CA2481095C - A spacer for inertial removal of the non-respirable fraction of medicinal aerosols - Google Patents
A spacer for inertial removal of the non-respirable fraction of medicinal aerosols Download PDFInfo
- Publication number
- CA2481095C CA2481095C CA2481095A CA2481095A CA2481095C CA 2481095 C CA2481095 C CA 2481095C CA 2481095 A CA2481095 A CA 2481095A CA 2481095 A CA2481095 A CA 2481095A CA 2481095 C CA2481095 C CA 2481095C
- Authority
- CA
- Canada
- Prior art keywords
- chamber
- spacer
- outlet
- inlet
- medicinal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 125000006850 spacer group Chemical group 0.000 title claims abstract description 53
- 239000000443 aerosol Substances 0.000 title claims abstract description 44
- 239000002245 particle Substances 0.000 claims description 38
- 238000004891 communication Methods 0.000 claims description 10
- 239000012530 fluid Substances 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 5
- 238000002663 nebulization Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 6
- 229940079593 drug Drugs 0.000 abstract description 5
- 210000004072 lung Anatomy 0.000 abstract description 3
- 238000000034 method Methods 0.000 abstract description 3
- 241000124008 Mammalia Species 0.000 abstract description 2
- 238000000151 deposition Methods 0.000 description 7
- 230000008021 deposition Effects 0.000 description 6
- 238000013461 design Methods 0.000 description 5
- 229940112141 dry powder inhaler Drugs 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229940071648 metered dose inhaler Drugs 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 241001135254 Bisgaard taxa Species 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000003116 impacting effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0086—Inhalation chambers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Nozzles (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37394502P | 2002-04-19 | 2002-04-19 | |
| US60/373,945 | 2002-04-19 | ||
| PCT/US2003/005205 WO2003089036A1 (en) | 2002-04-19 | 2003-02-20 | A spacer for inertial removal of the non-respirable fraction of medicinal aerosols |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2481095A1 CA2481095A1 (en) | 2003-10-30 |
| CA2481095C true CA2481095C (en) | 2013-02-19 |
Family
ID=29251105
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2481095A Expired - Fee Related CA2481095C (en) | 2002-04-19 | 2003-02-20 | A spacer for inertial removal of the non-respirable fraction of medicinal aerosols |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6932082B2 (https=) |
| EP (2) | EP2186536B1 (https=) |
| JP (2) | JP4913325B2 (https=) |
| AT (2) | ATE551087T1 (https=) |
| AU (2) | AU2003215347A1 (https=) |
| CA (1) | CA2481095C (https=) |
| DE (1) | DE60330761D1 (https=) |
| ES (1) | ES2382038T3 (https=) |
| WO (1) | WO2003089036A1 (https=) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050121025A1 (en) * | 2003-12-04 | 2005-06-09 | Gamard Stephan C.F. | Portable gas operating inhaler |
| GB0427028D0 (en) * | 2004-12-09 | 2005-01-12 | Cambridge Consultants | Dry powder inhalers |
| FR2879465B1 (fr) | 2004-12-21 | 2008-02-15 | Diffusion Tech Francaise Sarl | Dispositif de transfert d'aerosols pour generateurs d'aerosols medicaux ou systemes de generation d'aerosols medicaux |
| US8763605B2 (en) | 2005-07-20 | 2014-07-01 | Manta Devices, Llc | Inhalation device |
| US7659725B2 (en) * | 2006-03-24 | 2010-02-09 | 3M Innovative Properties Company | Method for assessing the suitability of metered dose inhaler actuators |
| GB0611656D0 (en) * | 2006-06-13 | 2006-07-19 | Cambridge Consultants | Dry powder inhalers |
| GB0611659D0 (en) * | 2006-06-13 | 2006-07-19 | Cambridge Consultants | Dry powder inhalers |
| WO2009002267A1 (en) * | 2007-06-28 | 2008-12-31 | Dustgun Technologies Ab | Exposure system |
| US11224704B2 (en) | 2007-07-06 | 2022-01-18 | Manta Devices, Llc | Dose delivery device for inhalation |
| JP5528336B2 (ja) | 2007-07-06 | 2014-06-25 | マンタ デバイシス，エルエルシー | デリバリー装置及び関連方法 |
| EP2534957B1 (en) | 2007-12-14 | 2015-05-27 | AeroDesigns, Inc | Delivering aerosolizable products |
| US8176766B1 (en) * | 2008-03-27 | 2012-05-15 | Alcotek, Inc. | Liquid and solid trapping mouthpiece |
| PT2285439E (pt) | 2008-04-04 | 2014-03-25 | Nektar Therapeutics | Dispositivo de aerossolização |
| WO2010083042A1 (en) * | 2009-01-15 | 2010-07-22 | Manta Devices, Llc | Delivery device |
| WO2011116293A2 (en) | 2010-03-19 | 2011-09-22 | Manta Devices, Llc | Delivery device and related methods |
| US11103659B2 (en) | 2011-07-06 | 2021-08-31 | Manta Devices, Llc | Delivery device and related methods |
| US9649454B2 (en) | 2012-05-03 | 2017-05-16 | Manta Devices, Llc | Delivery device and related methods |
| CN104812301B (zh) | 2012-09-25 | 2018-02-09 | 吸入科学瑞典股份公司 | 暴露系统 |
| WO2014143173A1 (en) | 2013-03-15 | 2014-09-18 | Ciancone Chris V | Inhaler spacer and storage apparatus |
| WO2015168572A2 (en) | 2014-05-02 | 2015-11-05 | Manta Devices, Llc | Delivery device and related methods |
| EP3194033B1 (en) * | 2014-09-19 | 2022-05-04 | Aerovu Technologies, Inc. | Spacer device with flow rate spirometer |
| WO2017192782A1 (en) | 2016-05-03 | 2017-11-09 | Pneuma Respiratory, Inc. | Systems and methods comprising a droplet delivery device and a breathing assist device for therapeutic treatment |
| WO2017192774A1 (en) | 2016-05-03 | 2017-11-09 | Pneuma Respiratory, Inc. | Methods for the systemic delivery of therapeutic agents to the pulmonary system using a droplet delivery device |
| WO2017192773A1 (en) * | 2016-05-03 | 2017-11-09 | Pneuma Respiratory, Inc. | Methods for treatment of pulmonary lung diseases with improved therapeutic efficacy and improved dose efficiency |
| EP3452152B1 (en) | 2016-05-03 | 2025-07-02 | Pneuma Respiratory, Inc. | A droplet delivery device for generating and delivering droplets to the pulmonary system |
| EP3452150B1 (en) | 2016-05-03 | 2024-01-17 | Pneuma Respiratory, Inc. | Droplet delivery device for delivery of fluids to the pulmonary system |
| EP4223335A3 (en) | 2017-05-19 | 2023-11-08 | Pneuma Respiratory, Inc. | Dry powder delivery device and methods of use |
| JP2020536614A (ja) | 2017-10-04 | 2020-12-17 | ニューマ・リスパイラトリー・インコーポレイテッド | 呼吸により電気的に作動するインライン液滴送達装置および使用方法 |
| CA3079189A1 (en) | 2017-10-17 | 2019-04-25 | Pneuma Respiratory, Inc. | Nasal drug delivery apparatus and methods of use |
| JP2021502178A (ja) | 2017-11-08 | 2021-01-28 | ニューマ・リスパイラトリー・インコーポレイテッド | 小容積アンプルを有して呼吸により電気的に作動するインライン液滴送達装置および使用方法 |
| TWI662264B (zh) * | 2018-04-20 | 2019-06-11 | National Taiwan University | 分徑採樣器 |
| US11577033B2 (en) | 2018-06-05 | 2023-02-14 | Medline Industries, Lp | Valved spacer for inhalation device |
| WO2022013088A1 (en) * | 2020-07-14 | 2022-01-20 | Stamford Devices Limited | A vaccine administration apparatus and method |
| JP6958950B1 (ja) * | 2020-11-27 | 2021-11-02 | ニップファーマ株式会社 | 吸入補助器 |
| US11452474B1 (en) | 2021-04-14 | 2022-09-27 | Satio, Inc. | Dual lever dermal patch system |
| US12178979B2 (en) | 2021-10-13 | 2024-12-31 | Satio, Inc. | Dermal patch for delivering a pharmaceutical |
| US11877848B2 (en) | 2021-11-08 | 2024-01-23 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US12048543B2 (en) | 2021-11-08 | 2024-07-30 | Satio, Inc. | Dermal patch for collecting a physiological sample with removable vial |
| US11964121B2 (en) | 2021-10-13 | 2024-04-23 | Satio, Inc. | Mono dose dermal patch for pharmaceutical delivery |
| US12214346B2 (en) | 2021-10-13 | 2025-02-04 | Satio, Inc. | Dermal patch with a diagnostic test strip |
| US12023156B2 (en) | 2021-10-13 | 2024-07-02 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| US12053284B2 (en) | 2021-11-08 | 2024-08-06 | Satio, Inc. | Dermal patch for collecting a physiological sample |
| PL4359046T3 (pl) | 2021-06-22 | 2025-10-13 | Pneuma Respiratory, Inc. | Urządzenie do podawania kropelkowego z wyrzutem wypychającym |
| JP1700983S (https=) * | 2021-06-23 | 2021-11-29 | ||
| US12161795B2 (en) | 2022-07-18 | 2024-12-10 | Pneuma Respiratory, Inc. | Small step size and high resolution aerosol generation system and method |
| KR102842879B1 (ko) * | 2022-10-31 | 2025-08-07 | 주식회사 케이티앤지 | 인헤일러 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US506368A (en) * | 1893-10-10 | Inhaling apparatus | ||
| US1263079A (en) * | 1915-10-04 | 1918-04-16 | Leon S Leon | Inhaling apparatus. |
| US1853242A (en) * | 1930-09-24 | 1932-04-12 | Howard A Sliter | Means for nebulizing liquids |
| US2381558A (en) * | 1943-07-15 | 1945-08-07 | Gerard B Robinson | Plastic atomizer |
| US3038532A (en) * | 1960-01-12 | 1962-06-12 | Bernard J Eisenkraft | Spray process equipment |
| US3362405A (en) * | 1964-04-06 | 1968-01-09 | Hamilton O. Hazel | Method and apparatus for admixing gas with solid particles |
| US4069819A (en) | 1973-04-13 | 1978-01-24 | Societa Farmaceutici S.P.A. | Inhalation device |
| US4228795A (en) * | 1977-03-08 | 1980-10-21 | Babington Robert S | Apparatus for producing finely divided liquid spray |
| IT1116047B (it) | 1979-04-27 | 1986-02-10 | Sigma Tau Ind Farmaceuti | Dispositivo per la rapida inalazione di farmaci in polvere da parte di persone sofferenti di asma |
| FI89458C (fi) | 1986-11-06 | 1993-10-11 | Leiras Oy | Inhaleringsanordning |
| UA26915C2 (uk) | 1990-09-12 | 1999-12-29 | Ханс БІСГОРД | Іhгаляторhий пристрій для вдихаhhя активhої порошкоподібhої або рідкої речовиhи |
| DE59107894D1 (de) * | 1991-03-21 | 1996-07-11 | Ritzau Pari Werk Gmbh Paul | Vernebler insbesondere zur Anwendung in Geräten für die Inhalationstherapie |
| DE69230613T2 (de) | 1991-07-02 | 2000-12-28 | Inhale Inc | Verfahren und vorrichtung zum abgeben von medikamenten in aerosolform |
| US5170782A (en) | 1991-09-12 | 1992-12-15 | Devilbiss Health Care, Inc. | Medicament nebulizer with improved aerosol chamber |
| DE4211475A1 (de) | 1991-12-14 | 1993-06-17 | Asta Medica Ag | Pulverinhalator |
| US5476093A (en) * | 1992-02-14 | 1995-12-19 | Huhtamaki Oy | Device for more effective pulverization of a powdered inhalation medicament |
| US5186166A (en) * | 1992-03-04 | 1993-02-16 | Riggs John H | Powder nebulizer apparatus and method of nebulization |
| DE4208880A1 (de) | 1992-03-19 | 1993-09-23 | Boehringer Ingelheim Kg | Separator fuer pulverinhalatoren |
| JPH0678997A (ja) * | 1992-09-02 | 1994-03-22 | Izumi Kenkyusho:Kk | 肺胞到達液粒子発生方法及びそれを利用した治療器 |
| EP0682955B1 (de) * | 1994-05-19 | 2001-09-05 | PARI GmbH Spezialisten für effektive Inhalation | Vorrichtung zur Trocknung und Pufferung von Aerosolen |
| DE19523516C1 (de) | 1995-06-30 | 1996-10-31 | Asta Medica Ag | Inhalator zum Verabreichen von Medikamenten aus Blisterpackungen |
| US6042628A (en) * | 1996-11-12 | 2000-03-28 | Toyo Gijutsu Kogyo Co., Ltd. | Cyclone type dust collector |
| US5685291A (en) | 1996-11-15 | 1997-11-11 | Marsh; Jean Ann | Nebulizer adapter system for premature babies |
| GB9626263D0 (en) | 1996-12-18 | 1997-02-05 | Innovata Biomed Ltd | Powder inhaler |
| US6073629A (en) | 1997-09-25 | 2000-06-13 | Norton Healthcare Ltd. | Inhaler spacer |
| KR100312018B1 (ko) | 1999-03-10 | 2001-11-03 | 김효근 | 공기에 포함된 분진제거용 이중 원심분리기 |
| GB2353222B (en) | 1999-06-23 | 2001-09-19 | Cambridge Consultants | Inhalers |
| EP1129705A1 (en) | 2000-02-17 | 2001-09-05 | Rijksuniversiteit te Groningen | Powder formulation for inhalation |
| GB2364919A (en) | 2000-07-21 | 2002-02-13 | Cambridge Consultants | Inhalers |
-
2003
- 2003-02-20 DE DE60330761T patent/DE60330761D1/de not_active Expired - Lifetime
- 2003-02-20 AU AU2003215347A patent/AU2003215347A1/en not_active Abandoned
- 2003-02-20 WO PCT/US2003/005205 patent/WO2003089036A1/en not_active Ceased
- 2003-02-20 CA CA2481095A patent/CA2481095C/en not_active Expired - Fee Related
- 2003-02-20 AT AT09178276T patent/ATE551087T1/de active
- 2003-02-20 US US10/370,973 patent/US6932082B2/en not_active Expired - Lifetime
- 2003-02-20 JP JP2003585787A patent/JP4913325B2/ja not_active Expired - Fee Related
- 2003-02-20 AT AT03711168T patent/ATE453422T1/de not_active IP Right Cessation
- 2003-02-20 ES ES09178276T patent/ES2382038T3/es not_active Expired - Lifetime
- 2003-02-20 EP EP09178276A patent/EP2186536B1/en not_active Expired - Lifetime
- 2003-02-20 EP EP03711168A patent/EP1496966B1/en not_active Expired - Lifetime
-
2009
- 2009-06-03 AU AU2009202201A patent/AU2009202201A1/en not_active Abandoned
-
2010
- 2010-02-22 JP JP2010036090A patent/JP5215339B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003089036A1 (en) | 2003-10-30 |
| EP1496966B1 (en) | 2009-12-30 |
| DE60330761D1 (de) | 2010-02-11 |
| US20030196654A1 (en) | 2003-10-23 |
| US6932082B2 (en) | 2005-08-23 |
| JP5215339B2 (ja) | 2013-06-19 |
| ES2382038T3 (es) | 2012-06-04 |
| JP4913325B2 (ja) | 2012-04-11 |
| JP2010115526A (ja) | 2010-05-27 |
| EP2186536B1 (en) | 2012-03-28 |
| JP2005523083A (ja) | 2005-08-04 |
| CA2481095A1 (en) | 2003-10-30 |
| AU2009202201A1 (en) | 2009-06-25 |
| EP2186536A1 (en) | 2010-05-19 |
| ATE453422T1 (de) | 2010-01-15 |
| EP1496966A1 (en) | 2005-01-19 |
| AU2003215347A1 (en) | 2003-11-03 |
| ATE551087T1 (de) | 2012-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20190220 |