CA2439410C - Analogs of thalidomide as potential angiogenesis inhibitors - Google Patents
Analogs of thalidomide as potential angiogenesis inhibitors Download PDFInfo
- Publication number
- CA2439410C CA2439410C CA2439410A CA2439410A CA2439410C CA 2439410 C CA2439410 C CA 2439410C CA 2439410 A CA2439410 A CA 2439410A CA 2439410 A CA2439410 A CA 2439410A CA 2439410 C CA2439410 C CA 2439410C
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- Canada
- Prior art keywords
- pharmaceutically acceptable
- thalidomide
- angiogenesis
- compound
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
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- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US27194101P | 2001-02-27 | 2001-02-27 | |
| US60/271,941 | 2001-02-27 | ||
| PCT/US2002/005868 WO2002068414A2 (en) | 2001-02-27 | 2002-02-26 | Analogs of thalidomide as potential angiogenesis inhibitors |
Publications (2)
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| CA2439410A1 CA2439410A1 (en) | 2002-09-06 |
| CA2439410C true CA2439410C (en) | 2011-09-06 |
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| CA2439410A Expired - Fee Related CA2439410C (en) | 2001-02-27 | 2002-02-26 | Analogs of thalidomide as potential angiogenesis inhibitors |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7320991B2 (https=) |
| EP (1) | EP1389203B8 (https=) |
| JP (2) | JP4361273B2 (https=) |
| AT (1) | ATE450529T1 (https=) |
| AU (1) | AU2002306596B2 (https=) |
| CA (1) | CA2439410C (https=) |
| DE (1) | DE60234585D1 (https=) |
| ES (1) | ES2338534T3 (https=) |
| WO (1) | WO2002068414A2 (https=) |
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| HU228769B1 (en) * | 1996-07-24 | 2013-05-28 | Celgene Corp | Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha |
| US7629360B2 (en) * | 1999-05-07 | 2009-12-08 | Celgene Corporation | Methods for the treatment of cachexia and graft v. host disease |
| US6458810B1 (en) | 2000-11-14 | 2002-10-01 | George Muller | Pharmaceutically active isoindoline derivatives |
| ATE374609T1 (de) * | 2000-11-30 | 2007-10-15 | Childrens Medical Center | Synthese von 4-aminothalidomid enantiomeren |
| US7320991B2 (en) | 2001-02-27 | 2008-01-22 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health | Analogs of thalidomide as potential angiogenesis inhibitors |
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| JP2004523561A (ja) | 2004-08-05 |
| US7320991B2 (en) | 2008-01-22 |
| EP1389203B1 (en) | 2009-12-02 |
| US20040077685A1 (en) | 2004-04-22 |
| US20070293519A1 (en) | 2007-12-20 |
| WO2002068414A2 (en) | 2002-09-06 |
| JP2009263376A (ja) | 2009-11-12 |
| WO2002068414A8 (en) | 2010-02-25 |
| AU2002306596B2 (en) | 2008-01-17 |
| EP1389203A2 (en) | 2004-02-18 |
| JP4361273B2 (ja) | 2009-11-11 |
| ATE450529T1 (de) | 2009-12-15 |
| US8716315B2 (en) | 2014-05-06 |
| WO2002068414A3 (en) | 2002-10-17 |
| EP1389203B8 (en) | 2010-03-10 |
| ES2338534T3 (es) | 2010-05-10 |
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