EP1942947A2 - Fibronectin-polypeptide und anwendungsverfahren - Google Patents

Fibronectin-polypeptide und anwendungsverfahren

Info

Publication number
EP1942947A2
EP1942947A2 EP06836177A EP06836177A EP1942947A2 EP 1942947 A2 EP1942947 A2 EP 1942947A2 EP 06836177 A EP06836177 A EP 06836177A EP 06836177 A EP06836177 A EP 06836177A EP 1942947 A2 EP1942947 A2 EP 1942947A2
Authority
EP
European Patent Office
Prior art keywords
xaa
amino acid
physiologically acceptable
fragment
acceptable composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06836177A
Other languages
English (en)
French (fr)
Other versions
EP1942947A4 (de
Inventor
Richard A. Clark
Xiang-Dong Ren
Fubao Lin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Foundation of State University of New York
Original Assignee
Research Foundation of State University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Foundation of State University of New York filed Critical Research Foundation of State University of New York
Publication of EP1942947A2 publication Critical patent/EP1942947A2/de
Publication of EP1942947A4 publication Critical patent/EP1942947A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/24—Thermal properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/001—Preparations for care of the lips

Definitions

  • Fibronectin can also play a role in organizing cellular interactions by binding to components of the ECM and to membrane-bound fibronectin receptors on cell surfaces. Forms of fibronectin are found in vertebrates, including mammals, birds, amphibians, fish, and reptiles.
  • Other examples include naphthylalanine, which can be substituted for trytophan to facilitate synthesis, L- hydroxypropyl, L-3,4-dihydroxyphenylalanyl, alpha-amino acids such as L-alpha- hydroxylysyl and D-alpha-methylalanyl, L-alpha-methylalanyl, beta-amino acids, and isoquinolyl.
  • Fragments having non-naturally occurring amino acid residues may be referred to as synthetic fragments of fibronectin and constitute one type of variant as described herein.
  • Other variants include fragments of fibronectin in which a naturally occurring side chain of an amino acid residue (in either the L- or D-form) is replaced with a non-naturally occurring side chain.
  • the patient can be suffering from an injury or loss to the brain, spinal cord or nerves or a disorder resulting in brain, spinal cord or nerve dysfunction; an injury or loss to the heart or blood vessels or a disorder resulting in heart or blood vessel dysfunction; an injury or loss to the lung, nasopharyngeal tract, sinuses, trachea or airways or a disorder resulting in lung, nasopharyngeal tract, sinus, trachea or airway dysfunction; an injury or loss to the gastrointestinal tract, liver or pancreas or a disorder resulting in gastrointestinal tract, liver or pancreas dysfunction; an injury or loss to a kidney, ureters, bladder or urethra or a disorder resulting in kidney, ureters, bladder or urethra dysfunction; an injury or loss to cartilage, synovium, menicus, ligament, tendon or nucleus pulposis or a disorder resulting in cartilage, synovium, menicus, ligament, tendon or nucleus pulposis or
  • the FN fragments, or FN fragment/GF-containing complexes can be incorporated into engineered three- dimensional extracellular matrices (which we may abbreviate herein as engECM or refer to as synthetic matrices), and these can include any of, or any combination of, the fibronectin fragments described herein ⁇ e.g., a FN polypeptide conforming to any of Formulas I, II, or III) or biologically active variants thereof.
  • engineered three- dimensional extracellular matrices which we may abbreviate herein as engECM or refer to as synthetic matrices
  • these can include any of, or any combination of, the fibronectin fragments described herein ⁇ e.g., a FN polypeptide conforming to any of Formulas I, II, or III) or biologically active variants thereof.
  • compositions of the invention can include a fragment of fibronectin that has, or that includes, the sequence QPSHISKYILRWRPK (SEQ ID NO:_).
  • Biologically active variants of a fragment of fibronectin may differ from the wild type fragment by virtue of having one or more substitutions, additions or deletions of one or more amino acid residues.
  • the substitutions can be conservative or non-conservative substitutions, and the amino acid side chains may also be modified.
  • composition and/or nucleic acid constructs should be stable under the conditions of manufacture and storage and should be preserved against the contaminating action of microorganisms such as bacteria and fungi.
  • Preservatives against microorganisms can include various antibacterial and antifungal agents, for example, parabens, chlorobutanol, phenol, ascorbic acid, thimerosal, and the like.
  • the biodegradable polymer can be a ⁇ oly(lactide), a poly(glycolide), a poly(lactide-coglycolide), a poly(lactic acid), a ⁇ oly(glycolic acid), a poly(lactic acid-co-glycolic acid), a poly(caprolactone), a polycarbonate, a polyesteramide, a polyanhydride, a poly(amino acid), a poly(ortho ester), a polycyanoacrylate, a polyamide, a polyacetal, a poly(ether ester), a copolymer of poly(ethylene glycol) and a poly(ortho ester), a poly(dioxanone), a poly(alkylene alkylate)s, a biodegradable polyurethane, or any blend or copolymer thereof.
  • Other useful polymers include an alginate polymer and a carboxy- vinyl polymer (e.g., a polymer including at
  • Open cutaneous wounds represent one major category of wounds and include burn wounds, neuropathic ulcers, pressure sores, venous stasis ulcers, and diabetic ulcers. Open cutaneous wounds routinely heal by a process which comprises six major components: i) inflammation, ii) fibroblast proliferation, iii) blood vessel proliferation, iv) connective tissue synthesis v) epithelialization, and vi) wound contraction. Wound healing is impaired when these components, either individually or as a whole, do not function properly.
  • fibroblast activation and migration is the rate limiting step in granulation tissue development (which normally has a 3-day lag after injury).
  • a reinjured porcine cutaneous wound model was developed to establish whether fibrin matrix maturation was the limiting step.
  • Full-thickness wounds were allowed to heal for 5 or 7 days and then reinjured with aggressive curretting to remove all granulation tissue.
  • a new fibrin clot formed in the re-injured wounds, which was replaced by a fibroblast-rich granulation tissue within just 24 to 48 hours.
  • ADHF Adult Human Dermal Fibroblast
  • the engineered ECM also provides a useful 3-D complex ECM for studies on cell responses to complex ECM containing different FNfds. Rapid (within just 18 hours) and robust migration of adult human dermal fibroblasts (AHDFs) occurred on engineered ECM peaking at a FNfd density of 0.26 ⁇ M in a typical bell- shaped manner. Migration appeared to occur en masse rather than as single cells. AHDF spreading and proliferation also reached 90% of maximal at 0.26 ⁇ M. Thus, 0.26 ⁇ M appeared optimal for FNfds stimulation of AHDF functional responses.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP06836177A 2005-10-04 2006-10-04 Fibronectin-polypeptide und anwendungsverfahren Withdrawn EP1942947A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72349605P 2005-10-04 2005-10-04
PCT/US2006/038778 WO2007044396A2 (en) 2005-10-04 2006-10-04 Fibronectin polypeptides and methods of use

Publications (2)

Publication Number Publication Date
EP1942947A2 true EP1942947A2 (de) 2008-07-16
EP1942947A4 EP1942947A4 (de) 2010-09-01

Family

ID=37943344

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06836177A Withdrawn EP1942947A4 (de) 2005-10-04 2006-10-04 Fibronectin-polypeptide und anwendungsverfahren

Country Status (4)

Country Link
US (1) US8691944B2 (de)
EP (1) EP1942947A4 (de)
CA (1) CA2624900A1 (de)
WO (1) WO2007044396A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2624900A1 (en) 2005-10-04 2007-04-19 The Research Foundation Of State University Of New York Fibronectin polypeptides and methods of use
EP2167111A4 (de) 2007-06-14 2010-06-09 Univ New York State Res Found Polypeptide und anwendungsverfahren
WO2013142229A1 (en) * 2012-03-19 2013-09-26 President And Fellows Of Harvard College Designing novel peptides for inducing fibronectin matrix assembly
WO2013154709A1 (en) 2012-04-13 2013-10-17 Diabetomics, Llc Maternal biomarkers for gestational diabetes
US11180812B2 (en) 2012-08-17 2021-11-23 Cornell University Use of DNA in circulating exosomes as a diagnostic marker for metastatic disease
US10844436B2 (en) 2014-04-01 2020-11-24 Cornell University Use of double-stranded DNA in exosomes: a novel biomarker in cancer detection
JP2017513833A (ja) * 2014-04-08 2017-06-01 ユニヴァーシティー オブ サザン カリフォルニア Ｖｉｉ型コラーゲンフィブロネクチンｉｉｉ型様リピートを有するポリペプチド組成物ならびに創傷の閉鎖および治癒のための治療方法
US11397182B2 (en) 2014-10-07 2022-07-26 Cornell University Methods for prognosing and preventing metastatic liver disease
EP3207022B1 (de) 2014-10-14 2020-01-29 Ecolab USA Inc. Reduzierung von polymerverschmutzung und -agglomeration in acrylat-/methacrylatverfahren
TWI680964B (zh) 2015-03-18 2020-01-01 美商藝康美國公司 用於抑制乙烯基單體聚合作用之穩定親脂性羥胺化合物的用途
US9957209B2 (en) 2015-03-31 2018-05-01 Ecolab Usa Inc. Use of quinone methides as antipolymerants for vinylic monomers
BR112017022431B1 (pt) 2015-04-20 2023-03-28 Ecolab Usa Inc Método para inibir polimerização durante refino, transporte ou armazenamento de uma corrente de hidrocarboneto
US11971402B2 (en) 2015-04-24 2024-04-30 Cornell University Methods and reagents for determination and treatment of organotropic metastasis
US10590184B2 (en) * 2016-09-26 2020-03-17 National Yang-Ming University Process for a preparation of the modified porcine plasma fibronectin for enhance wound healing
JP6953537B2 (ja) 2016-10-14 2021-10-27 ネオマトリクス・セラピューティクス・インコーポレイテッド 生物活性が改善され好中球エラスターゼ分解に対する感受性が低下した、フィブロネクチンに由来するペプチド
US10729741B2 (en) * 2017-03-27 2020-08-04 Neomatrix Therapeutics Inc. Methods of treating burns with i.v. cP12 in a window from 2 to 6 hours after injury
WO2019146673A1 (ja) * 2018-01-25 2019-08-01 タカラバイオ株式会社 リンパ球の製造方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5302701A (en) * 1991-10-14 1994-04-12 Takara Shuzo Co., Ltd. Polypeptide having human fibronectin-like cell adhesive activity
US5453489A (en) * 1992-01-31 1995-09-26 La Jolla Cancer Research Foundation Polypeptide fragments of fibronectin which can modulate extracellular matrix assembly
US5629291A (en) * 1992-01-31 1997-05-13 La Jolla Cancer Research Foundation Methods of modulating fibronectin extracellular matrix assembly
WO1998012226A1 (en) * 1996-09-20 1998-03-26 The Burnham Institute Methods of ameliorating cancer and of inhibiting angiogenesis by using fibronectin
FR2758885A1 (fr) * 1997-07-10 1998-07-31 Centre Nat Rech Scient Methode pour selectionner ou identifier un recepteur cellulaire d'un virus dans un echantillon approprie

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS6023084B2 (ja) * 1979-07-11 1985-06-05 味の素株式会社 代用血液
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4522811A (en) * 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4640935A (en) * 1982-12-09 1987-02-03 The Dow Chemical Company Addition polymerizable adducts for nonaqueous dispersions
US4496689A (en) * 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
US5051448A (en) * 1984-07-24 1991-09-24 The Mclean Hospital Corporation GABA esters and GABA analog esters
EP0206448B1 (de) * 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hämoglobin, das an ein Poly(alkenylenoxid) gebunden ist
US4791192A (en) * 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US5166320A (en) 1987-04-22 1992-11-24 University Of Connecticut Carrier system and method for the introduction of genes into mammalian cells
JP2594123B2 (ja) * 1987-09-12 1997-03-26 株式会社林原生物化学研究所 減感作剤
US5053388A (en) * 1987-11-09 1991-10-01 Chiron Ophthalmics, Inc. Wound healing composition and method
US5169862A (en) * 1989-07-07 1992-12-08 Peptide Technologies Corporation Analogs of viscosin and their uses
EP0502060A4 (en) 1989-11-13 1993-05-05 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
JP2714588B2 (ja) * 1989-12-13 1998-02-16 株式会社ブリヂストン タイヤ点検装置
US5283173A (en) * 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
US5270168A (en) * 1990-02-21 1993-12-14 Board Of Regents, The University Of Texas System Method for diagnosing non-healing ulcers
US5192746A (en) * 1990-07-09 1993-03-09 Tanabe Seiyaku Co., Ltd. Cyclic cell adhesion modulation compounds
EP1046421B8 (de) 1990-12-06 2006-01-11 Affymetrix, Inc. (a Delaware Corporation) Verfahren und Reagenzien für immobilisierten Polymersynthese in sehr grossem Masstab
DE69233331T3 (de) 1991-11-22 2007-08-30 Affymetrix, Inc., Santa Clara Kombinatorische Strategien zur Polymersynthese
US5359115A (en) * 1992-03-26 1994-10-25 Affymax Technologies, N.V. Methods for the synthesis of phosphonate esters
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5288514A (en) * 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
PT665897E (pt) 1992-10-01 2003-11-28 Trustees Of Columbia U In The Bibliotecas quimicas combinatorias complexas codificadas com etiquetas
US5559103A (en) * 1993-07-21 1996-09-24 Cytel Corporation Bivalent sialyl X saccharides
US5539085A (en) * 1993-08-20 1996-07-23 Onyx Pharmaceuticals, Inc. Bcl-2 and R-ras complex
US5362899A (en) * 1993-09-09 1994-11-08 Affymax Technologies, N.V. Chiral synthesis of alpha-aminophosponic acids
JPH07113623A (ja) 1993-10-19 1995-05-02 Shiseido Co Ltd ３次元形状データの位置合わせのための方法と装置
US5576423A (en) * 1994-12-02 1996-11-19 Schering Corporation Antibodies to the slam protein expressed on activated T cells
US6818209B1 (en) * 1998-05-22 2004-11-16 Oxford Biomedica (Uk) Limited Retroviral delivery system
US6924123B2 (en) * 1996-10-29 2005-08-02 Oxford Biomedica (Uk) Limited Lentiviral LTR-deleted vector
WO2000055335A1 (en) * 1999-03-16 2000-09-21 Dana-Farber Cancer Institute, Inc. Pseudotyped lentiviral vectors and uses thereof
WO2000072886A1 (en) * 1999-05-26 2000-12-07 Dana-Farber Cancer Institute, Inc. Episomally replicating lentiviral vectors
AU2001247296A1 (en) * 2000-03-06 2001-09-17 Rigel Pharmaceuticals, Inc. In vivo production of cyclic peptides
US20030027751A1 (en) * 2001-04-10 2003-02-06 Genvec, Inc. VEGF fusion proteins
US6989815B2 (en) * 2001-09-13 2006-01-24 E-Book Systems Pte Ltd. Method for flipping pages via electromechanical information browsing device
US6863884B2 (en) * 2002-05-01 2005-03-08 Cell Genesys, Inc. Pseudotyped retroviral vectors
US6799657B2 (en) * 2002-10-02 2004-10-05 Carrier Corporation Absorptive/reactive muffler for variable speed compressors
FR2854897B1 (fr) * 2003-05-12 2007-05-04 Sederma Sa Compositions cosmetiques ou dermopharmaceutiques pour reduire les signes du vieillissement cutane.
BRPI0411341A (pt) * 2003-06-17 2006-07-11 Du Pont proteìnas modificadas da soja em composições para enrijecimento da pele
CA2530407A1 (en) 2003-07-23 2005-02-03 The Regents Of The University Of California Penetration enhancer combinations for transdermal delivery
US20050282747A1 (en) * 2003-10-01 2005-12-22 The Research Foundation Of State University Of New York At Stony Brook Methods and compositions for wound healing
DK1755660T3 (da) 2004-05-07 2010-07-19 Univ North Carolina Fremgangsmåde til forbedring eller hæmning af insulin-lignende vækstfaktor-I
CA2624900A1 (en) 2005-10-04 2007-04-19 The Research Foundation Of State University Of New York Fibronectin polypeptides and methods of use

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5302701A (en) * 1991-10-14 1994-04-12 Takara Shuzo Co., Ltd. Polypeptide having human fibronectin-like cell adhesive activity
US5453489A (en) * 1992-01-31 1995-09-26 La Jolla Cancer Research Foundation Polypeptide fragments of fibronectin which can modulate extracellular matrix assembly
US5629291A (en) * 1992-01-31 1997-05-13 La Jolla Cancer Research Foundation Methods of modulating fibronectin extracellular matrix assembly
US5747452A (en) * 1992-01-31 1998-05-05 La Jolla Cancer Research Foundation Method of modulating tumor cell migration using fibronectin type III peptides
WO1998012226A1 (en) * 1996-09-20 1998-03-26 The Burnham Institute Methods of ameliorating cancer and of inhibiting angiogenesis by using fibronectin
FR2758885A1 (fr) * 1997-07-10 1998-07-31 Centre Nat Rech Scient Methode pour selectionner ou identifier un recepteur cellulaire d'un virus dans un echantillon approprie

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2007044396A2 *

Also Published As

Publication number Publication date
US8691944B2 (en) 2014-04-08
CA2624900A1 (en) 2007-04-19
US20090111738A1 (en) 2009-04-30
WO2007044396A2 (en) 2007-04-19
WO2007044396A3 (en) 2008-09-04
EP1942947A4 (de) 2010-09-01

Similar Documents

Publication Publication Date Title
US8691944B2 (en) Fibronectin polypeptides and methods of use
US8759300B2 (en) Polypeptides and methods of use
US8076294B2 (en) Collagen-related peptides and uses thereof
EP1636250B1 (de) Selbstorganisierendes, modifikationen enthaltende peptide und deren anwendung
EP2409988B1 (de) Peptidfragmente zur Induzierung der Synthese extrazellulärer Matrixproteine
CA2751132C (en) Collagen-related peptides and uses thereof and hemostatic foam substrates
EP2938626A1 (de) Selbstanordnende ultrakurze peptidhydrogele für wundheilungs-, hautpflege- und kosmetikanwendungen
JPH08503198A (ja) Ｏｐ−３誘導形態形成
US20090299034A1 (en) Collagen-related peptides
JPH09505555A (ja) ＴＧＦ−βの活性を刺激および阻害する方法および組成物
CN110023325B (zh) 具有提高的生物活性和降低的对嗜中性粒细胞弹性蛋白酶降解易感性的来源于纤连蛋白的肽
Vazquez-Portalatin The Use of Biopolymers for Tissue Engineering
Portalatin The use of Biopolymers for Tissue Engineering
AU2008282500B2 (en) Collagen-related peptides and uses thereof
NZ752999B2 (en) Peptides derived from fibronectin with improved bioactivity and reduced susceptibility to neutrophil elastase degradation
AU2007357143A1 (en) Collagen-related peptides
CA2530482A1 (en) Self-assembling peptides incorporating modifications and methods of use thereof

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20080429

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA HR MK RS

R17D Deferred search report published (corrected)

Effective date: 20080904

RIC1 Information provided on ipc code assigned before grant

Ipc: C07K 2/00 20060101ALI20081027BHEP

Ipc: C07K 14/745 20060101ALI20081027BHEP

Ipc: C07K 14/75 20060101ALI20081027BHEP

Ipc: A61K 38/02 20060101ALI20081027BHEP

Ipc: A61K 38/00 20060101ALI20081027BHEP

Ipc: A61K 38/36 20060101AFI20081027BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20100730

DAX Request for extension of the european patent (deleted)
17Q First examination report despatched

Effective date: 20121001

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20130412