CA2481186C - Bacteries gram negatives attenuees - Google Patents
Bacteries gram negatives attenuees Download PDFInfo
- Publication number
- CA2481186C CA2481186C CA2481186A CA2481186A CA2481186C CA 2481186 C CA2481186 C CA 2481186C CA 2481186 A CA2481186 A CA 2481186A CA 2481186 A CA2481186 A CA 2481186A CA 2481186 C CA2481186 C CA 2481186C
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- Prior art keywords
- leu
- ala
- ile
- lys
- glu
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
L'invention concerne un mutant d'une bactérie gram négative, cette bactérie possédant au moins une mutation dans une séquence nucléotidique codant un polypeptide d'une identité supérieure ou égale à 70 %, 75 %, 80 %, 85 %, 90 %, 95 %, 96 %, 97 %, 98 %, ou 99 % avec une séquence d'acides aminés codée par une séquence nucléotidique choisie dans le groupe comprenant les séquences nucléotidiques appelées SEQ ID NO: 2, 6, 9, 12, 16, 19, 22, 25, 28, 31, 34, 37, 40, 43, 46, 49, 52, 55, 58, 61, 64, 67, 70, 75, 78, 81, 84, 87, 90, 93. Cette mutation a pour résultat une virulence atténuée de la bactérie. L'invention concerne également des compositions immunogènes ainsi que des vaccins contenant un tel mutant.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37028202P | 2002-04-05 | 2002-04-05 | |
| US60/370,282 | 2002-04-05 | ||
| US10/406,686 US7449178B2 (en) | 2002-04-05 | 2003-04-03 | Attenuated gram negative bacteria |
| US10/406,686 | 2003-04-03 | ||
| PCT/US2003/010308 WO2003086277A2 (fr) | 2002-04-05 | 2003-04-04 | Bacteries gram negatives attenuees |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2481186A1 CA2481186A1 (fr) | 2003-10-23 |
| CA2481186C true CA2481186C (fr) | 2015-10-06 |
Family
ID=29254405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2481186A Expired - Lifetime CA2481186C (fr) | 2002-04-05 | 2003-04-04 | Bacteries gram negatives attenuees |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US7449178B2 (fr) |
| EP (1) | EP1575483B1 (fr) |
| JP (1) | JP4338528B2 (fr) |
| KR (1) | KR101037566B1 (fr) |
| CN (2) | CN1934240A (fr) |
| AT (1) | ATE518955T1 (fr) |
| AU (2) | AU2003223447C1 (fr) |
| BR (1) | BRPI0309001B1 (fr) |
| CA (1) | CA2481186C (fr) |
| CO (1) | CO5640065A1 (fr) |
| ES (1) | ES2371498T3 (fr) |
| HK (1) | HK1078271A1 (fr) |
| MX (1) | MXPA04009730A (fr) |
| NZ (1) | NZ535993A (fr) |
| PT (1) | PT1575483E (fr) |
| WO (1) | WO2003086277A2 (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996017951A2 (fr) * | 1994-12-09 | 1996-06-13 | Rpms Technology Limited | Identification de genes responsables de la survie de microorganismes in vivo |
| DK1108034T3 (da) * | 1998-09-04 | 2008-11-10 | Emergent Product Dev Uk Ltd | Svækkede salmonella SPI2-mutanter som antigenbærere |
| GB9910812D0 (en) * | 1999-05-10 | 1999-07-07 | Microscience Ltd | Vaccine composition |
| US7449178B2 (en) * | 2002-04-05 | 2008-11-11 | Merial Limited | Attenuated gram negative bacteria |
| ATE420105T1 (de) * | 2002-04-05 | 2009-01-15 | Merial Sas | Attenuirte gram-negative bakterien |
| SI1638598T1 (sl) * | 2003-07-02 | 2007-04-30 | Biotechnology Res & Dev | Acapsularna bakterija p. multocida mutanta z delecijo gena hyae |
| CA2591624A1 (fr) * | 2004-12-22 | 2006-11-23 | Intervet International B.V. | Vaccin de pasteurella multocida |
| EP2326344A4 (fr) | 2008-06-16 | 2013-08-07 | Prokarium Ltd | Vaccins vectorisés de salmonella contre chlamydia et procédés d utilisation |
| US8917497B2 (en) * | 2012-07-23 | 2014-12-23 | Knaack Llc | Jobsite storage cabinet for housing electronic equipment |
| WO2015066292A1 (fr) | 2013-11-01 | 2015-05-07 | Merial Limited | Vaccins atténués de pasteurella multocida et leurs procédés de fabrication et d'utilisation |
| CN107075562B (zh) * | 2014-09-30 | 2021-09-24 | 深圳华大基因科技有限公司 | 用于肥胖症相关疾病的生物标记物 |
| TW202214294A (zh) * | 2020-09-30 | 2022-04-16 | 美商碩騰服務公司 | 具有ｈｙａＣ及ｎａｎＰ缺失之新穎多殺性巴斯德氏菌株及疫苗 |
| TW202219269A (zh) * | 2020-09-30 | 2022-05-16 | 美國農業部 | 新型多殺性巴斯德氏菌株及具有ｈｙａＣ與ｎａｎＰ缺失之疫苗 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0668779A4 (fr) * | 1992-11-06 | 1996-08-21 | Univ Minnesota | COMPOSITION PROTEGEANT DE L'INFECTION PAR LA PASTEURELLOSE A -i(P. MULTOCIDA). |
| US6793927B1 (en) * | 1993-12-06 | 2004-09-21 | The United States Of America As Represented By The Secretary Of The Department Of Agriculture | Construction of Pasteurella haemolytica vaccines |
| WO1996017951A2 (fr) | 1994-12-09 | 1996-06-13 | Rpms Technology Limited | Identification de genes responsables de la survie de microorganismes in vivo |
| CA2206575A1 (fr) * | 1996-05-31 | 1997-11-30 | Akzo Nobel Nv | Bacteries vivantes attenuees de la famille ses pasteurellaceae produisant des rtx |
| US6086894A (en) * | 1996-06-27 | 2000-07-11 | Virginia Tech Intellectual Properties, Inc. | Recombinant vaccine for diseases caused by encapsulated organisms |
| US6783764B1 (en) * | 1997-04-10 | 2004-08-31 | Akzo Nobel Nv | Actinobacillus pleuropneumoniae subunit vaccine |
| CH692179A5 (de) | 1997-06-25 | 2002-03-15 | Kueschall Design Ag | Rollstuhl und Sitzmodul für den Rollstuhl, |
| US20010018055A1 (en) * | 1997-09-25 | 2001-08-30 | Briggs Robert E. | Deletion mutants of virulence factors of pasteurellaceae |
| CA2366520C (fr) | 1999-04-09 | 2013-10-01 | Pharmacia & Upjohn Company | Compositions vaccinales anti-bacteriennes |
| US6790950B2 (en) * | 1999-04-09 | 2004-09-14 | Pharmacia & Upjohn Company | Anti-bacterial vaccine compositions |
| GB9910812D0 (en) * | 1999-05-10 | 1999-07-07 | Microscience Ltd | Vaccine composition |
| US6780405B1 (en) * | 2000-04-28 | 2004-08-24 | Avant Immunotherapeutics, Inc. | Regulated antigen delivery system (RADS) |
| WO2002018601A2 (fr) * | 2000-08-25 | 2002-03-07 | Abbott Laboratories | Genes bacteriens essentiels et lecture du genome dans haemophilius influenzae pour l'identification de 'genes essentiels' |
| US20040029129A1 (en) * | 2001-10-25 | 2004-02-12 | Liangsu Wang | Identification of essential genes in microorganisms |
| US7449178B2 (en) * | 2002-04-05 | 2008-11-11 | Merial Limited | Attenuated gram negative bacteria |
| ATE420105T1 (de) * | 2002-04-05 | 2009-01-15 | Merial Sas | Attenuirte gram-negative bakterien |
| WO2004087749A2 (fr) * | 2003-03-27 | 2004-10-14 | Children's Hospital, Inc. | Facteur de virulence d'hemophilus influenzae non classifiable en type |
| UA100370C2 (uk) * | 2006-12-11 | 2012-12-25 | Мериал Лимитед | Спосіб вакцинації птахів проти salmonella |
| TWI328458B (en) * | 2007-03-09 | 2010-08-11 | Univ Nat Chunghsing | Subunit vaccine of pasteurella multocida in veterinary uses |
-
2003
- 2003-04-03 US US10/406,686 patent/US7449178B2/en not_active Expired - Lifetime
- 2003-04-04 CN CNA038123800A patent/CN1934240A/zh active Pending
- 2003-04-04 AU AU2003223447A patent/AU2003223447C1/en not_active Expired
- 2003-04-04 MX MXPA04009730A patent/MXPA04009730A/es active IP Right Grant
- 2003-04-04 PT PT03719577T patent/PT1575483E/pt unknown
- 2003-04-04 JP JP2003583304A patent/JP4338528B2/ja not_active Expired - Lifetime
- 2003-04-04 AT AT03719577T patent/ATE518955T1/de active
- 2003-04-04 EP EP03719577A patent/EP1575483B1/fr not_active Expired - Lifetime
- 2003-04-04 ES ES03719577T patent/ES2371498T3/es not_active Expired - Lifetime
- 2003-04-04 WO PCT/US2003/010308 patent/WO2003086277A2/fr active Application Filing
- 2003-04-04 CA CA2481186A patent/CA2481186C/fr not_active Expired - Lifetime
- 2003-04-04 KR KR1020047015890A patent/KR101037566B1/ko active IP Right Grant
- 2003-04-04 BR BRPI0309001-9A patent/BRPI0309001B1/pt not_active IP Right Cessation
- 2003-04-04 CN CN2011104311167A patent/CN102864090A/zh active Pending
- 2003-04-04 NZ NZ535993A patent/NZ535993A/en not_active IP Right Cessation
-
2004
- 2004-11-04 CO CO04111105A patent/CO5640065A1/es not_active Application Discontinuation
-
2005
- 2005-12-02 HK HK05111055.4A patent/HK1078271A1/xx not_active IP Right Cessation
-
2008
- 2008-10-07 US US12/246,809 patent/US7943125B2/en not_active Expired - Lifetime
-
2010
- 2010-08-04 AU AU2010206113A patent/AU2010206113B2/en not_active Expired
-
2011
- 2011-04-20 US US13/091,046 patent/US8329163B2/en not_active Expired - Lifetime
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| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20230404 |