CA2438813C - Alkoxycarbonylamino heteroaryl carboxylic acid derivatives as ip antagonists - Google Patents

Alkoxycarbonylamino heteroaryl carboxylic acid derivatives as ip antagonists Download PDF

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Publication number
CA2438813C
CA2438813C CA002438813A CA2438813A CA2438813C CA 2438813 C CA2438813 C CA 2438813C CA 002438813 A CA002438813 A CA 002438813A CA 2438813 A CA2438813 A CA 2438813A CA 2438813 C CA2438813 C CA 2438813C
Authority
CA
Canada
Prior art keywords
compound
phenyl
formula
group
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002438813A
Other languages
English (en)
French (fr)
Other versions
CA2438813A1 (en
Inventor
Francisco Javier Lopez-Tapia
Dov Nitzan
Counde O'yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2438813A1 publication Critical patent/CA2438813A1/en
Application granted granted Critical
Publication of CA2438813C publication Critical patent/CA2438813C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002438813A 2001-03-02 2002-02-25 Alkoxycarbonylamino heteroaryl carboxylic acid derivatives as ip antagonists Expired - Fee Related CA2438813C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US27284901P 2001-03-02 2001-03-02
US60/272,849 2001-03-02
PCT/EP2002/001942 WO2002070514A1 (en) 2001-03-02 2002-02-25 Alkoxycarbonylamino heteroaryl carboxylic acid derivatives as ip antagonists

Publications (2)

Publication Number Publication Date
CA2438813A1 CA2438813A1 (en) 2002-09-12
CA2438813C true CA2438813C (en) 2008-07-29

Family

ID=23041569

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002438813A Expired - Fee Related CA2438813C (en) 2001-03-02 2002-02-25 Alkoxycarbonylamino heteroaryl carboxylic acid derivatives as ip antagonists

Country Status (14)

Country Link
US (1) US6569860B2 (enExample)
EP (1) EP1368345B1 (enExample)
JP (1) JP2004526721A (enExample)
KR (1) KR100589990B1 (enExample)
CN (1) CN1280289C (enExample)
AR (1) AR033429A1 (enExample)
AT (1) ATE321041T1 (enExample)
BR (1) BR0207730A (enExample)
CA (1) CA2438813C (enExample)
DE (1) DE60210058T2 (enExample)
ES (1) ES2260425T3 (enExample)
MX (1) MXPA03007864A (enExample)
WO (1) WO2002070514A1 (enExample)
ZA (1) ZA200306283B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040054008A1 (en) * 2002-09-13 2004-03-18 Tohru Araki Medicament for treatment of nocturia
JP2006517576A (ja) * 2003-02-14 2006-07-27 メディカル リサーチ カウンシル 病理的子宮症状の治療のためのｉｐレセプターアンタゴニスト
US7262313B2 (en) * 2005-10-20 2007-08-28 Lg Chem, Ltd. Organic silane compound
KR100840114B1 (ko) * 2005-10-20 2008-06-19 주식회사 엘지화학 점착제 조성물
AR069650A1 (es) * 2007-12-14 2010-02-10 Actelion Pharmaceuticals Ltd Derivados de aminopirazol como agonistas no peptidicos del receptor alx humano
US9295665B2 (en) 2013-03-12 2016-03-29 Allergan, Inc. Inhibition of neovascularization by simultaneous inhibition of prostanoid IP and EP4 receptors
WO2014143592A1 (en) 2013-03-12 2014-09-18 Allergan, Inc. Inhibition of neovascularization by inhibition of prostanoid ip receptors
RS63124B1 (sr) 2018-03-08 2022-05-31 Incyte Corp Aminopirazin diol jedinjenja kao pi3k-y inhibitori
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
EP4119138A1 (en) * 2021-07-12 2023-01-18 Universität Hamburg Dhodh inhibitors and their use as antiviral agents

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5908842A (en) 1995-12-08 1999-06-01 Merck & Co., Inc. Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase
US6184242B1 (en) 1997-09-04 2001-02-06 Syntex Usa (Llc) 2-(substituted-phenyl)amino-imidazoline derivatives
WO1999026925A1 (en) * 1997-11-26 1999-06-03 Yoshitomi Pharmaceutical Industries, Ltd. Tryptase inhibitors comprising heterocyclic amide compounds
HUP0104026A3 (en) * 1998-10-06 2002-06-28 Dainippon Pharmaceutical Co 2,3-disubstituted pyridine derivatives, process for the preparation thereof, drug compositions containing the same and intermediates for the preparation
US6335459B1 (en) * 1998-12-23 2002-01-01 Syntex (U.S.A.) Llc Aryl carboxylic acid and aryl tetrazole derivatives as IP receptor modulators
HUP0203542A3 (en) * 1999-08-12 2003-07-28 Upjohn Co 3(5)-amino-pyrazole derivatives, process for their preparation, their use and pharmaceutical compositions containing the same
EP1265853A1 (en) * 2000-03-16 2002-12-18 F. Hoffmann-La Roche AG Carboxylic acid derivatives as ip antagonists

Also Published As

Publication number Publication date
BR0207730A (pt) 2004-03-23
ZA200306283B (en) 2004-11-15
ES2260425T3 (es) 2006-11-01
CN1280289C (zh) 2006-10-18
EP1368345A1 (en) 2003-12-10
AR033429A1 (es) 2003-12-17
CA2438813A1 (en) 2002-09-12
MXPA03007864A (es) 2003-12-04
DE60210058T2 (de) 2006-11-09
DE60210058D1 (de) 2006-05-11
WO2002070514A1 (en) 2002-09-12
US6569860B2 (en) 2003-05-27
ATE321041T1 (de) 2006-04-15
KR100589990B1 (ko) 2006-06-15
EP1368345B1 (en) 2006-03-22
US20020169171A1 (en) 2002-11-14
JP2004526721A (ja) 2004-09-02
CN1494544A (zh) 2004-05-05
KR20030078962A (ko) 2003-10-08

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