CA2481819A1 - Acyl-3-carboxyphenylurea derivatives, method for production and use thereof - Google Patents

Acyl-3-carboxyphenylurea derivatives, method for production and use thereof Download PDF

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Publication number
CA2481819A1
CA2481819A1 CA002481819A CA2481819A CA2481819A1 CA 2481819 A1 CA2481819 A1 CA 2481819A1 CA 002481819 A CA002481819 A CA 002481819A CA 2481819 A CA2481819 A CA 2481819A CA 2481819 A1 CA2481819 A1 CA 2481819A1
Authority
CA
Canada
Prior art keywords
alkyl
cycloalkyl
alkynyl
alkenyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002481819A
Other languages
English (en)
French (fr)
Inventor
Elisabeth Defossa
Dieter Kadereit
Karl Schoenafinger
Thomas Klabunde
Hans-Joerg Burger
Andreas Herling
Karl-Ulrich Wendt
Erich Von Roedern
Alfons Enhsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2481819A1 publication Critical patent/CA2481819A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
    • C07C275/48—Y being a hydrogen or a carbon atom
    • C07C275/54—Y being a carbon atom of a six-membered aromatic ring, e.g. benzoylureas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002481819A 2002-04-11 2003-03-28 Acyl-3-carboxyphenylurea derivatives, method for production and use thereof Abandoned CA2481819A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10215908A DE10215908B4 (de) 2002-04-11 2002-04-11 Acyl-3-carboxyphenyl-harnstoffderivate und deren Verwendung als Arzneimittel
DE10215908.4 2002-04-11
PCT/EP2003/003254 WO2003084923A1 (de) 2002-04-11 2003-03-28 Acyl-3-carboxyphenyl-harnstoffderivate, verfahren zu deren herstellung und deren verwendung

Publications (1)

Publication Number Publication Date
CA2481819A1 true CA2481819A1 (en) 2003-10-16

Family

ID=28684936

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002481819A Abandoned CA2481819A1 (en) 2002-04-11 2003-03-28 Acyl-3-carboxyphenylurea derivatives, method for production and use thereof

Country Status (23)

Country Link
EP (1) EP1497263B1 (https=)
JP (1) JP4328212B2 (https=)
KR (1) KR20040097332A (https=)
CN (1) CN1263734C (https=)
AR (1) AR039402A1 (https=)
AT (1) ATE404532T1 (https=)
AU (1) AU2003232192A1 (https=)
BR (1) BR0309130A (https=)
CA (1) CA2481819A1 (https=)
DE (2) DE10215908B4 (https=)
HR (1) HRP20040931A2 (https=)
HU (1) HUP0500203A2 (https=)
IL (1) IL164248A0 (https=)
MA (1) MA27195A1 (https=)
MX (1) MXPA04009239A (https=)
NO (1) NO20044881L (https=)
NZ (1) NZ535833A (https=)
PL (1) PL371317A1 (https=)
RS (1) RS88704A (https=)
RU (1) RU2004133046A (https=)
TW (1) TW200401765A (https=)
WO (1) WO2003084923A1 (https=)
ZA (1) ZA200407361B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10215907A1 (de) * 2002-04-11 2003-11-06 Aventis Pharma Gmbh Acyl-4-carboxyphenyl-harnstoffderivate, Verfahren zu deren Herstellung und deren Verwendung
DE10306502B4 (de) * 2003-02-17 2005-03-17 Aventis Pharma Deutschland Gmbh Substituierte 3-(Benzoylureido)-thiophenderivate und sie enthaltende Arzneimittel
DE10308352A1 (de) 2003-02-27 2004-09-09 Aventis Pharma Deutschland Gmbh Arylcycloalkylderivate mit verzweigten Seitenketten, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
US7148246B2 (en) 2003-02-27 2006-12-12 Sanofi-Aventis Deutschland Gmbh Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals
DE10308355A1 (de) 2003-02-27 2004-12-23 Aventis Pharma Deutschland Gmbh Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
DE10308353A1 (de) 2003-02-27 2004-12-02 Aventis Pharma Deutschland Gmbh Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE10308351A1 (de) 2003-02-27 2004-11-25 Aventis Pharma Deutschland Gmbh 1,3-substituierte Cycloalkylderivate mit sauren, meist heterocyclischen Gruppen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US7241787B2 (en) 2004-01-25 2007-07-10 Sanofi-Aventis Deutschland Gmbh Substituted N-cycloexylimidazolinones, process for their preparation and their use as medicaments
EP1586573B1 (en) 2004-04-01 2007-02-07 Sanofi-Aventis Deutschland GmbH Oxadiazolones, processes for their preparation and their use as pharmaceuticals
DE102005026762A1 (de) 2005-06-09 2006-12-21 Sanofi-Aventis Deutschland Gmbh Azolopyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA867420B (en) * 1985-09-30 1987-05-27 Union Carbide Corp Pesticidal 1-(4-aryloxyphenyl)-3-benzoyl urea compounds and process for preparation
GB9313268D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Chemical compounds
FI974437A7 (fi) * 1995-06-06 1997-12-05 Pfizer Substituoituja N-(indoli-2-karbonyyli)amideja ja johdannaisia glykogee nifosforylaasi-inhibiittoreina
WO2000056707A1 (en) * 1999-03-24 2000-09-28 Sepracor, Inc. Diaryl thioethers, compositions and uses thereof
US20010053791A1 (en) * 2000-03-16 2001-12-20 Babcock Walter C. Glycogen phosphorylase inhibitor
TR200401029T4 (tr) * 2000-06-09 2004-06-21 Aventis Pharma Deutschland Gmbh Asilfenil-üre türevleri, imalat yöntemleri ve ilaç maddesi olarak kullanımları
GB0021831D0 (en) * 2000-09-06 2000-10-18 Astrazeneca Ab Chemical compounds
PE20021091A1 (es) * 2001-05-25 2003-02-04 Aventis Pharma Gmbh Derivados de fenilurea sustituidos con carbonamida y procedimiento para su preparacion

Also Published As

Publication number Publication date
HK1075650A1 (en) 2005-12-23
CN1263734C (zh) 2006-07-12
PL371317A1 (en) 2005-06-13
IL164248A0 (en) 2005-12-18
EP1497263B1 (de) 2008-08-13
TW200401765A (en) 2004-02-01
NZ535833A (en) 2006-03-31
DE10215908B4 (de) 2005-08-18
WO2003084923A1 (de) 2003-10-16
AR039402A1 (es) 2005-02-16
HRP20040931A2 (en) 2005-02-28
ATE404532T1 (de) 2008-08-15
BR0309130A (pt) 2005-02-01
JP2005522481A (ja) 2005-07-28
CN1646486A (zh) 2005-07-27
MXPA04009239A (es) 2005-01-25
AU2003232192A1 (en) 2003-10-20
ZA200407361B (en) 2006-02-22
MA27195A1 (fr) 2005-01-03
DE50310320D1 (de) 2008-09-25
RS88704A (sr) 2007-02-05
DE10215908A1 (de) 2003-11-06
NO20044881L (no) 2005-01-07
KR20040097332A (ko) 2004-11-17
RU2004133046A (ru) 2005-04-20
EP1497263A1 (de) 2005-01-19
JP4328212B2 (ja) 2009-09-09
HUP0500203A2 (hu) 2005-06-28

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Legal Events

Date Code Title Description
FZDE Discontinued