CA2440238C - Novel amines as histamine-3 receptor ligands and their therapeutic applications - Google Patents

Novel amines as histamine-3 receptor ligands and their therapeutic applications Download PDF

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Publication number
CA2440238C
CA2440238C CA2440238A CA2440238A CA2440238C CA 2440238 C CA2440238 C CA 2440238C CA 2440238 A CA2440238 A CA 2440238A CA 2440238 A CA2440238 A CA 2440238A CA 2440238 C CA2440238 C CA 2440238C
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Canada
Prior art keywords
ethyl
benzofuran
methyl
pyrrolidinyl
pyrrolidin
Prior art date
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Expired - Fee Related
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CA2440238A
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English (en)
French (fr)
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CA2440238A1 (en
Inventor
Marlon D. Cowart
Youssef L. Bennani
Ramin Faghih
Gregory A. Gfesser
Lawrence A. Black
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AbbVie Inc
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Abbott Laboratories
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Publication date
Priority claimed from US09/810,648 external-priority patent/US20020177589A1/en
Priority claimed from US10/044,495 external-priority patent/US20020183309A1/en
Priority claimed from US10/081,207 external-priority patent/US6969730B2/en
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of CA2440238A1 publication Critical patent/CA2440238A1/en
Application granted granted Critical
Publication of CA2440238C publication Critical patent/CA2440238C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07—ORGANIC CHEMISTRY
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
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    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
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    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
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  • Neurology (AREA)
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  • Pain & Pain Management (AREA)
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  • Diabetes (AREA)
  • Hematology (AREA)
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  • Hospice & Palliative Care (AREA)
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  • Anesthesiology (AREA)
  • Communicable Diseases (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2440238A 2001-03-16 2002-03-11 Novel amines as histamine-3 receptor ligands and their therapeutic applications Expired - Fee Related CA2440238C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US09/810,648 2001-03-16
US09/810,648 US20020177589A1 (en) 2001-03-16 2001-03-16 Novel amines as histamine-3 receptor ligands and their therapeutic applications
US10/044,495 2002-01-11
US10/044,495 US20020183309A1 (en) 2001-03-16 2002-01-11 Novel amines as histamine-3 receptor ligands and their therapeutic applications
US10/081,207 US6969730B2 (en) 2001-03-16 2002-02-25 Amines as histamine-3 receptor ligands and their therapeutic applications
US10/081,207 2002-02-25
PCT/US2002/007107 WO2002074758A2 (en) 2001-03-16 2002-03-11 Novel amines as histamine-3 receptor ligands and their therapeutic applications

Publications (2)

Publication Number Publication Date
CA2440238A1 CA2440238A1 (en) 2002-09-26
CA2440238C true CA2440238C (en) 2011-09-13

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CA2440238A Expired - Fee Related CA2440238C (en) 2001-03-16 2002-03-11 Novel amines as histamine-3 receptor ligands and their therapeutic applications

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EP (2) EP2258694A1 (https=)
JP (1) JP4612990B2 (https=)
AR (1) AR035783A1 (https=)
BR (1) BR0205829A (https=)
CA (1) CA2440238C (https=)
MX (1) MXPA03008319A (https=)
WO (1) WO2002074758A2 (https=)

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US7314937B2 (en) 2002-03-21 2008-01-01 Eli Lilly And Company Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses
US6822101B2 (en) 2002-09-16 2004-11-23 Abbott Laboratories Process for preparing amine-substituted benzofurans
US7153889B2 (en) 2002-11-12 2006-12-26 Abbott Laboratories Bicyclic-substituted amines as histamine-3 receptor ligands
JP4820094B2 (ja) * 2002-11-12 2011-11-24 アボット・ラボラトリーズ ヒスタミン−３受容体リガンドとしての２環式置換アミン
US7244852B2 (en) 2003-02-27 2007-07-17 Abbott Laboratories Process for preparing 2-methylpyrrolidine and specific enantiomers thereof
WO2004080966A1 (ja) 2003-03-14 2004-09-23 Ono Pharmaceutical Co., Ltd. 含窒素複素環誘導体およびそれらを有効成分とする薬剤
WO2004089410A1 (ja) * 2003-04-03 2004-10-21 Kyowa Hakko Kogyo Co., Ltd. 神経因性疼痛の予防及び／または治療剤
US20040224952A1 (en) * 2003-05-07 2004-11-11 Cowart Marlon D. Fused bicyclic-substituted amines as histamine-3 receptor ligands
WO2004101559A1 (en) * 2003-05-07 2004-11-25 Abbott Laboratories Fused bicyclic-substituted amines as histamine-3 receptor ligands
US7094790B2 (en) 2003-05-07 2006-08-22 Abbott Laboratories Fused bicyclic-substituted amines as histamine-3 receptor ligands
EP1723126A2 (en) * 2003-10-22 2006-11-22 Eli Lilly And Company Novel mch receptor antagonists
US7435837B2 (en) 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
SE0303480D0 (sv) * 2003-12-19 2003-12-19 Biovitrum Ab Benzofuranes
WO2005085214A1 (ja) * 2004-03-05 2005-09-15 Banyu Pharmaceutical Co., Ltd ジアリール置換複素５員環誘導体
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