CA2464306A1 - Dihydrate-ii d'olanzapine: son procede de preparation et son utilisation - Google Patents

Dihydrate-ii d'olanzapine: son procede de preparation et son utilisation Download PDF

Info

Publication number
CA2464306A1
CA2464306A1 CA002464306A CA2464306A CA2464306A1 CA 2464306 A1 CA2464306 A1 CA 2464306A1 CA 002464306 A CA002464306 A CA 002464306A CA 2464306 A CA2464306 A CA 2464306A CA 2464306 A1 CA2464306 A1 CA 2464306A1
Authority
CA
Canada
Prior art keywords
olanzapine
dehydrate
product
methyl
hours
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002464306A
Other languages
English (en)
Inventor
Reguri Buchi Reddy
Chakka Ramesh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Reddys Laboratories Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2464306A1 publication Critical patent/CA2464306A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne une nouvelle forme de dihydrate 2-methyl-4-(4-methyl-1-piperazinyl)-10<I>H</I>-thieno[2,3-b][1,5 benzodiazepine (appelé dihydrate-II d'olanzapine), son procédé de préparation et sa conversion en olanzapine de forme II. L'invention concerne également des compositions contenant le dihydrate-II d'olanzapine, l'utilisation dudit dihydrate-II d'olanzapine et des compositions contenant le dihydrate-II d'olanzapine permettant de traiter des troubles du système nerveux central.
CA002464306A 2001-10-29 2002-10-29 Dihydrate-ii d'olanzapine: son procede de preparation et son utilisation Abandoned CA2464306A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN877/MAS/2001 2001-10-29
IN877CH2001 2001-10-29
PCT/US2002/034701 WO2003037903A1 (fr) 2001-10-29 2002-10-29 Dihydrate-ii d'olanzapine: son procede de preparation et son utilisation

Publications (1)

Publication Number Publication Date
CA2464306A1 true CA2464306A1 (fr) 2003-05-08

Family

ID=11097012

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002464306A Abandoned CA2464306A1 (fr) 2001-10-29 2002-10-29 Dihydrate-ii d'olanzapine: son procede de preparation et son utilisation

Country Status (4)

Country Link
EP (1) EP1440074A1 (fr)
AU (1) AU2002340328A1 (fr)
CA (1) CA2464306A1 (fr)
WO (1) WO2003037903A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7297789B2 (en) 2002-05-31 2007-11-20 Sandoz, Inc. Process of preparation of olanzapine form I
US7323459B2 (en) 2002-12-24 2008-01-29 Teva Pharmaceutical Industries Ltd. Crystal forms, methods for their preparation and method for preparation of olanzapine
DE05783995T1 (de) * 2004-07-14 2007-10-11 Shasun Chemicals and Drugs Ltd., Chennai Verbessertes verfahren zur herstellung von form i aus olanzapin
JP4940152B2 (ja) * 2005-01-05 2012-05-30 イーライ リリー アンド カンパニー パモ酸オランザピン二水和物
CN103185759A (zh) * 2011-12-27 2013-07-03 天津药物研究院 奥氮平中溶剂残留的检测方法及其应用
CN103848847B (zh) * 2012-12-04 2018-02-06 广东东阳光药业有限公司 一种改进制备奥氮平及其晶型ii的方法
JP6008734B2 (ja) * 2012-12-20 2016-10-19 株式会社トクヤマ オランザピンｉｉ型結晶の製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229382A (en) * 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
EG23659A (en) * 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine
ZA978515B (en) * 1996-09-23 1999-03-23 Lilly Co Eli Intermediates and process for preparing olanzapine
UA56184C2 (uk) * 1996-09-23 2003-05-15 Елі Ліллі Енд Компані Поліморфна модифікація оланзапіну дигідрату d, фармацевтична композиція та спосіб лікування психотичного стану
SK2502003A3 (en) * 2000-08-31 2004-03-02 Reddys Lab Ltd Dr Process for preparation of hydrates of olanzapine and their conversion into crystalline forms of olanzapine

Also Published As

Publication number Publication date
AU2002340328A1 (en) 2003-05-12
WO2003037903A8 (fr) 2004-02-12
WO2003037903A1 (fr) 2003-05-08
EP1440074A1 (fr) 2004-07-28

Similar Documents

Publication Publication Date Title
CA2683040C (fr) Formes polymorphes de chlorhydrate de 1-[4-(5-cyanoindol-3-yl)butyl-4-(2-carbamoylbenzofuran-5-yl)piperazine
JP4145492B2 (ja) テトラヒドロピリドエーテル
SI9520091B (sl) Soli anti-migrenskega derivata indola
EP1296951B1 (fr) 5-chloro-3-(4-methanesulfonylphenyl)-6&#39;-methyl- [2,3&#39;] bipyridinyl sous forme cristalline pure et procede de synthese
WO2001014379A2 (fr) Nouvelle forme cristalline de disodium n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-l- sel d&#39;acide glutamique et procedes de preparation
EP3428159B1 (fr) Formes cristallines de sel de mésylate de dérivé de pyridinyl-aminopyrimidine, procédés de préparation et applications associés
KR20140098074A (ko) 7-((3s,4s)-3-[(사이클로프로필아미노)메틸]-4-플루오로피롤리딘-1-일)-6-플루오로-1-(2-플루오로에틸)-8-메톡시-4-옥소-1,4-다이하이드로퀴놀린-3-카복실산 결정
NO323980B1 (no) Krystallinsk dihydrat B eller E olanzapin, fremgangsmate for fremstilling av Form II olanzapin samt preparat
CA2464306A1 (fr) Dihydrate-ii d&#39;olanzapine: son procede de preparation et son utilisation
KR20090082399A (ko) 벤조티오펜 화합물의 결정형 및 그의 제조방법
WO2000078729A1 (fr) Formes cristallines du lansoprazole
EP1551414B1 (fr) Procede de preparation de forme i de l&#39;olanzapine
PT752857E (pt) Processo aperfeicoado de sintese para 6,9-bis¬(2-aminoetil)-amino|-benzo¬g|isoquinolina-5,10-diona e o seu sal dimaleato
EP0406719A1 (fr) 4H-Indolo(1,2-d)(1,2,4)triazolo(4,3-a)(1,4)benzodiazépines, un procédé pour leur préparation et leur utilisation comme médicaments
US20040067936A1 (en) Process for preparation of hydrates of olanzapine and their conversion into crystalline forms of olanzapine
KR102496869B1 (ko) 이미다조[1,2-a]피리딘 화합물의 신규 염, 이의 결정형 및 제조방법
CZ286654B6 (cs) 2-/2-/(2-hydroxyethyl) amino/ethyl/-5-//(2-methylamino)ethyl/amino/indazol/4,3-gh/isochinolin-6(2H) on, způsob jeho výroby a farmaceutický prostředek s jeho obsahem
KR100825530B1 (ko) (-)-시스-2-(2-클로로페닐)-5,7-디하이드록시-8-[4ｒ-(3ｓ-하이드록시-1-메틸)피페리디닐]-4ｈ-1-벤조피란-4-온의 에탄올 용매화물
EP0024582A1 (fr) Benzodiazépinones, procédé pour leur préparation et médicaments les contenant
CN117321054A (zh) 三环衍生物化合物的结晶形式、制备其的方法和包含其的药物组合物
CA2007513A1 (fr) 7-aryl- et heteroaryl ethers de la desacetyl forskoline, procede de preparation et utilisation comme medicaments
AU613259B2 (en) 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines
WO2003091260A9 (fr) Nouvelle forme vi polymorphe cristalline d&#39;olanzapine et procede de preparation
EP0864572A1 (fr) Cristal d&#39;hydrate et son procede de preparation
WO2008068767A2 (fr) Nouvelle forme cristalline du lansoprazole

Legal Events

Date Code Title Description
FZDE Discontinued