CA2487655A1 - Methods and compositions for inhibiting hiv replication - Google Patents

Methods and compositions for inhibiting hiv replication Download PDF

Info

Publication number
CA2487655A1
CA2487655A1 CA002487655A CA2487655A CA2487655A1 CA 2487655 A1 CA2487655 A1 CA 2487655A1 CA 002487655 A CA002487655 A CA 002487655A CA 2487655 A CA2487655 A CA 2487655A CA 2487655 A1 CA2487655 A1 CA 2487655A1
Authority
CA
Canada
Prior art keywords
hiv
formula
vpr
compound
individual
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002487655A
Other languages
English (en)
French (fr)
Inventor
David B. Weiner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2487655A1 publication Critical patent/CA2487655A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002487655A 2002-05-24 2003-05-23 Methods and compositions for inhibiting hiv replication Abandoned CA2487655A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38340902P 2002-05-24 2002-05-24
US60/383,409 2002-05-24
PCT/US2003/016524 WO2003099851A2 (en) 2002-05-24 2003-05-23 Methods and compositions for inhibiting hiv replication

Publications (1)

Publication Number Publication Date
CA2487655A1 true CA2487655A1 (en) 2003-12-04

Family

ID=29584565

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002487655A Abandoned CA2487655A1 (en) 2002-05-24 2003-05-23 Methods and compositions for inhibiting hiv replication

Country Status (6)

Country Link
US (1) US20060068389A1 (enExample)
EP (1) EP1523328A4 (enExample)
JP (1) JP2005531589A (enExample)
AU (1) AU2003234637B2 (enExample)
CA (1) CA2487655A1 (enExample)
WO (1) WO2003099851A2 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8071063B2 (en) * 2008-02-21 2011-12-06 Exxonmobile Research And Engineering Company Separation of hydrogen from hydrocarbons utilizing zeolitic imidazolate framework materials

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0222385B1 (en) * 1985-11-13 1993-02-03 Research Development Corporation of Japan Sex hormones for the treatment of immunodeficiency diseases
AU8166191A (en) * 1990-08-10 1992-02-13 Ortho Pharmaceutical Corporation Method for treatment of bone wasting diseases
US5874225A (en) * 1993-02-19 1999-02-23 Trustees Of The University Of Pennsylvania Identification of compounds that modulate HIV-1 vpr protein activity
WO1995016705A1 (en) * 1993-12-15 1995-06-22 The Trustees Of The University Of Pennsylvania Vpr receptor protein
US5639598A (en) * 1994-05-19 1997-06-17 The Trustees Of The University Of Pennsylvania Method and kit for identification of antiviral agents capable of abrogating HIV Vpr-Rip-1 binding interactions
US5780220A (en) * 1994-05-19 1998-07-14 Trustees Of The University Of Pennsylvania Methods and compositions for inhibiting HIV replication
US5763190A (en) * 1994-09-21 1998-06-09 The Trustees Of The University Of Pennsylvania Methods for the identification of compounds capable of inducing the nuclear translocation of a receptor complex comprising the glucocoticoid receptor type II and viral protein R interacting protein
JPH08239306A (ja) * 1995-03-03 1996-09-17 Sunstar Inc 忌避剤
IL120263A0 (en) * 1996-02-28 1997-06-10 Pfizer Combination therapy to prevent bone loss-progesterone and estrogen agonists
US6113920A (en) * 1996-10-31 2000-09-05 Glaxo Wellcome Inc. Pharmaceutical compositions
US6117446A (en) * 1999-01-26 2000-09-12 Place; Virgil A. Drug dosage unit for buccal administration of steroidal active agents
AUPQ127399A0 (en) * 1999-06-29 1999-07-22 Guangzhou University Of Traditional Chinese Medicine Compositions and methods for treating or preventing osteoporosis

Also Published As

Publication number Publication date
US20060068389A1 (en) 2006-03-30
WO2003099851A3 (en) 2005-02-24
EP1523328A2 (en) 2005-04-20
JP2005531589A (ja) 2005-10-20
AU2003234637A1 (en) 2003-12-12
AU2003234637B2 (en) 2009-04-30
WO2003099851A2 (en) 2003-12-04
EP1523328A4 (en) 2007-10-31

Similar Documents

Publication Publication Date Title
US11154587B2 (en) Use of peptides to stimulate the immune system
JP2009512716A (ja) Ｈｉｖ−１キャプシド構築の低分子阻害剤
EP1206273A2 (en) Peptides that block viral infectivity and methods of use thereof
CN101466392A (zh) 用于预防或治疗hiv感染的药用组合物及其应用
US7919101B2 (en) Highly potent synergistic combinations of human immunodeficiency virus (HIV) fusion inhibitors
US20070259014A1 (en) Compositions for and Methods for Treating Hiv
JP2023524434A (ja) 新規療法
US20090074721A1 (en) Methods for treating viral infection with oral or injectibel drug solution
RU2290197C2 (ru) Фармацевтическое средство для лечения вич-инфекции, содержащая его композиция и способы его применения
AU2003234637B2 (en) Methods and compositions for inhibiting HIV replication
US6455670B1 (en) Pentamer peptide amide, ALGPG-NH2, that inhibits viral infectivity and methods of use thereof
WO1997037661A1 (en) Preventive and remedy for viral infections
US20070190652A1 (en) Anti-HIV Agent
Mazza et al. Recombinant interleukin‐2 (rIL‐2) in acquired immune deficiency syndrome (AIDS): Preliminary report in patients with lymphoma associated with HIV infection
Doria Role of the CD4 down-modulation activity of Nef in HIV-1 infectivity
Lorenzen et al. CCR5 Antagonists in the Treatment of Treatment-experienced Patients Infects with CCR5 Tropic HIV-1
JPH10501217A (ja) Ｈｉｖの被爆後阻止
CN120131646A (zh) 小分子prt4165在制备抗hiv潜伏药物中的应用
Gupta et al. X Protein of hepatitis B virus potently activates HIV-1 subtype C long terminal repeat promoter: implications for faster spread of HIV-1 subtype C
AU3831889A (en) Combinations of soluble t4 proteins and anti-retroviral agents and methods for treating or preventing aids, arc and hiv infection
KR20070114806A (ko) 바이러스 감염 치료에의 티오포스포노포름산 및 ｎｒｔｉ의용도
WO2006091661A1 (en) Compositions for and methods of modulating platelet levels
TW201110976A (en) Medicinal agent and method for treatment of intractable chronic hepatitis c

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued