CA2438707A1 - Preparation contenant un mucopolysaccharide et son procede de production - Google Patents
Preparation contenant un mucopolysaccharide et son procede de production Download PDFInfo
- Publication number
- CA2438707A1 CA2438707A1 CA002438707A CA2438707A CA2438707A1 CA 2438707 A1 CA2438707 A1 CA 2438707A1 CA 002438707 A CA002438707 A CA 002438707A CA 2438707 A CA2438707 A CA 2438707A CA 2438707 A1 CA2438707 A1 CA 2438707A1
- Authority
- CA
- Canada
- Prior art keywords
- mucopolysaccharide
- formulation
- absorption enhancer
- formulation according
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
Abstract
On produit une préparation entérique à administrer par voie orale, contenant un mucopolysaccharide, en utilisant un agent augmentant l'absorption pour le mucopolysaccharide, comprenant un acide gras possédant 6 à 14 atomes de carbone ou un sel, un ester ou un dérivé amide de celui-ci ; de l'acide carboxylique stéroïde, ou un sel, un ester ou un dérivé amide de celui-ci ; et un acide polybasique aliphatique, ou un sel, un ester ou un dérivé amide de celui-ci ; ou des mélanges de ceux-ci. Ledit mucopolysaccharide a seulement été administré dans des préparations à injecter et la concentration effective dans le sang de mucopolysaccharide n'a pas été obtenue par administration orale.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001040661 | 2001-02-16 | ||
JP2001-40661 | 2001-02-16 | ||
JP2001299632 | 2001-09-28 | ||
JP2001-299632 | 2001-09-28 | ||
PCT/JP2002/001299 WO2002064148A2 (fr) | 2001-02-16 | 2002-02-15 | Preparation contenant un mucopolysaccharide et son procede de production |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2438707A1 true CA2438707A1 (fr) | 2002-08-22 |
Family
ID=26609566
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002438707A Abandoned CA2438707A1 (fr) | 2001-02-16 | 2002-02-15 | Preparation contenant un mucopolysaccharide et son procede de production |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1390048A2 (fr) |
JP (1) | JP2004525110A (fr) |
KR (1) | KR20040018333A (fr) |
CA (1) | CA2438707A1 (fr) |
WO (1) | WO2002064148A2 (fr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7658938B2 (en) | 1999-02-22 | 2010-02-09 | Merrion Reasearch III Limited | Solid oral dosage form containing an enhancer |
US11207805B2 (en) | 2001-10-12 | 2021-12-28 | Aquestive Therapeutics, Inc. | Process for manufacturing a resulting pharmaceutical film |
US20190328679A1 (en) | 2001-10-12 | 2019-10-31 | Aquestive Therapeutics, Inc. | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
US8603514B2 (en) | 2002-04-11 | 2013-12-10 | Monosol Rx, Llc | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
US20110033542A1 (en) | 2009-08-07 | 2011-02-10 | Monosol Rx, Llc | Sublingual and buccal film compositions |
US10285910B2 (en) | 2001-10-12 | 2019-05-14 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
US8765167B2 (en) | 2001-10-12 | 2014-07-01 | Monosol Rx, Llc | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
US7357891B2 (en) | 2001-10-12 | 2008-04-15 | Monosol Rx, Llc | Process for making an ingestible film |
DE10332160A1 (de) | 2003-07-15 | 2005-02-03 | Röhm GmbH & Co. KG | Multipartikuläre Arzneiform, enthaltend mucoadhaesiv formulierte Peptid- oder Protein-Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform |
BRPI0710503A2 (pt) | 2006-04-07 | 2011-08-16 | Merrion Res Iii Ltd | uso de uma composição farmacêutica, composição farmacêutica, e, forma de dosagem oral |
CA2723541A1 (fr) | 2008-05-07 | 2009-11-12 | Merrion Research Iii Limited | Compositions de peptides et leurs procedes de preparation |
JP4630931B2 (ja) * | 2009-03-10 | 2011-02-09 | 有限会社エヌアール・ラボラトリー | 消化管溶性剤型 |
WO2011120033A1 (fr) | 2010-03-26 | 2011-09-29 | Merrion Research Iii Limited | Compositions pharmaceutiques d'inhibiteurs de facteur xa sélectifs destinées à une administration orale |
IT1400232B1 (it) * | 2010-05-07 | 2013-05-24 | Advance Holdings Ltd | Composizione farmaceutica topica comprendente eparina |
KR101005981B1 (ko) * | 2010-08-13 | 2011-01-05 | 이흥재 | 핸들부를 앞뒤로 왕복시키는 동작으로 전륜을 구동하는 자전거 |
US9149959B2 (en) | 2010-10-22 | 2015-10-06 | Monosol Rx, Llc | Manufacturing of small film strips |
BR112013014940A2 (pt) * | 2010-12-15 | 2016-09-13 | Merrion Reserarch Iii Ltd | composições farmacêuticas de inibidores de fator xa seletivos para administração oral |
BR112013017169A2 (pt) | 2011-01-07 | 2016-10-04 | Merrion Res Iii Ltd | composições farmacêuticas de ferro para administração oral |
EP2834635A4 (fr) * | 2012-04-03 | 2015-09-02 | Smiths Medical Asd Inc | Compositions d'agents de charge d'héparine et procédés associés |
ITMI20130682A1 (it) * | 2013-04-24 | 2014-10-25 | Giuliani Spa | Forme di dosaggio per la somministrazione orale di sostanze attive |
EP3250191B1 (fr) | 2015-01-29 | 2024-01-17 | Novo Nordisk A/S | Comprimés contenant un agoniste de glp-1 et revêtement gastro-résistant |
US11273131B2 (en) | 2016-05-05 | 2022-03-15 | Aquestive Therapeutics, Inc. | Pharmaceutical compositions with enhanced permeation |
KR20230137362A (ko) | 2016-05-05 | 2023-10-04 | 어퀘스티브 테라퓨틱스, 아이엔씨. | 강화된 전달 에프네프린 조성물 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1245761B (it) * | 1991-01-30 | 1994-10-14 | Alfa Wassermann Spa | Formulazioni farmaceutiche contenenti glicosaminoglicani assorbibili per via orale. |
GB9516268D0 (en) * | 1995-08-08 | 1995-10-11 | Danbiosyst Uk | Compositiion for enhanced uptake of polar drugs from the colon |
US7097851B1 (en) * | 1998-11-27 | 2006-08-29 | Kanji Takada | Oral formulation for gastrointestinal drug delivery |
WO2000050012A1 (fr) * | 1999-02-22 | 2000-08-31 | Elan Corporation, Plc | Dose orale solide contenant un agent de potentialisation |
US6458383B2 (en) * | 1999-08-17 | 2002-10-01 | Lipocine, Inc. | Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin |
-
2002
- 2002-02-15 WO PCT/JP2002/001299 patent/WO2002064148A2/fr not_active Application Discontinuation
- 2002-02-15 KR KR10-2003-7010649A patent/KR20040018333A/ko not_active Application Discontinuation
- 2002-02-15 CA CA002438707A patent/CA2438707A1/fr not_active Abandoned
- 2002-02-15 JP JP2002563941A patent/JP2004525110A/ja active Pending
- 2002-02-15 EP EP02712385A patent/EP1390048A2/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
WO2002064148A3 (fr) | 2002-11-21 |
KR20040018333A (ko) | 2004-03-03 |
WO2002064148A2 (fr) | 2002-08-22 |
JP2004525110A (ja) | 2004-08-19 |
EP1390048A2 (fr) | 2004-02-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |