CA2458905A1 - Produits intermediaires de zosinamide et synthese y relative - Google Patents

Produits intermediaires de zosinamide et synthese y relative Download PDF

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Publication number
CA2458905A1
CA2458905A1 CA002458905A CA2458905A CA2458905A1 CA 2458905 A1 CA2458905 A1 CA 2458905A1 CA 002458905 A CA002458905 A CA 002458905A CA 2458905 A CA2458905 A CA 2458905A CA 2458905 A1 CA2458905 A1 CA 2458905A1
Authority
CA
Canada
Prior art keywords
bos
mixture
benzisoxazole
crystalline
process according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002458905A
Other languages
English (en)
Inventor
Tamar Nidam
Marioara Mendelovici
Eduard Schwartz
Shlomit Wizel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2458905A1 publication Critical patent/CA2458905A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems

Abstract

L'invention concerne une nouvelle sulfonation d'un produit intermédiaire de zosinamide. Elle concerne en particulier le processus de sulfonation au moyen d'acide chlorosulfonique, ou d'anhydride acétique et d'acide sulfurique dans un solvant organique. L'invention concerne en outre des formes cristallines de l'acide benzisoxazole méthane sulfonique (BOS-H) et de ses sels (BOS-Na, BOS-Ca, et BOS-Ba) et de nouveaux procédés de préparation de ces composés.
CA002458905A 2001-08-30 2002-08-29 Produits intermediaires de zosinamide et synthese y relative Abandoned CA2458905A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US31610901P 2001-08-30 2001-08-30
US60/316,109 2001-08-30
US34443901P 2001-10-24 2001-10-24
US60/344,439 2001-10-24
PCT/US2002/027593 WO2003020708A1 (fr) 2001-08-30 2002-08-29 Produits intermediaires de zosinamide et synthese y relative

Publications (1)

Publication Number Publication Date
CA2458905A1 true CA2458905A1 (fr) 2003-03-13

Family

ID=26980239

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002458905A Abandoned CA2458905A1 (fr) 2001-08-30 2002-08-29 Produits intermediaires de zosinamide et synthese y relative

Country Status (5)

Country Link
EP (1) EP1430037A4 (fr)
JP (1) JP2005506980A (fr)
CA (1) CA2458905A1 (fr)
IL (1) IL158239A0 (fr)
WO (1) WO2003020708A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9938217B2 (en) 2016-07-01 2018-04-10 Res Usa, Llc Fluidized bed membrane reactor
US9981896B2 (en) 2016-07-01 2018-05-29 Res Usa, Llc Conversion of methane to dimethyl ether
US10189763B2 (en) 2016-07-01 2019-01-29 Res Usa, Llc Reduction of greenhouse gas emission

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003072552A1 (fr) * 2002-02-22 2003-09-04 Teva Pharmaceutical Industries Ltd. Procede servant a la preparation de chlorure de benzisoxazole methane sulfonyle et a son amidation pour former un zonisamide
WO2004063173A1 (fr) * 2003-01-10 2004-07-29 Dipharma S.P.A. Procede de preparation d'acide methanesulfonique benzo[d]isoxazol-3-yle et ses intermediaires
DE60331257D1 (de) 2003-01-13 2010-03-25 Dainippon Sumitomo Pharma Co Verfahren zur herstellung von 1,2-dichlorethan freien kristallen von zonisamid und hochreinezonisamidkristalle
WO2005030738A1 (fr) * 2003-09-29 2005-04-07 Suven Life Sciences Limited Procede ameliore de fabrication d'intermediaires utilises pour l'obtention de zonisamide
US7745471B2 (en) 2004-06-18 2010-06-29 Chemagis Ltd. Derivatives of 1,2-benzisoxazole-3-methane sulfonic acid as novel intermediates for the synthesis of zonisamide
EP1935888A4 (fr) * 2005-09-16 2011-07-13 Dainippon Sumitomo Pharma Co Procédé de sulfonation de l' acide 1,2-benzisoxazole-3-acétique
US7375233B2 (en) 2005-12-16 2008-05-20 Apotex Pharmachem Inc. Process for the preparation of zonisamide and the intermediates thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6033114B2 (ja) * 1976-12-16 1985-08-01 大日本製薬株式会社 １，２−ベンズイソキサゾ−ル誘導体
US4172896A (en) * 1978-06-05 1979-10-30 Dainippon Pharmaceutical Co., Ltd. Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same
FR2428033A1 (fr) * 1978-06-09 1980-01-04 Dainippon Pharmaceutical Co Nouveaux derives heterocycliques de methanesulfonamide utiles notamment comme anticonvulsivants et leur procede de preparation
JPS54163570A (en) * 1978-06-12 1979-12-26 Dainippon Pharmaceutical Co Benzooxazole derivative
JPS54163823A (en) * 1978-06-12 1979-12-26 Dainippon Pharmaceutical Co Antiiepileptic agent based on 33sulphamoylmethyll 1*22benzisoxazole
IL157709A0 (en) * 2001-03-02 2004-03-28 Teva Pharma Process for the preparation of 1,2-benzisoxazole-3-acetic acid

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9938217B2 (en) 2016-07-01 2018-04-10 Res Usa, Llc Fluidized bed membrane reactor
US9981896B2 (en) 2016-07-01 2018-05-29 Res Usa, Llc Conversion of methane to dimethyl ether
US10189763B2 (en) 2016-07-01 2019-01-29 Res Usa, Llc Reduction of greenhouse gas emission

Also Published As

Publication number Publication date
EP1430037A4 (fr) 2004-11-17
EP1430037A1 (fr) 2004-06-23
IL158239A0 (en) 2004-05-12
JP2005506980A (ja) 2005-03-10
WO2003020708A1 (fr) 2003-03-13

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued