CA2492081C - Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders - Google Patents

Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders Download PDF

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Publication number
CA2492081C
CA2492081C CA2492081A CA2492081A CA2492081C CA 2492081 C CA2492081 C CA 2492081C CA 2492081 A CA2492081 A CA 2492081A CA 2492081 A CA2492081 A CA 2492081A CA 2492081 C CA2492081 C CA 2492081C
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CA
Canada
Prior art keywords
dextromethorphan
salts
quinidine
day
subjects
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2492081A
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English (en)
French (fr)
Other versions
CA2492081A1 (en
Inventor
Gerald Yakatan
James Berg
Laura E. Pope
Richard A. Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Avanir Pharmaceuticals Inc
Original Assignee
Avanir Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=30116047&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2492081(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Avanir Pharmaceuticals Inc filed Critical Avanir Pharmaceuticals Inc
Publication of CA2492081A1 publication Critical patent/CA2492081A1/en
Application granted granted Critical
Publication of CA2492081C publication Critical patent/CA2492081C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/49—Cinchonan derivatives, e.g. quinine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
CA2492081A 2002-07-17 2003-07-17 Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders Expired - Lifetime CA2492081C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39666102P 2002-07-17 2002-07-17
US60/396,661 2002-07-17
PCT/US2003/022303 WO2004006930A1 (en) 2002-07-17 2003-07-17 Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders

Publications (2)

Publication Number Publication Date
CA2492081A1 CA2492081A1 (en) 2004-01-22
CA2492081C true CA2492081C (en) 2010-09-07

Family

ID=30116047

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2492081A Expired - Lifetime CA2492081C (en) 2002-07-17 2003-07-17 Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders

Country Status (24)

Country Link
US (12) US7659282B2 (US06780888-20040824-C00057.png)
EP (6) EP1980252B1 (US06780888-20040824-C00057.png)
JP (12) JP5082032B2 (US06780888-20040824-C00057.png)
KR (7) KR20120089706A (US06780888-20040824-C00057.png)
AT (1) ATE399553T1 (US06780888-20040824-C00057.png)
AU (3) AU2003251971B9 (US06780888-20040824-C00057.png)
BE (1) BE2013C064I2 (US06780888-20040824-C00057.png)
CA (1) CA2492081C (US06780888-20040824-C00057.png)
CY (2) CY1110405T1 (US06780888-20040824-C00057.png)
DE (1) DE60321929D1 (US06780888-20040824-C00057.png)
DK (2) DK1980252T3 (US06780888-20040824-C00057.png)
ES (2) ES2309351T3 (US06780888-20040824-C00057.png)
FR (1) FR13C0062I2 (US06780888-20040824-C00057.png)
HK (2) HK1076052A1 (US06780888-20040824-C00057.png)
HU (2) HUE028100T2 (US06780888-20040824-C00057.png)
IL (7) IL166166A0 (US06780888-20040824-C00057.png)
LU (1) LU92323I2 (US06780888-20040824-C00057.png)
NO (2) NO330626B1 (US06780888-20040824-C00057.png)
PL (2) PL398445A1 (US06780888-20040824-C00057.png)
PT (2) PT1980252E (US06780888-20040824-C00057.png)
RU (1) RU2341265C2 (US06780888-20040824-C00057.png)
SI (2) SI1980252T1 (US06780888-20040824-C00057.png)
TW (1) TWI326214B (US06780888-20040824-C00057.png)
WO (1) WO2004006930A1 (US06780888-20040824-C00057.png)

Families Citing this family (136)

* Cited by examiner, † Cited by third party
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TWI326214B (en) * 2002-07-17 2010-06-21 Avanir Pharmaceuticals Inc Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of neurological disorders
WO2004043365A2 (en) * 2002-11-06 2004-05-27 Azaya Therapeutics, Inc. Method for treatment of premature ejaculation in humans
EP1734962A4 (en) * 2004-03-30 2010-07-14 Painceptor Pharma Corp COMPOSITIONS AND METHOD FOR MODULATING CONTROLLED ION CHANNELS
US20070191411A1 (en) * 2004-10-07 2007-08-16 Smith Richard A Enhancement of impaired motor and mental functions, using dextromethorphan and oxidase enzyme inhibitor
US20060205822A1 (en) * 2004-12-22 2006-09-14 Forest Laboratories, Inc. 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect
KR20080097443A (ko) * 2006-02-03 2008-11-05 아바니르 파마슈티컬스 덱스트로메토판 및 퀴니딘을 포함하는, 우울, 불안 및 신경퇴행성 장애 치료용 약제학적 조성물
US20160143901A1 (en) * 2006-02-03 2016-05-26 Avanir Pharmaceuticals, Inc. Pharmaceutical compositions comprising dextromethorphan and quinidine for the treatment of agitation in dementia
EP4183787A1 (en) 2007-05-01 2023-05-24 Concert Pharmaceuticals Inc. Morphinan compounds
LT3825306T (lt) 2007-05-01 2023-08-10 Sun Pharmaceutical Industries, Inc. Morfinano junginiai
CN102964302B (zh) 2007-05-01 2015-10-21 康塞特医药品公司 吗啡烷化合物
WO2009006194A1 (en) * 2007-06-28 2009-01-08 Avanir Pharmaceuticals Pharmaceutical compositions for the treatment of involuntary emotional expression disorder
KR101716512B1 (ko) 2008-09-19 2017-03-14 콘서트 파마슈티컬즈, 인크. 모르피난 화합물
US20120122848A1 (en) * 2009-07-29 2012-05-17 Green Cross Corporation (+)-3-hydroxymorphinan derivatives as neuroprotectants
CA2712848A1 (en) * 2009-08-28 2011-02-28 Avanir Pharmaceuticals, Inc. A method of reducing cns and gastrointestinal side affects associated with long-term, dextromethorphan/low-dose quinidine combination therapy
EP2566478A4 (en) * 2010-05-03 2014-04-30 Tsh Biopharm Corp Ltd PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATING HYPERTENSION
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US8569328B1 (en) * 2011-05-24 2013-10-29 Antecip Bioventures Ii Llc Compositions and methods comprising tilidine or related compounds and dextromethorphan
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US20130274282A1 (en) * 2012-04-16 2013-10-17 Herriot Tabuteau Compositions and methods comprising celecoxib or related compounds and dextromethorphan
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