CA2487590C - Film-shaped preparations with improved chemical stability containing active substances and method for the production thereof - Google Patents

Film-shaped preparations with improved chemical stability containing active substances and method for the production thereof Download PDF

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Publication number
CA2487590C
CA2487590C CA2487590A CA2487590A CA2487590C CA 2487590 C CA2487590 C CA 2487590C CA 2487590 A CA2487590 A CA 2487590A CA 2487590 A CA2487590 A CA 2487590A CA 2487590 C CA2487590 C CA 2487590C
Authority
CA
Canada
Prior art keywords
preparation according
cellulose
preparation
film
peroxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2487590A
Other languages
English (en)
French (fr)
Other versions
CA2487590A1 (en
Inventor
Christian von Falkenhausen
Walter Mueller
Markus Krumme
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
LTS Lohmann Therapie Systeme AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LTS Lohmann Therapie Systeme AG filed Critical LTS Lohmann Therapie Systeme AG
Publication of CA2487590A1 publication Critical patent/CA2487590A1/en
Application granted granted Critical
Publication of CA2487590C publication Critical patent/CA2487590C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CA2487590A 2002-06-04 2003-05-08 Film-shaped preparations with improved chemical stability containing active substances and method for the production thereof Expired - Fee Related CA2487590C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10224612.2 2002-06-04
DE10224612A DE10224612A1 (de) 2002-06-04 2002-06-04 Wirkstoffhaltige filmförmige Zubereitungen mit verbesserter chemischer Stabilität, und Verfahren zu deren Herstellung
PCT/EP2003/004816 WO2003101421A1 (de) 2002-06-04 2003-05-08 Wirkstoffhaltige filmförmige zubereitungen mit verbesserter chemischer stabilität, und verfahren zu deren herstellung

Publications (2)

Publication Number Publication Date
CA2487590A1 CA2487590A1 (en) 2003-12-11
CA2487590C true CA2487590C (en) 2011-01-11

Family

ID=29594232

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2487590A Expired - Fee Related CA2487590C (en) 2002-06-04 2003-05-08 Film-shaped preparations with improved chemical stability containing active substances and method for the production thereof

Country Status (15)

Country Link
US (1) US20050226823A1 (https=)
EP (1) EP1509201B1 (https=)
JP (1) JP2005528427A (https=)
KR (1) KR20050010024A (https=)
CN (1) CN1658833A (https=)
AR (1) AR039955A1 (https=)
AT (1) ATE426400T1 (https=)
AU (1) AU2003236632B2 (https=)
BR (1) BR0311663A (https=)
CA (1) CA2487590C (https=)
DE (2) DE10224612A1 (https=)
ES (1) ES2324909T3 (https=)
RU (1) RU2311900C2 (https=)
TW (1) TWI344373B (https=)
WO (1) WO2003101421A1 (https=)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1648421B1 (en) * 2003-07-24 2017-10-18 GlaxoSmithKline LLC Orally dissolving films
DE10361306A1 (de) * 2003-12-24 2005-07-28 Lts Lohmann Therapie-Systeme Ag Wundauflage und Wundschnellverband mit einem vasokonstriktorischen Inhaltsstoff, sowie Herstellungsverfahren hierfür
AR051397A1 (es) * 2004-10-21 2007-01-10 Novartis Ag Composicion farmaceutica
DE102005005974A1 (de) * 2005-02-09 2006-08-10 Basf Ag Verfahren zur Stabilisierung von Polyvinylpyrrolidonen
WO2006135491A2 (en) * 2005-06-08 2006-12-21 Basf Aktiengesellschaft Medicament carrier composition and method of forming a film therefrom
WO2007034287A2 (en) * 2005-09-19 2007-03-29 University Of The Witwatersrand, Johannesburg Oramucosal pharmaceutical dosage form
KR100742432B1 (ko) 2005-12-27 2007-07-24 한미약품 주식회사 암로디핀 캠실레이트 및 심바스타틴을 포함하는 복합제제,및 이의 제조방법
FR2902655B1 (fr) * 2006-06-23 2008-11-28 Oreal Compositon topique a effet froid
RU2418574C2 (ru) * 2007-02-08 2011-05-20 Медтроник Ксомед Инк. Сольватирующая система и герметик для медицинского применения
WO2009116417A1 (ja) 2008-03-18 2009-09-24 日本たばこ産業株式会社 シガレット主流煙成分吸着剤およびシガレット用フィルタ
US20100105743A1 (en) * 2008-08-01 2010-04-29 Gopal Krishna Pharmaceutical compositions and methods for stabilizing the same
PT2952191T (pt) 2009-06-12 2018-11-30 Sunovion Pharmaceuticals Inc Apomorfina sublingual
NZ612686A (en) 2010-12-16 2015-11-27 Cynapsus Therapeutics Inc Sublingual films
JP5725940B2 (ja) * 2011-04-01 2015-05-27 日東電工株式会社 ニコチン含有貼付製剤
CN103788552B (zh) * 2012-10-26 2016-12-21 厦门加岩高分子材料有限公司 聚乙烯醇共混物
MY185605A (en) * 2014-06-20 2021-05-25 Ctc Bio Inc Pharmaceutical preparation containing entecavir as active ingredient, and preparation method therefor
JP7211706B2 (ja) 2015-04-21 2023-01-24 サノヴィオン ファーマシュティカルズ インコーポレーテッド 口腔粘膜へのアポモルフィンの投与によるパーキンソン病の治療方法
WO2017081725A1 (ja) * 2015-11-09 2017-05-18 花王株式会社 口腔用組成物
US11648212B2 (en) * 2016-02-03 2023-05-16 Intelgenx Corp. Loxapine film oral dosage form
DE102017127452A1 (de) * 2017-11-21 2019-05-23 Lts Lohmann Therapie-Systeme Ag Wasserlösliche Polymerklebschichten
CN111818903B (zh) * 2018-03-05 2024-05-24 松下知识产权经营株式会社 化妆料或医疗材料
IT201800011125A1 (it) 2018-12-14 2020-06-14 Dpl Pharma S P A Composizioni farmaceutiche orali solide comprendenti matrici monolitiche complesse per la somministrazione cronotropica di medicamenti nel tratto gastroenterico
CN110339118B (zh) * 2019-08-19 2022-08-16 广州明辉化妆品有限公司 具有美白保湿功效的美白霜
SE544672C2 (en) 2020-05-07 2022-10-11 Liw Innovation Ab New compositions for oral or nasal use
IT202000011053A1 (it) 2020-05-14 2021-11-14 Int Health Science S R L Composizioni orali solide comprendenti matrici monolitiche composite per la somministrazione cronotropica nel tratto gastroenterico di alimenti, integratori alimentari, nutraceutici, dispositivi medici
IT202000011050A1 (it) 2020-05-14 2021-11-14 Mogon Pharmaceuticals Sagl Composizioni orali solide comprendenti matrici monolitiche composite per la somministrazione cronotropica nel tratto gastroenterico di ingredienti attivi

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE59289T1 (de) * 1985-10-09 1991-01-15 Desitin Arzneimittel Gmbh Verfahren zur herstellung einer darreichungsund dosierungsform fuer arzneimittel-wirkstoffe, reagentien oder andere wirkstoffe.
US5032384A (en) * 1989-01-27 1991-07-16 Block Drug Company, Inc. Compositions and method for the treatment of disease
IL97930A (en) * 1991-04-23 1996-06-18 Perio Prod Ltd Preparations for whitening two controlled release products that contain a super-oxygen compound
NZ244862A (en) * 1991-10-23 1995-07-26 Block Drug Co Use of vitamin e in topical pharmaceuticals to enhance penetration of the active agent
EP0648114B1 (de) * 1992-07-08 1997-09-17 DIANORM G. Maierhofer GmbH Liposomen, verfahren zu ihrer herstellung und ihre verwendung zur herstellung eines arzneimittels
PT906089E (pt) * 1996-05-13 2004-01-30 Novartis Consumer Health Sa Sistema de administracao bucal
US6375963B1 (en) * 1999-06-16 2002-04-23 Michael A. Repka Bioadhesive hot-melt extruded film for topical and mucosal adhesion applications and drug delivery and process for preparation thereof
RU2155071C1 (ru) * 1999-08-10 2000-08-27 Мизина Прасковья Георгиевна Способ получения лекарственной фитопленки
EP1233763B1 (de) * 1999-11-29 2003-07-30 LTS Lohmann Therapie-Systeme AG Transdermale therapeutische systeme mit verbesserter stabilität und ein verfahren zu ihrer herstellung
DE10018834A1 (de) * 2000-04-15 2001-10-25 Lohmann Therapie Syst Lts Transdermale oder transmucosale Darreichungsformen mit einer nicotinhaltigen Wirkstoffkombination zur Raucherentwöhnung
DE10107659B4 (de) * 2001-02-19 2008-03-13 Lts Lohmann Therapie-Systeme Ag Mucoadhäsive zerfallsfähige Arzneizubereitung zur Wirkstoffverabreichung in der Veterinär- und Humanmedizin
RU2195545C1 (ru) * 2001-08-14 2002-12-27 Хаминов Николай Иванович Способ изоляции промытых зон в добывающей и нагнетательной скважинах

Also Published As

Publication number Publication date
ATE426400T1 (de) 2009-04-15
EP1509201A1 (de) 2005-03-02
ES2324909T3 (es) 2009-08-19
WO2003101421A8 (de) 2005-04-21
KR20050010024A (ko) 2005-01-26
AR039955A1 (es) 2005-03-09
RU2311900C2 (ru) 2007-12-10
JP2005528427A (ja) 2005-09-22
AU2003236632A1 (en) 2003-12-19
CA2487590A1 (en) 2003-12-11
BR0311663A (pt) 2005-06-28
WO2003101421A1 (de) 2003-12-11
RU2004136576A (ru) 2005-08-27
CN1658833A (zh) 2005-08-24
US20050226823A1 (en) 2005-10-13
AU2003236632B2 (en) 2008-07-31
EP1509201B1 (de) 2009-03-25
TWI344373B (en) 2011-07-01
TW200307566A (en) 2003-12-16
DE50311338D1 (de) 2009-05-07
DE10224612A1 (de) 2003-12-24

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EEER Examination request
MKLA Lapsed

Effective date: 20210510