CA2405798A1 - Pyrido¬2,3-d|pyrimidine and pyrimido¬4,5-d|pyrimidine nucleosides - Google Patents
Pyrido¬2,3-d|pyrimidine and pyrimido¬4,5-d|pyrimidine nucleosides Download PDFInfo
- Publication number
- CA2405798A1 CA2405798A1 CA002405798A CA2405798A CA2405798A1 CA 2405798 A1 CA2405798 A1 CA 2405798A1 CA 002405798 A CA002405798 A CA 002405798A CA 2405798 A CA2405798 A CA 2405798A CA 2405798 A1 CA2405798 A1 CA 2405798A1
- Authority
- CA
- Canada
- Prior art keywords
- cell
- formula
- pyrimidine
- pyrido
- contemplated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000002718 pyrimidine nucleoside Substances 0.000 title description 6
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title description 5
- 150000001875 compounds Chemical class 0.000 claims abstract description 140
- 229940002612 prodrug Drugs 0.000 claims abstract description 19
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- 239000002777 nucleoside Substances 0.000 claims description 42
- 150000003833 nucleoside derivatives Chemical class 0.000 claims description 34
- 238000000034 method Methods 0.000 claims description 25
- 230000005764 inhibitory process Effects 0.000 claims description 14
- 125000000217 alkyl group Chemical group 0.000 claims description 12
- 125000000304 alkynyl group Chemical group 0.000 claims description 12
- 229910052739 hydrogen Inorganic materials 0.000 claims description 12
- 125000003342 alkenyl group Chemical group 0.000 claims description 11
- 229910052731 fluorine Inorganic materials 0.000 claims description 9
- 229910052760 oxygen Inorganic materials 0.000 claims description 9
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- 230000006907 apoptotic process Effects 0.000 claims description 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
- 229910052717 sulfur Inorganic materials 0.000 claims description 7
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 6
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 6
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
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- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21641800P | 2000-07-06 | 2000-07-06 | |
| US60/216,418 | 2000-07-06 | ||
| PCT/US2001/041242 WO2002003997A1 (en) | 2000-07-06 | 2001-07-03 | Pyrido[2,3-d]pyrimidine and pyrimido[4,5-d]pyrimidine nucleosides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2405798A1 true CA2405798A1 (en) | 2002-01-17 |
Family
ID=22806989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002405798A Abandoned CA2405798A1 (en) | 2000-07-06 | 2001-07-03 | Pyrido¬2,3-d|pyrimidine and pyrimido¬4,5-d|pyrimidine nucleosides |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7081449B2 (enExample) |
| EP (1) | EP1303282A4 (enExample) |
| JP (1) | JP2004522694A (enExample) |
| KR (1) | KR20030032944A (enExample) |
| CN (1) | CN1440292A (enExample) |
| AU (2) | AU2001273670B2 (enExample) |
| BR (1) | BR0111531A (enExample) |
| CA (1) | CA2405798A1 (enExample) |
| CZ (1) | CZ20024052A3 (enExample) |
| HU (1) | HUP0301614A3 (enExample) |
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| US3423398A (en) * | 1965-05-10 | 1969-01-21 | Pfizer & Co C | Sangivamycin and derivatives thereof |
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| US5034393A (en) * | 1989-07-27 | 1991-07-23 | Dowelanco | Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives |
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2001
- 2001-03-07 UA UA2002119182A patent/UA72612C2/uk unknown
- 2001-07-03 AU AU2001273670A patent/AU2001273670B2/en not_active Expired - Fee Related
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- 2001-07-03 US US10/221,397 patent/US7081449B2/en not_active Expired - Fee Related
- 2001-07-03 IL IL15184901A patent/IL151849A0/xx unknown
- 2001-07-03 HU HU0301614A patent/HUP0301614A3/hu unknown
- 2001-07-03 CA CA002405798A patent/CA2405798A1/en not_active Abandoned
- 2001-07-03 KR KR1020027014601A patent/KR20030032944A/ko not_active Abandoned
- 2001-07-03 CZ CZ20024052A patent/CZ20024052A3/cs unknown
- 2001-07-03 JP JP2002508451A patent/JP2004522694A/ja not_active Withdrawn
- 2001-07-03 EP EP01952967A patent/EP1303282A4/en not_active Withdrawn
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- 2001-07-03 NZ NZ521457A patent/NZ521457A/en unknown
- 2001-07-03 PL PL01359559A patent/PL359559A1/xx not_active Application Discontinuation
- 2001-07-03 MX MXPA02012156A patent/MXPA02012156A/es unknown
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2002
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| HUP0301614A2 (hu) | 2003-09-29 |
| EP1303282A1 (en) | 2003-04-23 |
| JP2004522694A (ja) | 2004-07-29 |
| NO20030033L (no) | 2003-01-03 |
| MXPA02012156A (es) | 2004-08-19 |
| NO20030033D0 (no) | 2003-01-03 |
| SK112003A3 (en) | 2003-04-01 |
| EP1303282A4 (en) | 2004-04-07 |
| WO2002003997A1 (en) | 2002-01-17 |
| CN1440292A (zh) | 2003-09-03 |
| BR0111531A (pt) | 2004-07-06 |
| UA72612C2 (en) | 2005-03-15 |
| US20030144502A1 (en) | 2003-07-31 |
| NZ521457A (en) | 2005-03-24 |
| AU7367001A (en) | 2002-01-21 |
| KR20030032944A (ko) | 2003-04-26 |
| IL151849A0 (en) | 2003-04-10 |
| CZ20024052A3 (cs) | 2003-03-12 |
| AU2001273670B2 (en) | 2005-07-14 |
| ZA200208010B (en) | 2004-04-28 |
| PL359559A1 (en) | 2004-08-23 |
| US7081449B2 (en) | 2006-07-25 |
| HUP0301614A3 (en) | 2005-02-28 |
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