CA2460075A1 - Substituted 7-aza[2.2.1] bicycloheptanes for the treatment of diseases - Google Patents

Info

Publication number

CA2460075A1

CA2460075A1 CA002460075A CA2460075A CA2460075A1 CA 2460075 A1 CA2460075 A1 CA 2460075A1 CA 002460075 A CA002460075 A CA 002460075A CA 2460075 A CA2460075 A CA 2460075A CA 2460075 A1 CA2460075 A1 CA 2460075A1

Authority

CA

Canada

Prior art keywords

azabicyclo

hept

carboxamide

pyridine

benzofuran

Prior art date

2001-09-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 80
• 201000010099 disease Diseases 0.000 title claims abstract description 62
• 238000011282 treatment Methods 0.000 title description 47
• 150000001875 compounds Chemical class 0.000 claims abstract description 205
• 150000003839 salts Chemical class 0.000 claims abstract description 60
• 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 claims abstract description 18
• 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 claims abstract description 18
• -1 -C(O)NR16R16 Chemical group 0.000 claims description 297
• 125000000217 alkyl group Chemical group 0.000 claims description 196
• 125000001424 substituent group Chemical group 0.000 claims description 166
• 229910052794 bromium Inorganic materials 0.000 claims description 129
• 229910052801 chlorine Inorganic materials 0.000 claims description 129
• 229910052731 fluorine Inorganic materials 0.000 claims description 128
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 115
• 241000350052 Daniellia ogea Species 0.000 claims description 106
• 239000003814 drug Substances 0.000 claims description 91
• 229910052740 iodine Inorganic materials 0.000 claims description 88
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 84
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 83
• 229940079593 drug Drugs 0.000 claims description 80
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 73
• 125000003342 alkenyl group Chemical group 0.000 claims description 53
• CZXIPBIBWCODNX-UHFFFAOYSA-N thieno[2,3-c]pyridine-5-carboxamide Chemical compound C1=NC(C(=O)N)=CC2=C1SC=C2 CZXIPBIBWCODNX-UHFFFAOYSA-N 0.000 claims description 48
• 208000024891 symptom Diseases 0.000 claims description 47
• 125000000547 substituted alkyl group Chemical group 0.000 claims description 45
• 125000000304 alkynyl group Chemical group 0.000 claims description 42
• 229910052757 nitrogen Inorganic materials 0.000 claims description 42
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 40
• 229910052799 carbon Inorganic materials 0.000 claims description 37
• 238000000034 method Methods 0.000 claims description 36
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 34
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 34
• 208000024827 Alzheimer disease Diseases 0.000 claims description 33
• ZSOLVRRGFFRUNE-UHFFFAOYSA-N 1-benzofuran-5-carboxamide Chemical compound NC(=O)C1=CC=C2OC=CC2=C1 ZSOLVRRGFFRUNE-UHFFFAOYSA-N 0.000 claims description 31
• TUPZWIXDHKKDRH-UHFFFAOYSA-N thieno[3,2-c]pyridine-6-carboxamide Chemical compound C1=NC(C(=O)N)=CC2=C1C=CS2 TUPZWIXDHKKDRH-UHFFFAOYSA-N 0.000 claims description 30
• 241000124008 Mammalia Species 0.000 claims description 29
• 239000000164 antipsychotic agent Substances 0.000 claims description 29
• 239000008194 pharmaceutical composition Substances 0.000 claims description 29
• 229910052760 oxygen Inorganic materials 0.000 claims description 27
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 27
• 229910052717 sulfur Inorganic materials 0.000 claims description 27
• 208000019901 Anxiety disease Diseases 0.000 claims description 26
• 150000001408 amides Chemical class 0.000 claims description 25
• 125000005017 substituted alkenyl group Chemical group 0.000 claims description 25
• 125000004426 substituted alkynyl group Chemical group 0.000 claims description 25
• 125000004432 carbon atom Chemical group C* 0.000 claims description 24
• 230000006735 deficit Effects 0.000 claims description 24
• 125000001624 naphthyl group Chemical group 0.000 claims description 24
• 201000000980 schizophrenia Diseases 0.000 claims description 23
• 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims description 22
• 206010012289 Dementia Diseases 0.000 claims description 22
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 22
• 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 22
• 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims description 21
• 208000019022 Mood disease Diseases 0.000 claims description 21
• 125000005346 substituted cycloalkyl group Chemical group 0.000 claims description 21
• 208000002193 Pain Diseases 0.000 claims description 20
• 208000028017 Psychotic disease Diseases 0.000 claims description 20
• 208000010412 Glaucoma Diseases 0.000 claims description 19
• 208000010877 cognitive disease Diseases 0.000 claims description 19
• 230000001149 cognitive effect Effects 0.000 claims description 18
• UORVCLMRJXCDCP-UHFFFAOYSA-N propynoic acid Chemical compound OC(=O)C#C UORVCLMRJXCDCP-UHFFFAOYSA-N 0.000 claims description 18
• 125000001391 thioamide group Chemical group 0.000 claims description 18
• SNZSSCZJMVIOCR-UHFFFAOYSA-N 7-azabicyclo[2.2.1]heptane Chemical group C1CC2CCC1N2 SNZSSCZJMVIOCR-UHFFFAOYSA-N 0.000 claims description 17
• 230000036506 anxiety Effects 0.000 claims description 17
• 125000003118 aryl group Chemical group 0.000 claims description 17
• 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims description 17
• 230000004770 neurodegeneration Effects 0.000 claims description 17
• IQQNMLSLUVURHZ-UHFFFAOYSA-N furo[2,3-c]pyridine-5-carboxamide Chemical compound C1=NC(C(=O)N)=CC2=C1OC=C2 IQQNMLSLUVURHZ-UHFFFAOYSA-N 0.000 claims description 16
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 16
• 206010043118 Tardive Dyskinesia Diseases 0.000 claims description 15
• 239000003795 chemical substances by application Substances 0.000 claims description 15
• 208000027061 mild cognitive impairment Diseases 0.000 claims description 13
• SIOXPEMLGUPBBT-UHFFFAOYSA-M picolinate Chemical compound [O-]C(=O)C1=CC=CC=N1 SIOXPEMLGUPBBT-UHFFFAOYSA-M 0.000 claims description 13
• UORVCLMRJXCDCP-UHFFFAOYSA-M propynoate Chemical compound [O-]C(=O)C#C UORVCLMRJXCDCP-UHFFFAOYSA-M 0.000 claims description 13
• VVHLRXBWCJUTGG-UHFFFAOYSA-N 1-benzofuran-6-carboxamide Chemical compound NC(=O)C1=CC=C2C=COC2=C1 VVHLRXBWCJUTGG-UHFFFAOYSA-N 0.000 claims description 12
• 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims description 12
• 208000028173 post-traumatic stress disease Diseases 0.000 claims description 12
• 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 11
• 201000010374 Down Syndrome Diseases 0.000 claims description 11
• 208000023105 Huntington disease Diseases 0.000 claims description 11
• 206010039966 Senile dementia Diseases 0.000 claims description 11
• 206010044688 Trisomy 21 Diseases 0.000 claims description 11
• 206010064930 age-related macular degeneration Diseases 0.000 claims description 11
• 230000003542 behavioural effect Effects 0.000 claims description 11
• 231100000870 cognitive problem Toxicity 0.000 claims description 11
• 125000005842 heteroatom Chemical group 0.000 claims description 11
• 208000002780 macular degeneration Diseases 0.000 claims description 11
• 125000006239 protecting group Chemical group 0.000 claims description 11
• 125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims description 10
• 208000000103 Anorexia Nervosa Diseases 0.000 claims description 10
• 201000011240 Frontotemporal dementia Diseases 0.000 claims description 10
• JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 claims description 10
• 125000004429 atom Chemical group 0.000 claims description 10
• UZIYZYPHBOMKBY-UHFFFAOYSA-N furo[3,2-c]pyridine-6-carboxamide Chemical compound C1=NC(C(=O)N)=CC2=C1C=CO2 UZIYZYPHBOMKBY-UHFFFAOYSA-N 0.000 claims description 10
• 229910052739 hydrogen Inorganic materials 0.000 claims description 10
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 10
• 208000003174 Brain Neoplasms Diseases 0.000 claims description 9
• 208000000609 Pick Disease of the Brain Diseases 0.000 claims description 9
• 206010036631 Presenile dementia Diseases 0.000 claims description 9
• 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims description 9
• 208000030886 Traumatic Brain injury Diseases 0.000 claims description 9
• 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims description 9
• 231100000871 behavioral problem Toxicity 0.000 claims description 9
• 208000030963 borderline personality disease Diseases 0.000 claims description 9
• 230000008482 dysregulation Effects 0.000 claims description 9
• 230000037406 food intake Effects 0.000 claims description 9
• 235000012631 food intake Nutrition 0.000 claims description 9
• 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims description 9
• 230000036651 mood Effects 0.000 claims description 9
• IBBMAWULFFBRKK-UHFFFAOYSA-N picolinamide Chemical compound NC(=O)C1=CC=CC=N1 IBBMAWULFFBRKK-UHFFFAOYSA-N 0.000 claims description 9
• 230000009529 traumatic brain injury Effects 0.000 claims description 9
• 229940122578 Acetylcholine receptor agonist Drugs 0.000 claims description 8
• 208000000323 Tourette Syndrome Diseases 0.000 claims description 8
• 230000037396 body weight Effects 0.000 claims description 8
• 125000001072 heteroaryl group Chemical group 0.000 claims description 8
• 210000004558 lewy body Anatomy 0.000 claims description 8
• 208000018737 Parkinson disease Diseases 0.000 claims description 7
• PVNIIMVLHYAWGP-UHFFFAOYSA-M nicotinate Chemical compound [O-]C(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-M 0.000 claims description 7
• 238000002360 preparation method Methods 0.000 claims description 7
• 230000005586 smoking cessation Effects 0.000 claims description 7
• PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 6
• 125000002619 bicyclic group Chemical group 0.000 claims description 6
• 206010065040 AIDS dementia complex Diseases 0.000 claims description 5
• 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims description 5
• QORAITNQTGPVHV-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-benzofuran-5-carboxamide Chemical compound C1=C2OC=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 QORAITNQTGPVHV-FRRDWIJNSA-N 0.000 claims description 5
• UTXFCHDGQZNPQX-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-ethynyl-1-benzofuran-5-carboxamide Chemical compound C1=C2OC=C(C#C)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 UTXFCHDGQZNPQX-VHDGCEQUSA-N 0.000 claims description 5
• ZLMSGVIRFQKMCL-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-prop-1-ynyl-1-benzofuran-5-carboxamide Chemical compound C1=C2OC=C(C#CC)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 ZLMSGVIRFQKMCL-VNQPRFMTSA-N 0.000 claims description 5
• UZVGSSNIUNSOFA-UHFFFAOYSA-N dibenzofuran-1-carboxylic acid Chemical compound O1C2=CC=CC=C2C2=C1C=CC=C2C(=O)O UZVGSSNIUNSOFA-UHFFFAOYSA-N 0.000 claims description 4
• 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims description 4
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 4
• SIOXPEMLGUPBBT-UHFFFAOYSA-N picolinic acid Chemical compound OC(=O)C1=CC=CC=N1 SIOXPEMLGUPBBT-UHFFFAOYSA-N 0.000 claims description 4
• LEIAZUKOBVWTEH-UHFFFAOYSA-N pyridine-2,5-dicarboxamide Chemical compound NC(=O)C1=CC=C(C(N)=O)N=C1 LEIAZUKOBVWTEH-UHFFFAOYSA-N 0.000 claims description 4
• IYWRCNFZPNEADN-CXODAYGWSA-N tert-butyl n-[(2s)-1-[(2s,4r)-2-[[(1r,2s)-1-(cyclopropylsulfonylcarbamoyl)-2-ethenylcyclopropyl]carbamoyl]-4-(6-methoxyisoquinolin-1-yl)oxypyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate Chemical compound O=C([C@@H]1C[C@H](CN1C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)(C)C)OC=1C2=CC=C(C=C2C=CN=1)OC)N[C@]1(C(=O)NS(=O)(=O)C2CC2)C[C@H]1C=C IYWRCNFZPNEADN-CXODAYGWSA-N 0.000 claims description 4
• 101000585507 Solanum tuberosum Cytochrome b-c1 complex subunit 7 Proteins 0.000 claims description 3
• RFOVUHSTYGVHJC-FRRDWIJNSA-N methyl 5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]-1-benzofuran-2-carboxylate Chemical compound C1=C2OC(C(=O)OC)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 RFOVUHSTYGVHJC-FRRDWIJNSA-N 0.000 claims description 3
• ZGECCYXUQLBZGQ-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2h-isoindole-5-carboxamide Chemical compound C1=CC2=CNC=C2C=C1C(=O)N[C@H](C1)[C@]2([H])CC[C@@]1([H])N2 ZGECCYXUQLBZGQ-HZSPNIEDSA-N 0.000 claims description 3
• CQTSWGRKQJNPAJ-PPKCKEKNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-chlorofuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC=C2Cl CQTSWGRKQJNPAJ-PPKCKEKNSA-N 0.000 claims description 3
• GVTAEXAHUOLBHM-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-ethylfuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC=C2CC GVTAEXAHUOLBHM-KGYLQXTDSA-N 0.000 claims description 3
• NXLMYAUSMMKVBE-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-methyl-1-benzofuran-5-carboxamide Chemical compound C1=C2OC=C(C)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 NXLMYAUSMMKVBE-KWCYVHTRSA-N 0.000 claims description 3
• WLKCRJJYTNXAMF-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-methyl-1-benzofuran-6-carboxamide Chemical compound C1=C2C(C)=COC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 WLKCRJJYTNXAMF-KWCYVHTRSA-N 0.000 claims description 3
• ZHATVBLTFXQKKQ-UHOFOFEASA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-propan-2-yl-1-benzofuran-5-carboxamide Chemical compound C1=C2OC=C(C(C)C)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 ZHATVBLTFXQKKQ-UHOFOFEASA-N 0.000 claims description 3
• BMVGRAVMMPZGSM-SUZMYJTESA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3h-benzimidazole-5-carboxamide Chemical compound C1=C2NC=NC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 BMVGRAVMMPZGSM-SUZMYJTESA-N 0.000 claims description 3
• XFOIJTSLLPVOHG-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-6-methylisoquinoline-3-carboxamide Chemical compound CC1=CC=C2C=NC(C(=O)N[C@H]3[C@]4([H])CC[C@@](N4)(C3)[H])=CC2=C1 XFOIJTSLLPVOHG-QLFBSQMISA-N 0.000 claims description 3
• NPCSQVZOWIHQOZ-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC=C2 NPCSQVZOWIHQOZ-OUAUKWLOSA-N 0.000 claims description 3
• 235000001968 nicotinic acid Nutrition 0.000 claims description 3
• 239000011664 nicotinic acid Substances 0.000 claims description 3
• 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims description 3
• GIXLDUCXMCTCPM-FRRDWIJNSA-N 2,2,2-trifluoroethyl 5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]-1-benzofuran-2-carboxylate Chemical compound C1=C2OC(C(=O)OCC(F)(F)F)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 GIXLDUCXMCTCPM-FRRDWIJNSA-N 0.000 claims description 2
• HXTOOBVCWMDKHY-VHDGCEQUSA-N 2-(3-amino-3-oxoprop-1-ynyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-benzofuran-5-carboxamide Chemical compound C1=C2OC(C#CC(N)=O)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 HXTOOBVCWMDKHY-VHDGCEQUSA-N 0.000 claims description 2
• BPDOHIVTTLRGHT-VHDGCEQUSA-N 2-(3-amino-3-oxoprop-1-ynyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC(C#CC(N)=O)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 BPDOHIVTTLRGHT-VHDGCEQUSA-N 0.000 claims description 2
• XLBVKQFBQAJIHY-KGYLQXTDSA-N 2-(3-amino-3-oxoprop-1-ynyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC(C#CC(N)=O)=C2 XLBVKQFBQAJIHY-KGYLQXTDSA-N 0.000 claims description 2
• TVUBQBNWOFCXLA-KGYLQXTDSA-N 2-(3-amino-3-oxoprop-1-ynyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(C#CC(N)=O)S2 TVUBQBNWOFCXLA-KGYLQXTDSA-N 0.000 claims description 2
• WHWAISHKFBYCHY-QLFBSQMISA-N 2-[acetyl(methyl)amino]-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-benzofuran-6-carboxamide Chemical compound C1=C2C=C(N(C)C(C)=O)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 WHWAISHKFBYCHY-QLFBSQMISA-N 0.000 claims description 2
• UYZPZTIELKBPOG-QLFBSQMISA-N 2-[acetyl(methyl)amino]-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC(N(C)C(C)=O)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 UYZPZTIELKBPOG-QLFBSQMISA-N 0.000 claims description 2
• HOPTYBDYAPJPRC-QLFBSQMISA-N 2-[acetyl(methyl)amino]-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-benzothiophene-6-carboxamide Chemical compound C1=C2C=C(N(C)C(C)=O)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 HOPTYBDYAPJPRC-QLFBSQMISA-N 0.000 claims description 2
• CQZZIKGPWXCICE-FRRDWIJNSA-N 2-[acetyl(methyl)amino]-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC(N(C)C(C)=O)=C2 CQZZIKGPWXCICE-FRRDWIJNSA-N 0.000 claims description 2
• OZMWDBGWCZBFLP-HZSPNIEDSA-N 2-acetamido-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-benzofuran-6-carboxamide Chemical compound C1=C2C=C(NC(C)=O)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 OZMWDBGWCZBFLP-HZSPNIEDSA-N 0.000 claims description 2
• HZEJNWOWYLBRHB-HZSPNIEDSA-N 2-acetamido-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC(NC(C)=O)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 HZEJNWOWYLBRHB-HZSPNIEDSA-N 0.000 claims description 2
• ISLMYSYLSZFOAS-GRYCIOLGSA-N 2-acetamido-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC(NC(C)=O)=C2 ISLMYSYLSZFOAS-GRYCIOLGSA-N 0.000 claims description 2
• AJHCSSFUOFCTFE-GRYCIOLGSA-N 2-acetamido-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(NC(C)=O)S2 AJHCSSFUOFCTFE-GRYCIOLGSA-N 0.000 claims description 2
• SGIQTYHHDUSGNU-HZSPNIEDSA-N 2-acetyl-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-benzofuran-5-carboxamide Chemical compound C1=C2OC(C(C)=O)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 SGIQTYHHDUSGNU-HZSPNIEDSA-N 0.000 claims description 2
• VJWQMJCHLHMUIC-HZSPNIEDSA-N 2-acetyl-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-benzofuran-6-carboxamide Chemical compound C1=C2C=C(C(C)=O)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 VJWQMJCHLHMUIC-HZSPNIEDSA-N 0.000 claims description 2
• LZVNBQBDLCTDHU-HZSPNIEDSA-N 2-acetyl-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC(C(C)=O)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 LZVNBQBDLCTDHU-HZSPNIEDSA-N 0.000 claims description 2
• SXEWWPOSBXWWLE-HZSPNIEDSA-N 2-acetyl-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-benzothiophene-6-carboxamide Chemical compound C1=C2C=C(C(C)=O)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 SXEWWPOSBXWWLE-HZSPNIEDSA-N 0.000 claims description 2
• RJXZOIAGJHETRK-KXUCPTDWSA-N 2-amino-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-benzothiazole-5-carboxamide Chemical compound C1=C2SC(N)=NC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 RJXZOIAGJHETRK-KXUCPTDWSA-N 0.000 claims description 2
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• 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims description 2
• 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims description 2
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• PEDXTMOJAXZLCS-KGYLQXTDSA-N 3-[5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]thieno[2,3-c]pyridin-3-yl]prop-2-ynoic acid Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC=C2C#CC(O)=O PEDXTMOJAXZLCS-KGYLQXTDSA-N 0.000 claims description 2
• WXROFKGCSMCGQW-VHDGCEQUSA-N 3-[acetyl(methyl)amino]-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-benzofuran-5-carboxamide Chemical compound C1=C2OC=C(N(C)C(C)=O)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 WXROFKGCSMCGQW-VHDGCEQUSA-N 0.000 claims description 2
• WVDDQAHBCJNFSI-VHDGCEQUSA-N 3-[acetyl(methyl)amino]-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC=C(N(C)C(C)=O)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 WVDDQAHBCJNFSI-VHDGCEQUSA-N 0.000 claims description 2
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• OOGGMTVRIMPTFU-KWCYVHTRSA-N 3-acetamido-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC=C(NC(C)=O)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 OOGGMTVRIMPTFU-KWCYVHTRSA-N 0.000 claims description 2
• DFEYDHAYPGQANZ-ADEWGFFLSA-N 3-acetamido-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC=C2NC(C)=O DFEYDHAYPGQANZ-ADEWGFFLSA-N 0.000 claims description 2
• PQLLJXOWUFCXGO-BYCMXARLSA-N 3-acetyl-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC=C(C(C)=O)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 PQLLJXOWUFCXGO-BYCMXARLSA-N 0.000 claims description 2
• JPZBKFIVRFCQDI-JIMOISOXSA-N 3-acetyl-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC=C2C(C)=O JPZBKFIVRFCQDI-JIMOISOXSA-N 0.000 claims description 2
• 125000004531 indol-5-yl group Chemical group [H]N1C([H])=C([H])C2=C([H])C(*)=C([H])C([H])=C12 0.000 claims description 2
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• SKEOYQMZBPEYKX-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3-hydroxyprop-1-ynyl)-1-benzofuran-6-carboxamide Chemical compound C1=C2C=C(C#CCO)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 SKEOYQMZBPEYKX-VNQPRFMTSA-N 0.000 claims description 2
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• SXOLZIWVMMFYCN-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3-oxothiomorpholin-4-yl)furo[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1OC=2N1CCSCC1=O SXOLZIWVMMFYCN-FRRDWIJNSA-N 0.000 claims description 2
• KJSFWIGFZILEFC-IXDOHACOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-methylpiperazin-1-yl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1SC=2N1CCN(C)CC1 KJSFWIGFZILEFC-IXDOHACOSA-N 0.000 claims description 2
• AVWGIHLZFGQNLF-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-methylpiperazin-1-yl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1O2)=CC=1C=C2N1CCN(C)CC1 AVWGIHLZFGQNLF-QLFBSQMISA-N 0.000 claims description 2
• ZKJAVUMUEJNLQF-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-methylpiperazin-1-yl)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1S2)=CC=1C=C2N1CCN(C)CC1 ZKJAVUMUEJNLQF-QLFBSQMISA-N 0.000 claims description 2
• RRWZCJUDOPDCGT-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-methylpiperazin-1-yl)thieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1SC=2N1CCN(C)CC1 RRWZCJUDOPDCGT-QLFBSQMISA-N 0.000 claims description 2
• OYMJOTSBCASZFM-IXDOHACOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-methylpiperazine-1-carbonyl)-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1OC=2C(=O)N1CCN(C)CC1 OYMJOTSBCASZFM-IXDOHACOSA-N 0.000 claims description 2
• HXPJNVJLFDHWQB-IXDOHACOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-methylpiperazine-1-carbonyl)-1-benzofuran-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1O2)=CC=C1C=C2C(=O)N1CCN(C)CC1 HXPJNVJLFDHWQB-IXDOHACOSA-N 0.000 claims description 2
• GZEMZMOJYAQRRB-IXDOHACOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-methylpiperazine-1-carbonyl)-1-benzothiophene-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1S2)=CC=C1C=C2C(=O)N1CCN(C)CC1 GZEMZMOJYAQRRB-IXDOHACOSA-N 0.000 claims description 2
• ZXMUYEKFVQUNCR-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(azetidine-1-carbonyl)-1-benzofuran-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1O2)=CC=C1C=C2C(=O)N1CCC1 ZXMUYEKFVQUNCR-QLFBSQMISA-N 0.000 claims description 2
• MTDDXABWSBCLIV-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(azetidine-1-carbonyl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1SC=2C(=O)N1CCC1 MTDDXABWSBCLIV-QLFBSQMISA-N 0.000 claims description 2
• BTAIPTANZMTQNY-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(azetidine-1-carbonyl)-1-benzothiophene-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1S2)=CC=C1C=C2C(=O)N1CCC1 BTAIPTANZMTQNY-QLFBSQMISA-N 0.000 claims description 2
• GXALOCINDLDPHP-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(azetidine-1-carbonyl)furo[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1OC=2C(=O)N1CCC1 GXALOCINDLDPHP-FRRDWIJNSA-N 0.000 claims description 2
• HANXOYYMCVHMMN-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(azetidine-1-carbonyl)thieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1SC=2C(=O)N1CCC1 HANXOYYMCVHMMN-FRRDWIJNSA-N 0.000 claims description 2
• MRXQROJZLMPERL-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(aziridine-1-carbonyl)-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1OC=2C(=O)N1CC1 MRXQROJZLMPERL-HZSPNIEDSA-N 0.000 claims description 2
• IDYDYCHHDHCWFH-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(aziridine-1-carbonyl)-1-benzofuran-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1O2)=CC=C1C=C2C(=O)N1CC1 IDYDYCHHDHCWFH-HZSPNIEDSA-N 0.000 claims description 2
• SPBUZYDOFKQSSV-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(aziridine-1-carbonyl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1SC=2C(=O)N1CC1 SPBUZYDOFKQSSV-HZSPNIEDSA-N 0.000 claims description 2
• JFKMDTWXQPYYPT-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(aziridine-1-carbonyl)-1-benzothiophene-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1S2)=CC=C1C=C2C(=O)N1CC1 JFKMDTWXQPYYPT-HZSPNIEDSA-N 0.000 claims description 2
• PRBQSDZULZCWJV-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(aziridine-1-carbonyl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1O2)=CC=1C=C2C(=O)N1CC1 PRBQSDZULZCWJV-GRYCIOLGSA-N 0.000 claims description 2
• FDEZTXLYHSGITK-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(cyclopropylamino)-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1OC=2NC1CC1 FDEZTXLYHSGITK-QLFBSQMISA-N 0.000 claims description 2
• FAUSWCLLSUOJPV-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(cyclopropylamino)-1-benzofuran-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1O2)=CC=C1C=C2NC1CC1 FAUSWCLLSUOJPV-QLFBSQMISA-N 0.000 claims description 2
• LVJQJEOBMSNQLV-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(cyclopropylamino)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1SC=2NC1CC1 LVJQJEOBMSNQLV-QLFBSQMISA-N 0.000 claims description 2
• OYNXMOPIONODRN-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(cyclopropylamino)-1-benzothiophene-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1S2)=CC=C1C=C2NC1CC1 OYNXMOPIONODRN-QLFBSQMISA-N 0.000 claims description 2
• WSAJRXKEVAMQLT-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(cyclopropylamino)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1O2)=CC=1C=C2NC1CC1 WSAJRXKEVAMQLT-FRRDWIJNSA-N 0.000 claims description 2
• YKFGHBHIBMIHNT-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(cyclopropylamino)furo[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1OC=2NC1CC1 YKFGHBHIBMIHNT-FRRDWIJNSA-N 0.000 claims description 2
• MEEFRGNRZVHTPF-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(cyclopropylamino)thieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1SC=2NC1CC1 MEEFRGNRZVHTPF-FRRDWIJNSA-N 0.000 claims description 2
• IMDGAZQCEDCMHQ-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(diethylamino)-1-benzofuran-5-carboxamide Chemical compound C1=C2OC(N(CC)CC)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 IMDGAZQCEDCMHQ-OWCLPIDISA-N 0.000 claims description 2
• GHMJHUNBZRNOAS-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(diethylamino)-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC(N(CC)CC)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 GHMJHUNBZRNOAS-OWCLPIDISA-N 0.000 claims description 2
• CPVCWECBMBPQGA-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(diethylamino)-1-benzothiophene-6-carboxamide Chemical compound C1=C2C=C(N(CC)CC)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 CPVCWECBMBPQGA-OWCLPIDISA-N 0.000 claims description 2
• PXLYCPYQJAWIJK-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(diethylamino)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC(N(CC)CC)=C2 PXLYCPYQJAWIJK-HZSPNIEDSA-N 0.000 claims description 2
• VDRXWFGGOTWESX-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(dimethylamino)-1-benzofuran-5-carboxamide Chemical compound C1=C2OC(N(C)C)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 VDRXWFGGOTWESX-HZSPNIEDSA-N 0.000 claims description 2
• NTPHCDJDSWAJOF-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(dimethylamino)-1-benzofuran-6-carboxamide Chemical compound C1=C2C=C(N(C)C)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 NTPHCDJDSWAJOF-HZSPNIEDSA-N 0.000 claims description 2
• KJYKYDGUCBFSTG-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(dimethylamino)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC(N(C)C)=C2 KJYKYDGUCBFSTG-GRYCIOLGSA-N 0.000 claims description 2
• QENSPPQHBRJUJQ-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(methylamino)-1-benzofuran-5-carboxamide Chemical compound C1=C2OC(NC)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 QENSPPQHBRJUJQ-FRRDWIJNSA-N 0.000 claims description 2
• XAORIOULEUGMJY-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(methylamino)-1-benzofuran-6-carboxamide Chemical compound C1=C2C=C(NC)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 XAORIOULEUGMJY-FRRDWIJNSA-N 0.000 claims description 2
• HAWUGGAPKDJDNZ-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(methylamino)-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC(NC)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 HAWUGGAPKDJDNZ-FRRDWIJNSA-N 0.000 claims description 2
• KEYFEHGMMMHCDO-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(methylamino)-1-benzothiophene-6-carboxamide Chemical compound C1=C2C=C(NC)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 KEYFEHGMMMHCDO-FRRDWIJNSA-N 0.000 claims description 2
• IVZBOTCSCJIVCV-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(morpholine-4-carbonyl)-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1OC=2C(=O)N1CCOCC1 IVZBOTCSCJIVCV-OWCLPIDISA-N 0.000 claims description 2
• COXQHYCAMRGJQT-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(morpholine-4-carbonyl)-1-benzofuran-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1O2)=CC=C1C=C2C(=O)N1CCOCC1 COXQHYCAMRGJQT-OWCLPIDISA-N 0.000 claims description 2
• PVSZBZICPKPVKM-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(morpholine-4-carbonyl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1SC=2C(=O)N1CCOCC1 PVSZBZICPKPVKM-OWCLPIDISA-N 0.000 claims description 2
• NYBNWBPLYJXBHQ-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(morpholine-4-carbonyl)-1-benzothiophene-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1S2)=CC=C1C=C2C(=O)N1CCOCC1 NYBNWBPLYJXBHQ-OWCLPIDISA-N 0.000 claims description 2
• CTNIEXWPOKKRKL-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(morpholine-4-carbonyl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1O2)=CC=1C=C2C(=O)N1CCOCC1 CTNIEXWPOKKRKL-HZSPNIEDSA-N 0.000 claims description 2
• OOFCJPSUHXIBLG-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(morpholine-4-carbonyl)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1S2)=CC=1C=C2C(=O)N1CCOCC1 OOFCJPSUHXIBLG-HZSPNIEDSA-N 0.000 claims description 2
• DFJBIMBGPLFFGE-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(morpholine-4-carbonyl)thieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1SC=2C(=O)N1CCOCC1 DFJBIMBGPLFFGE-HZSPNIEDSA-N 0.000 claims description 2
• KXNGYRQBEAMTAL-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(piperazine-1-carbonyl)-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1OC=2C(=O)N1CCNCC1 KXNGYRQBEAMTAL-OWCLPIDISA-N 0.000 claims description 2
• DXDYZBDBEJNCSL-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(piperazine-1-carbonyl)-1-benzofuran-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1O2)=CC=C1C=C2C(=O)N1CCNCC1 DXDYZBDBEJNCSL-OWCLPIDISA-N 0.000 claims description 2
• WCLZYQCJNJGIFF-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(piperazine-1-carbonyl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1O2)=CC=1C=C2C(=O)N1CCNCC1 WCLZYQCJNJGIFF-HZSPNIEDSA-N 0.000 claims description 2
• YKVQPYNPHWNUOZ-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(piperazine-1-carbonyl)furo[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1OC=2C(=O)N1CCNCC1 YKVQPYNPHWNUOZ-HZSPNIEDSA-N 0.000 claims description 2
• YWHROOYKOCHHIX-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(piperazine-1-carbonyl)thieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1SC=2C(=O)N1CCNCC1 YWHROOYKOCHHIX-HZSPNIEDSA-N 0.000 claims description 2
• QUEIOJDFXJPUCJ-IXDOHACOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(piperidine-1-carbonyl)-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1OC=2C(=O)N1CCCCC1 QUEIOJDFXJPUCJ-IXDOHACOSA-N 0.000 claims description 2
• MZYBBFREBFTBKY-IXDOHACOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(piperidine-1-carbonyl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1SC=2C(=O)N1CCCCC1 MZYBBFREBFTBKY-IXDOHACOSA-N 0.000 claims description 2
• QMZCHOGCTSXQLV-IXDOHACOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(piperidine-1-carbonyl)-1-benzothiophene-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1S2)=CC=C1C=C2C(=O)N1CCCCC1 QMZCHOGCTSXQLV-IXDOHACOSA-N 0.000 claims description 2
• IACSJSRWLDHVKM-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(piperidine-1-carbonyl)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1S2)=CC=1C=C2C(=O)N1CCCCC1 IACSJSRWLDHVKM-QLFBSQMISA-N 0.000 claims description 2
• VUFXRRNFTBQVBP-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(pyrrolidine-1-carbonyl)-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1OC=2C(=O)N1CCCC1 VUFXRRNFTBQVBP-OWCLPIDISA-N 0.000 claims description 2
• ITEMEUVZINOFQH-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(pyrrolidine-1-carbonyl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1SC=2C(=O)N1CCCC1 ITEMEUVZINOFQH-OWCLPIDISA-N 0.000 claims description 2
• ZWTFTEXRNPRJLO-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(pyrrolidine-1-carbonyl)-1-benzothiophene-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1S2)=CC=C1C=C2C(=O)N1CCCC1 ZWTFTEXRNPRJLO-OWCLPIDISA-N 0.000 claims description 2
• MVGSHYVQVHQTMR-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(pyrrolidine-1-carbonyl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1O2)=CC=1C=C2C(=O)N1CCCC1 MVGSHYVQVHQTMR-HZSPNIEDSA-N 0.000 claims description 2
• LXJKDWVILXIOTF-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(pyrrolidine-1-carbonyl)furo[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1OC=2C(=O)N1CCCC1 LXJKDWVILXIOTF-HZSPNIEDSA-N 0.000 claims description 2
• QQGVISJTZRCCPW-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(thiomorpholine-4-carbonyl)-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1OC=2C(=O)N1CCSCC1 QQGVISJTZRCCPW-OWCLPIDISA-N 0.000 claims description 2
• PVECXBKMZYWDML-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(thiomorpholine-4-carbonyl)-1-benzothiophene-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1S2)=CC=C1C=C2C(=O)N1CCSCC1 PVECXBKMZYWDML-OWCLPIDISA-N 0.000 claims description 2
• RVGNYEDADMYIOB-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(triazol-1-yl)-1-benzothiophene-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1S2)=CC=C1C=C2N1C=CN=N1 RVGNYEDADMYIOB-HZSPNIEDSA-N 0.000 claims description 2
• FAUKDMAQHRXJSG-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(triazol-1-yl)furo[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1OC=2N1C=CN=N1 FAUKDMAQHRXJSG-GRYCIOLGSA-N 0.000 claims description 2
• RYERRTBMFMLLTG-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(triazol-1-yl)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1S2)=CC=1C=C2N1C=CN=N1 RYERRTBMFMLLTG-GRYCIOLGSA-N 0.000 claims description 2
• GYDKHGHAGFUTQW-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(triazol-1-yl)thieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1SC=2N1C=CN=N1 GYDKHGHAGFUTQW-GRYCIOLGSA-N 0.000 claims description 2
• PAJYRXCJMCOKBH-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(trifluoromethyl)-1-benzofuran-5-carboxamide Chemical compound C1=C2OC(C(F)(F)F)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 PAJYRXCJMCOKBH-GRYCIOLGSA-N 0.000 claims description 2
• DPKJBPDUFSCBPW-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(trifluoromethyl)-1-benzofuran-6-carboxamide Chemical compound C1=C2C=C(C(F)(F)F)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 DPKJBPDUFSCBPW-GRYCIOLGSA-N 0.000 claims description 2
• YTNLAMNMYGLKGL-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(trifluoromethyl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC(C(F)(F)F)=C2 YTNLAMNMYGLKGL-KXUCPTDWSA-N 0.000 claims description 2
• SMVGYALXTCYYQI-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[(2,2,2-trifluoroacetyl)amino]-1-benzofuran-6-carboxamide Chemical compound C1=C2C=C(NC(=O)C(F)(F)F)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 SMVGYALXTCYYQI-GRYCIOLGSA-N 0.000 claims description 2
• GLDFHVJOINBYCY-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[(2,2,2-trifluoroacetyl)amino]-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC(NC(=O)C(F)(F)F)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 GLDFHVJOINBYCY-GRYCIOLGSA-N 0.000 claims description 2
• BZSLLKKUYJITAK-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[(2,2,2-trifluoroacetyl)amino]-1-benzothiophene-6-carboxamide Chemical compound C1=C2C=C(NC(=O)C(F)(F)F)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 BZSLLKKUYJITAK-GRYCIOLGSA-N 0.000 claims description 2
• WSORIVJXBVGHGY-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[(2,2,2-trifluoroacetyl)amino]thieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(NC(=O)C(F)(F)F)S2 WSORIVJXBVGHGY-KXUCPTDWSA-N 0.000 claims description 2
• QWVJPWVVRNYLGR-FGTMMUONSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[di(propan-2-yl)amino]-1-benzofuran-5-carboxamide Chemical compound C1=C2OC(N(C(C)C)C(C)C)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 QWVJPWVVRNYLGR-FGTMMUONSA-N 0.000 claims description 2
• CRSUDDJUSZIIMU-FGTMMUONSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[di(propan-2-yl)amino]-1-benzothiophene-6-carboxamide Chemical compound C1=C2C=C(N(C(C)C)C(C)C)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 CRSUDDJUSZIIMU-FGTMMUONSA-N 0.000 claims description 2
• KNYPPEYWIHOLHE-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[di(propan-2-yl)amino]furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC(N(C(C)C)C(C)C)=C2 KNYPPEYWIHOLHE-OWCLPIDISA-N 0.000 claims description 2
• SKZMOJLBTATORS-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[di(propan-2-yl)amino]thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC(N(C(C)C)C(C)C)=C2 SKZMOJLBTATORS-OWCLPIDISA-N 0.000 claims description 2
• CZRSOWMDKFZZHI-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[formyl(methyl)amino]-1-benzofuran-5-carboxamide Chemical compound C1=C2OC(N(C)C=O)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 CZRSOWMDKFZZHI-HZSPNIEDSA-N 0.000 claims description 2
• DNGYMWJFLUVFQE-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[formyl(methyl)amino]-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC(N(C)C=O)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 DNGYMWJFLUVFQE-HZSPNIEDSA-N 0.000 claims description 2
• QKBRFMLIAFLTHR-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[formyl(methyl)amino]-1-benzothiophene-6-carboxamide Chemical compound C1=C2C=C(N(C)C=O)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 QKBRFMLIAFLTHR-HZSPNIEDSA-N 0.000 claims description 2
• JRTCSGLLLALBFT-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[formyl(methyl)amino]thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC(N(C)C=O)=C2 JRTCSGLLLALBFT-GRYCIOLGSA-N 0.000 claims description 2
• SZKOVMMPWJWCOO-FGTMMUONSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-benzamido-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1OC=2NC(=O)C1=CC=CC=C1 SZKOVMMPWJWCOO-FGTMMUONSA-N 0.000 claims description 2
• MAHKGZPIBAQRMG-FGTMMUONSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-benzamido-1-benzofuran-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1O2)=CC=C1C=C2NC(=O)C1=CC=CC=C1 MAHKGZPIBAQRMG-FGTMMUONSA-N 0.000 claims description 2
• OQFUWZHQXCZNOH-FGTMMUONSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-benzamido-1-benzothiophene-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1S2)=CC=C1C=C2NC(=O)C1=CC=CC=C1 OQFUWZHQXCZNOH-FGTMMUONSA-N 0.000 claims description 2
• LWKJCQFUZGGZRI-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-benzamidothieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1S2)=CC=1C=C2NC(=O)C1=CC=CC=C1 LWKJCQFUZGGZRI-OWCLPIDISA-N 0.000 claims description 2
• KAIQASOKMRJIDS-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-bromo-1,3-benzothiazole-5-carboxamide Chemical compound C1=C2SC(Br)=NC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 KAIQASOKMRJIDS-KXUCPTDWSA-N 0.000 claims description 2
• BYQFYHYMZLWPAM-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-chloro-1,3-benzothiazole-5-carboxamide Chemical compound C1=C2SC(Cl)=NC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 BYQFYHYMZLWPAM-KXUCPTDWSA-N 0.000 claims description 2
• WABFXPPLHZJHOQ-WCABBAIRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-chloro-1,3-benzothiazole-6-carboxamide Chemical compound C1=C2N=C(Cl)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 WABFXPPLHZJHOQ-WCABBAIRSA-N 0.000 claims description 2
• WRWKURIQEPSBDF-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-chloro-1-benzofuran-5-carboxamide Chemical compound C1=C2OC(Cl)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 WRWKURIQEPSBDF-GRYCIOLGSA-N 0.000 claims description 2
• KMQIGGWEXZNRAO-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-chloro-1-benzofuran-6-carboxamide Chemical compound C1=C2C=C(Cl)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 KMQIGGWEXZNRAO-GRYCIOLGSA-N 0.000 claims description 2
• XXHGTSJJLNUUJQ-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-chloro-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC(Cl)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 XXHGTSJJLNUUJQ-GRYCIOLGSA-N 0.000 claims description 2
• XTYBARTXYOQZMA-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-chlorofuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC(Cl)=C2 XTYBARTXYOQZMA-KXUCPTDWSA-N 0.000 claims description 2
• VCOIJVAUSTVEEX-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-chlorofuro[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(Cl)O2 VCOIJVAUSTVEEX-KXUCPTDWSA-N 0.000 claims description 2
• NZLTUPFGHXWJJP-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-cyano-1-benzofuran-5-carboxamide Chemical compound C1=C2OC(C#N)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 NZLTUPFGHXWJJP-KWCYVHTRSA-N 0.000 claims description 2
• LMAAZKDAMBOXGO-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-cyano-1-benzofuran-6-carboxamide Chemical compound C1=C2C=C(C#N)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 LMAAZKDAMBOXGO-KWCYVHTRSA-N 0.000 claims description 2
• ORRSPYLNLBEHCR-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-cyano-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC(C#N)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 ORRSPYLNLBEHCR-KWCYVHTRSA-N 0.000 claims description 2
• MELJPPYJKVAXMS-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-cyano-1-benzothiophene-6-carboxamide Chemical compound C1=C2C=C(C#N)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 MELJPPYJKVAXMS-KWCYVHTRSA-N 0.000 claims description 2
• GLWVZUQKDUTGTH-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-cyanofuro[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(C#N)O2 GLWVZUQKDUTGTH-ADEWGFFLSA-N 0.000 claims description 2
• OKGIMONAWJUTBF-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-cyanothieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(C#N)S2 OKGIMONAWJUTBF-ADEWGFFLSA-N 0.000 claims description 2
• QVCSFTHSXDZARN-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-ethenyl-1-benzofuran-5-carboxamide Chemical compound C1=C2OC(C=C)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 QVCSFTHSXDZARN-VHDGCEQUSA-N 0.000 claims description 2
• QVLIDXSCJWKWPC-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-ethenyl-1-benzofuran-6-carboxamide Chemical compound C1=C2C=C(C=C)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 QVLIDXSCJWKWPC-VHDGCEQUSA-N 0.000 claims description 2
• PVVVBWPIEMNTBZ-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-ethenyl-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC(C=C)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 PVVVBWPIEMNTBZ-VHDGCEQUSA-N 0.000 claims description 2
• MUWZDRGOSQIKQR-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-ethenyl-1-benzothiophene-6-carboxamide Chemical compound C1=C2C=C(C=C)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 MUWZDRGOSQIKQR-VHDGCEQUSA-N 0.000 claims description 2
• VJQFKPHXTJXWAC-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-ethenylfuro[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(C=C)O2 VJQFKPHXTJXWAC-KGYLQXTDSA-N 0.000 claims description 2
• LKCOWWBFJDRAEY-GFPRJFBKSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-ethyl-1,3-benzodioxole-5-carboxamide Chemical compound C1=C2OC(CC)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 LKCOWWBFJDRAEY-GFPRJFBKSA-N 0.000 claims description 2
• HZURSKDCPZGGNV-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-ethyl-1,3-benzothiazole-5-carboxamide Chemical compound C1=C2SC(CC)=NC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 HZURSKDCPZGGNV-GRYCIOLGSA-N 0.000 claims description 2
• XLNFKMULGFEGDK-NTZNESFSSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-ethyl-1,3-benzothiazole-6-carboxamide Chemical compound C1=C2N=C(CC)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 XLNFKMULGFEGDK-NTZNESFSSA-N 0.000 claims description 2
• DVQXOYGYZPDWLG-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-ethynyl-1-benzothiophene-6-carboxamide Chemical compound C1=C2C=C(C#C)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 DVQXOYGYZPDWLG-VHDGCEQUSA-N 0.000 claims description 2
• CNIABSYAVGJONM-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-ethynylfuro[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(C#C)O2 CNIABSYAVGJONM-KGYLQXTDSA-N 0.000 claims description 2
• NHFMQONERUAMMR-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-ethynylthieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC(C#C)=C2 NHFMQONERUAMMR-KGYLQXTDSA-N 0.000 claims description 2
• JSIRIPNCMQRUQF-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-ethynylthieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(C#C)S2 JSIRIPNCMQRUQF-KGYLQXTDSA-N 0.000 claims description 2
• UDLKEBGAJTVBES-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-fluoro-1-benzofuran-5-carboxamide Chemical compound C1=C2OC(F)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 UDLKEBGAJTVBES-GRYCIOLGSA-N 0.000 claims description 2
• CKSNOXMGOCPJOI-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-fluoro-1-benzofuran-6-carboxamide Chemical compound C1=C2C=C(F)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 CKSNOXMGOCPJOI-GRYCIOLGSA-N 0.000 claims description 2
• JADCNENITNQZLH-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-fluoro-1-benzothiophene-6-carboxamide Chemical compound C1=C2C=C(F)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 JADCNENITNQZLH-GRYCIOLGSA-N 0.000 claims description 2
• RNRZOBAFFCDSKD-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-fluorofuro[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(F)O2 RNRZOBAFFCDSKD-KXUCPTDWSA-N 0.000 claims description 2
• IYBWYIIJHHHKGR-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-fluorothieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(F)S2 IYBWYIIJHHHKGR-KXUCPTDWSA-N 0.000 claims description 2
• RYAXHNUHLVSVBR-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-formamido-1-benzofuran-6-carboxamide Chemical compound C1=C2C=C(NC=O)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 RYAXHNUHLVSVBR-FRRDWIJNSA-N 0.000 claims description 2
• YIVWJPSVDGSZLR-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-formamido-1-benzothiophene-6-carboxamide Chemical compound C1=C2C=C(NC=O)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 YIVWJPSVDGSZLR-FRRDWIJNSA-N 0.000 claims description 2
• YGYVQUPJUHPNGR-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-formamidothieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC(NC=O)=C2 YGYVQUPJUHPNGR-OUAUKWLOSA-N 0.000 claims description 2
• SHEHJEPLIBECNC-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-formamidothieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(NC=O)S2 SHEHJEPLIBECNC-OUAUKWLOSA-N 0.000 claims description 2
• JAQINASYULNGPB-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-formyl-1-benzofuran-5-carboxamide Chemical compound C1=C2OC(C=O)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 JAQINASYULNGPB-KWCYVHTRSA-N 0.000 claims description 2
• KKZBRPXXBQMAJB-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-formyl-1-benzofuran-6-carboxamide Chemical compound C1=C2C=C(C=O)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 KKZBRPXXBQMAJB-KWCYVHTRSA-N 0.000 claims description 2
• AJRSNIDJWCENAF-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-formyl-1-benzothiophene-6-carboxamide Chemical compound C1=C2C=C(C=O)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 AJRSNIDJWCENAF-KWCYVHTRSA-N 0.000 claims description 2
• SSNFRLZHOCLSAH-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-formylfuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC(C=O)=C2 SSNFRLZHOCLSAH-ADEWGFFLSA-N 0.000 claims description 2
• YMHUOOQIWANJLH-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-formylthieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(C=O)S2 YMHUOOQIWANJLH-ADEWGFFLSA-N 0.000 claims description 2
• XBZXWMFFXPDMDS-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-imidazol-1-yl-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1OC=2N1C=CN=C1 XBZXWMFFXPDMDS-QLFBSQMISA-N 0.000 claims description 2
• GGJSKRBOOLYCIM-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-imidazol-1-yl-1-benzothiophene-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1S2)=CC=C1C=C2N1C=CN=C1 GGJSKRBOOLYCIM-QLFBSQMISA-N 0.000 claims description 2
• LXOHDBVLQPWMMF-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-imidazol-1-ylfuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1O2)=CC=1C=C2N1C=CN=C1 LXOHDBVLQPWMMF-FRRDWIJNSA-N 0.000 claims description 2
• SNWMRRADCUJZLY-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-imidazol-1-ylfuro[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1OC=2N1C=CN=C1 SNWMRRADCUJZLY-FRRDWIJNSA-N 0.000 claims description 2
• ZYNASUFFJPUTIT-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-imidazol-1-ylthieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1S2)=CC=1C=C2N1C=CN=C1 ZYNASUFFJPUTIT-FRRDWIJNSA-N 0.000 claims description 2
• SYHDRXVLMSTKJB-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-iodo-1-benzofuran-5-carboxamide Chemical compound C1=C2OC(I)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 SYHDRXVLMSTKJB-GRYCIOLGSA-N 0.000 claims description 2
• YOZOKZVZRDQKRH-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-iodo-1-benzofuran-6-carboxamide Chemical compound C1=C2C=C(I)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 YOZOKZVZRDQKRH-GRYCIOLGSA-N 0.000 claims description 2
• VUUHMIBGUKGINS-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-iodo-1-benzothiophene-6-carboxamide Chemical compound C1=C2C=C(I)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 VUUHMIBGUKGINS-GRYCIOLGSA-N 0.000 claims description 2
• RJAWOJAUATVOAM-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-iodofuro[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(I)O2 RJAWOJAUATVOAM-KXUCPTDWSA-N 0.000 claims description 2
• HSXMYZNVNMWQPR-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-iodothieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC(I)=C2 HSXMYZNVNMWQPR-KXUCPTDWSA-N 0.000 claims description 2
• ALEGCTRLZMGKQP-JFGNBEQYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-methoxy-1,3-benzothiazole-6-carboxamide Chemical compound C1=C2N=C(OC)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 ALEGCTRLZMGKQP-JFGNBEQYSA-N 0.000 claims description 2
• VXBOHEYLHBOZKF-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-methyl-1-benzofuran-6-carboxamide Chemical compound C1=C2C=C(C)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 VXBOHEYLHBOZKF-HZSPNIEDSA-N 0.000 claims description 2
• DWZAJDORBRWHAT-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-methylsulfanyl-1-benzofuran-5-carboxamide Chemical compound C1=C2OC(SC)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 DWZAJDORBRWHAT-FRRDWIJNSA-N 0.000 claims description 2
• SYHNUKLYPSQJAH-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-methylsulfanyl-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC(SC)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 SYHNUKLYPSQJAH-FRRDWIJNSA-N 0.000 claims description 2
• FQILACKGDSXERY-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-methylsulfanyl-1-benzothiophene-6-carboxamide Chemical compound C1=C2C=C(SC)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 FQILACKGDSXERY-FRRDWIJNSA-N 0.000 claims description 2
• JMAMAEIFZFZZEU-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-methylsulfanylthieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC(SC)=C2 JMAMAEIFZFZZEU-OUAUKWLOSA-N 0.000 claims description 2
• KSEDPDYJJCIWJX-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-methylsulfanylthieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(SC)S2 KSEDPDYJJCIWJX-OUAUKWLOSA-N 0.000 claims description 2
• JDXHXNKPYZSVKL-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-methylsulfonyl-1-benzofuran-5-carboxamide Chemical compound C1=C2OC(S(C)(=O)=O)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 JDXHXNKPYZSVKL-FRRDWIJNSA-N 0.000 claims description 2
• KHCONRDPSNOOOB-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-morpholin-4-yl-1-benzofuran-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1O2)=CC=C1C=C2N1CCOCC1 KHCONRDPSNOOOB-OWCLPIDISA-N 0.000 claims description 2
• OUGUOUNPZXZLRI-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-morpholin-4-ylfuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1O2)=CC=1C=C2N1CCOCC1 OUGUOUNPZXZLRI-HZSPNIEDSA-N 0.000 claims description 2
• IZWFPPACOJNXMJ-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-morpholin-4-ylfuro[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1OC=2N1CCOCC1 IZWFPPACOJNXMJ-HZSPNIEDSA-N 0.000 claims description 2
• OLAKFXSHHWMCBC-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-morpholin-4-ylthieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1S2)=CC=1C=C2N1CCOCC1 OLAKFXSHHWMCBC-HZSPNIEDSA-N 0.000 claims description 2
• MGMCIJYWGUTSMB-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-morpholin-4-ylthieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1SC=2N1CCOCC1 MGMCIJYWGUTSMB-HZSPNIEDSA-N 0.000 claims description 2
• UTSJUTWVONPDOL-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-phenoxy-1,3-benzothiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1N=2)=CC=C1SC=2OC1=CC=CC=C1 UTSJUTWVONPDOL-VNQPRFMTSA-N 0.000 claims description 2
• JOZUNYZCDUZKEF-UKPHBRMFSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-phenoxy-1,3-benzothiazole-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1S2)=CC=C1N=C2OC1=CC=CC=C1 JOZUNYZCDUZKEF-UKPHBRMFSA-N 0.000 claims description 2
• VKEIFXBYNPPXSZ-VNHYZAJKSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-piperazin-1-yl-1,3-benzothiazole-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1S2)=CC=C1N=C2N1CCNCC1 VKEIFXBYNPPXSZ-VNHYZAJKSA-N 0.000 claims description 2
• ZANZPGZDIMVFKX-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-piperazin-1-yl-1-benzofuran-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1O2)=CC=C1C=C2N1CCNCC1 ZANZPGZDIMVFKX-OWCLPIDISA-N 0.000 claims description 2
• RPBQLSNNHSHHFY-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-piperazin-1-ylfuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1O2)=CC=1C=C2N1CCNCC1 RPBQLSNNHSHHFY-HZSPNIEDSA-N 0.000 claims description 2
• GLAILFULPVOZBT-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-piperazin-1-ylfuro[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1OC=2N1CCNCC1 GLAILFULPVOZBT-HZSPNIEDSA-N 0.000 claims description 2
• HDXWTUHJNYYTLY-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-piperazin-1-ylthieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1S2)=CC=1C=C2N1CCNCC1 HDXWTUHJNYYTLY-HZSPNIEDSA-N 0.000 claims description 2
• DVEHNRQNPFHZGV-IXDOHACOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-piperidin-1-yl-1-benzofuran-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1O2)=CC=C1C=C2N1CCCCC1 DVEHNRQNPFHZGV-IXDOHACOSA-N 0.000 claims description 2
• UNFPOIPTXSHWGE-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-piperidin-1-ylfuro[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1OC=2N1CCCCC1 UNFPOIPTXSHWGE-QLFBSQMISA-N 0.000 claims description 2
• BXAFMKKXJOYVHU-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-piperidin-1-ylthieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1SC=2N1CCCCC1 BXAFMKKXJOYVHU-QLFBSQMISA-N 0.000 claims description 2
• CAGBAKSEBLHGJO-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-prop-1-ynyl-1-benzofuran-6-carboxamide Chemical compound C1=C2C=C(C#CC)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 CAGBAKSEBLHGJO-VNQPRFMTSA-N 0.000 claims description 2
• DUIOBNMEBXUBRN-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-prop-1-ynyl-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC(C#CC)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 DUIOBNMEBXUBRN-VNQPRFMTSA-N 0.000 claims description 2
• GRRSQGYRWSAXBI-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-prop-1-ynyl-1-benzothiophene-6-carboxamide Chemical compound C1=C2C=C(C#CC)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 GRRSQGYRWSAXBI-VNQPRFMTSA-N 0.000 claims description 2
• PHTYOXNIPTWMIK-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-pyrrol-1-yl-1-benzofuran-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1O2)=CC=C1C=C2N1C=CC=C1 PHTYOXNIPTWMIK-OWCLPIDISA-N 0.000 claims description 2
• XBUWMDQRFIXPKV-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-pyrrolidin-1-yl-1-benzofuran-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1O2)=CC=C1C=C2N1CCCC1 XBUWMDQRFIXPKV-OWCLPIDISA-N 0.000 claims description 2
• BCKVJPIDZBFBSG-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-pyrrolidin-1-yl-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1SC=2N1CCCC1 BCKVJPIDZBFBSG-OWCLPIDISA-N 0.000 claims description 2
• QTFVUUIRYINGSP-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-pyrrolidin-1-ylfuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1O2)=CC=1C=C2N1CCCC1 QTFVUUIRYINGSP-HZSPNIEDSA-N 0.000 claims description 2
• UIYUJINPMKJQLW-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-pyrrolidin-1-ylfuro[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1OC=2N1CCCC1 UIYUJINPMKJQLW-HZSPNIEDSA-N 0.000 claims description 2
• YMNYIXNHVNJGJX-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-pyrrolidin-1-ylthieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1S2)=CC=1C=C2N1CCCC1 YMNYIXNHVNJGJX-HZSPNIEDSA-N 0.000 claims description 2
• VRZXWWFNNPQFQY-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-sulfanyl-1-benzofuran-5-carboxamide Chemical compound C1=C2OC(S)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 VRZXWWFNNPQFQY-GRYCIOLGSA-N 0.000 claims description 2
• UKCAFHNPXOMNNH-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-sulfanyl-1-benzofuran-6-carboxamide Chemical compound C1=C2C=C(S)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 UKCAFHNPXOMNNH-GRYCIOLGSA-N 0.000 claims description 2
• BOQOCEWPLLOYTM-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-sulfanyl-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC(S)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 BOQOCEWPLLOYTM-GRYCIOLGSA-N 0.000 claims description 2
• PYYNMXSXOGAQJL-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-sulfanyl-1-benzothiophene-6-carboxamide Chemical compound C1=C2C=C(S)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 PYYNMXSXOGAQJL-GRYCIOLGSA-N 0.000 claims description 2
• KRWRPJJXHJNHKW-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-sulfanylfuro[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(S)O2 KRWRPJJXHJNHKW-KXUCPTDWSA-N 0.000 claims description 2
• DMAKOLFUKRGLHH-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-thiomorpholin-4-ylfuro[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1OC=2N1CCSCC1 DMAKOLFUKRGLHH-HZSPNIEDSA-N 0.000 claims description 2
• PUCPZWMUESZFPP-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3,4-dihydro-2h-chromene-6-carboxamide Chemical compound O1CCCC2=CC(C(=O)N[C@H]3[C@]4([H])CC[C@@](N4)(C3)[H])=CC=C21 PUCPZWMUESZFPP-HZSPNIEDSA-N 0.000 claims description 2
• HEAVWMSTAWHMTC-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(1,2,4-triazol-1-yl)-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1OC=C2N1C=NC=N1 HEAVWMSTAWHMTC-KWCYVHTRSA-N 0.000 claims description 2
• MCSRMCQBQJHHMT-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(1,2,4-triazol-1-yl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1OC=2)=CC=1C=2N1C=NC=N1 MCSRMCQBQJHHMT-ADEWGFFLSA-N 0.000 claims description 2
• YOWLWFMWXCAWSU-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(1,2,4-triazol-1-yl)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1SC=2)=CC=1C=2N1C=NC=N1 YOWLWFMWXCAWSU-ADEWGFFLSA-N 0.000 claims description 2
• CVRMCPWEPYOFFB-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(3-hydroxyprop-1-ynyl)-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC=C(C#CCO)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 CVRMCPWEPYOFFB-VNQPRFMTSA-N 0.000 claims description 2
• UPZUWZYMOMHHGS-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(3-hydroxyprop-1-ynyl)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC=C2C#CCO UPZUWZYMOMHHGS-KWCYVHTRSA-N 0.000 claims description 2
• BRNCFPAVRHXHOR-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(3-oxomorpholin-4-yl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1SC=C2N1CCOCC1=O BRNCFPAVRHXHOR-VHDGCEQUSA-N 0.000 claims description 2
• VSVTXTVBSLRJTA-HYVNUMGLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(4-methylpiperazin-1-yl)-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1OC=C2N1CCN(C)CC1 VSVTXTVBSLRJTA-HYVNUMGLSA-N 0.000 claims description 2
• SSUWXBGIEORCQD-HYVNUMGLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(4-methylpiperazin-1-yl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1SC=C2N1CCN(C)CC1 SSUWXBGIEORCQD-HYVNUMGLSA-N 0.000 claims description 2
• MLPAWQBRTHQHCU-FHLIZLRMSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(4-methylpiperazine-1-carbonyl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1SC=C2C(=O)N1CCN(C)CC1 MLPAWQBRTHQHCU-FHLIZLRMSA-N 0.000 claims description 2
• UCJOFJXMWYROIR-UHOFOFEASA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(azetidine-1-carbonyl)-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1OC=C2C(=O)N1CCC1 UCJOFJXMWYROIR-UHOFOFEASA-N 0.000 claims description 2
• MXPFAHBPAUEHKX-UHOFOFEASA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(azetidine-1-carbonyl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1SC=C2C(=O)N1CCC1 MXPFAHBPAUEHKX-UHOFOFEASA-N 0.000 claims description 2
• QKSSVMVWSDVIBO-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(azetidine-1-carbonyl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1OC=2)=CC=1C=2C(=O)N1CCC1 QKSSVMVWSDVIBO-DDTOSNHZSA-N 0.000 claims description 2
• WAXCLEQUXXUBCR-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(azetidine-1-carbonyl)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1SC=2)=CC=1C=2C(=O)N1CCC1 WAXCLEQUXXUBCR-DDTOSNHZSA-N 0.000 claims description 2
• CCIGOJWBDGYXDA-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(aziridine-1-carbonyl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1SC=C2C(=O)N1CC1 CCIGOJWBDGYXDA-BYCMXARLSA-N 0.000 claims description 2
• GBZZBFNMNXVFCF-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(aziridine-1-carbonyl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1OC=2)=CC=1C=2C(=O)N1CC1 GBZZBFNMNXVFCF-JIMOISOXSA-N 0.000 claims description 2
• MRVHMMDOVUEFAE-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(aziridine-1-carbonyl)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1SC=2)=CC=1C=2C(=O)N1CC1 MRVHMMDOVUEFAE-JIMOISOXSA-N 0.000 claims description 2
• ILBYPPFLEGEBGI-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(cyclopropylamino)-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1OC=C2NC1CC1 ILBYPPFLEGEBGI-VHDGCEQUSA-N 0.000 claims description 2
• CATJJZOBESUVSN-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(cyclopropylamino)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1SC=C2NC1CC1 CATJJZOBESUVSN-VHDGCEQUSA-N 0.000 claims description 2
• FDBSOOXPBCZHRT-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(cyclopropylamino)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1OC=2)=CC=1C=2NC1CC1 FDBSOOXPBCZHRT-KGYLQXTDSA-N 0.000 claims description 2
• CDLWPVROOJRERE-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(diethylamino)-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC=C(N(CC)CC)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 CDLWPVROOJRERE-VNQPRFMTSA-N 0.000 claims description 2
• IRCWIHNYGJGJCQ-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(dimethylamino)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC=C2N(C)C IRCWIHNYGJGJCQ-ADEWGFFLSA-N 0.000 claims description 2
• TWRLYOZUSYOQNA-DVVUODLYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(methylamino)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC=C2NC TWRLYOZUSYOQNA-DVVUODLYSA-N 0.000 claims description 2
• VAXRNKOJGXJPBF-XOKHGSTOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(morpholine-4-carbonyl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1SC=C2C(=O)N1CCOCC1 VAXRNKOJGXJPBF-XOKHGSTOSA-N 0.000 claims description 2
• VYPIIIUBYCXIBA-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(morpholine-4-carbonyl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1OC=2)=CC=1C=2C(=O)N1CCOCC1 VYPIIIUBYCXIBA-BYCMXARLSA-N 0.000 claims description 2
• LKKPVOCMWOPFQJ-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(piperazine-1-carbonyl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1OC=2)=CC=1C=2C(=O)N1CCNCC1 LKKPVOCMWOPFQJ-BYCMXARLSA-N 0.000 claims description 2
• FERDPFUUAZKZEJ-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(piperazine-1-carbonyl)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1SC=2)=CC=1C=2C(=O)N1CCNCC1 FERDPFUUAZKZEJ-BYCMXARLSA-N 0.000 claims description 2
• OQUDVWFRMNICJM-FHLIZLRMSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(piperidine-1-carbonyl)-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1OC=C2C(=O)N1CCCCC1 OQUDVWFRMNICJM-FHLIZLRMSA-N 0.000 claims description 2
• FNILWQPSGVKVNY-FHLIZLRMSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(piperidine-1-carbonyl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1SC=C2C(=O)N1CCCCC1 FNILWQPSGVKVNY-FHLIZLRMSA-N 0.000 claims description 2
• XERLILBUSNVCLL-UHOFOFEASA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(piperidine-1-carbonyl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1OC=2)=CC=1C=2C(=O)N1CCCCC1 XERLILBUSNVCLL-UHOFOFEASA-N 0.000 claims description 2
• RLILQJZUGOWPIB-XOKHGSTOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(pyrrolidine-1-carbonyl)-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1OC=C2C(=O)N1CCCC1 RLILQJZUGOWPIB-XOKHGSTOSA-N 0.000 claims description 2
• VKSCJBVQTWDGSN-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(pyrrolidine-1-carbonyl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1OC=2)=CC=1C=2C(=O)N1CCCC1 VKSCJBVQTWDGSN-BYCMXARLSA-N 0.000 claims description 2
• HVFUPPRFOXTESQ-XOKHGSTOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(thiomorpholine-4-carbonyl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1SC=C2C(=O)N1CCSCC1 HVFUPPRFOXTESQ-XOKHGSTOSA-N 0.000 claims description 2
• YVSKHYRTWAWKIF-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(triazol-1-yl)-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1OC=C2N1C=CN=N1 YVSKHYRTWAWKIF-KWCYVHTRSA-N 0.000 claims description 2
• NAFMAWXUSBUHSN-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(triazol-1-yl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1OC=2)=CC=1C=2N1C=CN=N1 NAFMAWXUSBUHSN-ADEWGFFLSA-N 0.000 claims description 2
• MGYUOQQNLGNVCG-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(triazol-1-yl)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1SC=2)=CC=1C=2N1C=CN=N1 MGYUOQQNLGNVCG-ADEWGFFLSA-N 0.000 claims description 2
• MBEWNOGQRWYVQA-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(trifluoromethyl)-1-benzofuran-5-carboxamide Chemical compound C1=C2OC=C(C(F)(F)F)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 MBEWNOGQRWYVQA-JIMOISOXSA-N 0.000 claims description 2
• ZSEOLXCRCFGBMI-PPKCKEKNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(trifluoromethyl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC=C2C(F)(F)F ZSEOLXCRCFGBMI-PPKCKEKNSA-N 0.000 claims description 2
• ODLIXRYJMVWAOX-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-[(2,2,2-trifluoroacetyl)amino]-1-benzofuran-5-carboxamide Chemical compound C1=C2OC=C(NC(=O)C(F)(F)F)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 ODLIXRYJMVWAOX-ADEWGFFLSA-N 0.000 claims description 2
• WVSXAFWZEAZIKS-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-[(2,2,2-trifluoroacetyl)amino]-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC=C(NC(=O)C(F)(F)F)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 WVSXAFWZEAZIKS-ADEWGFFLSA-N 0.000 claims description 2
• ZYFGRROARSQDDZ-BPQIPLTHSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-[di(propan-2-yl)amino]-1-benzofuran-5-carboxamide Chemical compound C1=C2OC=C(N(C(C)C)C(C)C)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 ZYFGRROARSQDDZ-BPQIPLTHSA-N 0.000 claims description 2
• OXPVDPLIARDMCJ-BPQIPLTHSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-[di(propan-2-yl)amino]-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC=C(N(C(C)C)C(C)C)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 OXPVDPLIARDMCJ-BPQIPLTHSA-N 0.000 claims description 2
• WFWMPRZCEOJFHP-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-[formyl(methyl)amino]-1-benzofuran-5-carboxamide Chemical compound C1=C2OC=C(N(C)C=O)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 WFWMPRZCEOJFHP-KWCYVHTRSA-N 0.000 claims description 2
• RDTYDSLLXVDIQZ-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-[formyl(methyl)amino]-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC=C(N(C)C=O)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 RDTYDSLLXVDIQZ-KWCYVHTRSA-N 0.000 claims description 2
• TUTPEGULIIMSNO-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-[formyl(methyl)amino]thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC=C2N(C)C=O TUTPEGULIIMSNO-ADEWGFFLSA-N 0.000 claims description 2
• GADXEGNCUMVVEQ-BPQIPLTHSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-benzamido-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1OC=C2NC(=O)C1=CC=CC=C1 GADXEGNCUMVVEQ-BPQIPLTHSA-N 0.000 claims description 2
• CIGANSBWWMFRQZ-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-benzamidothieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1SC=2)=CC=1C=2NC(=O)C1=CC=CC=C1 CIGANSBWWMFRQZ-VNQPRFMTSA-N 0.000 claims description 2
• BLLHFHIATYMMTI-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-chloro-1-benzofuran-5-carboxamide Chemical compound C1=C2OC=C(Cl)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 BLLHFHIATYMMTI-JIMOISOXSA-N 0.000 claims description 2
• XJZKOZKNPQPHAL-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-chloro-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC=C(Cl)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 XJZKOZKNPQPHAL-JIMOISOXSA-N 0.000 claims description 2
• WBADVJVMYQJFFI-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-cyano-1-benzofuran-5-carboxamide Chemical compound C1=C2OC=C(C#N)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 WBADVJVMYQJFFI-KWCYVHTRSA-N 0.000 claims description 2
• OMJCKXIDRBIISD-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-cyanofuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC=C2C#N OMJCKXIDRBIISD-ADEWGFFLSA-N 0.000 claims description 2
• OAOOFVWLQQLDRC-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-ethenyl-1-benzofuran-5-carboxamide Chemical compound C1=C2OC=C(C=C)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 OAOOFVWLQQLDRC-VHDGCEQUSA-N 0.000 claims description 2
• PCPPRAHSEDSEHN-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-ethenylfuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC=C2C=C PCPPRAHSEDSEHN-KGYLQXTDSA-N 0.000 claims description 2
• WYHFCPPLHUPPSP-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-ethyl-1,2-benzothiazole-6-carboxamide Chemical compound C1=C2C(CC)=NSC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 WYHFCPPLHUPPSP-DDTOSNHZSA-N 0.000 claims description 2
• SFBSIUJETIOVMC-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-ethynylfuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC=C2C#C SFBSIUJETIOVMC-KGYLQXTDSA-N 0.000 claims description 2
• QHSYIWMRWJHSQI-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-ethynylthieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC=C2C#C QHSYIWMRWJHSQI-KGYLQXTDSA-N 0.000 claims description 2
• WXHPQBORSLBQLN-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-fluoro-1-benzofuran-5-carboxamide Chemical compound C1=C2OC=C(F)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 WXHPQBORSLBQLN-JIMOISOXSA-N 0.000 claims description 2
• OOZMNNHTBXEQCY-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-fluoro-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC=C(F)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 OOZMNNHTBXEQCY-JIMOISOXSA-N 0.000 claims description 2
• LWAQBDNLBGEUJM-PPKCKEKNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-fluorofuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC=C2F LWAQBDNLBGEUJM-PPKCKEKNSA-N 0.000 claims description 2
• YOCABGWXCCAVEE-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-formamido-1-benzofuran-5-carboxamide Chemical compound C1=C2OC=C(NC=O)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 YOCABGWXCCAVEE-KGYLQXTDSA-N 0.000 claims description 2
• SZCZMRQCAHJQFI-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-formamido-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC=C(NC=O)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 SZCZMRQCAHJQFI-KGYLQXTDSA-N 0.000 claims description 2
• CNFNRNHPGUNGPH-DVVUODLYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-formamidothieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC=C2NC=O CNFNRNHPGUNGPH-DVVUODLYSA-N 0.000 claims description 2
• DHPGXEJGCCRLMN-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-formyl-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC=C(C=O)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 DHPGXEJGCCRLMN-KWCYVHTRSA-N 0.000 claims description 2
• JVKAASQYFSOKTF-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-formylfuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC=C2C=O JVKAASQYFSOKTF-ADEWGFFLSA-N 0.000 claims description 2
• LUKBHDOBXPLMMG-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-formylthieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC=C2C=O LUKBHDOBXPLMMG-ADEWGFFLSA-N 0.000 claims description 2
• CEFVCKWTMBIPDL-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-imidazol-1-ylfuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1OC=2)=CC=1C=2N1C=CN=C1 CEFVCKWTMBIPDL-KGYLQXTDSA-N 0.000 claims description 2
• OTGWXVFCSVEGNS-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-imidazol-1-ylthieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1SC=2)=CC=1C=2N1C=CN=C1 OTGWXVFCSVEGNS-KGYLQXTDSA-N 0.000 claims description 2
• LQIOSEBFMAHUIG-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-iodo-1-benzofuran-5-carboxamide Chemical compound C1=C2OC=C(I)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 LQIOSEBFMAHUIG-JIMOISOXSA-N 0.000 claims description 2
• NLFLACNZLNMLTA-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-iodo-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC=C(I)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 NLFLACNZLNMLTA-JIMOISOXSA-N 0.000 claims description 2
• ZCERHBHEFUVJFB-PPKCKEKNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-iodofuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC=C2I ZCERHBHEFUVJFB-PPKCKEKNSA-N 0.000 claims description 2
• MCXWNDYRALCLCP-PPKCKEKNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-iodothieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC=C2I MCXWNDYRALCLCP-PPKCKEKNSA-N 0.000 claims description 2
• YDVCSBWAAOQBQC-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-methyl-1,2-benzothiazole-6-carboxamide Chemical compound C1=C2C(C)=NSC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 YDVCSBWAAOQBQC-KGYLQXTDSA-N 0.000 claims description 2
• ZSPOIQAEZAUXNT-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-methyl-2h-indazole-5-carboxamide Chemical compound C1=C2NN=C(C)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 ZSPOIQAEZAUXNT-DDTOSNHZSA-N 0.000 claims description 2
• LRFFZDKYIUNYAN-SCDSUCTJSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-methyl-2h-indazole-6-carboxamide Chemical compound C1=C2C(C)=NNC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 LRFFZDKYIUNYAN-SCDSUCTJSA-N 0.000 claims description 2
• JOPAAAJNEYYFQW-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-methylsulfanyl-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC=C(SC)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 JOPAAAJNEYYFQW-KGYLQXTDSA-N 0.000 claims description 2
• LDWPOLJTHCGFGS-DVVUODLYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-methylsulfonylthieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC=C2S(C)(=O)=O LDWPOLJTHCGFGS-DVVUODLYSA-N 0.000 claims description 2
• IALMZLLORWQFRJ-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-morpholin-4-ylfuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1OC=2)=CC=1C=2N1CCOCC1 IALMZLLORWQFRJ-KWCYVHTRSA-N 0.000 claims description 2
• QNJHHKWVKSSERN-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-piperazin-1-yl-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1OC=C2N1CCNCC1 QNJHHKWVKSSERN-VNQPRFMTSA-N 0.000 claims description 2
• PVWWGFMRLLHSSD-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-piperazin-1-ylfuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1OC=2)=CC=1C=2N1CCNCC1 PVWWGFMRLLHSSD-KWCYVHTRSA-N 0.000 claims description 2
• MXPQJHCMXZIZRJ-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-piperazin-1-ylthieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1SC=2)=CC=1C=2N1CCNCC1 MXPQJHCMXZIZRJ-KWCYVHTRSA-N 0.000 claims description 2
• VGOSBOUDLYKUOA-HYVNUMGLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-piperidin-1-yl-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1OC=C2N1CCCCC1 VGOSBOUDLYKUOA-HYVNUMGLSA-N 0.000 claims description 2
• CYBLWVSAJJVNEF-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-piperidin-1-ylfuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1OC=2)=CC=1C=2N1CCCCC1 CYBLWVSAJJVNEF-VHDGCEQUSA-N 0.000 claims description 2
• SPTIVTNFRNVKNZ-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-prop-1-ynyl-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC=C(C#CC)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 SPTIVTNFRNVKNZ-VNQPRFMTSA-N 0.000 claims description 2
• GTIXJDWSEAVJBH-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-pyrrolidin-1-yl-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1OC=C2N1CCCC1 GTIXJDWSEAVJBH-VNQPRFMTSA-N 0.000 claims description 2
• GUMNLLQPNLLSPS-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-sulfanyl-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC=C(S)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 GUMNLLQPNLLSPS-ADEWGFFLSA-N 0.000 claims description 2
• SSVAMVLPVXMDST-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-thiomorpholin-4-ylfuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1OC=2)=CC=1C=2N1CCSCC1 SSVAMVLPVXMDST-KWCYVHTRSA-N 0.000 claims description 2
• PQYXERWZYDEDDT-KHQFGBGNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3h-imidazo[4,5-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1N=CN2 PQYXERWZYDEDDT-KHQFGBGNSA-N 0.000 claims description 2
• RYLNYLHGRALFIJ-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-chloro-1-benzofuran-6-carboxamide Chemical compound ClC1=C2C=COC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 RYLNYLHGRALFIJ-JIMOISOXSA-N 0.000 claims description 2
• OKFPZSYJXMRWIE-FKTZTGRPSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-chlorothieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1Cl)=CC2=C1C=CS2 OKFPZSYJXMRWIE-FKTZTGRPSA-N 0.000 claims description 2
• HZLYDRYAJGDCIN-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-methoxy-1-benzofuran-6-carboxamide Chemical compound COC1=C2C=COC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 HZLYDRYAJGDCIN-KGYLQXTDSA-N 0.000 claims description 2
• CHUHTXNTGQQRPT-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-methoxy-1-benzothiophene-6-carboxamide Chemical compound COC1=C2C=CSC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 CHUHTXNTGQQRPT-KGYLQXTDSA-N 0.000 claims description 2
• AEUSSHDUFCKCGH-DVVUODLYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-methoxythieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1OC)=CC2=C1C=CS2 AEUSSHDUFCKCGH-DVVUODLYSA-N 0.000 claims description 2
• FSKAUUDLCMZQJG-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-methylsulfanyl-1-benzofuran-6-carboxamide Chemical compound CSC1=C2C=COC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 FSKAUUDLCMZQJG-KGYLQXTDSA-N 0.000 claims description 2
• PQQORMVCWZMHTE-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-methylsulfanyl-1-benzothiophene-6-carboxamide Chemical compound CSC1=C2C=CSC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 PQQORMVCWZMHTE-KGYLQXTDSA-N 0.000 claims description 2
• HEHVPYRHNWJWLF-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-4-methylthieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1C)=CC2=C1C=CS2 HEHVPYRHNWJWLF-ADEWGFFLSA-N 0.000 claims description 2
• LTOXGYLEIDBVAX-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-6-bromoisoquinoline-3-carboxamide Chemical compound BrC1=CC=C2C=NC(C(=O)N[C@H]3[C@]4([H])CC[C@@](N4)(C3)[H])=CC2=C1 LTOXGYLEIDBVAX-HZSPNIEDSA-N 0.000 claims description 2
• HGKVHUCIRKTUEL-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-6-chloroisoquinoline-3-carboxamide Chemical compound ClC1=CC=C2C=NC(C(=O)N[C@H]3[C@]4([H])CC[C@@](N4)(C3)[H])=CC2=C1 HGKVHUCIRKTUEL-HZSPNIEDSA-N 0.000 claims description 2
• FUUWFVBAGTZXHA-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-6-ethenylisoquinoline-3-carboxamide Chemical compound C=CC1=CC=C2C=NC(C(=O)N[C@H]3[C@]4([H])CC[C@@](N4)(C3)[H])=CC2=C1 FUUWFVBAGTZXHA-OWCLPIDISA-N 0.000 claims description 2
• IXUQGMPEYQTQKS-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-6-iodoisoquinoline-3-carboxamide Chemical compound IC1=CC=C2C=NC(C(=O)N[C@H]3[C@]4([H])CC[C@@](N4)(C3)[H])=CC2=C1 IXUQGMPEYQTQKS-HZSPNIEDSA-N 0.000 claims description 2
• BQDPLESKYCZNSA-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-6-methoxyisoquinoline-3-carboxamide Chemical compound COC1=CC=C2C=NC(C(=O)N[C@H]3[C@]4([H])CC[C@@](N4)(C3)[H])=CC2=C1 BQDPLESKYCZNSA-VHDGCEQUSA-N 0.000 claims description 2
• YZKCLMQTCNBLNA-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-6-nitroisoquinoline-3-carboxamide Chemical compound [O-][N+](=O)C1=CC=C2C=NC(C(=O)N[C@H]3[C@]4([H])CC[C@@](N4)(C3)[H])=CC2=C1 YZKCLMQTCNBLNA-KWCYVHTRSA-N 0.000 claims description 2
• WXJHCPFGXQVWLI-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-7-chloro-1-benzothiophene-5-carboxamide Chemical compound ClC1=C2SC=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 WXJHCPFGXQVWLI-KGYLQXTDSA-N 0.000 claims description 2
• KOVNSEZLEFGOCH-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-7-chlorothieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1Cl)=CC2=C1SC=C2 KOVNSEZLEFGOCH-KXUCPTDWSA-N 0.000 claims description 2
• FKQZMPCAWFQAGN-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-7-methoxy-1-benzofuran-5-carboxamide Chemical compound COC1=C2OC=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 FKQZMPCAWFQAGN-FRRDWIJNSA-N 0.000 claims description 2
• PTSIVGGISUREDP-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-7-methoxy-1-benzothiophene-5-carboxamide Chemical compound COC1=C2SC=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 PTSIVGGISUREDP-FRRDWIJNSA-N 0.000 claims description 2
• TYYFLRHDKDMEGR-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-7-methoxythieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1OC)=CC2=C1SC=C2 TYYFLRHDKDMEGR-OUAUKWLOSA-N 0.000 claims description 2
• HCLZFGUHAWFLCF-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-7-methyl-1-benzofuran-5-carboxamide Chemical compound CC1=C2OC=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 HCLZFGUHAWFLCF-HZSPNIEDSA-N 0.000 claims description 2
• PJSFSWNBIUXZPN-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-7-methyl-1-benzothiophene-5-carboxamide Chemical compound CC1=C2SC=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 PJSFSWNBIUXZPN-HZSPNIEDSA-N 0.000 claims description 2
• ZQFIRFTUAXJPTJ-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-7-methylsulfanyl-1-benzofuran-5-carboxamide Chemical compound CSC1=C2OC=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 ZQFIRFTUAXJPTJ-FRRDWIJNSA-N 0.000 claims description 2
• KBVYZSVQKNUWMX-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-7-methylsulfanyl-1-benzothiophene-5-carboxamide Chemical compound CSC1=C2SC=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 KBVYZSVQKNUWMX-FRRDWIJNSA-N 0.000 claims description 2
• DMJQIPVGBDMGGD-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-7-methylthieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1C)=CC2=C1SC=C2 DMJQIPVGBDMGGD-GRYCIOLGSA-N 0.000 claims description 2
• YMACVCSVKGATAE-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-[1]benzofuro[2,3-c]pyridine-3-carboxamide Chemical compound O1C2=CC=CC=C2C2=C1C=NC(C(=O)N[C@H]1[C@]3([H])CC[C@@](N3)(C1)[H])=C2 YMACVCSVKGATAE-DDTOSNHZSA-N 0.000 claims description 2
• DPJZZHLEHCWYKV-DDTOSNHZSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-[1]benzothiolo[2,3-c]pyridine-3-carboxamide Chemical compound S1C2=CC=CC=C2C2=C1C=NC(C(=O)N[C@H]1[C@]3([H])CC[C@@](N3)(C1)[H])=C2 DPJZZHLEHCWYKV-DDTOSNHZSA-N 0.000 claims description 2
• JBNHXCXBKUGXSE-UHOFOFEASA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]dibenzofuran-2-carboxamide Chemical compound C1=CC=C2C3=CC(C(=O)N[C@H]4[C@]5([H])CC[C@@](N5)(C4)[H])=CC=C3OC2=C1 JBNHXCXBKUGXSE-UHOFOFEASA-N 0.000 claims description 2
• UROOPEBYODQRCX-UHOFOFEASA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]dibenzothiophene-2-carboxamide Chemical compound C1=CC=C2C3=CC(C(=O)N[C@H]4[C@]5([H])CC[C@@](N5)(C4)[H])=CC=C3SC2=C1 UROOPEBYODQRCX-UHOFOFEASA-N 0.000 claims description 2
• RRESJGKZMPGLKG-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thieno[3,4-c]pyridine-6-carboxamide Chemical compound C=1C2=CSC=C2C=NC=1C(=O)N[C@H](C1)[C@]2([H])CC[C@@]1([H])N2 RRESJGKZMPGLKG-GRYCIOLGSA-N 0.000 claims description 2
• MBLUSAWUWIKWEX-NSHDSACASA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-[1,3]dioxolo[4,5-c]pyridine-6-carboxamide Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)C(N=C1)=CC2=C1OCO2 MBLUSAWUWIKWEX-NSHDSACASA-N 0.000 claims description 2
• XCIXZKZDZTUSKD-LBPRGKRZSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-[1,3]thiazolo[4,5-c]pyridine-6-carboxamide Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)C(N=C1)=CC2=C1N=CS2 XCIXZKZDZTUSKD-LBPRGKRZSA-N 0.000 claims description 2
• ZJSTUWBKJZCXGE-LBPRGKRZSA-N n-[(3r)-1-azabicyclo[2.2.2]octan-3-yl]-[1,3]thiazolo[5,4-c]pyridine-6-carboxamide Chemical compound N([C@@H]1C2CCN(CC2)C1)C(=O)C(N=C1)=CC2=C1SC=N2 ZJSTUWBKJZCXGE-LBPRGKRZSA-N 0.000 claims description 2
• 235000005152 nicotinamide Nutrition 0.000 claims description 2
• 239000011570 nicotinamide Substances 0.000 claims description 2
• DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 2
• HDBNVDQMRWKEDE-QLFBSQMISA-N propan-2-yl 5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]-1-benzofuran-2-carboxylate Chemical compound C1=C2OC(C(=O)OC(C)C)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 HDBNVDQMRWKEDE-QLFBSQMISA-N 0.000 claims description 2
• STWNGMSGPBZFMX-UHFFFAOYSA-N pyridine-3-carboxamide Chemical compound NC(=O)C1=CC=CN=C1.NC(=O)C1=CC=CN=C1 STWNGMSGPBZFMX-UHFFFAOYSA-N 0.000 claims description 2
• GSIWUKSQASDQRX-UHFFFAOYSA-N thieno[3,2-c]pyridine-2,6-dicarboxamide Chemical compound NC(=O)c1cc2cnc(cc2s1)C(N)=O GSIWUKSQASDQRX-UHFFFAOYSA-N 0.000 claims description 2
• YUYHUUKVQXJYHW-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 YUYHUUKVQXJYHW-FRRDWIJNSA-N 0.000 claims 2
• JBZOXDSNRFHSKK-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-methyl-1-benzofuran-5-carboxamide Chemical compound C1=C2OC(C)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 JBZOXDSNRFHSKK-HZSPNIEDSA-N 0.000 claims 2
• VXKZWONIPFUBTC-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-bromo-1-benzofuran-5-carboxamide Chemical compound C1=C2OC=C(Br)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 VXKZWONIPFUBTC-JIMOISOXSA-N 0.000 claims 2
• SPCKBNQVHUDAFY-PPKCKEKNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-bromofuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC=C2Br SPCKBNQVHUDAFY-PPKCKEKNSA-N 0.000 claims 2
• HESCDCQCRMYSQH-PPKCKEKNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-bromothieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC=C2Br HESCDCQCRMYSQH-PPKCKEKNSA-N 0.000 claims 2
• MJEICMZGYNFOGL-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-methylfuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC=C2C MJEICMZGYNFOGL-ADEWGFFLSA-N 0.000 claims 2
• VHELPCXGSUQVHP-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]furo[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=CO2 VHELPCXGSUQVHP-OUAUKWLOSA-N 0.000 claims 2
• IIKNJLHPBKHGAL-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=CS2 IIKNJLHPBKHGAL-OUAUKWLOSA-N 0.000 claims 2
• QZDJEEVXFBKLNK-MCIONIFRSA-N n-[(1r,3r,4s)-7-methyl-7-azabicyclo[2.2.1]heptan-3-yl]-1-benzofuran-5-carboxamide Chemical compound C1=C2OC=CC2=CC(C(=O)N[C@H]2[C@@]3(CC[C@](C2)(N3C)[H])[H])=C1 QZDJEEVXFBKLNK-MCIONIFRSA-N 0.000 claims 2
• CXTWXTBVPNTLFP-VQXHTEKXSA-N n-[(3r)-7-azabicyclo[2.2.1]heptan-3-yl]furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1C2CCC(N2)C1)C(=O)C(N=C1)=CC2=C1OC=C2 CXTWXTBVPNTLFP-VQXHTEKXSA-N 0.000 claims 2
• ZQPKQDZUJPSMJJ-DDTOSNHZSA-N 2,2,2-trifluoroethyl 5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]-1-benzofuran-3-carboxylate Chemical compound C1=C2OC=C(C(=O)OCC(F)(F)F)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 ZQPKQDZUJPSMJJ-DDTOSNHZSA-N 0.000 claims 1
• OQORKOHDIFOHAZ-FRRDWIJNSA-N 2,2,2-trifluoroethyl 5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]-1-benzothiophene-2-carboxylate Chemical compound C1=C2SC(C(=O)OCC(F)(F)F)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 OQORKOHDIFOHAZ-FRRDWIJNSA-N 0.000 claims 1
• KRTPBBKWJSKEPG-OUAUKWLOSA-N 2,2,2-trifluoroethyl 5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]furo[2,3-c]pyridine-2-carboxylate Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC(C(=O)OCC(F)(F)F)=C2 KRTPBBKWJSKEPG-OUAUKWLOSA-N 0.000 claims 1
• DNGSJKCOTUPQSL-JFUSQASVSA-N 2,2,2-trifluoroethyl 5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]furo[2,3-c]pyridine-3-carboxylate Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC=C2C(=O)OCC(F)(F)F DNGSJKCOTUPQSL-JFUSQASVSA-N 0.000 claims 1
• UZOWDSHGXGXIFX-OUAUKWLOSA-N 2,2,2-trifluoroethyl 5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]thieno[2,3-c]pyridine-2-carboxylate Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC(C(=O)OCC(F)(F)F)=C2 UZOWDSHGXGXIFX-OUAUKWLOSA-N 0.000 claims 1
• IWLAARNEFJFAKU-JFUSQASVSA-N 2,2,2-trifluoroethyl 5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]thieno[2,3-c]pyridine-3-carboxylate Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC=C2C(=O)OCC(F)(F)F IWLAARNEFJFAKU-JFUSQASVSA-N 0.000 claims 1
• STCSLQABSTXHDZ-FRRDWIJNSA-N 2,2,2-trifluoroethyl 6-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]-1-benzofuran-2-carboxylate Chemical compound C1=C2C=C(C(=O)OCC(F)(F)F)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 STCSLQABSTXHDZ-FRRDWIJNSA-N 0.000 claims 1
• QKGCGIRNIHBNSH-FRRDWIJNSA-N 2,2,2-trifluoroethyl 6-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]-1-benzothiophene-2-carboxylate Chemical compound C1=C2C=C(C(=O)OCC(F)(F)F)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 QKGCGIRNIHBNSH-FRRDWIJNSA-N 0.000 claims 1
• ZBNMKCSDOKTUPR-OUAUKWLOSA-N 2,2,2-trifluoroethyl 6-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]furo[3,2-c]pyridine-2-carboxylate Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(C(=O)OCC(F)(F)F)O2 ZBNMKCSDOKTUPR-OUAUKWLOSA-N 0.000 claims 1
• SDWNRHXIUDEIOP-OUAUKWLOSA-N 2,2,2-trifluoroethyl 6-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]thieno[3,2-c]pyridine-2-carboxylate Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(C(=O)OCC(F)(F)F)S2 SDWNRHXIUDEIOP-OUAUKWLOSA-N 0.000 claims 1
• FESDSEIBLNWJBC-VHDGCEQUSA-N 2-(3-amino-3-oxoprop-1-ynyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-benzofuran-6-carboxamide Chemical compound C1=C2C=C(C#CC(N)=O)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 FESDSEIBLNWJBC-VHDGCEQUSA-N 0.000 claims 1
• FPGFTDLNLRLWRS-VHDGCEQUSA-N 2-(3-amino-3-oxoprop-1-ynyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-benzothiophene-6-carboxamide Chemical compound C1=C2C=C(C#CC(N)=O)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 FPGFTDLNLRLWRS-VHDGCEQUSA-N 0.000 claims 1
• VXAQFOFXCMGVLI-KGYLQXTDSA-N 2-(3-amino-3-oxoprop-1-ynyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC(C#CC(N)=O)=C2 VXAQFOFXCMGVLI-KGYLQXTDSA-N 0.000 claims 1
• OVEYCKLNUBODTH-KGYLQXTDSA-N 2-(3-amino-3-oxoprop-1-ynyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]furo[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(C#CC(N)=O)O2 OVEYCKLNUBODTH-KGYLQXTDSA-N 0.000 claims 1
• RDRTUERLZVWWFT-FRRDWIJNSA-N 2-[acetyl(methyl)amino]-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC(N(C)C(C)=O)=C2 RDRTUERLZVWWFT-FRRDWIJNSA-N 0.000 claims 1
• DWGQEVHLLMBISF-FRRDWIJNSA-N 2-[acetyl(methyl)amino]-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]furo[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(N(C)C(C)=O)O2 DWGQEVHLLMBISF-FRRDWIJNSA-N 0.000 claims 1
• HHDSKIPUMXGKRQ-FRRDWIJNSA-N 2-[acetyl(methyl)amino]-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(N(C)C(C)=O)S2 HHDSKIPUMXGKRQ-FRRDWIJNSA-N 0.000 claims 1
• SWZQIZCPMYWAKU-HZSPNIEDSA-N 2-acetamido-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-benzothiophene-6-carboxamide Chemical compound C1=C2C=C(NC(C)=O)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 SWZQIZCPMYWAKU-HZSPNIEDSA-N 0.000 claims 1
• SHUCDPXQMHLFME-GRYCIOLGSA-N 2-acetamido-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC(NC(C)=O)=C2 SHUCDPXQMHLFME-GRYCIOLGSA-N 0.000 claims 1
• JVROOWKUWLNLCQ-GRYCIOLGSA-N 2-acetamido-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]furo[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(NC(C)=O)O2 JVROOWKUWLNLCQ-GRYCIOLGSA-N 0.000 claims 1
• OIIBETCKJILGAV-GRYCIOLGSA-N 2-acetyl-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC(C(C)=O)=C2 OIIBETCKJILGAV-GRYCIOLGSA-N 0.000 claims 1
• BSPBKVIIHKNIHV-GRYCIOLGSA-N 2-acetyl-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]furo[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(C(C)=O)O2 BSPBKVIIHKNIHV-GRYCIOLGSA-N 0.000 claims 1
• FMPAJAPTRXSADV-GRYCIOLGSA-N 2-acetyl-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC(C(C)=O)=C2 FMPAJAPTRXSADV-GRYCIOLGSA-N 0.000 claims 1
• JNIYINXUVRBWIJ-WCABBAIRSA-N 2-amino-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-benzothiazole-6-carboxamide Chemical compound C1=C2N=C(N)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 JNIYINXUVRBWIJ-WCABBAIRSA-N 0.000 claims 1
• VIOILRUNEFXCLX-HLLBOEOZSA-N 2-anilino-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-benzothiazole-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1S2)=CC=C1N=C2NC1=CC=CC=C1 VIOILRUNEFXCLX-HLLBOEOZSA-N 0.000 claims 1
• DWKZWLXSZDQIJG-VHDGCEQUSA-N 3-(3-amino-3-oxoprop-1-ynyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-benzofuran-5-carboxamide Chemical compound C1=C2OC=C(C#CC(N)=O)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 DWKZWLXSZDQIJG-VHDGCEQUSA-N 0.000 claims 1
• ZFEZOIPPWRKZNG-KGYLQXTDSA-N 3-(3-amino-3-oxoprop-1-ynyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC=C2C#CC(N)=O ZFEZOIPPWRKZNG-KGYLQXTDSA-N 0.000 claims 1
• MLZMKWOGKALZOC-KGYLQXTDSA-N 3-(3-amino-3-oxoprop-1-ynyl)-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC=C2C#CC(N)=O MLZMKWOGKALZOC-KGYLQXTDSA-N 0.000 claims 1
• WTVIMKGPGDMUBX-VHDGCEQUSA-N 3-[5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]-1-benzofuran-3-yl]prop-2-ynoic acid Chemical compound C1=C2OC=C(C#CC(O)=O)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 WTVIMKGPGDMUBX-VHDGCEQUSA-N 0.000 claims 1
• DDAMWRHMNLHTAH-VHDGCEQUSA-N 3-[5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]-1-benzothiophen-2-yl]prop-2-ynoic acid Chemical compound C1=C2SC(C#CC(O)=O)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 DDAMWRHMNLHTAH-VHDGCEQUSA-N 0.000 claims 1
• FDZCRKBBEIPFHU-VHDGCEQUSA-N 3-[5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]-1-benzothiophen-3-yl]prop-2-ynoic acid Chemical compound C1=C2SC=C(C#CC(O)=O)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 FDZCRKBBEIPFHU-VHDGCEQUSA-N 0.000 claims 1
• GREDWISHBIANLE-KGYLQXTDSA-N 3-[5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]furo[2,3-c]pyridin-3-yl]prop-2-ynoic acid Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC=C2C#CC(O)=O GREDWISHBIANLE-KGYLQXTDSA-N 0.000 claims 1
• DSTCWWRLTQXQMB-KGYLQXTDSA-N 3-[acetyl(methyl)amino]-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC=C2N(C)C(C)=O DSTCWWRLTQXQMB-KGYLQXTDSA-N 0.000 claims 1
• YEYXQRLKMAGFSP-BYCMXARLSA-N 3-acetyl-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-benzofuran-5-carboxamide Chemical compound C1=C2OC=C(C(C)=O)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 YEYXQRLKMAGFSP-BYCMXARLSA-N 0.000 claims 1
• SYVMFMRYCWDZGF-JIMOISOXSA-N 3-acetyl-n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC=C2C(C)=O SYVMFMRYCWDZGF-JIMOISOXSA-N 0.000 claims 1
• CJFZKNAVYHSJFE-GRYCIOLGSA-N 5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]-1-benzofuran-2-carboxylic acid Chemical compound C1=C2OC(C(O)=O)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 CJFZKNAVYHSJFE-GRYCIOLGSA-N 0.000 claims 1
• GARLUJFXQHWUEU-JIMOISOXSA-N 5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]-1-benzofuran-3-carboxylic acid Chemical compound C1=C2OC=C(C(O)=O)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 GARLUJFXQHWUEU-JIMOISOXSA-N 0.000 claims 1
• BUMPKWLDUOYYCQ-GRYCIOLGSA-N 5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]-1-benzothiophene-2-carboxylic acid Chemical compound C1=C2SC(C(O)=O)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 BUMPKWLDUOYYCQ-GRYCIOLGSA-N 0.000 claims 1
• XKNZWZAFZHYECU-JIMOISOXSA-N 5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]-1-benzothiophene-3-carboxylic acid Chemical compound C1=C2SC=C(C(O)=O)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 XKNZWZAFZHYECU-JIMOISOXSA-N 0.000 claims 1
• UCZCBVTXBPWIFZ-KXUCPTDWSA-N 5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]furo[2,3-c]pyridine-2-carboxylic acid Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC(C(O)=O)=C2 UCZCBVTXBPWIFZ-KXUCPTDWSA-N 0.000 claims 1
• NNJFDBWRUWITMP-PPKCKEKNSA-N 5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]furo[2,3-c]pyridine-3-carboxylic acid Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC=C2C(O)=O NNJFDBWRUWITMP-PPKCKEKNSA-N 0.000 claims 1
• ADECQCJZIZRQOE-KXUCPTDWSA-N 5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]thieno[2,3-c]pyridine-2-carboxylic acid Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC(C(O)=O)=C2 ADECQCJZIZRQOE-KXUCPTDWSA-N 0.000 claims 1
• YHGLKBJEPNMCAF-GRYCIOLGSA-N 6-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]-1-benzofuran-2-carboxylic acid Chemical compound C1=C2C=C(C(O)=O)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 YHGLKBJEPNMCAF-GRYCIOLGSA-N 0.000 claims 1
• NEHZNHXMRZYVGS-GRYCIOLGSA-N 6-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]-1-benzothiophene-2-carboxylic acid Chemical compound C1=C2C=C(C(O)=O)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 NEHZNHXMRZYVGS-GRYCIOLGSA-N 0.000 claims 1
• FENRWAUBGRJSCD-KXUCPTDWSA-N 6-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]furo[3,2-c]pyridine-2-carboxylic acid Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(C(O)=O)O2 FENRWAUBGRJSCD-KXUCPTDWSA-N 0.000 claims 1
• DCCIKUHJLZHRIV-HZSPNIEDSA-N N-[(1S,2R,4R)-7-azabicyclo[2.2.1]heptan-2-yl]-2-benzofuran-5-carboxamide Chemical compound C1=CC2=COC=C2C=C1C(=O)N[C@H](C1)[C@]2([H])CC[C@@]1([H])N2 DCCIKUHJLZHRIV-HZSPNIEDSA-N 0.000 claims 1
• VDGSYZCBJJEKPN-KXUCPTDWSA-N N-[(1S,2R,4R)-7-azabicyclo[2.2.1]heptan-2-yl]-2-sulfanylfuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC(S)=C2 VDGSYZCBJJEKPN-KXUCPTDWSA-N 0.000 claims 1
• DEMNSYOTZRHGGL-KXUCPTDWSA-N N-[(1S,2R,4R)-7-azabicyclo[2.2.1]heptan-2-yl]-2-sulfanylthieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC(S)=C2 DEMNSYOTZRHGGL-KXUCPTDWSA-N 0.000 claims 1
• BKWDHDRGACDLPV-GRYCIOLGSA-N N-[(1S,2R,4R)-7-azabicyclo[2.2.1]heptan-2-yl]furo[3,4-c]pyridine-6-carboxamide Chemical compound C=1C2=COC=C2C=NC=1C(=O)N[C@H](C1)[C@]2([H])CC[C@@]1([H])N2 BKWDHDRGACDLPV-GRYCIOLGSA-N 0.000 claims 1
• PPFWJHGTTCSSQG-UHFFFAOYSA-N [1,3]oxazolo[4,5-c]pyridine-6-carboxamide Chemical compound O1C=NC=2C=NC(=CC=21)C(=O)N PPFWJHGTTCSSQG-UHFFFAOYSA-N 0.000 claims 1
• MVTCXSGPYZCCHC-UHFFFAOYSA-N furo[2,3-c]pyridine-3,5-dicarboxamide Chemical compound O1C=C(C=2C1=CN=C(C=2)C(=O)N)C(=O)N MVTCXSGPYZCCHC-UHFFFAOYSA-N 0.000 claims 1
• PAYJWQZDXBKDIP-UHFFFAOYSA-N furo[3,2-c]pyridine-2,6-dicarboxamide Chemical compound O1C(=CC=2C=NC(=CC=21)C(=O)N)C(=O)N PAYJWQZDXBKDIP-UHFFFAOYSA-N 0.000 claims 1
• 125000002249 indol-2-yl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([*])=C([H])C2=C1[H] 0.000 claims 1
• WSNSSIXOAOIPNB-VNQPRFMTSA-N methyl 3-[5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]-1-benzofuran-2-yl]prop-2-ynoate Chemical compound C1=C2OC(C#CC(=O)OC)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 WSNSSIXOAOIPNB-VNQPRFMTSA-N 0.000 claims 1
• XGVBYESQOWYXBU-VNQPRFMTSA-N methyl 3-[5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]-1-benzofuran-3-yl]prop-2-ynoate Chemical compound C1=C2OC=C(C#CC(=O)OC)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 XGVBYESQOWYXBU-VNQPRFMTSA-N 0.000 claims 1
• XTOFJPMIXNAZHF-VNQPRFMTSA-N methyl 3-[5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]-1-benzothiophen-2-yl]prop-2-ynoate Chemical compound C1=C2SC(C#CC(=O)OC)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 XTOFJPMIXNAZHF-VNQPRFMTSA-N 0.000 claims 1
• SQKSBUKFMCUOKZ-KWCYVHTRSA-N methyl 3-[5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]furo[2,3-c]pyridin-2-yl]prop-2-ynoate Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC(C#CC(=O)OC)=C2 SQKSBUKFMCUOKZ-KWCYVHTRSA-N 0.000 claims 1
• QXXIRDDRYJQDLA-KWCYVHTRSA-N methyl 3-[5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]furo[2,3-c]pyridin-3-yl]prop-2-ynoate Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC=C2C#CC(=O)OC QXXIRDDRYJQDLA-KWCYVHTRSA-N 0.000 claims 1
• KHLDIGXENQKIAU-KWCYVHTRSA-N methyl 3-[5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]thieno[2,3-c]pyridin-2-yl]prop-2-ynoate Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC(C#CC(=O)OC)=C2 KHLDIGXENQKIAU-KWCYVHTRSA-N 0.000 claims 1
• WFPQLXBKLQZRJK-KWCYVHTRSA-N methyl 3-[5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]thieno[2,3-c]pyridin-3-yl]prop-2-ynoate Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC=C2C#CC(=O)OC WFPQLXBKLQZRJK-KWCYVHTRSA-N 0.000 claims 1
• RBABVCUZWWGKAW-VNQPRFMTSA-N methyl 3-[6-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]-1-benzofuran-2-yl]prop-2-ynoate Chemical compound C1=C2C=C(C#CC(=O)OC)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 RBABVCUZWWGKAW-VNQPRFMTSA-N 0.000 claims 1
• UDLULXXRWGYGBW-VNQPRFMTSA-N methyl 3-[6-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]-1-benzothiophen-2-yl]prop-2-ynoate Chemical compound C1=C2C=C(C#CC(=O)OC)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 UDLULXXRWGYGBW-VNQPRFMTSA-N 0.000 claims 1
• NSPFPQRIARGWGV-KWCYVHTRSA-N methyl 3-[6-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]furo[3,2-c]pyridin-2-yl]prop-2-ynoate Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(C#CC(=O)OC)O2 NSPFPQRIARGWGV-KWCYVHTRSA-N 0.000 claims 1
• HNYUNIHQEGNLKB-DDTOSNHZSA-N methyl 5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]-1-benzothiophene-3-carboxylate Chemical compound C1=C2SC=C(C(=O)OC)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 HNYUNIHQEGNLKB-DDTOSNHZSA-N 0.000 claims 1
• IVRKHIZLNQPEJJ-JFUSQASVSA-N methyl 5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]furo[2,3-c]pyridine-3-carboxylate Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC=C2C(=O)OC IVRKHIZLNQPEJJ-JFUSQASVSA-N 0.000 claims 1
• KDNWOMMHZKAETD-OUAUKWLOSA-N methyl 5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]thieno[2,3-c]pyridine-2-carboxylate Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC(C(=O)OC)=C2 KDNWOMMHZKAETD-OUAUKWLOSA-N 0.000 claims 1
• FHVUPHFZYMHTDP-JFUSQASVSA-N methyl 5-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]thieno[2,3-c]pyridine-3-carboxylate Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC=C2C(=O)OC FHVUPHFZYMHTDP-JFUSQASVSA-N 0.000 claims 1
• KRNBTIIGOUMVGI-FRRDWIJNSA-N methyl 6-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]-1-benzofuran-2-carboxylate Chemical compound C1=C2C=C(C(=O)OC)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 KRNBTIIGOUMVGI-FRRDWIJNSA-N 0.000 claims 1
• LWQQZMVQXITGFK-FRRDWIJNSA-N methyl 6-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]-1-benzothiophene-2-carboxylate Chemical compound C1=C2C=C(C(=O)OC)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 LWQQZMVQXITGFK-FRRDWIJNSA-N 0.000 claims 1
• AEEJGGYZEOCWAX-OUAUKWLOSA-N methyl 6-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]furo[3,2-c]pyridine-2-carboxylate Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(C(=O)OC)O2 AEEJGGYZEOCWAX-OUAUKWLOSA-N 0.000 claims 1
• DPRUTKDGQMKRAB-OUAUKWLOSA-N methyl 6-[[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]carbamoyl]thieno[3,2-c]pyridine-2-carboxylate Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(C(=O)OC)S2 DPRUTKDGQMKRAB-OUAUKWLOSA-N 0.000 claims 1
• ZSHWRPDBTVZHLB-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1,3-benzodioxole-5-carboxamide Chemical compound C1=C2OCOC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 ZSHWRPDBTVZHLB-OUAUKWLOSA-N 0.000 claims 1
• YFYUYLQVFFGKTF-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1-benzofuran-2-carboxamide Chemical compound C1=CC=C2OC(C(=O)N[C@H]3[C@]4([H])CC[C@@](N4)(C3)[H])=CC2=C1 YFYUYLQVFFGKTF-GRYCIOLGSA-N 0.000 claims 1
• DUADILLBTGOERC-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-1h-pyrrolo[2,3-c]pyridine-2-carboxamide Chemical compound C1=NC=C2NC(C(=O)N[C@H]3[C@]4([H])CC[C@@](N4)(C3)[H])=CC2=C1 DUADILLBTGOERC-OUAUKWLOSA-N 0.000 claims 1
• GWFMIUVOKMEMHD-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(1,2,4-triazol-1-yl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1SC=2N1C=NC=N1 GWFMIUVOKMEMHD-HZSPNIEDSA-N 0.000 claims 1
• BJCCLEIHJUBMEV-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(1,2,4-triazol-1-yl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1O2)=CC=1C=C2N1C=NC=N1 BJCCLEIHJUBMEV-GRYCIOLGSA-N 0.000 claims 1
• BCDTYAHURYLPDP-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2,2,2-trifluoroacetyl)-1-benzofuran-6-carboxamide Chemical compound C1=C2C=C(C(=O)C(F)(F)F)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 BCDTYAHURYLPDP-GRYCIOLGSA-N 0.000 claims 1
• PWXAFTSCBWWXBZ-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2,2,2-trifluoroacetyl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC(C(=O)C(F)(F)F)=C2 PWXAFTSCBWWXBZ-KXUCPTDWSA-N 0.000 claims 1
• GCXKYIYAMZPQBD-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2,2,2-trifluoroacetyl)furo[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(C(=O)C(F)(F)F)O2 GCXKYIYAMZPQBD-KXUCPTDWSA-N 0.000 claims 1
• SBQFESADBVVFMM-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2-oxopiperazin-1-yl)-1-benzothiophene-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1S2)=CC=C1C=C2N1CCNCC1=O SBQFESADBVVFMM-QLFBSQMISA-N 0.000 claims 1
• SDGUUXLHMUHHAD-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2-oxopiperazin-1-yl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1O2)=CC=1C=C2N1CCNCC1=O SDGUUXLHMUHHAD-FRRDWIJNSA-N 0.000 claims 1
• BMEUCMSBLDSOSZ-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2-oxopiperazin-1-yl)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1S2)=CC=1C=C2N1CCNCC1=O BMEUCMSBLDSOSZ-FRRDWIJNSA-N 0.000 claims 1
• SXHUCRIKGIMJEW-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2-oxopiperidin-1-yl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1SC=2N1CCCCC1=O SXHUCRIKGIMJEW-OWCLPIDISA-N 0.000 claims 1
• KEOBMBAUGUGQHZ-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2-oxopiperidin-1-yl)-1-benzothiophene-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1S2)=CC=C1C=C2N1CCCCC1=O KEOBMBAUGUGQHZ-OWCLPIDISA-N 0.000 claims 1
• DJFBXIFTYJGLSZ-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2-oxopiperidin-1-yl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1O2)=CC=1C=C2N1CCCCC1=O DJFBXIFTYJGLSZ-HZSPNIEDSA-N 0.000 claims 1
• BTHKZULPHZKBFX-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2-oxopiperidin-1-yl)furo[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1OC=2N1CCCCC1=O BTHKZULPHZKBFX-HZSPNIEDSA-N 0.000 claims 1
• YRLMSDOKERTRHT-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2-oxopiperidin-1-yl)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1S2)=CC=1C=C2N1CCCCC1=O YRLMSDOKERTRHT-HZSPNIEDSA-N 0.000 claims 1
• KROTTWWVVPBWLW-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(2-oxopiperidin-1-yl)thieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1SC=2N1CCCCC1=O KROTTWWVVPBWLW-HZSPNIEDSA-N 0.000 claims 1
• VNGXPSDLXJKBNC-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3-hydroxyprop-1-ynyl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC(C#CCO)=C2 VNGXPSDLXJKBNC-KWCYVHTRSA-N 0.000 claims 1
• JSZSUZUBIXKLRH-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3-oxomorpholin-4-yl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1O2)=CC=1C=C2N1CCOCC1=O JSZSUZUBIXKLRH-FRRDWIJNSA-N 0.000 claims 1
• QHAUEZMUIGOSPH-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3-oxomorpholin-4-yl)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1S2)=CC=1C=C2N1CCOCC1=O QHAUEZMUIGOSPH-FRRDWIJNSA-N 0.000 claims 1
• BKEBMLFCECFXSQ-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3-oxopiperazin-1-yl)-1-benzothiophene-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1S2)=CC=C1C=C2N1CCNC(=O)C1 BKEBMLFCECFXSQ-QLFBSQMISA-N 0.000 claims 1
• WTFLRDIISIEQRV-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3-oxopiperazin-1-yl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1O2)=CC=1C=C2N1CCNC(=O)C1 WTFLRDIISIEQRV-FRRDWIJNSA-N 0.000 claims 1
• YSLPCRPFKVBCBY-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3-oxopiperazin-1-yl)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1S2)=CC=1C=C2N1CCNC(=O)C1 YSLPCRPFKVBCBY-FRRDWIJNSA-N 0.000 claims 1
• YXSVASABXWOUTP-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3-oxothiomorpholin-4-yl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1O2)=CC=1C=C2N1CCSCC1=O YXSVASABXWOUTP-FRRDWIJNSA-N 0.000 claims 1
• MOKBXMMFKACYFO-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3-oxothiomorpholin-4-yl)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1S2)=CC=1C=C2N1CCSCC1=O MOKBXMMFKACYFO-FRRDWIJNSA-N 0.000 claims 1
• ONKUFHZJTRGVSX-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(3-oxothiomorpholin-4-yl)thieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1SC=2N1CCSCC1=O ONKUFHZJTRGVSX-FRRDWIJNSA-N 0.000 claims 1
• IBKZMPVCFDARLH-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-methyl-2-oxopiperazin-1-yl)-1-benzofuran-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1O2)=CC=C1C=C2N1CCN(C)CC1=O IBKZMPVCFDARLH-OWCLPIDISA-N 0.000 claims 1
• GJAZIWSTNLGZOY-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-methyl-2-oxopiperazin-1-yl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1SC=2N1CCN(C)CC1=O GJAZIWSTNLGZOY-OWCLPIDISA-N 0.000 claims 1
• JXGGWOFKGZBOPV-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-methyl-2-oxopiperazin-1-yl)-1-benzothiophene-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1S2)=CC=C1C=C2N1CCN(C)CC1=O JXGGWOFKGZBOPV-OWCLPIDISA-N 0.000 claims 1
• UMIBXKLUMYCRBD-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-methyl-2-oxopiperazin-1-yl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1O2)=CC=1C=C2N1CCN(C)CC1=O UMIBXKLUMYCRBD-HZSPNIEDSA-N 0.000 claims 1
• HLCKCTQNTXIMRG-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-methyl-2-oxopiperazin-1-yl)furo[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1OC=2N1CCN(C)CC1=O HLCKCTQNTXIMRG-HZSPNIEDSA-N 0.000 claims 1
• YVFGNMSQRXHGJI-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-methyl-2-oxopiperazin-1-yl)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1S2)=CC=1C=C2N1CCN(C)CC1=O YVFGNMSQRXHGJI-HZSPNIEDSA-N 0.000 claims 1
• LZRRHMIVNFSGHX-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-methyl-3-oxopiperazin-1-yl)-1-benzofuran-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1O2)=CC=C1C=C2N1CCN(C)C(=O)C1 LZRRHMIVNFSGHX-OWCLPIDISA-N 0.000 claims 1
• BPGIUDTYGBPCLK-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-methyl-3-oxopiperazin-1-yl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1SC=2N1CCN(C)C(=O)C1 BPGIUDTYGBPCLK-OWCLPIDISA-N 0.000 claims 1
• OVBJNFXRKQXJQY-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-methyl-3-oxopiperazin-1-yl)-1-benzothiophene-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1S2)=CC=C1C=C2N1CCN(C)C(=O)C1 OVBJNFXRKQXJQY-OWCLPIDISA-N 0.000 claims 1
• WZPPKYWZRKUSIE-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-methyl-3-oxopiperazin-1-yl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1O2)=CC=1C=C2N1CCN(C)C(=O)C1 WZPPKYWZRKUSIE-HZSPNIEDSA-N 0.000 claims 1
• AIWFOHPUBANZOX-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-methyl-3-oxopiperazin-1-yl)furo[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1OC=2N1CCN(C)C(=O)C1 AIWFOHPUBANZOX-HZSPNIEDSA-N 0.000 claims 1
• ORQGPDFMHCVTPQ-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-methyl-3-oxopiperazin-1-yl)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1S2)=CC=1C=C2N1CCN(C)C(=O)C1 ORQGPDFMHCVTPQ-HZSPNIEDSA-N 0.000 claims 1
• VHBWJTXWPAUMLU-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-methyl-3-oxopiperazin-1-yl)thieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1SC=2N1CCN(C)C(=O)C1 VHBWJTXWPAUMLU-HZSPNIEDSA-N 0.000 claims 1
• IILJRGYCLRJTQA-IXDOHACOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-methylpiperazin-1-yl)-1-benzofuran-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1O2)=CC=C1C=C2N1CCN(C)CC1 IILJRGYCLRJTQA-IXDOHACOSA-N 0.000 claims 1
• UZOYVOPLTRMRBP-IXDOHACOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-methylpiperazin-1-yl)-1-benzothiophene-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1S2)=CC=C1C=C2N1CCN(C)CC1 UZOYVOPLTRMRBP-IXDOHACOSA-N 0.000 claims 1
• SGBNJXASQVGCML-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-methylpiperazin-1-yl)furo[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1OC=2N1CCN(C)CC1 SGBNJXASQVGCML-QLFBSQMISA-N 0.000 claims 1
• RIGSRRKGRQGKAF-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-methylpiperazine-1-carbonyl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1O2)=CC=1C=C2C(=O)N1CCN(C)CC1 RIGSRRKGRQGKAF-QLFBSQMISA-N 0.000 claims 1
• VXERONIYOAWZRD-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(4-methylpiperazine-1-carbonyl)furo[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1OC=2C(=O)N1CCN(C)CC1 VXERONIYOAWZRD-QLFBSQMISA-N 0.000 claims 1
• UFJBRAOCPXKSQL-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(azetidine-1-carbonyl)-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1OC=2C(=O)N1CCC1 UFJBRAOCPXKSQL-QLFBSQMISA-N 0.000 claims 1
• ZUBFFKPGTZEYJQ-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(azetidine-1-carbonyl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1O2)=CC=1C=C2C(=O)N1CCC1 ZUBFFKPGTZEYJQ-FRRDWIJNSA-N 0.000 claims 1
• KBIUESSTVMFPAC-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(aziridine-1-carbonyl)furo[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1OC=2C(=O)N1CC1 KBIUESSTVMFPAC-GRYCIOLGSA-N 0.000 claims 1
• KZKQVJPFSIMTMH-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(aziridine-1-carbonyl)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1S2)=CC=1C=C2C(=O)N1CC1 KZKQVJPFSIMTMH-GRYCIOLGSA-N 0.000 claims 1
• ZGCBWJMYOZVTRR-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(aziridine-1-carbonyl)thieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1SC=2C(=O)N1CC1 ZGCBWJMYOZVTRR-GRYCIOLGSA-N 0.000 claims 1
• PFURVFZVUYDMSL-BPQIPLTHSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(benzenesulfonyl)-1-benzothiophene-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1S2)=CC=C1C=C2S(=O)(=O)C1=CC=CC=C1 PFURVFZVUYDMSL-BPQIPLTHSA-N 0.000 claims 1
• QMRAZWFJAISYQB-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(diethylamino)-1-benzofuran-6-carboxamide Chemical compound C1=C2C=C(N(CC)CC)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 QMRAZWFJAISYQB-OWCLPIDISA-N 0.000 claims 1
• SKIHBQQZOXIVKC-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(diethylamino)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC(N(CC)CC)=C2 SKIHBQQZOXIVKC-HZSPNIEDSA-N 0.000 claims 1
• YLEKBGMUBQXPKZ-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(diethylamino)furo[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(N(CC)CC)O2 YLEKBGMUBQXPKZ-HZSPNIEDSA-N 0.000 claims 1
• PAIHDQRRLHLCLW-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(diethylamino)thieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(N(CC)CC)S2 PAIHDQRRLHLCLW-HZSPNIEDSA-N 0.000 claims 1
• JCDLBIDPYBEOLU-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(dimethylamino)-1-benzothiophene-6-carboxamide Chemical compound C1=C2C=C(N(C)C)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 JCDLBIDPYBEOLU-HZSPNIEDSA-N 0.000 claims 1
• KKBADFQSRWQLKR-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(dimethylamino)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC(N(C)C)=C2 KKBADFQSRWQLKR-GRYCIOLGSA-N 0.000 claims 1
• BJYXOEZRSSIOKT-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(dimethylamino)furo[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(N(C)C)O2 BJYXOEZRSSIOKT-GRYCIOLGSA-N 0.000 claims 1
• MYXFVHOGGSXDLP-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(methylamino)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC(NC)=C2 MYXFVHOGGSXDLP-OUAUKWLOSA-N 0.000 claims 1
• SDZLCPWBRDBLJA-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(methylamino)furo[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(NC)O2 SDZLCPWBRDBLJA-OUAUKWLOSA-N 0.000 claims 1
• WKCRCHPOUBKJPE-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(methylamino)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC(NC)=C2 WKCRCHPOUBKJPE-OUAUKWLOSA-N 0.000 claims 1
• OUQMLBFPLHIXSV-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(methylamino)thieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(NC)S2 OUQMLBFPLHIXSV-OUAUKWLOSA-N 0.000 claims 1
• ILOFUQZMUUITJL-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(morpholine-4-carbonyl)furo[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1OC=2C(=O)N1CCOCC1 ILOFUQZMUUITJL-HZSPNIEDSA-N 0.000 claims 1
• VAAWNRHVZLFKFP-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(piperazine-1-carbonyl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1SC=2C(=O)N1CCNCC1 VAAWNRHVZLFKFP-OWCLPIDISA-N 0.000 claims 1
• OSIZZYMCSGLZHN-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(piperazine-1-carbonyl)-1-benzothiophene-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1S2)=CC=C1C=C2C(=O)N1CCNCC1 OSIZZYMCSGLZHN-OWCLPIDISA-N 0.000 claims 1
• MYRBYWDBCPMYOO-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(piperazine-1-carbonyl)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1S2)=CC=1C=C2C(=O)N1CCNCC1 MYRBYWDBCPMYOO-HZSPNIEDSA-N 0.000 claims 1
• NUJPXWDHOQVAJJ-IXDOHACOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(piperidine-1-carbonyl)-1-benzofuran-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1O2)=CC=C1C=C2C(=O)N1CCCCC1 NUJPXWDHOQVAJJ-IXDOHACOSA-N 0.000 claims 1
• RJNXOEQYRNPCLU-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(piperidine-1-carbonyl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1O2)=CC=1C=C2C(=O)N1CCCCC1 RJNXOEQYRNPCLU-QLFBSQMISA-N 0.000 claims 1
• NQWOULFEIAGZBL-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(piperidine-1-carbonyl)furo[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1OC=2C(=O)N1CCCCC1 NQWOULFEIAGZBL-QLFBSQMISA-N 0.000 claims 1
• BHGVYARYAWHBRH-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(thiomorpholine-4-carbonyl)-1-benzofuran-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1O2)=CC=C1C=C2C(=O)N1CCSCC1 BHGVYARYAWHBRH-OWCLPIDISA-N 0.000 claims 1
• BLLDLILMLPNDAJ-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(thiomorpholine-4-carbonyl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1SC=2C(=O)N1CCSCC1 BLLDLILMLPNDAJ-OWCLPIDISA-N 0.000 claims 1
• HKBCJZHDOAUROS-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(thiomorpholine-4-carbonyl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1O2)=CC=1C=C2C(=O)N1CCSCC1 HKBCJZHDOAUROS-HZSPNIEDSA-N 0.000 claims 1
• UBEKHURUFVBAFW-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(thiomorpholine-4-carbonyl)furo[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1OC=2C(=O)N1CCSCC1 UBEKHURUFVBAFW-HZSPNIEDSA-N 0.000 claims 1
• DXBOWQJSRNKHAO-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(triazol-1-yl)-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1OC=2N1C=CN=N1 DXBOWQJSRNKHAO-HZSPNIEDSA-N 0.000 claims 1
• UEQSKALDXABKQZ-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(triazol-1-yl)-1-benzofuran-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1O2)=CC=C1C=C2N1C=CN=N1 UEQSKALDXABKQZ-HZSPNIEDSA-N 0.000 claims 1
• AIMCKYOJLPUVML-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(triazol-1-yl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1SC=2N1C=CN=N1 AIMCKYOJLPUVML-HZSPNIEDSA-N 0.000 claims 1
• IGDCWDPXZGGNSU-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(trifluoromethyl)furo[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(C(F)(F)F)O2 IGDCWDPXZGGNSU-KXUCPTDWSA-N 0.000 claims 1
• SHYYVAXCLKQPEV-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(trifluoromethyl)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC(C(F)(F)F)=C2 SHYYVAXCLKQPEV-KXUCPTDWSA-N 0.000 claims 1
• UNZORZYULBEFLW-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-(trifluoromethyl)thieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(C(F)(F)F)S2 UNZORZYULBEFLW-KXUCPTDWSA-N 0.000 claims 1
• WHTSHHMLBKHKBU-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[(2,2,2-trifluoroacetyl)amino]-1-benzofuran-5-carboxamide Chemical compound C1=C2OC(NC(=O)C(F)(F)F)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 WHTSHHMLBKHKBU-GRYCIOLGSA-N 0.000 claims 1
• ITPKOGBMPPGLAG-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[(2,2,2-trifluoroacetyl)amino]furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC(NC(=O)C(F)(F)F)=C2 ITPKOGBMPPGLAG-KXUCPTDWSA-N 0.000 claims 1
• PFRYXMDKUSIFNW-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[(2,2,2-trifluoroacetyl)amino]furo[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(NC(=O)C(F)(F)F)O2 PFRYXMDKUSIFNW-KXUCPTDWSA-N 0.000 claims 1
• NCIVOWCAJWHDOX-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[(2,2,2-trifluoroacetyl)amino]thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC(NC(=O)C(F)(F)F)=C2 NCIVOWCAJWHDOX-KXUCPTDWSA-N 0.000 claims 1
• KFTUKLAFKLTVND-FGTMMUONSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[di(propan-2-yl)amino]-1-benzofuran-6-carboxamide Chemical compound C1=C2C=C(N(C(C)C)C(C)C)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 KFTUKLAFKLTVND-FGTMMUONSA-N 0.000 claims 1
• FTAGHUSKQAQHSW-FGTMMUONSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[di(propan-2-yl)amino]-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC(N(C(C)C)C(C)C)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 FTAGHUSKQAQHSW-FGTMMUONSA-N 0.000 claims 1
• ABHSMNKEBNKLRA-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[di(propan-2-yl)amino]furo[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(N(C(C)C)C(C)C)O2 ABHSMNKEBNKLRA-OWCLPIDISA-N 0.000 claims 1
• AAQYFCDKBGTZEI-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[formyl(methyl)amino]-1-benzofuran-6-carboxamide Chemical compound C1=C2C=C(N(C)C=O)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 AAQYFCDKBGTZEI-HZSPNIEDSA-N 0.000 claims 1
• RLSFXNAPUYSHCE-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[formyl(methyl)amino]furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC(N(C)C=O)=C2 RLSFXNAPUYSHCE-GRYCIOLGSA-N 0.000 claims 1
• WJEHIWHFWJCUNY-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[formyl(methyl)amino]furo[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(N(C)C=O)O2 WJEHIWHFWJCUNY-GRYCIOLGSA-N 0.000 claims 1
• ZLSAQJBGHSMCSE-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-[formyl(methyl)amino]thieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(N(C)C=O)S2 ZLSAQJBGHSMCSE-GRYCIOLGSA-N 0.000 claims 1
• JSTKDZIKCGTVRK-FGTMMUONSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-benzamido-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1SC=2NC(=O)C1=CC=CC=C1 JSTKDZIKCGTVRK-FGTMMUONSA-N 0.000 claims 1
• KKMJPKLFRYODBN-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-benzamidofuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1O2)=CC=1C=C2NC(=O)C1=CC=CC=C1 KKMJPKLFRYODBN-OWCLPIDISA-N 0.000 claims 1
• LKRLFHQAYQZBMJ-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-benzamidofuro[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1OC=2NC(=O)C1=CC=CC=C1 LKRLFHQAYQZBMJ-OWCLPIDISA-N 0.000 claims 1
• BBXKXGIXJIFFEQ-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-benzamidothieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1SC=2NC(=O)C1=CC=CC=C1 BBXKXGIXJIFFEQ-OWCLPIDISA-N 0.000 claims 1
• TXONIHOXYHTHKO-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-chloro-1-benzothiophene-6-carboxamide Chemical compound C1=C2C=C(Cl)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 TXONIHOXYHTHKO-GRYCIOLGSA-N 0.000 claims 1
• LIQOJRRYISNJQP-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-chlorothieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC(Cl)=C2 LIQOJRRYISNJQP-KXUCPTDWSA-N 0.000 claims 1
• KVMSYWNUZZPVQF-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-chlorothieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(Cl)S2 KVMSYWNUZZPVQF-KXUCPTDWSA-N 0.000 claims 1
• FSFOXEDODQRSQU-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-cyanofuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC(C#N)=C2 FSFOXEDODQRSQU-ADEWGFFLSA-N 0.000 claims 1
• HVRBRNNPQQTCHH-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-cyanothieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC(C#N)=C2 HVRBRNNPQQTCHH-ADEWGFFLSA-N 0.000 claims 1
• ORMWCEFFBMPZBN-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-ethenylfuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC(C=C)=C2 ORMWCEFFBMPZBN-KGYLQXTDSA-N 0.000 claims 1
• SBFOVBCCPCTXEY-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-ethenylthieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(C=C)S2 SBFOVBCCPCTXEY-KGYLQXTDSA-N 0.000 claims 1
• AZUUHKVUUAODBA-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-ethynyl-1-benzofuran-5-carboxamide Chemical compound C1=C2OC(C#C)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 AZUUHKVUUAODBA-VHDGCEQUSA-N 0.000 claims 1
• DIZBWXYSYOJYKC-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-ethynyl-1-benzofuran-6-carboxamide Chemical compound C1=C2C=C(C#C)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 DIZBWXYSYOJYKC-VHDGCEQUSA-N 0.000 claims 1
• RJMQMHXPDJEBIZ-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-ethynyl-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC(C#C)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 RJMQMHXPDJEBIZ-VHDGCEQUSA-N 0.000 claims 1
• WPGNTIYSDXEECX-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-ethynylfuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC(C#C)=C2 WPGNTIYSDXEECX-KGYLQXTDSA-N 0.000 claims 1
• KEKCYWHBRPALHX-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-fluoro-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC(F)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 KEKCYWHBRPALHX-GRYCIOLGSA-N 0.000 claims 1
• HVOGNTAXCZDUKD-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-fluorofuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC(F)=C2 HVOGNTAXCZDUKD-KXUCPTDWSA-N 0.000 claims 1
• FFVLJDRFECRDKI-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-fluorothieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC(F)=C2 FFVLJDRFECRDKI-KXUCPTDWSA-N 0.000 claims 1
• UGJRSLZQCVFKKU-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-formamido-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC(NC=O)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 UGJRSLZQCVFKKU-FRRDWIJNSA-N 0.000 claims 1
• JZLRPTNTERCOQO-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-formamidofuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC(NC=O)=C2 JZLRPTNTERCOQO-OUAUKWLOSA-N 0.000 claims 1
• DDBOOGRTXICFHS-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-formamidofuro[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(NC=O)O2 DDBOOGRTXICFHS-OUAUKWLOSA-N 0.000 claims 1
• FMGJKNWHNVMQQT-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-formylfuro[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(C=O)O2 FMGJKNWHNVMQQT-ADEWGFFLSA-N 0.000 claims 1
• IRIGABVRYCHGIO-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-imidazol-1-yl-1-benzofuran-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1O2)=CC=C1C=C2N1C=CN=C1 IRIGABVRYCHGIO-QLFBSQMISA-N 0.000 claims 1
• ONMTZGJKLHXSPN-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-imidazol-1-yl-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1SC=2N1C=CN=C1 ONMTZGJKLHXSPN-QLFBSQMISA-N 0.000 claims 1
• VZNNQPRFIHFMIM-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-imidazol-1-ylthieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1SC=2N1C=CN=C1 VZNNQPRFIHFMIM-FRRDWIJNSA-N 0.000 claims 1
• LQRRHWFXRZNACG-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-iodo-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC(I)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 LQRRHWFXRZNACG-GRYCIOLGSA-N 0.000 claims 1
• ULTIHZDPKLWHON-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-iodofuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC(I)=C2 ULTIHZDPKLWHON-KXUCPTDWSA-N 0.000 claims 1
• YIWMUNVCQPLWQM-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-iodothieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(I)S2 YIWMUNVCQPLWQM-KXUCPTDWSA-N 0.000 claims 1
• KQJSMHMEFVSXNW-OFLACMMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-methyl-1,3-benzodioxole-5-carboxamide Chemical compound C1=C2OC(C)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 KQJSMHMEFVSXNW-OFLACMMISA-N 0.000 claims 1
• AQZCQWFWWAVHHE-GRYCIOLGSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-methyl-1,3-benzothiazole-5-carboxamide Chemical compound C1=C2SC(C)=NC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 AQZCQWFWWAVHHE-GRYCIOLGSA-N 0.000 claims 1
• AOHGKDXIYAROCD-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-methylsulfanyl-1-benzofuran-6-carboxamide Chemical compound C1=C2C=C(SC)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 AOHGKDXIYAROCD-FRRDWIJNSA-N 0.000 claims 1
• ANKBUSJGXCVIOP-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-methylsulfanylfuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC(SC)=C2 ANKBUSJGXCVIOP-OUAUKWLOSA-N 0.000 claims 1
• AJJWKQFPQRQIIH-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-methylsulfanylfuro[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(SC)O2 AJJWKQFPQRQIIH-OUAUKWLOSA-N 0.000 claims 1
• AUSSYFKGRHIDAX-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-methylsulfonyl-1-benzofuran-6-carboxamide Chemical compound C1=C2C=C(S(C)(=O)=O)OC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 AUSSYFKGRHIDAX-FRRDWIJNSA-N 0.000 claims 1
• SEMWPQFDUFRBDL-FRRDWIJNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-methylsulfonyl-1-benzothiophene-6-carboxamide Chemical compound C1=C2C=C(S(C)(=O)=O)SC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 SEMWPQFDUFRBDL-FRRDWIJNSA-N 0.000 claims 1
• HFHDZHZLSZPAED-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-methylsulfonylfuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC(S(C)(=O)=O)=C2 HFHDZHZLSZPAED-OUAUKWLOSA-N 0.000 claims 1
• PFVOFHPVLIEIOO-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-methylsulfonylfuro[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(S(C)(=O)=O)O2 PFVOFHPVLIEIOO-OUAUKWLOSA-N 0.000 claims 1
• HUHHVSKUQBYBKS-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-methylsulfonylthieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC(S(C)(=O)=O)=C2 HUHHVSKUQBYBKS-OUAUKWLOSA-N 0.000 claims 1
• DEHWSCOKLBEPOL-OUAUKWLOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-methylsulfonylthieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(S(C)(=O)=O)S2 DEHWSCOKLBEPOL-OUAUKWLOSA-N 0.000 claims 1
• QBOFNQQUXQZCCZ-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-morpholin-4-yl-1,3-benzothiazole-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1N=2)=CC=C1SC=2N1CCOCC1 QBOFNQQUXQZCCZ-HZSPNIEDSA-N 0.000 claims 1
• REFZGJZCQRZSSE-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-morpholin-4-yl-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1OC=2N1CCOCC1 REFZGJZCQRZSSE-OWCLPIDISA-N 0.000 claims 1
• ITQGXTWQAHEYLD-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-morpholin-4-yl-1-benzothiophene-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1S2)=CC=C1C=C2N1CCOCC1 ITQGXTWQAHEYLD-OWCLPIDISA-N 0.000 claims 1
• OVRMLTLRUKNDQP-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-piperazin-1-yl-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1OC=2N1CCNCC1 OVRMLTLRUKNDQP-OWCLPIDISA-N 0.000 claims 1
• RLWFRIDMMJIQBY-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-piperazin-1-yl-1-benzothiophene-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1S2)=CC=C1C=C2N1CCNCC1 RLWFRIDMMJIQBY-OWCLPIDISA-N 0.000 claims 1
• AVCJBIKFCBSFBE-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-piperazin-1-ylthieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1SC=2N1CCNCC1 AVCJBIKFCBSFBE-HZSPNIEDSA-N 0.000 claims 1
• QUFUIXMGNRPKGE-IXDOHACOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-piperidin-1-yl-1-benzothiophene-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1S2)=CC=C1C=C2N1CCCCC1 QUFUIXMGNRPKGE-IXDOHACOSA-N 0.000 claims 1
• VJMJGIYRKLHXIH-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-piperidin-1-ylfuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1O2)=CC=1C=C2N1CCCCC1 VJMJGIYRKLHXIH-QLFBSQMISA-N 0.000 claims 1
• DKPRCVGGPCFWPM-QLFBSQMISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-piperidin-1-ylthieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1S2)=CC=1C=C2N1CCCCC1 DKPRCVGGPCFWPM-QLFBSQMISA-N 0.000 claims 1
• KRKKUDURGBDOGY-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-prop-1-ynyl-1-benzofuran-5-carboxamide Chemical compound C1=C2OC(C#CC)=CC2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 KRKKUDURGBDOGY-VNQPRFMTSA-N 0.000 claims 1
• HUTHEXHZIYTJTB-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-prop-1-ynylfuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC(C#CC)=C2 HUTHEXHZIYTJTB-KWCYVHTRSA-N 0.000 claims 1
• IYUUMNFOVYEIGK-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-pyrrol-1-yl-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1OC=2N1C=CC=C1 IYUUMNFOVYEIGK-OWCLPIDISA-N 0.000 claims 1
• QRZSJIFULUIZOA-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-pyrrol-1-yl-1-benzothiophene-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1S2)=CC=C1C=C2N1C=CC=C1 QRZSJIFULUIZOA-OWCLPIDISA-N 0.000 claims 1
• QWANSUVVOACEGP-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-pyrrol-1-ylfuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1O2)=CC=1C=C2N1C=CC=C1 QWANSUVVOACEGP-HZSPNIEDSA-N 0.000 claims 1
• RJBFJLVXYKQKJE-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-pyrrol-1-ylfuro[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1OC=2N1C=CC=C1 RJBFJLVXYKQKJE-HZSPNIEDSA-N 0.000 claims 1
• PLQDJQLQGFIYCE-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-pyrrol-1-ylthieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1S2)=CC=1C=C2N1C=CC=C1 PLQDJQLQGFIYCE-HZSPNIEDSA-N 0.000 claims 1
• PSGKCTCMPJVHRU-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-pyrrol-1-ylthieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1SC=2N1C=CC=C1 PSGKCTCMPJVHRU-HZSPNIEDSA-N 0.000 claims 1
• YFCCWKAJOBMVIK-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-pyrrolidin-1-yl-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1C=2)=CC=C1OC=2N1CCCC1 YFCCWKAJOBMVIK-OWCLPIDISA-N 0.000 claims 1
• JZNZZOOZNQTJDW-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-pyrrolidin-1-ylthieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1C=2)=CC=1SC=2N1CCCC1 JZNZZOOZNQTJDW-HZSPNIEDSA-N 0.000 claims 1
• XIBCJLQJFIJBKJ-KXUCPTDWSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-sulfanylthieno[3,2-c]pyridine-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1C=C(S)S2 XIBCJLQJFIJBKJ-KXUCPTDWSA-N 0.000 claims 1
• HBMVATKMVOZAKW-OWCLPIDISA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-thiomorpholin-4-yl-1-benzothiophene-6-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C1S2)=CC=C1C=C2N1CCSCC1 HBMVATKMVOZAKW-OWCLPIDISA-N 0.000 claims 1
• KJTHHCQAZSTKTM-HZSPNIEDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-2-thiomorpholin-4-ylfuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1O2)=CC=1C=C2N1CCSCC1 KJTHHCQAZSTKTM-HZSPNIEDSA-N 0.000 claims 1
• JQOJSTWMZPKTOQ-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(1,2,4-triazol-1-yl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1SC=C2N1C=NC=N1 JQOJSTWMZPKTOQ-KWCYVHTRSA-N 0.000 claims 1
• VITSRLUFZGPQGX-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(2,2,2-trifluoroacetyl)-1-benzofuran-5-carboxamide Chemical compound C1=C2OC=C(C(=O)C(F)(F)F)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 VITSRLUFZGPQGX-JIMOISOXSA-N 0.000 claims 1
• AXLNRVOAIPLDAN-PPKCKEKNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(2,2,2-trifluoroacetyl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC=C2C(=O)C(F)(F)F AXLNRVOAIPLDAN-PPKCKEKNSA-N 0.000 claims 1
• NOZPFKQFIUTIAG-PPKCKEKNSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(2,2,2-trifluoroacetyl)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC=C2C(=O)C(F)(F)F NOZPFKQFIUTIAG-PPKCKEKNSA-N 0.000 claims 1
• OCSQYDGCQXFPPZ-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(2-oxopiperazin-1-yl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1SC=C2N1CCNCC1=O OCSQYDGCQXFPPZ-VHDGCEQUSA-N 0.000 claims 1
• ITGNYNZAWIXFDO-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(2-oxopiperazin-1-yl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1OC=2)=CC=1C=2N1CCNCC1=O ITGNYNZAWIXFDO-KGYLQXTDSA-N 0.000 claims 1
• FRDUQEGIHQHNOV-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(2-oxopiperidin-1-yl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1SC=C2N1CCCCC1=O FRDUQEGIHQHNOV-VNQPRFMTSA-N 0.000 claims 1
• NIEKQIBTQLFXHB-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(2-oxopiperidin-1-yl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1OC=2)=CC=1C=2N1CCCCC1=O NIEKQIBTQLFXHB-KWCYVHTRSA-N 0.000 claims 1
• YZMYVTJVRQWMHB-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(3-hydroxyprop-1-ynyl)-1-benzofuran-5-carboxamide Chemical compound C1=C2OC=C(C#CCO)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 YZMYVTJVRQWMHB-VNQPRFMTSA-N 0.000 claims 1
• OHNNOLREZSBSME-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(3-hydroxyprop-1-ynyl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC=C2C#CCO OHNNOLREZSBSME-KWCYVHTRSA-N 0.000 claims 1
• QZLSBLLEUMQFFQ-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(3-oxomorpholin-4-yl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1OC=2)=CC=1C=2N1CCOCC1=O QZLSBLLEUMQFFQ-KGYLQXTDSA-N 0.000 claims 1
• GCVNPPGEJFYDGM-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(3-oxomorpholin-4-yl)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1SC=2)=CC=1C=2N1CCOCC1=O GCVNPPGEJFYDGM-KGYLQXTDSA-N 0.000 claims 1
• FIHMTLCWISVSMG-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(3-oxopiperazin-1-yl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1SC=C2N1CCNC(=O)C1 FIHMTLCWISVSMG-VHDGCEQUSA-N 0.000 claims 1
• XQMDSZGOLFLSNO-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(3-oxopiperazin-1-yl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1OC=2)=CC=1C=2N1CCNC(=O)C1 XQMDSZGOLFLSNO-KGYLQXTDSA-N 0.000 claims 1
• MPCRLGGHJXKOBK-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(3-oxopiperazin-1-yl)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1SC=2)=CC=1C=2N1CCNC(=O)C1 MPCRLGGHJXKOBK-KGYLQXTDSA-N 0.000 claims 1
• SCUOUIXIQKTPBW-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(3-oxothiomorpholin-4-yl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1SC=C2N1CCSCC1=O SCUOUIXIQKTPBW-VHDGCEQUSA-N 0.000 claims 1
• XBKSCQDFCGWYBK-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(3-oxothiomorpholin-4-yl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1OC=2)=CC=1C=2N1CCSCC1=O XBKSCQDFCGWYBK-KGYLQXTDSA-N 0.000 claims 1
• WKXCDNDAOJQNER-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(4-methyl-2-oxopiperazin-1-yl)-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1OC=C2N1CCN(C)CC1=O WKXCDNDAOJQNER-VNQPRFMTSA-N 0.000 claims 1
• ZXPCIBVDVIVCCN-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(4-methyl-2-oxopiperazin-1-yl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1SC=C2N1CCN(C)CC1=O ZXPCIBVDVIVCCN-VNQPRFMTSA-N 0.000 claims 1
• DWHZKOCGEFGRGQ-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(4-methyl-2-oxopiperazin-1-yl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1OC=2)=CC=1C=2N1CCN(C)CC1=O DWHZKOCGEFGRGQ-KWCYVHTRSA-N 0.000 claims 1
• WFHKXIGDELPQIT-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(4-methyl-2-oxopiperazin-1-yl)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1SC=2)=CC=1C=2N1CCN(C)CC1=O WFHKXIGDELPQIT-KWCYVHTRSA-N 0.000 claims 1
• FQMQQPAAORMQLZ-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(4-methyl-3-oxopiperazin-1-yl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1SC=C2N1CCN(C)C(=O)C1 FQMQQPAAORMQLZ-VNQPRFMTSA-N 0.000 claims 1
• NBWHRQFGRYSVQE-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(4-methyl-3-oxopiperazin-1-yl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1OC=2)=CC=1C=2N1CCN(C)C(=O)C1 NBWHRQFGRYSVQE-KWCYVHTRSA-N 0.000 claims 1
• MZATWLTUPKRFRE-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(4-methylpiperazin-1-yl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1OC=2)=CC=1C=2N1CCN(C)CC1 MZATWLTUPKRFRE-VHDGCEQUSA-N 0.000 claims 1
• GLNXZTUTUYSFAW-FHLIZLRMSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(4-methylpiperazine-1-carbonyl)-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1OC=C2C(=O)N1CCN(C)CC1 GLNXZTUTUYSFAW-FHLIZLRMSA-N 0.000 claims 1
• GQPIPTWULIYAFU-UHOFOFEASA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(4-methylpiperazine-1-carbonyl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1OC=2)=CC=1C=2C(=O)N1CCN(C)CC1 GQPIPTWULIYAFU-UHOFOFEASA-N 0.000 claims 1
• IBNVSXAGTLDQJX-UHOFOFEASA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(4-methylpiperazine-1-carbonyl)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1SC=2)=CC=1C=2C(=O)N1CCN(C)CC1 IBNVSXAGTLDQJX-UHOFOFEASA-N 0.000 claims 1
• DCEXVGSIOOOIPM-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(aziridine-1-carbonyl)-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1OC=C2C(=O)N1CC1 DCEXVGSIOOOIPM-BYCMXARLSA-N 0.000 claims 1
• GVXPIRJWXYEYNI-FHLIZLRMSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(benzenesulfonyl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1SC=C2S(=O)(=O)C1=CC=CC=C1 GVXPIRJWXYEYNI-FHLIZLRMSA-N 0.000 claims 1
• VAOPNJDFDYQPHN-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(cyclopropylamino)thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1SC=2)=CC=1C=2NC1CC1 VAOPNJDFDYQPHN-KGYLQXTDSA-N 0.000 claims 1
• ZYRJQNKPAKQVCS-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(diethylamino)-1-benzofuran-5-carboxamide Chemical compound C1=C2OC=C(N(CC)CC)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 ZYRJQNKPAKQVCS-VNQPRFMTSA-N 0.000 claims 1
• VGKAYZZUDHPKRK-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(diethylamino)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC=C2N(CC)CC VGKAYZZUDHPKRK-KWCYVHTRSA-N 0.000 claims 1
• YCLPQUUUDHKPED-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(dimethylamino)-1-benzofuran-5-carboxamide Chemical compound C1=C2OC=C(N(C)C)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 YCLPQUUUDHKPED-KWCYVHTRSA-N 0.000 claims 1
• ZPBUEYRYVTZEAS-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(dimethylamino)-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC=C(N(C)C)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 ZPBUEYRYVTZEAS-KWCYVHTRSA-N 0.000 claims 1
• AOWIKRMOOXSWIN-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(dimethylamino)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC=C2N(C)C AOWIKRMOOXSWIN-ADEWGFFLSA-N 0.000 claims 1
• FNGYQNPQHXWYRK-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(methylamino)-1-benzofuran-5-carboxamide Chemical compound C1=C2OC=C(NC)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 FNGYQNPQHXWYRK-KGYLQXTDSA-N 0.000 claims 1
• FPOXHCYGAQXHOF-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(methylamino)-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC=C(NC)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 FPOXHCYGAQXHOF-KGYLQXTDSA-N 0.000 claims 1
• VNZIKBGMODQHIZ-XOKHGSTOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(morpholine-4-carbonyl)-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1OC=C2C(=O)N1CCOCC1 VNZIKBGMODQHIZ-XOKHGSTOSA-N 0.000 claims 1
• BCOPGFPDHOUBIM-XOKHGSTOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(piperazine-1-carbonyl)-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1OC=C2C(=O)N1CCNCC1 BCOPGFPDHOUBIM-XOKHGSTOSA-N 0.000 claims 1
• FUFGOAOZMAEKBV-XOKHGSTOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(piperazine-1-carbonyl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1SC=C2C(=O)N1CCNCC1 FUFGOAOZMAEKBV-XOKHGSTOSA-N 0.000 claims 1
• NJUHQHPPLHNXDI-XOKHGSTOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(pyrrolidine-1-carbonyl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1SC=C2C(=O)N1CCCC1 NJUHQHPPLHNXDI-XOKHGSTOSA-N 0.000 claims 1
• OJQJTKZGUQILNV-XOKHGSTOSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(thiomorpholine-4-carbonyl)-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1OC=C2C(=O)N1CCSCC1 OJQJTKZGUQILNV-XOKHGSTOSA-N 0.000 claims 1
• YGAGFHSJNGJJGV-BYCMXARLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(thiomorpholine-4-carbonyl)furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1OC=2)=CC=1C=2C(=O)N1CCSCC1 YGAGFHSJNGJJGV-BYCMXARLSA-N 0.000 claims 1
• VJPSWGJDRPOSPL-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(triazol-1-yl)-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1SC=C2N1C=CN=N1 VJPSWGJDRPOSPL-KWCYVHTRSA-N 0.000 claims 1
• PMXUBUXEHFMMNU-JIMOISOXSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-(trifluoromethyl)-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC=C(C(F)(F)F)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 PMXUBUXEHFMMNU-JIMOISOXSA-N 0.000 claims 1
• GPMGANNLXIXALF-FKTZTGRPSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-[(2,2,2-trifluoroacetyl)amino]furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC=C2NC(=O)C(F)(F)F GPMGANNLXIXALF-FKTZTGRPSA-N 0.000 claims 1
• UQSQPSUKNZJQHH-FKTZTGRPSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-[(2,2,2-trifluoroacetyl)amino]thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC=C2NC(=O)C(F)(F)F UQSQPSUKNZJQHH-FKTZTGRPSA-N 0.000 claims 1
• ITSNMFHTJGTDAC-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-[di(propan-2-yl)amino]furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC=C2N(C(C)C)C(C)C ITSNMFHTJGTDAC-VNQPRFMTSA-N 0.000 claims 1
• RHMUTTKEWNYWME-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-[di(propan-2-yl)amino]thieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC=C2N(C(C)C)C(C)C RHMUTTKEWNYWME-VNQPRFMTSA-N 0.000 claims 1
• ZWOSNBIVLVEKTL-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-[formyl(methyl)amino]furo[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC=C2N(C)C=O ZWOSNBIVLVEKTL-ADEWGFFLSA-N 0.000 claims 1
• HGOBMCNKWJUDRG-BPQIPLTHSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-benzamido-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1SC=C2NC(=O)C1=CC=CC=C1 HGOBMCNKWJUDRG-BPQIPLTHSA-N 0.000 claims 1
• WJEITQFHDRCJAD-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-benzamidofuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1OC=2)=CC=1C=2NC(=O)C1=CC=CC=C1 WJEITQFHDRCJAD-VNQPRFMTSA-N 0.000 claims 1
• UAYDWEXCMFQFPN-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-cyano-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC=C(C#N)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 UAYDWEXCMFQFPN-KWCYVHTRSA-N 0.000 claims 1
• SVPSVIGTJHEOCF-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-ethenyl-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC=C(C=C)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 SVPSVIGTJHEOCF-VHDGCEQUSA-N 0.000 claims 1
• UZHXJYNIXRMCOY-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-ethenylthieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC=C2C=C UZHXJYNIXRMCOY-KGYLQXTDSA-N 0.000 claims 1
• CANFCEYFEXEFIX-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-ethynyl-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC=C(C#C)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 CANFCEYFEXEFIX-VHDGCEQUSA-N 0.000 claims 1
• OHCYMFMAMPHKTK-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-formyl-1-benzofuran-5-carboxamide Chemical compound C1=C2OC=C(C=O)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 OHCYMFMAMPHKTK-KWCYVHTRSA-N 0.000 claims 1
• NDQXQLIGGAMGAX-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-imidazol-1-yl-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1OC=C2N1C=CN=C1 NDQXQLIGGAMGAX-VHDGCEQUSA-N 0.000 claims 1
• BBQKHJQKQDNMRQ-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-imidazol-1-yl-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1SC=C2N1C=CN=C1 BBQKHJQKQDNMRQ-VHDGCEQUSA-N 0.000 claims 1
• HFILWPCNCOOLNX-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-methylsulfanyl-1-benzofuran-5-carboxamide Chemical compound C1=C2OC=C(SC)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 HFILWPCNCOOLNX-KGYLQXTDSA-N 0.000 claims 1
• WHOVCCPXNALDPL-DVVUODLYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-methylsulfanylthieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC=C2SC WHOVCCPXNALDPL-DVVUODLYSA-N 0.000 claims 1
• BRPBJOANHPNGKS-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-methylsulfonyl-1-benzofuran-5-carboxamide Chemical compound C1=C2OC=C(S(C)(=O)=O)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 BRPBJOANHPNGKS-KGYLQXTDSA-N 0.000 claims 1
• CPROAACUPXPGGB-KGYLQXTDSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-methylsulfonyl-1-benzothiophene-5-carboxamide Chemical compound C1=C2SC=C(S(C)(=O)=O)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 CPROAACUPXPGGB-KGYLQXTDSA-N 0.000 claims 1
• JLGMWXKWWSUSGJ-DVVUODLYSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-methylsulfonylfuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC=C2S(C)(=O)=O JLGMWXKWWSUSGJ-DVVUODLYSA-N 0.000 claims 1
• AMXUMFNJQURIOQ-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-morpholin-4-yl-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1OC=C2N1CCOCC1 AMXUMFNJQURIOQ-VNQPRFMTSA-N 0.000 claims 1
• YVERYQLAVTUSSD-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-morpholin-4-yl-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1SC=C2N1CCOCC1 YVERYQLAVTUSSD-VNQPRFMTSA-N 0.000 claims 1
• QCORUPVVFRXOKR-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-piperazin-1-yl-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1SC=C2N1CCNCC1 QCORUPVVFRXOKR-VNQPRFMTSA-N 0.000 claims 1
• KHRYUMBGWCGODZ-HYVNUMGLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-piperidin-1-yl-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1SC=C2N1CCCCC1 KHRYUMBGWCGODZ-HYVNUMGLSA-N 0.000 claims 1
• LTKXZSLMNWFCCA-VHDGCEQUSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-piperidin-1-ylthieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1SC=2)=CC=1C=2N1CCCCC1 LTKXZSLMNWFCCA-VHDGCEQUSA-N 0.000 claims 1
• FQYIWLNQFFURHC-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-prop-1-ynylfuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC=C2C#CC FQYIWLNQFFURHC-KWCYVHTRSA-N 0.000 claims 1
• TWQIQZIFHMDERC-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-prop-1-ynylthieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1SC=C2C#CC TWQIQZIFHMDERC-KWCYVHTRSA-N 0.000 claims 1
• QDGLNMQYQVLSAR-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-pyrrol-1-yl-1-benzofuran-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1OC=C2N1C=CC=C1 QDGLNMQYQVLSAR-VNQPRFMTSA-N 0.000 claims 1
• AHSGZUNMCMIRNK-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-pyrrol-1-yl-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1SC=C2N1C=CC=C1 AHSGZUNMCMIRNK-VNQPRFMTSA-N 0.000 claims 1
• MITYVQRQJURWKW-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-pyrrol-1-ylfuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1OC=2)=CC=1C=2N1C=CC=C1 MITYVQRQJURWKW-KWCYVHTRSA-N 0.000 claims 1
• IBDFGGQWXLJJTD-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-pyrrolidin-1-ylfuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1OC=2)=CC=1C=2N1CCCC1 IBDFGGQWXLJJTD-KWCYVHTRSA-N 0.000 claims 1
• OMRURFODAAZTBP-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-pyrrolidin-1-ylthieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1SC=2)=CC=1C=2N1CCCC1 OMRURFODAAZTBP-KWCYVHTRSA-N 0.000 claims 1
• XHMMCTQFUMYGAF-ADEWGFFLSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-sulfanyl-1-benzofuran-5-carboxamide Chemical compound C1=C2OC=C(S)C2=CC(C(=O)N[C@H]2[C@]3([H])CC[C@@](N3)(C2)[H])=C1 XHMMCTQFUMYGAF-ADEWGFFLSA-N 0.000 claims 1
• ISMVOINLOCGXJL-FKTZTGRPSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-sulfanylfuro[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=C1)=CC2=C1OC=C2S ISMVOINLOCGXJL-FKTZTGRPSA-N 0.000 claims 1
• MNVSKYFXZJDVCR-VNQPRFMTSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-thiomorpholin-4-yl-1-benzothiophene-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(C=C12)=CC=C1SC=C2N1CCSCC1 MNVSKYFXZJDVCR-VNQPRFMTSA-N 0.000 claims 1
• AXYMPKODRSLNNR-KWCYVHTRSA-N n-[(1r,3r,4s)-7-azabicyclo[2.2.1]heptan-3-yl]-3-thiomorpholin-4-ylthieno[2,3-c]pyridine-5-carboxamide Chemical compound N([C@H]1[C@]2([H])CC[C@@](N2)(C1)[H])C(=O)C(N=CC=1SC=2)=CC=1C=2N1CCSCC1 AXYMPKODRSLNNR-KWCYVHTRSA-N 0.000 claims 1
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