CA2404858A1 - Treatment of neurodegenerative disease - Google Patents
Treatment of neurodegenerative disease Download PDFInfo
- Publication number
- CA2404858A1 CA2404858A1 CA002404858A CA2404858A CA2404858A1 CA 2404858 A1 CA2404858 A1 CA 2404858A1 CA 002404858 A CA002404858 A CA 002404858A CA 2404858 A CA2404858 A CA 2404858A CA 2404858 A1 CA2404858 A1 CA 2404858A1
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- CA
- Canada
- Prior art keywords
- kit
- group
- drug
- treatment
- disease
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
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- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- General Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- Emergency Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Nanotechnology (AREA)
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19649700P | 2000-04-12 | 2000-04-12 | |
| US60/196,497 | 2000-04-12 | ||
| US21422100P | 2000-06-23 | 2000-06-23 | |
| US60/214,221 | 2000-06-23 | ||
| US24889000P | 2000-11-15 | 2000-11-15 | |
| US60/248,890 | 2000-11-15 | ||
| PCT/US2001/012484 WO2001078709A2 (en) | 2000-04-12 | 2001-04-12 | Treatment of neurodegenerative disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2404858A1 true CA2404858A1 (en) | 2001-10-25 |
Family
ID=27393612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002404858A Abandoned CA2404858A1 (en) | 2000-04-12 | 2001-04-12 | Treatment of neurodegenerative disease |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20030060487A1 (https=) |
| EP (1) | EP1328261A2 (https=) |
| JP (1) | JP2003530432A (https=) |
| AU (1) | AU2001253597A1 (https=) |
| CA (1) | CA2404858A1 (https=) |
| WO (1) | WO2001078709A2 (https=) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050148101A1 (en) * | 1999-01-23 | 2005-07-07 | Bamdad Cynthia C. | Interaction of colloid-immobilized species with species on non-colloidal structures |
| JP4585170B2 (ja) | 2000-10-03 | 2010-11-24 | ミナーヴァ・バイオテクノロジーズ・コーポレーション | 流動の中断に基づく相互作用の電子検出および相互作用の検出 |
| US7054758B2 (en) | 2001-01-30 | 2006-05-30 | Sciona Limited | Computer-assisted means for assessing lifestyle risk factors |
| WO2003013437A2 (en) * | 2001-08-07 | 2003-02-20 | University Of Delaware | Compositions and methods for the prevention and treatment of huntington's disease |
| US20040096880A1 (en) * | 2001-08-07 | 2004-05-20 | Kmiec Eric B. | Compositions and methods for the treatment of diseases exhibiting protein misassembly and aggregation |
| FR2828693B1 (fr) † | 2001-08-14 | 2004-06-18 | Exonhit Therapeutics Sa | Nouvelle cible moleculaire de la neurotoxicite |
| EP2329822A1 (en) | 2001-09-05 | 2011-06-08 | Minerva Biotechnologies Corporation | Compositions and methods of treatment of cancer |
| US20060280730A1 (en) * | 2001-10-12 | 2006-12-14 | Cedars-Sinai Medical Center | Induction of apoptosis of malignant cells by activation of calcium-activated potassium channels |
| JP2006517674A (ja) | 2002-12-20 | 2006-07-27 | ミネルバ バイオテクノロジーズ コーポレーション | ナノ粒子を含む光学デバイスおよび方法 |
| ES2272911T3 (es) * | 2003-04-25 | 2007-05-01 | Neurofit Sas | Uso de derivados de fenotiazina piperazina en la fabricacion de un medicamento con efectos neuroprotector y/o neurotroficos sobre cns y/o pns. |
| FR2856595B1 (fr) * | 2003-06-27 | 2008-05-30 | Exonhit Therapeutics Sa | Methodes et compositions pour le traitement de deficits cognitifs. |
| US20050059744A1 (en) * | 2003-09-12 | 2005-03-17 | Allergan, Inc. | Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions |
| CA2628074C (en) | 2005-10-25 | 2014-01-14 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivative |
| US8178509B2 (en) * | 2006-02-10 | 2012-05-15 | University Of Virginia Patent Foundation | Method to treat sickle cell disease |
| AU2007218217A1 (en) * | 2006-02-24 | 2007-08-30 | Axelar Ab | Use of cyclolignans for the treatment of type 2 diabetes and as contraceptives |
| JP5383484B2 (ja) | 2007-04-24 | 2014-01-08 | 塩野義製薬株式会社 | 環式基で置換されたアミノジヒドロチアジン誘導体 |
| US8653067B2 (en) | 2007-04-24 | 2014-02-18 | Shionogi & Co., Ltd. | Pharmaceutical composition for treating Alzheimer's disease |
| WO2009005469A2 (en) * | 2007-07-03 | 2009-01-08 | David Erlinge | The use of compounds such as pyridoxal derivatives for the treatment of diabetes or diseases associated with the metabolic syndrome |
| WO2013148740A1 (en) * | 2012-03-26 | 2013-10-03 | The Trustees Of Columbia University In The City Of New York | 4–aminopyridine as a therapeutic agent for spinal muscular atrophy |
| KR101324426B1 (ko) | 2008-06-13 | 2013-10-31 | 시오노기세야쿠 가부시키가이샤 | β 세크레타제 저해 작용을 갖는 황 함유 복소환 유도체 |
| CN102186841A (zh) | 2008-10-22 | 2011-09-14 | 盐野义制药株式会社 | 具有bace1抑制活性的2-氨基嘧啶-4-酮及2-氨基吡啶衍生物 |
| MX2012006491A (es) | 2009-12-11 | 2012-07-03 | Shionogi & Co | Derivados de oxazina. |
| US9662347B2 (en) * | 2010-05-11 | 2017-05-30 | Gachon University Of Industry-Academic Cooperation Foundation | Method for inhibiting the induction of cell death by inhibiting the synthesis or secretion of age-albumin in cells of the mononuclear phagocyte system |
| US20120101167A1 (en) * | 2010-10-25 | 2012-04-26 | Langham Maurice E | Treatment of ocular and cerebral ischemia |
| JP5816630B2 (ja) | 2010-10-29 | 2015-11-18 | 塩野義製薬株式会社 | ナフチリジン誘導体 |
| EP2634188A4 (en) | 2010-10-29 | 2014-05-07 | Shionogi & Co | FUSIONED AMINODIHYDROPYRIMIDINE DERIVATIVE |
| US8883779B2 (en) | 2011-04-26 | 2014-11-11 | Shinogi & Co., Ltd. | Oxazine derivatives and a pharmaceutical composition for inhibiting BACE1 containing them |
| EP2764863B1 (en) * | 2011-10-03 | 2020-03-11 | National Center for Geriatrics and Gerontology | Tau aggregation inhibitor |
| CN102381991A (zh) * | 2011-10-22 | 2012-03-21 | 杭州福斯特药业有限公司 | 一种章胺盐酸盐的合成方法 |
| EP2912035A4 (en) | 2012-10-24 | 2016-06-15 | Shionogi & Co | DERIVATIVES OF DIHYDROOXAZINE OR OXAZEPINE HAVING BACE1 INHIBITING ACTIVITY |
| EP2962687B1 (en) | 2013-04-02 | 2019-06-05 | The Doshisha | Tau aggregation inhibitor |
| US20160154928A1 (en) * | 2013-07-12 | 2016-06-02 | Immuneering Corporation | Systems, methods, and environment for automated review of genomic data to identify downregulated and/or upregulated gene expression indicative of a disease or condition |
| US11648212B2 (en) * | 2016-02-03 | 2023-05-16 | Intelgenx Corp. | Loxapine film oral dosage form |
| WO2017197324A1 (en) * | 2016-05-13 | 2017-11-16 | The Board Of Trustees Of The Leland Stanford Junior University | Adrenergic receptor modulating compounds and methods of using the same |
| WO2022087460A1 (en) * | 2020-10-22 | 2022-04-28 | Icahn School Of Medicine At Mount Sinai | Methods for identifying and targeting the molecular subtypes of alzheimer's disease |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3854480A (en) * | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
| US3832253A (en) * | 1973-03-21 | 1974-08-27 | Baxter Laboratories Inc | Method of making an inflatable balloon catheter |
| US4675189A (en) * | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
| US5525727A (en) * | 1982-05-18 | 1996-06-11 | University Of Florida | Brain-specific drug delivery |
| US4667014A (en) * | 1983-03-07 | 1987-05-19 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists |
| US4452775A (en) * | 1982-12-03 | 1984-06-05 | Syntex (U.S.A.) Inc. | Cholesterol matrix delivery system for sustained release of macromolecules |
| CA1200416A (en) * | 1983-05-13 | 1986-02-11 | Societe Des Produits Nestle S.A. | Food process |
| US5075109A (en) * | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| DE3853758T2 (de) * | 1987-10-05 | 1995-09-07 | Yamanouchi Pharma Co Ltd | Heterozyklische Spiroverbindungen und ihre Herstellung. |
| US5133974A (en) * | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| DE4023369A1 (de) * | 1990-07-23 | 1992-01-30 | Thomae Gmbh Dr K | Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| US5338663A (en) * | 1990-08-24 | 1994-08-16 | President And Fellows Of Harvard College | Method of identifying inhibitors of β-protein esterase activity |
| JPH04167172A (ja) * | 1990-10-31 | 1992-06-15 | Nec Corp | ベクトルプロセッサ |
| US5591762A (en) * | 1991-02-06 | 1997-01-07 | Dr. Karl Thomae Gmbh | Benzimidazoles useful as angiotensin-11 antagonists |
| US5668117A (en) * | 1991-02-22 | 1997-09-16 | Shapiro; Howard K. | Methods of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with previously known medicaments |
| US5238942A (en) * | 1991-05-10 | 1993-08-24 | Merck & Co., Inc. | Substituted quinazolinones bearing acidic functional groups as angiotensin ii antagonists |
| US5407686A (en) * | 1991-11-27 | 1995-04-18 | Sidmak Laboratories, Inc. | Sustained release composition for oral administration of active ingredient |
| US5962463A (en) * | 1992-10-09 | 1999-10-05 | Massachusetts Institute Of Technology | Methods of stimulating non-amyloidogenic processing of the amyloid precursor protein |
| US5721263A (en) * | 1993-06-07 | 1998-02-24 | Takeda Chemical Industries, Ltd. | Pharmaceutical composition for angiotensin II-mediated diseases |
| IL112567A (en) * | 1994-02-10 | 2000-02-29 | Wyeth John & Brother Ltd | Substituted quinolines their preparation and pharmaceutical compositions containing them |
| US5620850A (en) * | 1994-09-26 | 1997-04-15 | President And Fellows Of Harvard College | Molecular recognition at surfaces derivatized with self-assembled monolayers |
| US5605911A (en) * | 1995-01-31 | 1997-02-25 | Washington University | Use of alpha-2 adrenergic drugs to prevent adverse effects of NMDA receptor hypofunction (NRH) |
| US5736152A (en) * | 1995-10-27 | 1998-04-07 | Atrix Laboratories, Inc. | Non-polymeric sustained release delivery system |
| WO1997048391A2 (en) * | 1996-06-21 | 1997-12-24 | Advanced Research And Technology Institute | Methods and compositions comprising r-ibuprofen |
| US5965571A (en) * | 1996-08-22 | 1999-10-12 | New York University | Cholinesterase inhibitors for treatment of Parkinson's disease |
| ATE234298T1 (de) * | 1996-08-29 | 2003-03-15 | Takeda Chemical Industries Ltd | Zyklische etherverbindungen als natriumkanal- modulatoren |
| US6184248B1 (en) * | 1996-09-05 | 2001-02-06 | Robert K. K. Lee | Compositions and methods for treatment of neurological disorders and neurodegenerative diseases |
| ATE352614T1 (de) * | 1996-12-12 | 2007-02-15 | Yissum Res Dev Co | Synthetische antisense oligodeoxynukleotide und diese enthaltende pharmazeutische zusammensetzungen |
| FR2757161B1 (fr) * | 1996-12-13 | 1999-03-12 | Sanofi Sa | Diphenylalkyl-tetrahydropyridines |
| AU5727798A (en) * | 1996-12-23 | 1998-07-17 | Texas A & M University, The | Anti-amyloidogenic agents |
| US6130221A (en) * | 1997-03-05 | 2000-10-10 | Nymox Corporation | Pharmaceutical agents that impede the initiation and progression of primary and secondary DMS disruptions |
| US6514686B2 (en) * | 1997-04-28 | 2003-02-04 | The University Of British Columbia | Method and composition for modulating amyloidosis |
| WO1998048784A2 (en) * | 1997-04-28 | 1998-11-05 | The University Of British Columbia | Method and composition for modulating amyloidosis |
| ZA985765B (en) * | 1997-07-02 | 1999-08-04 | Merck & Co Inc | Polymorphic form of a tachykinin receptor antagonist. |
| US6136559A (en) * | 1998-10-07 | 2000-10-24 | Ortho Pharmaceutical Corporation | DNA encoding as human histamine receptor of the H3 subtype |
| US6586475B1 (en) * | 1998-11-20 | 2003-07-01 | Takeda Chemical Industries, Ltd. | β-amyloid protein production/secretion inhibitors |
| EP1132372A3 (en) * | 2000-03-06 | 2003-11-19 | Solvias AG | Bicyclic 1,3-aminoalcohols, d8-metal complexes and hydrogenation processes |
| JP4585170B2 (ja) * | 2000-10-03 | 2010-11-24 | ミナーヴァ・バイオテクノロジーズ・コーポレーション | 流動の中断に基づく相互作用の電子検出および相互作用の検出 |
| JP4516273B2 (ja) * | 2000-11-15 | 2010-08-04 | ミナーヴァ・バイオテクノロジーズ・コーポレーション | オリゴヌクレオチド識別子 |
| US20020156112A1 (en) * | 2000-11-15 | 2002-10-24 | Bamdad R. Shoshana | Endostatin-like angiogenesis inhibition |
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- 2001-04-12 US US09/835,099 patent/US20030060487A1/en not_active Abandoned
- 2001-04-12 JP JP2001576010A patent/JP2003530432A/ja active Pending
- 2001-04-12 AU AU2001253597A patent/AU2001253597A1/en not_active Abandoned
- 2001-04-12 CA CA002404858A patent/CA2404858A1/en not_active Abandoned
- 2001-04-12 WO PCT/US2001/012484 patent/WO2001078709A2/en not_active Ceased
- 2001-04-12 EP EP01927116A patent/EP1328261A2/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001253597A1 (en) | 2001-10-30 |
| US20030060487A1 (en) | 2003-03-27 |
| EP1328261A2 (en) | 2003-07-23 |
| JP2003530432A (ja) | 2003-10-14 |
| WO2001078709A3 (en) | 2003-04-17 |
| WO2001078709A2 (en) | 2001-10-25 |
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