CA2484994C - Peptide antagonists of tgf-beta family members and therapeutic uses thereof - Google Patents
Peptide antagonists of tgf-beta family members and therapeutic uses thereof Download PDFInfo
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- CA2484994C CA2484994C CA2484994A CA2484994A CA2484994C CA 2484994 C CA2484994 C CA 2484994C CA 2484994 A CA2484994 A CA 2484994A CA 2484994 A CA2484994 A CA 2484994A CA 2484994 C CA2484994 C CA 2484994C
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- Prior art keywords
- tgf
- beta
- seq
- peptide
- naturally occurring
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
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Landscapes
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- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13594602A | 2002-04-29 | 2002-04-29 | |
| US10/135,946 | 2002-04-29 | ||
| PCT/US2003/011437 WO2003093293A2 (en) | 2002-04-29 | 2003-04-15 | Peptide antagonists of tgf-beta family members and therapeutic uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2484994A1 CA2484994A1 (en) | 2003-11-13 |
| CA2484994C true CA2484994C (en) | 2016-06-14 |
Family
ID=29399231
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2484994A Expired - Lifetime CA2484994C (en) | 2002-04-29 | 2003-04-15 | Peptide antagonists of tgf-beta family members and therapeutic uses thereof |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1534737A4 (de) |
| AU (1) | AU2003234734A1 (de) |
| CA (1) | CA2484994C (de) |
| WO (1) | WO2003093293A2 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7723473B2 (en) | 1997-06-19 | 2010-05-25 | St. Louis University | Peptide antagonists of TGF-beta family members and therapeutic uses thereof |
| AU2005311098B2 (en) * | 2004-12-01 | 2011-08-11 | Allergan, Inc. | Non-cytotoxic protein conjugates |
| US8642031B2 (en) | 2006-11-02 | 2014-02-04 | Acceleron Pharma, Inc. | Antagonists of BMP9, BMP10, ALK1 and other ALK1 ligands, and uses thereof |
| US10059756B2 (en) | 2006-11-02 | 2018-08-28 | Acceleron Pharma Inc. | Compositions comprising ALK1-ECD protein |
| CN111518218A (zh) | 2006-11-02 | 2020-08-11 | 阿塞勒隆制药公司 | Alk1受体和配体拮抗剂及其用途 |
| KR100879239B1 (ko) * | 2007-04-19 | 2009-01-16 | (주)케어젠 | Ｔｇｆｐ－ｃａｐ 펩타이드 및 그의 용도 |
| US8946201B2 (en) | 2007-08-27 | 2015-02-03 | Saint Louis University | Methods for inhibiting TGF-β |
| JP5719766B2 (ja) | 2008-05-02 | 2015-05-20 | アクセルロン ファーマ， インコーポレイテッド | 血管新生および周皮細胞組成物を調節するための方法および組成物 |
| ES2337973B8 (es) | 2008-05-16 | 2011-07-21 | Proyecto De Biomedicina Cima, S.L. | Adenovirus auxiliares auto-inactivantes para la produccion de adenovirus recombinantes de alta capacidad. |
| ES2330826B1 (es) | 2008-06-04 | 2010-07-26 | Proyecto De Biomedicina Cima, S.L. | Sistema para empaquetamiento de adenovirus de alta capacidad. |
| CN102159219B (zh) | 2008-09-16 | 2015-06-24 | 圣路易斯大学 | 提高转化生长因子-β信号发送的方法 |
| US8691195B2 (en) * | 2009-04-14 | 2014-04-08 | Caregen Co., Ltd. | Peptide having activity of transforming growth factor and production method therefor |
| BR112012010755A2 (pt) | 2009-11-05 | 2015-09-22 | Proyecto Biomedicina Cima Sl | constructo de gene que permite a expressão hepato-específica induzível de um polinucleotídeo de interesse em resposta a um agente indutor, vetor, genoma viral recombinante, vírion, método in vitro para a expressão de um polinucleotídeo de interesse em uma célula de origem hepática, composição farmacêutica e operador-promotor bi-direcional induzível adequado para a expressão hepato-específica induzível de dois polinucleotídeos de interesse por um agente indutor |
| WO2012001196A2 (es) | 2010-06-28 | 2012-01-05 | Proyecto De Biomedicina Cima, S.L. | Vectores alfavirales y usos de los mismos para la expresión de genes heterólogos |
| EP2407534A1 (de) | 2010-07-14 | 2012-01-18 | Neo Virnatech, S.L. | Verfahren und Reagenzien zum Erhalt von transkriptionell aktiven virusähnlichen Artikeln und rekombinante Virionen |
| WO2013113755A1 (en) | 2012-01-30 | 2013-08-08 | Fundació Institut D'investigació Biomèdica De Bellvitge (Idibell) | Reagents and methods for the treatment of diseases based on the inhibition of calcineurin - nfat signalling pathway |
| ES2523016B1 (es) | 2013-05-20 | 2015-09-09 | 3P Biopharmaceuticals | Vectores alfavirales y líneas celulares para la producción de proteínas recombinantes |
| EP2878674A1 (de) | 2013-11-28 | 2015-06-03 | Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) | Stabile Episomen auf Basis von nichtintegrativen lentiviralen Vektoren |
| EP3089755A1 (de) | 2014-01-03 | 2016-11-09 | Fundacion Biofisica Bizkaia | Vlps, verfahren zu deren gewinnung und anwendungen davon |
| WO2023054712A1 (ja) * | 2021-09-30 | 2023-04-06 | ペプチドリーム株式会社 | ペプチド |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4423037A (en) * | 1982-05-13 | 1983-12-27 | The General Hospital Corporation | Inhibitors of peptide hormone action |
| US5571714A (en) * | 1988-12-22 | 1996-11-05 | Celtrix Pharmaceuticals, Inc. | Monoclonal antibodies which bind both transforming growth factors β1 and β2 and methods of use |
| ES2146552B1 (es) * | 1998-11-24 | 2001-04-16 | Inst Cientifico Tecnol Navarra | Peptidos inhibidores de tgf/31 |
-
2003
- 2003-04-15 WO PCT/US2003/011437 patent/WO2003093293A2/en not_active Ceased
- 2003-04-15 AU AU2003234734A patent/AU2003234734A1/en not_active Abandoned
- 2003-04-15 EP EP03728390A patent/EP1534737A4/de not_active Ceased
- 2003-04-15 CA CA2484994A patent/CA2484994C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003093293A2 (en) | 2003-11-13 |
| WO2003093293A3 (en) | 2005-04-07 |
| AU2003234734A1 (en) | 2003-11-17 |
| CA2484994A1 (en) | 2003-11-13 |
| EP1534737A2 (de) | 2005-06-01 |
| AU2003234734A8 (en) | 2003-11-17 |
| EP1534737A4 (de) | 2007-10-31 |
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| Date | Code | Title | Description |
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| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20230417 |