) | 2009-05-14 | 2012-11-01 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 腫瘍性及び線維性疾患の処置における新規な併用療法 |
| US20120107304A1 (en) | 2010-04-27 | 2012-05-03 | Boehringer Ingelheim International Gmbh | Combination therapy in treatment of oncological and fibrotic diseases |
| US20140350022A1 (en) | 2013-05-10 | 2014-11-27 | Boehringer Ingelheim International Gmbh | Efficacious treatment of NSCLC and predictive clinical marker of the responsiveness of a tumour to a treatment |
| AU2014296032A1 (en) * | 2013-07-31 | 2016-03-17 | Windward Pharma, Inc. | Aerosol tyrosine kinase inhibitor compounds and uses thereof |
| EP2837626A1 (en) * | 2013-08-16 | 2015-02-18 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Indolinone derivatives as GRK5 modulators |
| US10166183B2 (en) | 2014-02-07 | 2019-01-01 | Auspex Pharmaceuticals, Inc. | Pharmaceutical formulations |
| EP3442534A1 (en) | 2016-04-13 | 2019-02-20 | Boehringer Ingelheim International GmbH | Pharmaceutical combination of nintedanib, trifluridine and tipiracil for treating colorectal cancer |
| EP3246029A1 (en) | 2016-05-19 | 2017-11-22 | Boehringer Ingelheim International Gmbh | Pharmaceutical combination of nintedanib and capecitabine for the treatment of colorectal cancer |
| JP2019522638A (ja) | 2016-05-27 | 2019-08-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ニンテダニブ及びピルフェニドンによる治療開始を判定するためのｅｃｍバイオマーカーの使用 |
| WO2017207643A1 (en) | 2016-06-01 | 2017-12-07 | Boehringer Ingelheim International Gmbh | Use of ecm biomarkers for the determining the treatment onset with nintedanib and pirfenidone |
| JP2020512364A (ja) | 2017-03-28 | 2020-04-23 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 筋ジストロフィーの処置方法において使用するためのニンテダニブ |
| TWI866908B (zh) | 2018-04-23 | 2024-12-21 | 盈擘生技股份有限公司 | 用於治療肺部疾病的可吸入的緩釋組成物 |
| CN111285872B (zh) * | 2018-12-06 | 2022-05-17 | 北京志健金瑞生物医药科技有限公司 | 吲哚-2-酮衍生物及其制备方法与用途 |
| US20230135671A1 (en) | 2020-04-01 | 2023-05-04 | Boehringer Ingelheim International Gmbh | Use of biomarkers in the treatment of fibrotic conditions |
| NO346587B1 (en) * | 2021-06-02 | 2022-10-17 | Axichem Ab | Capsaicin derivatives in the treatment of idiopathic pulmonary fibrosis |
| JP2025525881A (ja) | 2022-08-16 | 2025-08-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 眼内使用するためのニンテダニブの医薬製剤 |
Family Cites Families (15)
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| JPH0892248A (ja) * | 1994-09-26 | 1996-04-09 | Yamanouchi Pharmaceut Co Ltd | インドリノン誘導体 |
| GB9608435D0 (en) * | 1996-04-24 | 1996-06-26 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9619284D0 (en) * | 1996-09-16 | 1996-10-30 | Celltech Therapeutics Ltd | Chemical compounds |
| WO1998024432A2 (en) * | 1996-12-05 | 1998-06-11 | Sugen, Inc. | Use of indolinone compounds as modulators of protein kinases |
| CZ296845B6 (cs) * | 1997-05-28 | 2006-07-12 | Aventis Pharmaceuticals Inc. | Derivát chinolinu a chinoxalinu, farmaceutický prostredek obsahující tento derivát a pouzití |
| DE19816624A1 (de) | 1998-04-15 | 1999-10-21 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| DE59906030D1 (de) * | 1998-09-25 | 2003-07-24 | Boehringer Ingelheim Pharma | Neue substituierte indolinone mit einer inhibierenden wirkung auf verschiedene kinasen und cyclin/cdk-komplexe |
| DE19924401A1 (de) | 1999-05-27 | 2000-11-30 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| JP5036112B2 (ja) * | 1999-10-06 | 2012-09-26 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | チロシンキナーゼのインヒビターとして有益な複素環化合物 |
| UA75054C2 (uk) * | 1999-10-13 | 2006-03-15 | Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг | Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу |
| DE19949209A1 (de) | 1999-10-13 | 2001-04-19 | Boehringer Ingelheim Pharma | In 5-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
| JP3522727B2 (ja) | 1999-11-05 | 2004-04-26 | アストラゼネカ アクチボラグ | Ｖｅｇｆ阻害剤としてのキナゾリン誘導体 |
| AU1047601A (en) * | 1999-11-30 | 2001-06-12 | Pfizer Products Inc. | 2,4-diaminopyrimidine compounds useful as immunosuppressants |
| AR035851A1 (es) * | 2000-03-28 | 2004-07-21 | Wyeth Corp | 3-cianoquinolinas, 3-ciano-1,6-naftiridinas y 3-ciano-1,7-naftiridinas como inhibidoras de proteina quinasas |
| DE10054019A1 (de) | 2000-11-01 | 2002-05-23 | Boehringer Ingelheim Pharma | Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
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2002
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2003
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- 2003-08-11 CA CA2495350A patent/CA2495350C/en not_active Expired - Lifetime
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| JP2006514611A (ja) | 2006-05-11 |
| AU2003255413A8 (en) | 2004-03-11 |
| EP1530466B1 (en) | 2014-12-10 |
| CY1116093T1 (el) | 2017-02-08 |
| WO2004017948A8 (en) | 2005-03-24 |
| EP2281561A3 (en) | 2012-05-09 |
| WO2004017948A2 (en) | 2004-03-04 |
| CA2495350A1 (en) | 2004-03-04 |
| DE10237423A1 (de) | 2004-02-19 |
| EP2281561A2 (en) | 2011-02-09 |
| EP1530466A2 (en) | 2005-05-18 |
| SI1530466T1 (sl) | 2015-03-31 |
| PT1530466E (pt) | 2015-02-24 |
| WO2004017948A3 (en) | 2004-04-22 |
| ES2530392T3 (es) | 2015-03-02 |
| AU2003255413A1 (en) | 2004-03-11 |
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