CA2458388A1 - Novel benzothiazine derivatives, their preparation and use - Google Patents
Novel benzothiazine derivatives, their preparation and use Download PDFInfo
- Publication number
- CA2458388A1 CA2458388A1 CA002458388A CA2458388A CA2458388A1 CA 2458388 A1 CA2458388 A1 CA 2458388A1 CA 002458388 A CA002458388 A CA 002458388A CA 2458388 A CA2458388 A CA 2458388A CA 2458388 A1 CA2458388 A1 CA 2458388A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- cycloalkyl
- sulfonyl
- nr9r8
- benzo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- UJVBZCCNLAAMOV-UHFFFAOYSA-N 2h-1,2-benzothiazine Chemical class C1=CC=C2C=CNSC2=C1 UJVBZCCNLAAMOV-UHFFFAOYSA-N 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 13
- -1 hydroxy, amino Chemical group 0.000 claims description 70
- 125000000217 alkyl group Chemical group 0.000 claims description 69
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- 239000001257 hydrogen Substances 0.000 claims description 43
- 229910052739 hydrogen Inorganic materials 0.000 claims description 43
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 42
- 229920006395 saturated elastomer Polymers 0.000 claims description 39
- 125000000623 heterocyclic group Chemical group 0.000 claims description 35
- 125000003342 alkenyl group Chemical group 0.000 claims description 33
- 125000000304 alkynyl group Chemical group 0.000 claims description 32
- 150000003839 salts Chemical class 0.000 claims description 28
- 125000003118 aryl group Chemical group 0.000 claims description 25
- 125000001072 heteroaryl group Chemical group 0.000 claims description 25
- 229910052736 halogen Inorganic materials 0.000 claims description 23
- 150000002367 halogens Chemical group 0.000 claims description 23
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 23
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- DKONITGDYUPUBA-UHFFFAOYSA-N 3-cyclopentyl-7-piperidin-1-ylsulfonyl-3,4-dihydro-2h-1$l^{6},2-benzothiazine 1,1-dioxide Chemical compound C=1C=C2CC(C3CCCC3)NS(=O)(=O)C2=CC=1S(=O)(=O)N1CCCCC1 DKONITGDYUPUBA-UHFFFAOYSA-N 0.000 claims description 2
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200101498 | 2001-10-10 | ||
| DKPA200101498 | 2001-10-10 | ||
| PCT/DK2002/000654 WO2003031422A1 (en) | 2001-10-10 | 2002-10-02 | Novel benzothiazine derivatives, their preparation and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2458388A1 true CA2458388A1 (en) | 2003-04-17 |
Family
ID=8160760
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002458388A Abandoned CA2458388A1 (en) | 2001-10-10 | 2002-10-02 | Novel benzothiazine derivatives, their preparation and use |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7199118B2 (https=) |
| EP (1) | EP1436270A1 (https=) |
| JP (1) | JP2005508352A (https=) |
| CN (1) | CN1275951C (https=) |
| CA (1) | CA2458388A1 (https=) |
| MX (1) | MXPA04003297A (https=) |
| NZ (1) | NZ531511A (https=) |
| WO (1) | WO2003031422A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3547859B2 (ja) * | 1995-07-14 | 2004-07-28 | 愛知機械工業株式会社 | ２方向差動クラッチ |
| FR2856064B1 (fr) * | 2003-06-13 | 2005-08-19 | Servier Lab | Nouveaux derives de benzothiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2879201B1 (fr) * | 2004-12-10 | 2007-02-16 | Servier Lab | Nouveaux derives de benzothiazine et benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2933698A1 (fr) | 2008-07-09 | 2010-01-15 | Servier Lab | Nouveaux derives de benzothiadiazines cycloalkylees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| FR2955107B1 (fr) * | 2010-01-08 | 2012-03-02 | Servier Lab | Nouveaux derives thiochromanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US9150591B2 (en) | 2010-08-10 | 2015-10-06 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
| CR20220160A (es) | 2019-09-16 | 2022-06-16 | Takeda Pharmaceuticals Co | Derivados de piridazin-3(2h)-ona fusionados con azol |
| CN111393385B (zh) * | 2020-04-15 | 2022-01-18 | 华南理工大学 | 一种苯并噻嗪甲醛衍生物的合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3113075A (en) * | 1960-10-17 | 1963-12-03 | Merck & Co Inc | Heterocyclic compounds |
| DE1302858B (https=) * | 1962-09-21 | 1972-05-04 | ||
| FR1552763A (https=) * | 1963-11-08 | 1969-01-10 | ||
| FR3136M (fr) * | 1963-11-08 | 1965-02-15 | Merck & Co Inc | Nouveaux médicaments diurétiques. |
| CN1293665A (zh) * | 1998-02-18 | 2001-05-02 | 神经研究公司 | 新化合物及其用作阳性ampa受体调节剂 |
| DE10004572A1 (de) * | 2000-02-02 | 2001-08-09 | Boehringer Ingelheim Pharma | Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
-
2002
- 2002-10-02 MX MXPA04003297A patent/MXPA04003297A/es unknown
- 2002-10-02 CA CA002458388A patent/CA2458388A1/en not_active Abandoned
- 2002-10-02 EP EP02800544A patent/EP1436270A1/en not_active Withdrawn
- 2002-10-02 WO PCT/DK2002/000654 patent/WO2003031422A1/en not_active Ceased
- 2002-10-02 NZ NZ531511A patent/NZ531511A/en unknown
- 2002-10-02 US US10/489,640 patent/US7199118B2/en not_active Expired - Fee Related
- 2002-10-02 CN CNB028195248A patent/CN1275951C/zh not_active Expired - Fee Related
- 2002-10-02 JP JP2003534405A patent/JP2005508352A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003031422A1 (en) | 2003-04-17 |
| EP1436270A1 (en) | 2004-07-14 |
| CN1564817A (zh) | 2005-01-12 |
| JP2005508352A (ja) | 2005-03-31 |
| CN1275951C (zh) | 2006-09-20 |
| MXPA04003297A (es) | 2004-07-23 |
| US20040242571A1 (en) | 2004-12-02 |
| US7199118B2 (en) | 2007-04-03 |
| NZ531511A (en) | 2006-01-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |