CA2444123C - Novel arylsulfonamides as antiviral agents - Google Patents

Novel arylsulfonamides as antiviral agents Download PDF

Info

Publication number
CA2444123C
CA2444123C CA2444123A CA2444123A CA2444123C CA 2444123 C CA2444123 C CA 2444123C CA 2444123 A CA2444123 A CA 2444123A CA 2444123 A CA2444123 A CA 2444123A CA 2444123 C CA2444123 C CA 2444123C
Authority
CA
Canada
Prior art keywords
group
hydroxyl
amino
alkyl
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2444123A
Other languages
English (en)
French (fr)
Other versions
CA2444123A1 (en
Inventor
Tobias Wunberg
Wolfgang Bender
Peter Eckenberg
Sabine Hallenberger
Kerstin Henninger
Joerg Keldenich
Armin Kern
Siegfried Raddatz
Juergen Reefschlaeger
Gunter Schmidt
Holger Zimmermann
Franz Zumpe
Martin Radtke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AIC246 AG and Co KG
Original Assignee
Aicuris GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10148598A external-priority patent/DE10148598A1/de
Application filed by Aicuris GmbH and Co KG filed Critical Aicuris GmbH and Co KG
Publication of CA2444123A1 publication Critical patent/CA2444123A1/en
Application granted granted Critical
Publication of CA2444123C publication Critical patent/CA2444123C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CA2444123A 2001-04-19 2002-04-08 Novel arylsulfonamides as antiviral agents Expired - Lifetime CA2444123C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE10119137 2001-04-19
DE10119137.5 2001-04-19
DE10148598.0 2001-10-02
DE10148598A DE10148598A1 (de) 2001-04-19 2001-10-02 Neue Arylsulfonamide als antivirale Mittel
PCT/EP2002/003858 WO2002085869A1 (de) 2001-04-19 2002-04-08 Arylsulfonamide als antivirale mittel

Publications (2)

Publication Number Publication Date
CA2444123A1 CA2444123A1 (en) 2002-10-31
CA2444123C true CA2444123C (en) 2010-09-21

Family

ID=26009118

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2444123A Expired - Lifetime CA2444123C (en) 2001-04-19 2002-04-08 Novel arylsulfonamides as antiviral agents

Country Status (20)

Country Link
US (1) US7115612B2 (https=)
EP (1) EP1383749B1 (https=)
JP (1) JP4480941B2 (https=)
CN (1) CN1516695A (https=)
AT (1) ATE308529T1 (https=)
BG (1) BG108272A (https=)
BR (1) BR0209054A (https=)
CA (1) CA2444123C (https=)
DE (1) DE50204780D1 (https=)
EE (1) EE200300515A (https=)
ES (1) ES2252455T3 (https=)
HU (1) HUP0303813A3 (https=)
IL (1) IL158324A0 (https=)
MX (1) MXPA03009548A (https=)
NO (1) NO20034667L (https=)
PL (1) PL363990A1 (https=)
RU (1) RU2003133750A (https=)
SK (1) SK12662003A3 (https=)
UY (1) UY27263A1 (https=)
WO (1) WO2002085869A1 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20050168A2 (en) * 2002-08-23 2005-10-31 Rigel Pharmaceuticals Pyridyl substituted heterocycles useful for treating or preventing hcv infection
DE10319612A1 (de) 2003-05-02 2004-11-18 Bayer Healthcare Ag Substituierte Dihydrochinazoline
EP4101846B1 (en) 2003-04-11 2023-08-02 PTC Therapeutics, Inc. 1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease
DE102006009928A1 (de) 2006-03-03 2007-09-06 Aicuris Gmbh & Co. Kg Substituierte Arylsulfonamide
EP2387995A1 (en) 2006-03-30 2011-11-23 PTC Therapeutics, Inc. Methods for the production of functional protein from DNA having a nonsense mutation and the treatment of disorders associated therewith
US20080255203A1 (en) * 2007-04-12 2008-10-16 Abbott Laboratories Heterocyclic compounds and their methods of use
US20100240657A1 (en) * 2007-07-02 2010-09-23 Boehringer Ingelheim International Gmbh Chemical compounds
EP2177521A1 (en) * 2008-10-14 2010-04-21 Almirall, S.A. New 2-Amidothiadiazole Derivatives
EP2202232A1 (en) * 2008-12-26 2010-06-30 Laboratorios Almirall, S.A. 1,2,4-oxadiazole derivatives and their therapeutic use
AR083431A1 (es) * 2010-06-28 2013-02-27 Bayer Cropscience Ag Compuestos heterociclicos como pesticidas
JP2013531687A (ja) 2010-07-16 2013-08-08 パーデュー、ファーマ、リミテッド、パートナーシップ ナトリウムチャネル遮断剤としてのピリジン化合物
WO2013136170A1 (en) 2012-03-16 2013-09-19 Purdue Pharma L.P. Substituted pyridines as sodium channel blockers
US9284310B2 (en) 2012-11-03 2016-03-15 Boehringer Ingelheim International Gmbh Inhibitors of cytomegalovirus
JP6372666B2 (ja) 2012-11-03 2018-08-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング サイトメガロウイルスの阻害剤
WO2014096941A1 (en) 2012-12-20 2014-06-26 Purdue Pharma L.P. Cyclic sulfonamides as sodium channel blockers
TWI695717B (zh) 2014-03-06 2020-06-11 美商 Ptc 治療公司 １,２,４-二唑苯甲酸之鹽及醫藥組合物
US10730866B2 (en) 2014-04-07 2020-08-04 Purdue Pharma L.P. Indole derivatives and use thereof
JP6749344B2 (ja) * 2015-02-13 2020-09-02 アジエンダ・オスペダリエラ・ウニベルシタリア・セネーゼ 治療剤としてのヒトヘリカーゼｄｄｘ３阻害剤
CN108348527A (zh) 2015-10-30 2018-07-31 Ptc医疗公司 用于治疗癫痫的方法
BR112019020252A2 (pt) * 2017-03-31 2020-04-22 Perenna Pharmaceuticals Inc compostos úteis como inibidores de alcat 1

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19802437A1 (de) 1998-01-23 1999-07-29 Bayer Ag Verwendung von substituierten Sulfonamiden als anitvirale Mittel und neue Stoffe
CN1347411A (zh) * 1999-04-19 2002-05-01 盐野义制药株式会社 含有噁二唑环的磺酰胺衍生物

Also Published As

Publication number Publication date
CA2444123A1 (en) 2002-10-31
EE200300515A (et) 2004-02-16
US7115612B2 (en) 2006-10-03
PL363990A1 (en) 2004-11-29
EP1383749A1 (de) 2004-01-28
BG108272A (bg) 2004-10-29
RU2003133750A (ru) 2005-05-10
CN1516695A (zh) 2004-07-28
WO2002085869A1 (de) 2002-10-31
NO20034667D0 (no) 2003-10-17
HUP0303813A2 (hu) 2004-03-29
MXPA03009548A (es) 2004-05-24
UY27263A1 (es) 2002-11-29
BR0209054A (pt) 2004-04-20
US20040176374A1 (en) 2004-09-09
EP1383749B1 (de) 2005-11-02
JP4480941B2 (ja) 2010-06-16
ATE308529T1 (de) 2005-11-15
JP2004531536A (ja) 2004-10-14
DE50204780D1 (de) 2005-12-08
IL158324A0 (en) 2004-05-12
ES2252455T3 (es) 2006-05-16
NO20034667L (no) 2003-12-12
HUP0303813A3 (en) 2005-05-30
SK12662003A3 (sk) 2004-04-06

Similar Documents

Publication Publication Date Title
CA2444123C (en) Novel arylsulfonamides as antiviral agents
AU2016288204B2 (en) Inhibitors of EGFR and methods of use thereof
ES2312471T3 (es) Compuestos de anillo de 5 miembros que contienen nitrogeno.
TWI309648B (en) Novel chemical compounds
CA2605899C (en) Triazole derivatives as vasopressin antagonists
JP5240899B2 (ja) トリアゾロフタラジン
ES2204101T3 (es) Compuestos heterociclicos como inhibidores de enzimas rotomasas.
OA13347A (en) Triazole derivatives as vasopressin antagonists.
AU2010307006A1 (en) Hematopoietic growth factor mimetic small molecule compounds and their uses
OA11450A (en) N-Ä(substituted five-membered di-or triaza diunsaturated ring)carbonylÜ guanidine derivatives for the treatment of ischemia.
AU2007344509A1 (en) 5-([1,3,4] oxadiazol-2-yl)-1H-indazol and 5-([1,3,4] thiadiazol-2-yl)-1H-indazol derivatives as SGK inhibitors for the treatment of diabetes
AU2005307383A1 (en) Amide compound
CA2608718A1 (en) 1, 2, 4-triazole derivatives as vasopressin antagonists
JP2011502984A (ja) サーチュインモジュレーターとしてのアミド誘導体
KR20030088509A (ko) 항바이러스제로서의 신규한 아릴술폰아미드
KR20090014223A (ko) 니코틴성 아세틸콜린 수용체 리간드로서의 2-페닐-5-아미노-1,3,4-옥사디아졸 및 그의 용도
CA2456235C (en) Heterocyclylarylsulphonamides
AU2011297669A1 (en) Heterocyclic compounds as DGAT1 inhibitors
EP4282862A1 (en) Flavivirus inhibitors
WO2023148481A1 (en) Smo modulator compounds
EP4563146A1 (en) Flavivirus inhibitors

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20220408