WO2010085039A2 - 노긴―유래 펩타이드 및 그의 용도 - Google Patents
노긴―유래 펩타이드 및 그의 용도 Download PDFInfo
- Publication number
- WO2010085039A2 WO2010085039A2 PCT/KR2009/006930 KR2009006930W WO2010085039A2 WO 2010085039 A2 WO2010085039 A2 WO 2010085039A2 KR 2009006930 W KR2009006930 W KR 2009006930W WO 2010085039 A2 WO2010085039 A2 WO 2010085039A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- present
- noggin
- peptide
- preventing
- treating
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 102000045246 noggin Human genes 0.000 title abstract 5
- 108700007229 noggin Proteins 0.000 title abstract 5
- 239000003814 drug Substances 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 239000003102 growth factor Substances 0.000 abstract 2
- 208000024891 symptom Diseases 0.000 abstract 2
- 201000004384 Alopecia Diseases 0.000 abstract 1
- 208000020084 Bone disease Diseases 0.000 abstract 1
- 206010041899 Stab wound Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000003779 hair growth Effects 0.000 abstract 1
- 208000024963 hair loss Diseases 0.000 abstract 1
- 230000003676 hair loss Effects 0.000 abstract 1
- 230000002018 overexpression Effects 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 231100000245 skin permeability Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
- Peptides Or Proteins (AREA)
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09838926.5T ES2548982T3 (es) | 2009-01-20 | 2009-11-24 | Péptido derivado de nogina y uso del mismo |
EP09838926.5A EP2383283B1 (en) | 2009-01-20 | 2009-11-24 | Noggin-derived peptide and use thereof |
CN200980157908.0A CN102348716B (zh) | 2009-01-20 | 2009-11-24 | 头蛋白-来源的肽及其用途 |
US13/145,390 US8729028B2 (en) | 2009-01-20 | 2009-11-24 | Noggin-derived peptide and use thereof |
JP2011547757A JP5492226B2 (ja) | 2009-01-20 | 2009-11-24 | ノギン由来のペプチド及びその用途 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2009-0004668 | 2009-01-20 | ||
KR1020090004668A KR101163171B1 (ko) | 2009-01-20 | 2009-01-20 | 노긴?유래 펩타이드 및 그의 용도 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2010085039A2 true WO2010085039A2 (ko) | 2010-07-29 |
WO2010085039A3 WO2010085039A3 (ko) | 2010-09-16 |
Family
ID=42356286
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2009/006930 WO2010085039A2 (ko) | 2009-01-20 | 2009-11-24 | 노긴―유래 펩타이드 및 그의 용도 |
Country Status (7)
Country | Link |
---|---|
US (1) | US8729028B2 (ko) |
EP (1) | EP2383283B1 (ko) |
JP (1) | JP5492226B2 (ko) |
KR (1) | KR101163171B1 (ko) |
CN (1) | CN102348716B (ko) |
ES (1) | ES2548982T3 (ko) |
WO (1) | WO2010085039A2 (ko) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101198918B1 (ko) * | 2009-09-01 | 2012-11-07 | (주)케어젠 | Wnt10?유래 펩타이드 및 그의 용도 |
KR101329411B1 (ko) * | 2012-05-31 | 2013-11-14 | 주식회사 엘지생활건강 | 피부투과성 펩타이드 |
KR101578901B1 (ko) | 2013-09-11 | 2015-12-28 | (주)셀아이콘랩 | 발모 촉진 펩타이드, 이의 제조방법, 및, 이를 함유하는 탈모방지 또는 발모촉진용 조성물 |
KR101600032B1 (ko) * | 2013-09-26 | 2016-03-04 | (주)피앤피바이오팜 | Bmp 활성 억제 기능을 갖는 신규 펩타이드 및 그의 용도 |
KR101632948B1 (ko) * | 2014-05-13 | 2016-06-27 | (주)케어젠 | 항염증, 골 형성 및 발모 촉진 활성을 갖는 펩타이드 및 이의 용도 |
KR101610861B1 (ko) * | 2014-07-28 | 2016-04-11 | (주)케어젠 | 골분화 촉진능 및 치주인대섬유모세포 활성 촉진능을 갖는 펩타이드 및 이의 용도 |
KR101576904B1 (ko) | 2014-07-31 | 2015-12-14 | (주)케어젠 | 파골세포 분화 및 활성 억제능을 갖는 펩타이드 및 이의 용도 |
KR101772574B1 (ko) * | 2015-07-14 | 2017-08-30 | (주)피앤피바이오팜 | 모낭 세포의 재생과 성장을 촉진하는 성장인자, 고안정성 섬유아세포 성장인자 변이체 및 노긴 펩타이드를 함유한 헤어케어 화장품 조성물 |
KR101800877B1 (ko) * | 2016-02-18 | 2017-11-27 | (주)케어젠 | 발모 촉진 활성 및 멜라닌 생성 촉진 활성을 나타내는 펩타이드 및 이의 용도 |
KR101791526B1 (ko) * | 2016-02-18 | 2017-11-01 | (주)케어젠 | 발모 촉진 활성을 나타내는 펩타이드 및 이의 용도 |
KR101831887B1 (ko) * | 2016-03-09 | 2018-02-27 | (주)케어젠 | 발모 촉진 활성 및 멜라닌 생성 촉진 활성을 나타내는 펩타이드 및 이의 용도 |
JP6835867B2 (ja) * | 2016-03-18 | 2021-02-24 | ケアジェン カンパニー, リミテッドCaregen Co., Ltd. | フィナステリドとペプチドの結合体 |
KR101948238B1 (ko) * | 2016-08-19 | 2019-02-14 | (주)케어젠 | 미녹시딜과 펩타이드의 결합체 |
CN106727682A (zh) * | 2017-01-20 | 2017-05-31 | 李玉红 | 一种用于治疗脱发的制剂 |
EP3583944A4 (en) * | 2017-02-16 | 2021-03-03 | Caregen Co., Ltd. | CONJUGATE OF SALICYLIC ACID AND PEPTIDE |
KR101951283B1 (ko) * | 2017-11-13 | 2019-02-22 | 양미경 | 탈모의 예방 또는 치료용, 또는 발모 또는 육모 촉진용 약학 또는 화장료 조성물 |
KR102160566B1 (ko) | 2019-01-16 | 2020-09-28 | (주)케어젠 | 미녹시딜과 펩타이드의 결합체 |
KR102221365B1 (ko) * | 2019-05-07 | 2021-03-02 | (주)케어젠 | 트롤록스-펩타이드 결합체 및 그의 용도 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5473054A (en) | 1992-05-08 | 1995-12-05 | Thomas Jefferson University | IGF-1 analogs |
WO1999061044A1 (en) | 1998-05-28 | 1999-12-02 | The Board Of Trustees Of The University Of Arkansas | Noggin and antagonists of bone morphogenetic proteins to suppress pathologic bone resorption |
WO2003048192A1 (fr) | 2001-12-03 | 2003-06-12 | Santen Pharmaceutical Co., Ltd. | Nouveaux peptides et leurs utilisations en tant que medicaments |
KR20060103159A (ko) | 2005-03-23 | 2006-09-28 | 정용지 | 모발과 피부의 치료를 위한 성장인자 |
US20060276385A1 (en) | 2003-01-13 | 2006-12-07 | Hanjoong Jo | Anti-inflammatory agents and methods of their use |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
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AU676847B2 (en) | 1992-09-03 | 1997-03-27 | Regeneron Pharmaceuticals, Inc. | Dorsal tissue affecting factor and compositions |
JP2002515730A (ja) * | 1995-10-16 | 2002-05-28 | カイロン コーポレイション | 遺伝子発現を変調する因子のスクリーニング方法 |
US6075007A (en) * | 1997-07-17 | 2000-06-13 | Regeneron Pharmaceuticals, Inc. | Modified noggin polypeptide and compositions |
US20030225021A1 (en) * | 2001-11-14 | 2003-12-04 | Mckay William F. | Methods of inducing the expression of bone morphogenetic proteins (BMPs) and transforming growth factor-beta proteins (TGF-betas) in cells |
US6331309B1 (en) * | 1998-09-04 | 2001-12-18 | Scios Inc. | Hydrogel compositions for the controlled release administration of growth factors |
JP4660471B2 (ja) * | 2003-03-14 | 2011-03-30 | セルテック アール アンド ディー, インコーポレイテッド | TGFβ結合タンパク質のリガンドおよびその使用 |
US20070224150A1 (en) * | 2005-03-24 | 2007-09-27 | Yongji Chung | Growth factor for hair and skin treatment |
CA2603365C (en) * | 2005-03-29 | 2017-06-06 | The Trustees Of The University Of Pennsylvania | Methods for generating new hair follicles, treating baldness, and hair removal |
EP2270039B1 (en) * | 2006-03-06 | 2013-05-29 | Caregen Co., Ltd. | Peptides having activities of insulin like growth factor-1 and their uses |
KR100824396B1 (ko) * | 2006-10-10 | 2008-04-22 | (주)케어젠 | 상피세포 성장인자의 활성을 가지는 펩타이드 및 그의 용도 |
KR101198918B1 (ko) * | 2009-09-01 | 2012-11-07 | (주)케어젠 | Wnt10?유래 펩타이드 및 그의 용도 |
-
2009
- 2009-01-20 KR KR1020090004668A patent/KR101163171B1/ko active IP Right Grant
- 2009-11-24 WO PCT/KR2009/006930 patent/WO2010085039A2/ko active Application Filing
- 2009-11-24 JP JP2011547757A patent/JP5492226B2/ja active Active
- 2009-11-24 EP EP09838926.5A patent/EP2383283B1/en active Active
- 2009-11-24 CN CN200980157908.0A patent/CN102348716B/zh active Active
- 2009-11-24 ES ES09838926.5T patent/ES2548982T3/es active Active
- 2009-11-24 US US13/145,390 patent/US8729028B2/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5473054A (en) | 1992-05-08 | 1995-12-05 | Thomas Jefferson University | IGF-1 analogs |
WO1999061044A1 (en) | 1998-05-28 | 1999-12-02 | The Board Of Trustees Of The University Of Arkansas | Noggin and antagonists of bone morphogenetic proteins to suppress pathologic bone resorption |
WO2003048192A1 (fr) | 2001-12-03 | 2003-06-12 | Santen Pharmaceutical Co., Ltd. | Nouveaux peptides et leurs utilisations en tant que medicaments |
US20060276385A1 (en) | 2003-01-13 | 2006-12-07 | Hanjoong Jo | Anti-inflammatory agents and methods of their use |
KR20060103159A (ko) | 2005-03-23 | 2006-09-28 | 정용지 | 모발과 피부의 치료를 위한 성장인자 |
Non-Patent Citations (17)
Title |
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"Remington's Pharmaceutical Sciences", 1995 |
AMERICAN JOURNAL OF PATH., vol. 165, no. 3, 2004, pages 729 - 740 |
COTSARELIS: "Towards a molecular understanding of hair loss and its treatment", TRENDS IN MOL. MED., vol. 7, 2001, pages 293 - 301 |
DOOLEY, T. P. ET AL., SKIN PHARMACOL., vol. 7, 1994, pages 188 - 200 |
HUSTON ET AL., METHODS IN ENZYMOLOGY, vol. 203, 1991, pages 46 - 88 |
KANAMI ET AL.: "Bone Morphogenetic Protein 2 Stimulates Osteoclast Differentiation and Survival Supported by Receptor Activator of Nuclear Factor-KB Ligand", ENDOCRINOLOGY, vol. 142, no. 8, 2001, pages 3656 - 662 |
KODAMA ET AL., AUTOIMMUNITY, vol. 37, 2004, pages 481 - 487 |
MACDONALD, N.: "Alopecia areata: identification and current treatment approaches", DERMATAL. NURS., vol. 11, 1999, pages 356 - 359 |
MERRIFIELD, J. AMER. CHEM. SOC., vol. 85, 1963, pages 2149 - 54 |
OLIVER, EMBRYOL. EXP. MORPH., vol. 15, 1966, pages 331 |
OLIVER, EMBRYOL. EXP. MORPH., vol. 16, 1967, pages 231 |
RIZZINO ET AL., CANCER RES., vol. 48, 1988, pages 4266 |
See also references of EP2383283A4 |
STENN, PAUS, PHYSIOL. REV., vol. 81, 2002, pages 449 |
STEWART ET AL.: "Solid Phase Peptide Synthesis", vol. 111, 1984, PIERCE CHEM. CO. |
VLADIMIR A. BOTCHKAREV, AMERICAN JOURNAL OF PATHOLOGY, vol. 162, no. 3, 2003, pages 709 - 712 |
WHITLOW ET AL., PROTEIN ENG., vol. 6, 1993, pages 989 |
Also Published As
Publication number | Publication date |
---|---|
KR101163171B1 (ko) | 2012-07-19 |
WO2010085039A3 (ko) | 2010-09-16 |
US8729028B2 (en) | 2014-05-20 |
ES2548982T3 (es) | 2015-10-22 |
KR20100085407A (ko) | 2010-07-29 |
EP2383283A2 (en) | 2011-11-02 |
EP2383283B1 (en) | 2015-07-08 |
CN102348716B (zh) | 2014-07-16 |
US20110312884A1 (en) | 2011-12-22 |
JP2012515769A (ja) | 2012-07-12 |
CN102348716A (zh) | 2012-02-08 |
JP5492226B2 (ja) | 2014-05-14 |
EP2383283A4 (en) | 2012-07-04 |
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