CA2479912A1 - Benzenesulphonate salt of a morpholine urea derivative for use as a ccr-3 antagonist in the treatment of inflammatory conditions - Google Patents
Benzenesulphonate salt of a morpholine urea derivative for use as a ccr-3 antagonist in the treatment of inflammatory conditions Download PDFInfo
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- CA2479912A1 CA2479912A1 CA002479912A CA2479912A CA2479912A1 CA 2479912 A1 CA2479912 A1 CA 2479912A1 CA 002479912 A CA002479912 A CA 002479912A CA 2479912 A CA2479912 A CA 2479912A CA 2479912 A1 CA2479912 A1 CA 2479912A1
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- 230000004968 inflammatory condition Effects 0.000 title claims abstract description 9
- 238000011282 treatment Methods 0.000 title claims description 14
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- GQJOLWWRVLESSJ-UHFFFAOYSA-N morpholine;urea Chemical class NC(N)=O.C1COCCN1 GQJOLWWRVLESSJ-UHFFFAOYSA-N 0.000 title description 2
- NDZYPHLNJZSQJY-QNWVGRARSA-N 1-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-[(1r,2s)-2-[[(3s)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]urea Chemical compound CC1=C(C(=O)C)SC(NC(=O)N[C@H]2[C@@H](CCCC2)CN2C[C@H](CC=3C=CC(F)=CC=3)CCC2)=N1 NDZYPHLNJZSQJY-QNWVGRARSA-N 0.000 title 1
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- -1 benzenesulphonate (besylate) anion Chemical class 0.000 claims abstract description 17
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 2
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- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229940080313 sodium starch Drugs 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000002511 suppository base Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229960000195 terbutaline Drugs 0.000 description 1
- 238000002217 thermospray mass spectrum Methods 0.000 description 1
- RZWIIPASKMUIAC-VQTJNVASSA-N thromboxane Chemical compound CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC RZWIIPASKMUIAC-VQTJNVASSA-N 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 229960002117 triamcinolone acetonide Drugs 0.000 description 1
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000002750 tryptase inhibitor Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0207432.6 | 2002-03-28 | ||
| GBGB0207432.6A GB0207432D0 (en) | 2002-03-28 | 2002-03-28 | Novel compounds |
| PCT/EP2003/003345 WO2003082293A1 (en) | 2002-03-28 | 2003-03-27 | Benzenesulphonate salt of a morpholine urea derivative for use as a ccr-3 antagonist in the treatment of inflammatory conditions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2479912A1 true CA2479912A1 (en) | 2003-10-09 |
Family
ID=9933984
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002479912A Abandoned CA2479912A1 (en) | 2002-03-28 | 2003-03-27 | Benzenesulphonate salt of a morpholine urea derivative for use as a ccr-3 antagonist in the treatment of inflammatory conditions |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7531651B2 (enExample) |
| EP (1) | EP1487456B1 (enExample) |
| JP (1) | JP2005526808A (enExample) |
| KR (1) | KR20040099375A (enExample) |
| CN (1) | CN1642554A (enExample) |
| AR (1) | AR039179A1 (enExample) |
| AT (1) | ATE317698T1 (enExample) |
| AU (1) | AU2003226761A1 (enExample) |
| BR (1) | BR0308480A (enExample) |
| CA (1) | CA2479912A1 (enExample) |
| DE (1) | DE60303603T2 (enExample) |
| ES (1) | ES2258724T3 (enExample) |
| GB (1) | GB0207432D0 (enExample) |
| IL (1) | IL163847A0 (enExample) |
| IS (1) | IS7432A (enExample) |
| MX (1) | MXPA04009456A (enExample) |
| NO (1) | NO20044323L (enExample) |
| PL (1) | PL372623A1 (enExample) |
| RU (1) | RU2004126948A (enExample) |
| TW (1) | TW200407145A (enExample) |
| WO (1) | WO2003082293A1 (enExample) |
| ZA (1) | ZA200407463B (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140335083A1 (en) * | 2011-12-01 | 2014-11-13 | Glaxo Group Limited | Methods of treatment and prevention of eye diseases |
| FR3022142B1 (fr) | 2014-06-16 | 2019-07-12 | Universite Paul Sabatier - Toulouse Iii | Inhibition de la chimiokine ccl7 ou de son recepteur ccr3 pour le traitement et le diagnostic du cancer de la prostate |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995031431A1 (en) | 1994-05-18 | 1995-11-23 | Nisshin Flour Milling Co., Ltd. | Novel diaminomethylidene derivative |
| BR9915520A (pt) | 1998-11-20 | 2001-07-17 | Hoffmann La Roche | Antagonistas receptores ccr-3 derivados de pirrolidina |
| IL155092A0 (en) | 2000-09-29 | 2003-10-31 | Glaxo Group Ltd | Compounds useful in the treatment of inflammatory diseases |
-
2002
- 2002-03-28 GB GBGB0207432.6A patent/GB0207432D0/en not_active Ceased
-
2003
- 2003-03-26 TW TW092106768A patent/TW200407145A/zh unknown
- 2003-03-27 AR ARP030101092A patent/AR039179A1/es unknown
- 2003-03-27 ES ES03745298T patent/ES2258724T3/es not_active Expired - Lifetime
- 2003-03-27 AU AU2003226761A patent/AU2003226761A1/en not_active Abandoned
- 2003-03-27 BR BR0308480-9A patent/BR0308480A/pt not_active Application Discontinuation
- 2003-03-27 AT AT03745298T patent/ATE317698T1/de not_active IP Right Cessation
- 2003-03-27 PL PL03372623A patent/PL372623A1/xx not_active Application Discontinuation
- 2003-03-27 RU RU2004126948/04A patent/RU2004126948A/ru not_active Application Discontinuation
- 2003-03-27 KR KR10-2004-7015442A patent/KR20040099375A/ko not_active Withdrawn
- 2003-03-27 CN CNA038073641A patent/CN1642554A/zh active Pending
- 2003-03-27 EP EP03745298A patent/EP1487456B1/en not_active Expired - Lifetime
- 2003-03-27 WO PCT/EP2003/003345 patent/WO2003082293A1/en not_active Ceased
- 2003-03-27 MX MXPA04009456A patent/MXPA04009456A/es unknown
- 2003-03-27 IL IL16384703A patent/IL163847A0/xx unknown
- 2003-03-27 DE DE60303603T patent/DE60303603T2/de not_active Expired - Lifetime
- 2003-03-27 JP JP2003579830A patent/JP2005526808A/ja active Pending
- 2003-03-27 US US10/509,521 patent/US7531651B2/en not_active Expired - Fee Related
- 2003-03-27 CA CA002479912A patent/CA2479912A1/en not_active Abandoned
-
2004
- 2004-08-31 IS IS7432A patent/IS7432A/is unknown
- 2004-09-16 ZA ZA200407463A patent/ZA200407463B/en unknown
- 2004-10-12 NO NO20044323A patent/NO20044323L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IS7432A (is) | 2004-08-31 |
| EP1487456B1 (en) | 2006-02-15 |
| EP1487456A1 (en) | 2004-12-22 |
| GB0207432D0 (en) | 2002-05-08 |
| CN1642554A (zh) | 2005-07-20 |
| TW200407145A (en) | 2004-05-16 |
| ES2258724T3 (es) | 2006-09-01 |
| AU2003226761A1 (en) | 2003-10-13 |
| RU2004126948A (ru) | 2005-07-10 |
| IL163847A0 (en) | 2005-12-18 |
| WO2003082293A1 (en) | 2003-10-09 |
| US20060089497A1 (en) | 2006-04-27 |
| BR0308480A (pt) | 2005-01-18 |
| US7531651B2 (en) | 2009-05-12 |
| PL372623A1 (en) | 2005-07-25 |
| JP2005526808A (ja) | 2005-09-08 |
| ZA200407463B (en) | 2005-10-12 |
| DE60303603T2 (de) | 2006-10-26 |
| AR039179A1 (es) | 2005-02-09 |
| ATE317698T1 (de) | 2006-03-15 |
| NO20044323L (no) | 2004-10-27 |
| MXPA04009456A (es) | 2005-01-25 |
| DE60303603D1 (de) | 2006-04-20 |
| KR20040099375A (ko) | 2004-11-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |