CA2488842A1 - Derives de nucleosides carbocycliques utilises comme inhibiteurs de l'arn polymerase arn-dependante virale - Google Patents

Derives de nucleosides carbocycliques utilises comme inhibiteurs de l'arn polymerase arn-dependante virale Download PDF

Info

Publication number
CA2488842A1
CA2488842A1 CA002488842A CA2488842A CA2488842A1 CA 2488842 A1 CA2488842 A1 CA 2488842A1 CA 002488842 A CA002488842 A CA 002488842A CA 2488842 A CA2488842 A CA 2488842A CA 2488842 A1 CA2488842 A1 CA 2488842A1
Authority
CA
Canada
Prior art keywords
amino
hydrogen
alkyl
hydroxy
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002488842A
Other languages
English (en)
Inventor
Balkrishen Bhat
Neelima Bhat
Prasad Dande
Anne B. Eldrup
David B. Olsen
Malcolm Maccoss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Ionis Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2488842A1 publication Critical patent/CA2488842A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La pr~sente invention concerne des compos~s de nucl~osides carbocycliques et certains de leurs d~riv~s qui sont des inhibiteurs de l'ARN polym~rase ARN-d~pendante virale. Ces compos~s sont des inhibiteurs de la r~plication virale de l'ARN ARN-d~pendante et sont utiles pour le traitement d'une infection virale ARN ARN-d~pendante. Ces compos~s sont tout particuli­rement utiles comme inhibiteurs de la polym~rase NS5B du virus de l'h~patite C (VHC), comme inhibiteurs de la r~plication du VHC, et/ou pour le traitement d'une infection par le virus de l'h~patite C. L'invention concerne ~galement des compositions pharmaceutiques contenant ces compos~s de nucl~osides carbocycliques seuls ou combin~s ~ d'autres agents actifs contre une infection virale ARN ARN-d~pendante, en particulier une infection par le virus de l'h~patite C. L'invention concerne ~galement des m~thodes permettant d'inhiber l'ARN polym~rase ARN-d~pendante, d'inhiber la r~plication virale de l'ARN ARN-d~pendante, et/ou de traiter une infection virale ARN ARN-d~pendante, utilisant les compos~s de nucl~osides carbocycliques de la pr~sente invention.
CA002488842A 2002-06-17 2003-06-14 Derives de nucleosides carbocycliques utilises comme inhibiteurs de l'arn polymerase arn-dependante virale Abandoned CA2488842A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38916102P 2002-06-17 2002-06-17
US60/389,161 2002-06-17
PCT/US2003/018841 WO2003105770A2 (fr) 2002-06-17 2003-06-14 Derives de nucleosides carbocycliques utilises comme inhibiteurs de l'arn polymerase arn-dependante virale

Publications (1)

Publication Number Publication Date
CA2488842A1 true CA2488842A1 (fr) 2003-12-24

Family

ID=29736594

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002488842A Abandoned CA2488842A1 (fr) 2002-06-17 2003-06-14 Derives de nucleosides carbocycliques utilises comme inhibiteurs de l'arn polymerase arn-dependante virale

Country Status (5)

Country Link
EP (1) EP1515971A2 (fr)
JP (1) JP2005533777A (fr)
AU (1) AU2003251524A1 (fr)
CA (1) CA2488842A1 (fr)
WO (1) WO2003105770A2 (fr)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
YU92202A (sh) 2000-05-26 2006-01-16 Idenix (Cayman) Limited Metode i smeše za lečenje flavi virusa i pesti virusa
CN104193791A (zh) * 2002-06-28 2014-12-10 埃迪尼克斯医药公司 用于治疗黄病毒感染的修饰的2’和3’-核苷前药
WO2004009020A2 (fr) 2002-07-24 2004-01-29 Merck & Co., Inc. Derives de thionucleosides utilises comme inhibiteurs de l'arn-polymerase arn-dependante virale
CN1849142A (zh) 2002-11-15 2006-10-18 埃迪尼克斯(开曼)有限公司 2′－支链核苷和黄病毒突变
EP3521297B1 (fr) 2003-05-30 2021-12-22 Gilead Pharmasset LLC Analogues de nucléoside fluorés modifiés
UA86962C2 (en) 2004-02-20 2009-06-10 Бёрингер Ингельхайм Интернациональ Гмбх Viral polymerase inhibitors
CN101023094B (zh) 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
ES2769377T3 (es) 2004-09-14 2020-06-25 Gilead Pharmasset Llc Intermedios de D-ribonolactona con sustitución de 2-fluoro-2-alquilo
EP1804811A4 (fr) * 2004-09-24 2011-04-27 Idenix Cayman Ltd Methodes et compositions de traitement des flavivirus, des pestivirus et des hepacivirus
WO2007113159A1 (fr) * 2006-04-04 2007-10-11 F. Hoffmann-La Roche Ag Nucléosides 3',5'-di-o-acylés destinés au traitement du vhc
BRPI0718714B8 (pt) 2006-11-09 2021-05-25 Hoffmann La Roche arilamidas substituídas por tiazol e oxazol, seu uso e composição farmacêutica que as compreende
US20080261913A1 (en) 2006-12-28 2008-10-23 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of liver disorders
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
US8933225B2 (en) 2007-08-02 2015-01-13 Millennium Pharmaceuticals, Inc. Process for the synthesis of E1 activating enzyme inhibitors
CN101903362B (zh) 2007-12-17 2013-07-17 霍夫曼-拉罗奇有限公司 四唑取代的芳基酰胺衍生物和它们作为p2x3和/或p2x2/3嘌呤能受体拮抗物的用途
ES2570628T3 (es) 2007-12-17 2016-05-19 Hoffmann La Roche Nuevas arilamidas con sustitución imidazol
BR122018070508B8 (pt) 2007-12-17 2021-07-27 Hoffmann La Roche derivados de arilamida triazol-substituída e seu uso
EP2234976B1 (fr) 2007-12-17 2013-04-10 F. Hoffmann-La Roche AG Nouvelles arylamides substituées pyrazole
WO2010002428A2 (fr) 2008-06-06 2010-01-07 Scynexis, Inc. Nouveaux peptides macrocycliques
AU2009282567B2 (en) * 2008-08-20 2014-10-02 Merck Sharp & Dohme Corp. Substituted pyridine and pyrimidine derivatives and their use in treating viral infections
PA8855801A1 (es) 2008-12-23 2010-07-27 Sintesis de nucleosidos de purina
WO2010075517A2 (fr) 2008-12-23 2010-07-01 Pharmasset, Inc. Analogues de nucléoside
NZ593648A (en) 2008-12-23 2013-09-27 Gilead Pharmasset Llc Nucleoside phosphoramidates
TWI576352B (zh) 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 核苷磷醯胺
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
EP2445897B1 (fr) 2009-06-22 2014-03-19 F.Hoffmann-La Roche Ag Nouveaux arylamides d'indazole comme antagonistes de p2x3 et/ou p2x2/3
ES2450891T3 (es) 2009-06-22 2014-03-25 F. Hoffmann-La Roche Ag Bifenilamidas útiles como moduladores de receptores P2X3 y/o P2X2/3
SG176640A1 (en) 2009-06-22 2012-01-30 Hoffmann La Roche Novel oxazolone and pyrrolidinone-substituted arylamides
KR20120104239A (ko) 2009-11-14 2012-09-20 에프. 호프만-라 로슈 아게 Ｈｃｖ 치료에 대한 신속한 반응을 예측하기 위한 바이오마커
WO2011067195A1 (fr) 2009-12-02 2011-06-09 F. Hoffmann-La Roche Ag Biomarqueurs pour prédire une réponse soutenue à un traitement du vhc
SI2609923T1 (sl) 2010-03-31 2017-10-30 Gilead Pharmasset Llc Postopek za kristalizacijo (s)-izopropil 2-(((s)-(perfluorofenoksi) (fenoksi)fosforil)amino)propanoata
ES2551944T3 (es) 2010-03-31 2015-11-24 Gilead Pharmasset Llc (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihidropirimidin-1-(2H)-il)-4-fluoro-3-hidroxi-4-metiltetrahidrofuran-2-il)metoxi)(fenoxi)fosforil)amino)propanoato de isopropilo cristalino
WO2011123586A1 (fr) 2010-04-01 2011-10-06 Idenix Pharmaceuticals, Inc. Composés et compositions pharmaceutiques pour le traitement d'infections virales
JP6069215B2 (ja) 2010-11-30 2017-02-01 ギリアド ファーマセット エルエルシー 化合物
CN103842369A (zh) 2011-03-31 2014-06-04 埃迪尼克斯医药公司 用于治疗病毒感染的化合物和药物组合物
TW201329096A (zh) 2011-09-12 2013-07-16 Idenix Pharmaceuticals Inc 經取代羰氧基甲基磷酸醯胺化合物及用於治療病毒感染之藥學組成物
DE202012013074U1 (de) 2011-09-16 2014-10-29 Gilead Pharmasset Lcc Zusammensetzungen zur Behandlung von HCV
EP2768838A1 (fr) 2011-10-14 2014-08-27 IDENIX Pharmaceuticals, Inc. Phosphates 3',5'-cycliques substitués de composés nucléotidiques purines et compositions pharmaceutiques pour le traitement d'infections virales
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
NZ702744A (en) 2012-05-22 2016-12-23 Idenix Pharmaceuticals Llc D-amino acid compounds for liver disease
WO2013177195A1 (fr) 2012-05-22 2013-11-28 Idenix Pharmaceuticals, Inc. Promédicaments de 3',5'-phosphate cyclique pour traiter une infection par le virus de l'hépatite c
WO2013177188A1 (fr) 2012-05-22 2013-11-28 Idenix Pharmaceuticals, Inc. Promédicaments de 3',5'-phosphoramidate cyclique pour traiter une infection par le virus de l'hépatite c
WO2013174962A1 (fr) 2012-05-25 2013-11-28 Janssen R&D Ireland Nucléosides d'uracyl spirooxétane
EP2900682A1 (fr) 2012-09-27 2015-08-05 IDENIX Pharmaceuticals, Inc. Esters et malonates de promédicaments à base de s-acyl-2-thioéthyle (sate)
KR102001280B1 (ko) 2012-10-08 2019-07-17 아이데닉스 파마슈티칼스 엘엘씨 Hcv 감염에 대한 2'-클로로 뉴클레오시드 유사체
US10723754B2 (en) 2012-10-22 2020-07-28 Idenix Pharmaceuticals Llc 2′,4′-bridged nucleosides for HCV infection
US9211300B2 (en) 2012-12-19 2015-12-15 Idenix Pharmaceuticals Llc 4′-fluoro nucleosides for the treatment of HCV
CN104144682A (zh) 2013-01-31 2014-11-12 吉利德法莫赛特有限责任公司 两个抗病毒化合物的联用制剂
US9339541B2 (en) 2013-03-04 2016-05-17 Merck Sharp & Dohme Corp. Thiophosphate nucleosides for the treatment of HCV
US9309275B2 (en) 2013-03-04 2016-04-12 Idenix Pharmaceuticals Llc 3′-deoxy nucleosides for the treatment of HCV
WO2014160484A1 (fr) 2013-03-13 2014-10-02 Idenix Pharmaceuticals, Inc. Pronucléotides de phosphoramidate d'acide aminé de 2'-cyano, azido et amino nucléosides pour le traitement du virus de l'hépatite c (vhc)
RU2534613C2 (ru) 2013-03-22 2014-11-27 Александр Васильевич Иващенко Алкил 2-{ [(2r,3s,5r)-5-(4-амино-2-оксо-2н-пиримидин-1-ил)- -гидрокси-тетрагидро-фуран-2-илметокси]-фенокси-фосфориламино} -пропионаты, нуклеозидные ингибиторы рнк-полимеразы hcv ns5b, способы их получения и применения
US9187515B2 (en) 2013-04-01 2015-11-17 Idenix Pharmaceuticals Llc 2′,4′-fluoro nucleosides for the treatment of HCV
CN104151360B (zh) * 2013-05-14 2019-02-22 北京美倍他药物研究有限公司 磷酸/膦酸衍生物及其医药用途
US10005779B2 (en) 2013-06-05 2018-06-26 Idenix Pharmaceuticals Llc 1′,4′-thio nucleosides for the treatment of HCV
WO2015017713A1 (fr) 2013-08-01 2015-02-05 Idenix Pharmaceuticals, Inc. Pronucléotides phosphoramidates avec acides aminés d de composés halogéno pyrimidines pour le traitement des hépatopathies
ES2900570T3 (es) 2013-08-27 2022-03-17 Gilead Pharmasset Llc Formulación de combinación de dos compuestos antivirales
CN103524423B (zh) * 2013-09-18 2015-11-04 苏州乔纳森新材料科技有限公司 4,6-二氯代嘧啶-5-乙醛的制备方法
CN103554035B (zh) * 2013-10-29 2015-07-15 苏州乔纳森新材料科技有限公司 4,6-二卤代嘧啶-5-乙醛的制备方法
EP3131914B1 (fr) 2014-04-16 2023-05-10 Idenix Pharmaceuticals LLC Nucléosides méthyle ou alcynyle substitués en position 3 pour le traitement du virus de l'hépatite c
WO2016134057A1 (fr) * 2015-02-18 2016-08-25 Abbvie Inc. Composés anti-viraux
WO2016134056A1 (fr) * 2015-02-18 2016-08-25 Abbvie Inc. Composés anti-viraux
WO2016134051A1 (fr) * 2015-02-18 2016-08-25 Abbvie Inc. Composés anti-viraux
WO2016134054A1 (fr) * 2015-02-18 2016-08-25 Abbvie Inc. Composés anti-viraux
WO2017040766A1 (fr) 2015-09-02 2017-03-09 Abbvie Inc. Dérivés anti-viraux de tétrahydrofurane
CN109956975B (zh) * 2017-12-22 2020-11-06 浙江柏拉阿图医药科技有限公司 肝递送恩替卡韦前体药物核苷环磷酸酯化合物及应用
CN109761984B (zh) * 2019-02-27 2020-07-07 河南师范大学 不对称氢转移合成手性五元碳环嘌呤核苷的方法
CN112274516B (zh) * 2020-10-26 2022-08-05 中山大学附属第三医院 一种新型含碘抗病毒药物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5215970A (en) * 1987-04-16 1993-06-01 Medivir Ab Nucleosides and nucleotide analogues, pharmaceutical composition and processes for the preparation of the compounds
SE9003151D0 (sv) * 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
US5723466A (en) * 1991-12-06 1998-03-03 Hoechst Marion Roussel, Inc. Trans cyclopentanyl purine analogs useful as immunosuppressants

Also Published As

Publication number Publication date
AU2003251524A1 (en) 2003-12-31
JP2005533777A (ja) 2005-11-10
WO2003105770A3 (fr) 2004-10-07
EP1515971A2 (fr) 2005-03-23
WO2003105770A2 (fr) 2003-12-24

Similar Documents

Publication Publication Date Title
CA2488842A1 (fr) Derives de nucleosides carbocycliques utilises comme inhibiteurs de l'arn polymerase arn-dependante virale
EP1539188B1 (fr) Derives de nucleoside comme inhibiteurs de l'arn polymerase virale arn-dependante
US7323449B2 (en) Thionucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
US7105499B2 (en) Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
US8481712B2 (en) Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase
US20060264389A1 (en) Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
US20080280842A1 (en) Fluorinated Pyrrolo[2,3-D]Pyrimidine Nucleosides for the Treatment of Rna-Dependent Rna Viral Infection
US20070004669A1 (en) Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
US20060234962A1 (en) Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
US20040229840A1 (en) Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase

Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead