CA2403818A1 - Matrices containing nitric oxide donors and reducing agents and their use - Google Patents
Matrices containing nitric oxide donors and reducing agents and their use Download PDFInfo
- Publication number
- CA2403818A1 CA2403818A1 CA002403818A CA2403818A CA2403818A1 CA 2403818 A1 CA2403818 A1 CA 2403818A1 CA 002403818 A CA002403818 A CA 002403818A CA 2403818 A CA2403818 A CA 2403818A CA 2403818 A1 CA2403818 A1 CA 2403818A1
- Authority
- CA
- Canada
- Prior art keywords
- nitric oxide
- matrix
- composition
- donor
- oxide donor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical class O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title claims abstract description 330
- 239000002840 nitric oxide donor Substances 0.000 title claims abstract description 74
- 239000003638 chemical reducing agent Substances 0.000 title claims abstract description 61
- 239000011159 matrix material Substances 0.000 claims abstract description 103
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 70
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- HYHSBSXUHZOYLX-WDSKDSINSA-N S-nitrosoglutathione Chemical group OC(=O)[C@@H](N)CCC(=O)N[C@@H](CSN=O)C(=O)NCC(O)=O HYHSBSXUHZOYLX-WDSKDSINSA-N 0.000 claims description 24
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Landscapes
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| US60/190,571 | 2000-03-20 | ||
| US60/190,546 | 2000-03-20 | ||
| PCT/US2001/008806 WO2001070199A1 (en) | 2000-03-20 | 2001-03-20 | Matrices containing nitric oxide donors and reducing agents and their use |
Publications (1)
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| CA2403818A1 true CA2403818A1 (en) | 2001-09-27 |
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| JP2003531179A (ja) | 2000-04-26 | 2003-10-21 | クイーンズ ユニバーシティ アット キングストン | 悪性細胞表現型に対し一酸化窒素模倣体を使用する処方および方法 |
| US7678391B2 (en) | 2000-04-26 | 2010-03-16 | Queen's University At Kingston | Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype |
| US7763769B2 (en) | 2001-02-16 | 2010-07-27 | Kci Licensing, Inc. | Biocompatible wound dressing |
| US7700819B2 (en) | 2001-02-16 | 2010-04-20 | Kci Licensing, Inc. | Biocompatible wound dressing |
| US7135189B2 (en) | 2001-08-23 | 2006-11-14 | Boston Scientific Scimed, Inc. | Compositions and techniques for localized therapy |
| US7972137B2 (en) * | 2003-06-30 | 2011-07-05 | Rosen Gerald M | Anti-microbial dental formulations for the prevention and treatment of oral mucosal disease |
| CA2912259C (en) | 2005-05-27 | 2020-04-28 | Mark H. Schoenfisch | Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications |
| EP1968664B1 (en) * | 2005-12-02 | 2010-10-27 | The Regents Of The University Of Michigan | Polymer compositions, coatings and devices, and methods of making and using the same |
| US9259535B2 (en) | 2006-06-22 | 2016-02-16 | Excelsior Medical Corporation | Antiseptic cap equipped syringe |
| US11229746B2 (en) | 2006-06-22 | 2022-01-25 | Excelsior Medical Corporation | Antiseptic cap |
| HU0800031D0 (en) * | 2008-01-16 | 2008-03-28 | Biotech Hungary Kutato Es Fejl | Method for stabilization of s-nitrosoglutathione and composition prepared by the same |
| US9078992B2 (en) | 2008-10-27 | 2015-07-14 | Pursuit Vascular, Inc. | Medical device for applying antimicrobial to proximal end of catheter |
| US11219706B2 (en) | 2009-03-11 | 2022-01-11 | Arrow International Llc | Enhanced formulations for coating medical devices |
| US20100233288A1 (en) * | 2009-03-11 | 2010-09-16 | Teleflex Medical Incorporated | Medical devices containing nitroprusside and antimicrobial agents |
| US9919072B2 (en) | 2009-08-21 | 2018-03-20 | Novan, Inc. | Wound dressings, methods of using the same and methods of forming the same |
| US9526738B2 (en) | 2009-08-21 | 2016-12-27 | Novan, Inc. | Topical gels and methods of using the same |
| US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
| WO2012118819A2 (en) | 2011-02-28 | 2012-09-07 | Novan, Inc. | Nitric oxide-releasing s-nitrosothiol-modified silica particles and methods of making the same |
| US10166381B2 (en) | 2011-05-23 | 2019-01-01 | Excelsior Medical Corporation | Antiseptic cap |
| ES2797649T3 (es) | 2011-07-12 | 2020-12-03 | Icu Medical Inc | Dispositivo para entrega de agente antimicrobiano en un catéter transdérmico |
| EP2953660B1 (en) * | 2013-02-07 | 2020-04-01 | The Regents Of The University Of Michigan | Thromboresistant/bactericidal s-nitroso-n-acetylpenicillamine (snap)-doped nitric oxide release polymers with enhanced stability |
| WO2015168677A1 (en) | 2014-05-02 | 2015-11-05 | Excelsior Medical Corporation | Strip package for antiseptic cap |
| AU2016262400B2 (en) | 2015-05-08 | 2021-01-21 | Icu Medical, Inc. | Medical connectors configured to receive emitters of therapeutic agents |
| ES2929769T3 (es) | 2016-10-14 | 2022-12-01 | Icu Medical Inc | Tapas desinfectantes para conectores médicos |
| CN110446521B (zh) | 2017-01-21 | 2022-05-06 | 生物克瑞德公司 | 配置用于一氧化氮的控制释放的医疗产品和方法 |
| WO2018204206A2 (en) | 2017-05-01 | 2018-11-08 | Icu Medical, Inc. | Medical fluid connectors and methods for providing additives in medical fluid lines |
| CN107823644B (zh) * | 2017-11-07 | 2021-03-02 | 福州大学 | 一种no供体化合物在制备抑制富含巯基分子的肿瘤细胞的侵袭和转移能力药物中的应用 |
| US11541221B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Tubing set with antimicrobial properties |
| US11534595B2 (en) | 2018-11-07 | 2022-12-27 | Icu Medical, Inc. | Device for delivering an antimicrobial composition into an infusion device |
| US11400195B2 (en) | 2018-11-07 | 2022-08-02 | Icu Medical, Inc. | Peritoneal dialysis transfer set with antimicrobial properties |
| US11541220B2 (en) | 2018-11-07 | 2023-01-03 | Icu Medical, Inc. | Needleless connector with antimicrobial properties |
| US11517732B2 (en) | 2018-11-07 | 2022-12-06 | Icu Medical, Inc. | Syringe with antimicrobial properties |
| EP3883638A1 (en) | 2018-11-21 | 2021-09-29 | ICU Medical, Inc. | Antimicrobial device comprising a cap with ring and insert |
| CA3204371A1 (en) | 2020-12-07 | 2022-06-16 | Icu Medical, Inc. | Peritoneal dialysis caps, systems and methods |
| CN114868846A (zh) * | 2022-04-25 | 2022-08-09 | 闽江学院 | 外源性一氧化氮供体gsno作为饲料添加剂的应用 |
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| US5770645A (en) * | 1996-08-02 | 1998-06-23 | Duke University Medical Center | Polymers for delivering nitric oxide in vivo |
| US5797887A (en) * | 1996-08-27 | 1998-08-25 | Novovasc Llc | Medical device with a surface adapted for exposure to a blood stream which is coated with a polymer containing a nitrosyl-containing organo-metallic compound which releases nitric oxide from the coating to mediate platelet aggregation |
| JP4777489B2 (ja) * | 1997-03-31 | 2011-09-21 | ザ チルドレンズ メディカル センター コーポレーション | アポトーシス性酵素を不活性化するためのニトロシル化 |
| US6171232B1 (en) * | 1997-06-26 | 2001-01-09 | Cordis Corporation | Method for targeting in vivo nitric oxide release |
| IL121527A0 (en) * | 1997-08-12 | 1998-02-08 | U E T Ltd | Heating systems based on alternating-current electrodes |
| US5994444A (en) * | 1997-10-16 | 1999-11-30 | Medtronic, Inc. | Polymeric material that releases nitric oxide |
| US6093743A (en) * | 1998-06-23 | 2000-07-25 | Medinox Inc. | Therapeutic methods employing disulfide derivatives of dithiocarbamates and compositions useful therefor |
| US6207855B1 (en) * | 1998-06-23 | 2001-03-27 | Duke University Medical Center | Stable no-delivering compounds |
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