CA2424021A1 - Catecholamine compositions and uses thereof - Google Patents
Catecholamine compositions and uses thereof Download PDFInfo
- Publication number
- CA2424021A1 CA2424021A1 CA002424021A CA2424021A CA2424021A1 CA 2424021 A1 CA2424021 A1 CA 2424021A1 CA 002424021 A CA002424021 A CA 002424021A CA 2424021 A CA2424021 A CA 2424021A CA 2424021 A1 CA2424021 A1 CA 2424021A1
- Authority
- CA
- Canada
- Prior art keywords
- pharmaceutical composition
- complement
- composition according
- ascorbate
- mixtures
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 150000003943 catecholamines Chemical class 0.000 title claims abstract description 42
- 238000000034 method Methods 0.000 claims abstract description 186
- 150000001875 compounds Chemical class 0.000 claims abstract description 180
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- 230000001800 adrenalinergic effect Effects 0.000 claims abstract description 155
- 230000000295 complement effect Effects 0.000 claims abstract description 145
- 235000010323 ascorbic acid Nutrition 0.000 claims abstract description 92
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 91
- 239000011668 ascorbic acid Substances 0.000 claims abstract description 88
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- PYMYPHUHKUWMLA-LMVFSUKVSA-N aldehydo-D-ribose Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims abstract description 56
- 238000011282 treatment Methods 0.000 claims abstract description 51
- 239000002253 acid Substances 0.000 claims abstract description 41
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- 150000003835 adenosine derivatives Chemical class 0.000 claims abstract description 28
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- WYWIFABBXFUGLM-UHFFFAOYSA-N oxymetazoline Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C)=C1CC1=NCCN1 WYWIFABBXFUGLM-UHFFFAOYSA-N 0.000 claims description 22
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- DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical compound C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 claims description 10
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- URLZCHNOLZSCCA-VABKMULXSA-N Leu-enkephalin Chemical class C([C@@H](C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 URLZCHNOLZSCCA-VABKMULXSA-N 0.000 claims description 9
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- A—HUMAN NECESSITIES
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
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- Pregnancy & Childbirth (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US23675100P | 2000-09-29 | 2000-09-29 | |
| US60/236,751 | 2000-09-29 | ||
| PCT/US2001/030272 WO2002026223A2 (en) | 2000-09-29 | 2001-09-27 | Catecholamine pharmaceutical compositions and methods |
Publications (1)
| Publication Number | Publication Date |
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| CA2424021A1 true CA2424021A1 (en) | 2002-04-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002424021A Abandoned CA2424021A1 (en) | 2000-09-29 | 2001-09-27 | Catecholamine compositions and uses thereof |
Country Status (6)
| Country | Link |
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| US (1) | US20030216413A1 (https=) |
| EP (1) | EP1326642A2 (https=) |
| JP (1) | JP2004509920A (https=) |
| AU (1) | AU2001294808A1 (https=) |
| CA (1) | CA2424021A1 (https=) |
| WO (1) | WO2002026223A2 (https=) |
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| DE10162704A1 (de) * | 2001-12-19 | 2003-07-10 | Gruenenthal Gmbh | Verwendung von Buprenorphin zur Therapie der Harninkontinenz |
| DE10141650C1 (de) | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
| EP1613266A4 (en) * | 2003-04-15 | 2009-05-06 | Theraquest Biosciences Llc | METHOD FOR TREATING PAIN AND COMPOSITIONS FOR USE THEREOF |
| DE102004008375B4 (de) * | 2004-02-20 | 2007-09-06 | Jaewak Gmbh | Verwendung von physiologisch verträglichen Ascorbatverbindungen in Kombination mit einem Sympathomimetikum als lokales Therapeutikum für Schleimhäute der Atemwege |
| WO2005123064A1 (en) * | 2004-06-10 | 2005-12-29 | Board Of Trustees Of Michigan State University | Adrenergic complement inhaler comprising compounds such as ascorbates tocopherols or polycaboxylic acid chelators |
| US20060045852A1 (en) * | 2004-08-26 | 2006-03-02 | Ortner Gerard T Jr | Materials and methods for tooth surface preparation for dental bonding |
| DE102004049008A1 (de) | 2004-10-05 | 2006-04-06 | Merck Patent Gmbh | Neue Verwendung für α-Sympathomimetika mit 2-Imidazolinstruktur |
| US20060189698A1 (en) * | 2005-02-24 | 2006-08-24 | Check Jerome H | Treatment of interstitial cystitis |
| JP2008537961A (ja) * | 2005-04-15 | 2008-10-02 | ボード、オブ、トラスティーズ、オブ、ミシガン、ステイト、ユニバーシティ | Ｇｐｃｒモジュレーター |
| JP2009506080A (ja) * | 2005-08-30 | 2009-02-12 | クィーンズ ユニバーシティー アット キングストン | 超低用量のα−２−受容体アンタゴニストを用いる、オピオイド受容体アゴニストの治療作用の増強方法および／またはオピオイド受容体アゴニストに対する耐性の阻害方法もしくは逆転方法 |
| US20160045457A1 (en) | 2005-09-09 | 2016-02-18 | Ousama Rachid | Epinephrine fine particles and methods for use thereof for treatment of conditions responsive to epinephrine |
| US9877921B2 (en) | 2005-09-09 | 2018-01-30 | Nova Southeastern University | Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine |
| WO2011109340A1 (en) | 2010-03-01 | 2011-09-09 | Nova Southeastern University | Epinephrine nanop articles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine |
| TW200800142A (en) * | 2005-09-09 | 2008-01-01 | Univ Manitoba | Fast-disintegrating epinephrine tablets for buccal or sublingual administration |
| US20070293581A1 (en) * | 2006-06-05 | 2007-12-20 | Malcolm Hill | Methods for Buccal, Lingual or Sublingual Dosing Regimens of Epinephrine for the Treatment of Allergic Emergencies |
| US20070293582A1 (en) * | 2006-06-05 | 2007-12-20 | Malcolm Hill | Epinephrine dosing regimens comprising buccal, lingual or sublingual and injectable dosage forms |
| EP2014288A1 (en) * | 2007-07-10 | 2009-01-14 | Laboratorios del Dr. Esteve S.A. | Combination of benzyl-4, 5-dihydro-1H-imidazole derivative and an opioid receptor ligand |
| ES2350439B1 (es) * | 2007-07-10 | 2011-10-17 | Laboratorios Del Dr. Esteve, S.A. | Combinacion de un derivado del bencil-4,5-dihidro 1h-imidazol y un receptor opioide. |
| US20110105449A1 (en) * | 2007-11-07 | 2011-05-05 | Astrazeneca R&D | Dry powder formulations comprising ascorbic acid derivates |
| RU2527680C2 (ru) | 2009-06-04 | 2014-09-10 | Альк Аг | Стабилизированная композиция, содержащая по меньшей мере одно адренергическое соединение |
| US8628805B2 (en) * | 2009-06-04 | 2014-01-14 | Alk Ag | Stabilized composition comprising at least one adrenergic compound |
| WO2011133226A2 (en) * | 2010-04-22 | 2011-10-27 | The Board Of Trustees Of The Leland Stanford Junior University | Method for enhancing learning and memory impaired by neurodegenerative disorders and compounds and compositions for effecting the same |
| US20120225918A1 (en) * | 2011-03-03 | 2012-09-06 | Voom, Llc | Compositions and Methods for Non-Surgical Treatment of Ptosis |
| PE20142043A1 (es) * | 2011-09-27 | 2014-12-18 | Univ Virginia Commonwealth | Enfoque metabolico selectivo para aumentar la biodisponibilidad oral de la fenilefrina y otros bioactivos metabolicos |
| CA2853084C (en) | 2011-10-21 | 2022-04-26 | Nova Southeastern University | Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine |
| CA3169368A1 (en) | 2012-06-15 | 2014-01-09 | Nova Southeastern University | Epinephrine nanoparticles, methods of fabrication thereof, and methods for use thereof for treatment of conditions responsive to epinephrine |
| WO2014120936A2 (en) | 2013-01-30 | 2014-08-07 | Pharmorx Therapeutics, Inc. | Treatments for depression and other diseases with a low dose agent |
| CA2907770C (en) | 2013-03-22 | 2022-02-15 | Nova Southeastern University | Epinephrine fine particles and methods for use thereof for treatment of conditions responsive to epinephrine |
| US10993921B2 (en) | 2013-10-03 | 2021-05-04 | Harrow Ip, Llc | Epinephrine-based ophthalmic compositions for intraocular administration and methods for fabricating thereof |
| US9849134B2 (en) | 2014-02-18 | 2017-12-26 | The Board Of Trustees Of The Leland Stanford Junior University | Method of improving cognition and social behavior in humans having deficits therein due to neurodegenerative disorders and compounds and compositions therefor |
| WO2015187932A1 (en) * | 2014-06-04 | 2015-12-10 | Mentinova Inc. | Compositions and methods of reducing sedation |
| ES2770731T3 (es) | 2014-08-28 | 2020-07-02 | Sun Pharmaceutical Ind Ltd | Forma de dosificación parenteral de norepinefrina |
| US11517525B2 (en) * | 2015-09-18 | 2022-12-06 | Hikma Pharmaceuticals Usa Inc. | Epinephrine spray formulations |
| AU2017315757A1 (en) | 2016-08-25 | 2019-03-07 | Harrow Ip, Llc | Epinephrine-based ophthalmic compositions for intraocular administration and methods for fabricating thereof |
| EP3773479A1 (en) | 2018-04-11 | 2021-02-17 | Quva Pharma, Inc. | Ready to use liquid reck formulation |
| US10952962B1 (en) | 2018-04-11 | 2021-03-23 | QuVa Pharma, Inc. | Ready to use liquid formulation |
| JP7657457B2 (ja) | 2018-10-19 | 2025-04-07 | ノバ サウスイースタン ユニバーシティー | ｐＨ修飾賦形剤及び浸入促進剤を含む舌下エピネフリン組成物及びそれを使用する方法 |
| KR20230005133A (ko) * | 2020-04-30 | 2023-01-09 | 퍼듀 퍼머 엘피 | 긴급 구조용 조성물 및 방법 |
| US12564561B2 (en) | 2021-02-15 | 2026-03-03 | Sintetica S.A. | Dilute ready to use large volume containers of phenylephrine |
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| US5679650A (en) * | 1993-11-24 | 1997-10-21 | Fukunaga; Atsuo F. | Pharmaceutical compositions including mixtures of an adenosine compound and a catecholamine |
| US5324633A (en) * | 1991-11-22 | 1994-06-28 | Affymax Technologies N.V. | Method and apparatus for measuring binding affinity |
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| US6117976A (en) * | 1993-11-04 | 2000-09-12 | Medical Research Council | Manufacture and use of polypeptides tagged using binding molecules |
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| US5586551A (en) * | 1995-07-17 | 1996-12-24 | Hilliard; Kenneth R. | Oxygen mask with nebulizer |
| US5879690A (en) * | 1995-09-07 | 1999-03-09 | Perricone; Nicholas V. | Topical administration of catecholamines and related compounds to subcutaneous muscle tissue using percutaneous penetration enhancers |
| US6017963A (en) * | 1995-11-14 | 2000-01-25 | Euro-Celtique, S.A. | Formulation for intranasal administration |
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| US5738873A (en) * | 1996-09-27 | 1998-04-14 | Herman Bleiweiss | Pharmaceutical formulations and methods for treating patients suffering from diseases that cause muscular hypotonia |
| DE19653969A1 (de) * | 1996-12-20 | 1998-06-25 | Boehringer Ingelheim Kg | Neue wässrige Arzneimittelzubereitung zur Erzeugung treibgasfreier Aerosole |
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| AU2001294808A1 (en) | 2002-04-08 |
| WO2002026223A2 (en) | 2002-04-04 |
| EP1326642A2 (en) | 2003-07-16 |
| JP2004509920A (ja) | 2004-04-02 |
| US20030216413A1 (en) | 2003-11-20 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued |