CA2435812C - Process and compositions for peptide, protein and peptidomimetic synthesis - Google Patents
Process and compositions for peptide, protein and peptidomimetic synthesis Download PDFInfo
- Publication number
- CA2435812C CA2435812C CA2435812A CA2435812A CA2435812C CA 2435812 C CA2435812 C CA 2435812C CA 2435812 A CA2435812 A CA 2435812A CA 2435812 A CA2435812 A CA 2435812A CA 2435812 C CA2435812 C CA 2435812C
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- CA
- Canada
- Prior art keywords
- translation system
- peptidomimetic
- translation
- amino acid
- trna
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- Expired - Lifetime
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- 235000007586 terpenes Nutrition 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 150000007970 thio esters Chemical class 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 108091006106 transcriptional activators Proteins 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 102000035160 transmembrane proteins Human genes 0.000 description 1
- 108091005703 transmembrane proteins Proteins 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
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- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
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- 230000029663 wound healing Effects 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1062—Isolating an individual clone by screening libraries mRNA-Display, e.g. polypeptide and encoding template are connected covalently
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Computational Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26414701P | 2001-01-25 | 2001-01-25 | |
| US60/264,147 | 2001-01-25 | ||
| PCT/US2002/002344 WO2002059293A2 (en) | 2001-01-25 | 2002-01-25 | Process and compositions for peptide, protein and peptidomimetic synthesis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2435812A1 CA2435812A1 (en) | 2002-08-01 |
| CA2435812C true CA2435812C (en) | 2012-03-27 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2435812A Expired - Lifetime CA2435812C (en) | 2001-01-25 | 2002-01-25 | Process and compositions for peptide, protein and peptidomimetic synthesis |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6977150B2 (https=) |
| EP (1) | EP1356036B1 (https=) |
| JP (2) | JP2004531225A (https=) |
| AT (1) | ATE394482T1 (https=) |
| CA (1) | CA2435812C (https=) |
| DE (1) | DE60226411D1 (https=) |
| WO (1) | WO2002059293A2 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4061043B2 (ja) | 2000-12-28 | 2008-03-12 | 株式会社ポストゲノム研究所 | ｉｎｖｉｔｒｏ転写／翻訳系によるペプチド等の製造方法 |
| AU2003225085A1 (en) * | 2002-04-19 | 2003-11-03 | California Institute Of Technology | Unnatural amino acid containing display libraries |
| WO2004110964A2 (en) * | 2003-06-16 | 2004-12-23 | Nuevolution A/S | Encoded molecules by translation (emt) |
| EP2327724A3 (en) | 2004-02-02 | 2011-07-27 | Ambrx, Inc. | Modified human growth hormone polypeptides and their uses |
| WO2007139573A1 (en) * | 2006-05-31 | 2007-12-06 | The Trustees Of Columbia University In The City Of New York | Ribosome and rna display of biologically active small molecules |
| WO2007140471A2 (en) * | 2006-05-31 | 2007-12-06 | The Trustees Of Columbia University In The City Of New York | Ribosome and rna display of biologically active small molecules |
| WO2008005529A2 (en) | 2006-07-07 | 2008-01-10 | The Trustees Columbia University In The City Of New York | Cell-mediated directed evolution |
| US9182406B2 (en) | 2008-08-04 | 2015-11-10 | Biodesy, Inc. | Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability |
| CN102348807B (zh) * | 2009-01-12 | 2015-04-15 | 苏特罗生物制药公司 | 利用体外蛋白合成体系将非天然氨基酸引入蛋白的单装载体系 |
| CA2843955A1 (en) | 2011-08-01 | 2013-02-07 | The General Hospital Corporation | Protein and peptide libraries |
| JP6421122B2 (ja) | 2012-10-12 | 2018-11-07 | ストロ バイオファーマ， インコーポレイテッド | 改善された発現のための、細菌抽出物中の選択タンパク質のタンパク質分解不活性化 |
| WO2014189768A1 (en) * | 2013-05-19 | 2014-11-27 | The Board Of Trustees Of The Leland | Devices and methods for display of encoded peptides, polypeptides, and proteins on dna |
| WO2015084867A1 (en) | 2013-12-02 | 2015-06-11 | Brandeis University | Multivalent glycopeptides that tightly bind to target proteins |
| EP3237906B8 (en) | 2014-12-23 | 2020-10-28 | Bluelight Therapeutics, Inc. | Attachment of proteins to interfaces for use in nonlinear optical detection |
| EP3274459A4 (en) * | 2015-03-27 | 2018-08-22 | The University of Queensland | Platform for non-natural amino acid incorporation into proteins |
| US11174479B2 (en) | 2018-08-13 | 2021-11-16 | The Board Of Trustees Of The Leland Stanford Junior University | Devices and methods for display of encoded peptides, PolyPeptides, and proteins on DNA |
| BR112022002365A2 (pt) | 2019-08-09 | 2022-04-26 | Nutcracker Therapeutics Inc | Métodos e aparelhos para fabricar e para remover material de uma composição terapêutica |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU8124694A (en) | 1993-10-29 | 1995-05-22 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
| US5643722A (en) * | 1994-05-11 | 1997-07-01 | Trustees Of Boston University | Methods for the detection and isolation of proteins |
| JP4061043B2 (ja) * | 2000-12-28 | 2008-03-12 | 株式会社ポストゲノム研究所 | ｉｎｖｉｔｒｏ転写／翻訳系によるペプチド等の製造方法 |
-
2002
- 2002-01-25 DE DE60226411T patent/DE60226411D1/de not_active Expired - Lifetime
- 2002-01-25 JP JP2002559580A patent/JP2004531225A/ja active Pending
- 2002-01-25 EP EP02724888A patent/EP1356036B1/en not_active Expired - Lifetime
- 2002-01-25 AT AT02724888T patent/ATE394482T1/de not_active IP Right Cessation
- 2002-01-25 CA CA2435812A patent/CA2435812C/en not_active Expired - Lifetime
- 2002-01-25 WO PCT/US2002/002344 patent/WO2002059293A2/en not_active Ceased
- 2002-01-25 US US10/057,783 patent/US6977150B2/en not_active Expired - Lifetime
-
2010
- 2010-07-02 JP JP2010152192A patent/JP4972191B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1356036A2 (en) | 2003-10-29 |
| WO2002059293A3 (en) | 2003-05-30 |
| WO2002059293A2 (en) | 2002-08-01 |
| US6977150B2 (en) | 2005-12-20 |
| JP2010259440A (ja) | 2010-11-18 |
| ATE394482T1 (de) | 2008-05-15 |
| US20040091955A1 (en) | 2004-05-13 |
| DE60226411D1 (de) | 2008-06-19 |
| AU2002255488A2 (en) | 2002-08-06 |
| JP4972191B2 (ja) | 2012-07-11 |
| CA2435812A1 (en) | 2002-08-01 |
| EP1356036B1 (en) | 2008-05-07 |
| JP2004531225A (ja) | 2004-10-14 |
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Effective date: 20220125 |