CA2445471A1 - Quinuclidine-substituted heteroaromatic compounds as ligands at nicotic acetylcholine receptors - Google Patents

Quinuclidine-substituted heteroaromatic compounds as ligands at nicotic acetylcholine receptors Download PDF

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Publication number
CA2445471A1
CA2445471A1 CA002445471A CA2445471A CA2445471A1 CA 2445471 A1 CA2445471 A1 CA 2445471A1 CA 002445471 A CA002445471 A CA 002445471A CA 2445471 A CA2445471 A CA 2445471A CA 2445471 A1 CA2445471 A1 CA 2445471A1
Authority
CA
Canada
Prior art keywords
azabicyclo
oct
carboxamide
disease
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002445471A
Other languages
English (en)
French (fr)
Inventor
Daniel Patrick Walker
Donn G. Wishka
Jeffrey W. Corbett
Mark R. Rauckhorst
David W. Piotrowski
Vincent E. Groppi Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2445471A1 publication Critical patent/CA2445471A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA002445471A 2001-06-12 2002-06-06 Quinuclidine-substituted heteroaromatic compounds as ligands at nicotic acetylcholine receptors Abandoned CA2445471A1 (en)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US29763201P 2001-06-12 2001-06-12
US29763301P 2001-06-12 2001-06-12
US29763101P 2001-06-12 2001-06-12
US29763001P 2001-06-12 2001-06-12
US29762901P 2001-06-12 2001-06-12
US60/297,629 2001-06-12
US60/297,633 2001-06-12
US60/297,632 2001-06-12
US60/297,631 2001-06-12
US60/297,630 2001-06-12
US32854801P 2001-10-11 2001-10-11
US60/328,548 2001-10-11
US37349602P 2002-04-18 2002-04-18
US60/373,496 2002-04-18
PCT/US2002/016570 WO2002100858A2 (en) 2001-06-12 2002-06-06 Quinuclidine-substituted heteroaromatic compounds as ligands at nicotinic acetylcholine receptors

Publications (1)

Publication Number Publication Date
CA2445471A1 true CA2445471A1 (en) 2002-12-19

Family

ID=27569622

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002445471A Abandoned CA2445471A1 (en) 2001-06-12 2002-06-06 Quinuclidine-substituted heteroaromatic compounds as ligands at nicotic acetylcholine receptors

Country Status (8)

Country Link
US (2) US6828330B2 (cg-RX-API-DMAC7.html)
EP (1) EP1404674A2 (cg-RX-API-DMAC7.html)
JP (1) JP2004534065A (cg-RX-API-DMAC7.html)
AR (1) AR036041A1 (cg-RX-API-DMAC7.html)
AU (1) AU2002348503A1 (cg-RX-API-DMAC7.html)
CA (1) CA2445471A1 (cg-RX-API-DMAC7.html)
PE (1) PE20030040A1 (cg-RX-API-DMAC7.html)
WO (1) WO2002100858A2 (cg-RX-API-DMAC7.html)

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Also Published As

Publication number Publication date
WO2002100858A2 (en) 2002-12-19
JP2004534065A (ja) 2004-11-11
EP1404674A2 (en) 2004-04-07
US20040224977A1 (en) 2004-11-11
WO2002100858A8 (en) 2003-12-24
PE20030040A1 (es) 2003-02-14
AU2002348503A8 (en) 2005-10-13
US20030073707A1 (en) 2003-04-17
AU2002348503A1 (en) 2002-12-23
AR036041A1 (es) 2004-08-04
US6828330B2 (en) 2004-12-07
WO2002100858A3 (en) 2003-02-20

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