WO2010119997A1 - 형질전환 성장인자의 활성을 가지는 펩타이드 및 그의 용도 - Google Patents

형질전환 성장인자의 활성을 가지는 펩타이드 및 그의 용도 Download PDF

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Publication number
WO2010119997A1
WO2010119997A1 PCT/KR2009/001918 KR2009001918W WO2010119997A1 WO 2010119997 A1 WO2010119997 A1 WO 2010119997A1 KR 2009001918 W KR2009001918 W KR 2009001918W WO 2010119997 A1 WO2010119997 A1 WO 2010119997A1
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WO
WIPO (PCT)
Prior art keywords
tgf
peptide
present
growth factor
transforming growth
Prior art date
Application number
PCT/KR2009/001918
Other languages
English (en)
French (fr)
Inventor
정용지
김영덕
김은미
최정진
최준영
Original Assignee
(주)케어젠
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by (주)케어젠 filed Critical (주)케어젠
Priority to JP2012505791A priority Critical patent/JP5611322B2/ja
Priority to US13/264,290 priority patent/US8691195B2/en
Priority to CN200980159838.2A priority patent/CN102498128B/zh
Priority to EP09843373.3A priority patent/EP2420511B1/en
Publication of WO2010119997A1 publication Critical patent/WO2010119997A1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

본 발명은 특정 아미노산 서열을 포함하는 TGF-β(transforming growth factor-beta)-미미킹 펩타이드 및 이를 포함하는 TGF-β-유효성(TGF-β-effective)의 질환 또는 상태(conditions)의 예방 또는 치료용 조성물에 관한 것이다. 본 발명의 펩타이드는 인간 TGF-β로부터 유래된 것으로서, 천연의 인간 TGF-β와 유사한 기능 또는 작용을 한다. 본 발명의 펩타이드는 천연 TGF-β 보다 안정성이 우수하고 천연 TGF-β의 큰 분자량에 의한 문제점을 개선할 수 있다. 본 발명의 펩타이드는 TGF-β가 적용되는 다양한 질환 또는 상태의 치료 또는 개선에 이용될 수 있으며, 특히 피부 미백 및 주름개선에 대하여 탁월한 효능을 발휘한다.
PCT/KR2009/001918 2009-04-14 2009-04-14 형질전환 성장인자의 활성을 가지는 펩타이드 및 그의 용도 WO2010119997A1 (ko)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2012505791A JP5611322B2 (ja) 2009-04-14 2009-04-14 形質転換成長因子の活性を有するペプチド及びその用途
US13/264,290 US8691195B2 (en) 2009-04-14 2009-04-14 Peptide having activity of transforming growth factor and production method therefor
CN200980159838.2A CN102498128B (zh) 2009-04-14 2009-04-14 具有转化生长因子的活性的肽及其用途
EP09843373.3A EP2420511B1 (en) 2009-04-14 2009-04-14 Peptide having activity of transforming growth factor and production method therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2009-0032052 2009-04-14
KR1020090032052A KR101001156B1 (ko) 2009-04-14 2009-04-14 형질전환 성장인자의 활성을 가지는 펩타이드 및 그의 용도

Publications (1)

Publication Number Publication Date
WO2010119997A1 true WO2010119997A1 (ko) 2010-10-21

Family

ID=41691980

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/001918 WO2010119997A1 (ko) 2009-04-14 2009-04-14 형질전환 성장인자의 활성을 가지는 펩타이드 및 그의 용도

Country Status (6)

Country Link
US (1) US8691195B2 (ko)
EP (1) EP2420511B1 (ko)
JP (1) JP5611322B2 (ko)
KR (1) KR101001156B1 (ko)
CN (1) CN102498128B (ko)
WO (1) WO2010119997A1 (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014109417A1 (ko) 2013-01-08 2014-07-17 (주)노바셀테크놀로지 콜라겐 합성능이 있는 신규 펩타이드 및 그의 용도
US9521655B2 (en) * 2013-07-30 2016-12-13 Qualcomm Incorporated Method and apparatus for avoiding power scaling in uplink data transmission
KR101841742B1 (ko) * 2015-12-18 2018-03-27 (주)케어젠 피부 미백 활성을 갖는 펩타이드 및 이의 용도
JP6787911B2 (ja) * 2017-04-27 2020-11-25 ケアジェン カンパニー, リミテッドCaregen Co., Ltd. 皮膚美白活性を有するペプチド及びその用途

Citations (9)

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WO2004091370A2 (en) * 2003-04-10 2004-10-28 The Trustees Of Boston University Method for stimulating angiogenesis and wound healing
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Also Published As

Publication number Publication date
KR101001156B1 (ko) 2010-12-15
EP2420511A4 (en) 2012-09-12
KR20090133068A (ko) 2009-12-31
EP2420511B1 (en) 2017-04-05
EP2420511A1 (en) 2012-02-22
CN102498128A (zh) 2012-06-13
US8691195B2 (en) 2014-04-08
CN102498128B (zh) 2015-02-18
JP2012523453A (ja) 2012-10-04
JP5611322B2 (ja) 2014-10-22
US20120114577A1 (en) 2012-05-10

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