CA2402597C - Composition for use in treatment of ocular hypertension and glaucoma - Google Patents
Composition for use in treatment of ocular hypertension and glaucoma Download PDFInfo
- Publication number
- CA2402597C CA2402597C CA2402597A CA2402597A CA2402597C CA 2402597 C CA2402597 C CA 2402597C CA 2402597 A CA2402597 A CA 2402597A CA 2402597 A CA2402597 A CA 2402597A CA 2402597 C CA2402597 C CA 2402597C
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- Prior art keywords
- alkyl
- composition
- aryl
- group
- hydroxy
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- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
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- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
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- NSPJNIDYTSSIIY-UHFFFAOYSA-N methoxy(methoxymethoxy)methane Chemical compound COCOCOC NSPJNIDYTSSIIY-UHFFFAOYSA-N 0.000 description 1
- DZNKOAWEHDKBEP-UHFFFAOYSA-N methyl 2-[6-[bis(2-methoxy-2-oxoethyl)amino]-5-[2-[2-[bis(2-methoxy-2-oxoethyl)amino]-5-methylphenoxy]ethoxy]-1-benzofuran-2-yl]-1,3-oxazole-5-carboxylate Chemical compound COC(=O)CN(CC(=O)OC)C1=CC=C(C)C=C1OCCOC(C(=C1)N(CC(=O)OC)CC(=O)OC)=CC2=C1OC(C=1OC(=CN=1)C(=O)OC)=C2 DZNKOAWEHDKBEP-UHFFFAOYSA-N 0.000 description 1
- XRISENIKJUKIHD-LHQZMKCDSA-N methyl 7-[(1r,2r,3r)-3-hydroxy-2-[(e,4r)-4-hydroxy-4-(1-propylcyclobutyl)but-1-enyl]-5-oxocyclopentyl]heptanoate Chemical compound CCCC1([C@H](O)C\C=C\[C@@H]2[C@H](C(=O)C[C@H]2O)CCCCCCC(=O)OC)CCC1 XRISENIKJUKIHD-LHQZMKCDSA-N 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
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- MGJXBDMLVWIYOQ-UHFFFAOYSA-N methylazanide Chemical compound [NH-]C MGJXBDMLVWIYOQ-UHFFFAOYSA-N 0.000 description 1
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- 125000002950 monocyclic group Chemical group 0.000 description 1
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- AIAKLPAJNLBVEA-UHFFFAOYSA-N n-[2-(2-benzamidophenoxy)phenyl]benzamide Chemical compound C=1C=CC=CC=1C(=O)NC1=CC=CC=C1OC1=CC=CC=C1NC(=O)C1=CC=CC=C1 AIAKLPAJNLBVEA-UHFFFAOYSA-N 0.000 description 1
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- 230000036961 partial effect Effects 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 125000004934 phenanthridinyl group Chemical group C1(=CC=CC2=NC=C3C=CC=CC3=C12)* 0.000 description 1
- 125000001484 phenothiazinyl group Chemical group C1(=CC=CC=2SC3=CC=CC=C3NC12)* 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 150000003053 piperidines Chemical class 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000003822 preparative gas chromatography Methods 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical class CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 235000010409 propane-1,2-diol alginate Nutrition 0.000 description 1
- 229960003712 propranolol Drugs 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 description 1
- 125000003072 pyrazolidinyl group Chemical group 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- 125000005412 pyrazyl group Chemical group 0.000 description 1
- 125000005495 pyridazyl group Chemical group 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 1
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- DCKVNWZUADLDEH-UHFFFAOYSA-N sec-butyl acetate Chemical compound CCC(C)OC(C)=O DCKVNWZUADLDEH-UHFFFAOYSA-N 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- UQZVCDCIMBLVNR-TWYODKAFSA-N sulprostone Chemical compound O[C@@H]1CC(=O)[C@H](C\C=C/CCCC(=O)NS(=O)(=O)C)[C@H]1\C=C\[C@@H](O)COC1=CC=CC=C1 UQZVCDCIMBLVNR-TWYODKAFSA-N 0.000 description 1
- 229960003400 sulprostone Drugs 0.000 description 1
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- 150000005621 tetraalkylammonium salts Chemical class 0.000 description 1
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- 125000003944 tolyl group Chemical group 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- RYYVLZVUVIJVGH-UHFFFAOYSA-N trimethylxanthine Natural products CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 1
- 210000001177 vas deferen Anatomy 0.000 description 1
- 229920001567 vinyl ester resin Polymers 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 125000005023 xylyl group Chemical group 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
- A61K31/5585—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes having five-membered rings containing oxygen as the only ring hetero atom, e.g. prostacyclin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52757300A | 2000-03-16 | 2000-03-16 | |
| US09/527,573 | 2000-03-16 | ||
| US09/730,830 | 2000-12-07 | ||
| US09/730,830 US20010034355A1 (en) | 2000-03-16 | 2000-12-07 | Treatment of ocular hypertension |
| PCT/JP2001/002035 WO2001068072A2 (en) | 2000-03-16 | 2001-03-15 | Composition for use in treatment of ocular hypertension and glaucoma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2402597A1 CA2402597A1 (en) | 2001-09-20 |
| CA2402597C true CA2402597C (en) | 2011-04-26 |
Family
ID=27062443
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2402597A Expired - Fee Related CA2402597C (en) | 2000-03-16 | 2001-03-15 | Composition for use in treatment of ocular hypertension and glaucoma |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20010056104A1 (https=) |
| EP (1) | EP1272194A2 (https=) |
| JP (1) | JP2003526660A (https=) |
| KR (1) | KR20080012407A (https=) |
| CN (1) | CN100506232C (https=) |
| AR (1) | AR029818A1 (https=) |
| AU (2) | AU4114301A (https=) |
| BR (1) | BR0109192A (https=) |
| CA (1) | CA2402597C (https=) |
| CZ (1) | CZ20023092A3 (https=) |
| HU (1) | HUP0300391A3 (https=) |
| IL (1) | IL151683A0 (https=) |
| MX (1) | MXPA02008967A (https=) |
| NO (1) | NO20024381L (https=) |
| NZ (1) | NZ521325A (https=) |
| RU (1) | RU2002127733A (https=) |
| TW (1) | TWI286932B (https=) |
| WO (1) | WO2001068072A2 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL124620A0 (en) † | 1995-12-18 | 1998-12-06 | Myriad Genetics Inc | Chromosome 13-linked breast cancer susceptibility gene |
| US20020035148A1 (en) * | 2000-07-20 | 2002-03-21 | Ryuji Ueno | Treatment of ocular hypertension |
| US6713268B2 (en) * | 2001-06-26 | 2004-03-30 | Allergan, Inc. | Methods of identifying ocular hypotensive compounds having reduced hyperpigmentation |
| CA2454422A1 (en) * | 2001-07-31 | 2003-02-13 | Ryuji Ueno | Treatment of ocular hypertension and glaucoma |
| AU2003215820A1 (en) * | 2002-03-28 | 2003-10-13 | Sucampo Ag | Method for treating ocular hypertension and glaucoma |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3850676T2 (de) * | 1987-09-18 | 1994-11-03 | Ueno Seiyaku Oyo Kenkyujo Kk | Hypotensive okulare Mittel. |
| US5321128A (en) * | 1988-09-06 | 1994-06-14 | Kabi Pharmacia Ab | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| DE1300150T1 (de) * | 1988-09-06 | 2003-09-18 | Pharmacia Ab, Stockholm | Prostaglandin-Derivate zur Behandlung von Glaukom oder Augenüberdruck |
| TW224942B (https=) * | 1990-04-04 | 1994-06-11 | Adka Ueno Kk | |
| AU687906B2 (en) * | 1993-12-15 | 1998-03-05 | Alcon Laboratories, Inc. | Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension |
| US6011062A (en) * | 1994-12-22 | 2000-01-04 | Alcon Laboratories, Inc. | Storage-stable prostaglandin compositions |
| AU7680096A (en) * | 1995-12-22 | 1997-07-17 | Alcon Laboratories, Inc. | Combinations of dp and fp type prostaglandins for lowering iop |
| US6232344B1 (en) * | 1997-12-22 | 2001-05-15 | Alcon Laboratories, Inc. | 13-Oxa prostaglandins for the treatment of glaucoma and ocular hypertension |
| EP1069913B1 (en) * | 1998-04-07 | 2003-07-23 | Alcon Laboratories, Inc. | Gelling ophthalmic compositions containing xanthan gum |
-
2001
- 2001-03-15 CA CA2402597A patent/CA2402597C/en not_active Expired - Fee Related
- 2001-03-15 EP EP01912374A patent/EP1272194A2/en not_active Ceased
- 2001-03-15 MX MXPA02008967A patent/MXPA02008967A/es active IP Right Grant
- 2001-03-15 AU AU4114301A patent/AU4114301A/xx active Pending
- 2001-03-15 WO PCT/JP2001/002035 patent/WO2001068072A2/en not_active Ceased
- 2001-03-15 JP JP2001566636A patent/JP2003526660A/ja active Pending
- 2001-03-15 NZ NZ521325A patent/NZ521325A/en not_active IP Right Cessation
- 2001-03-15 RU RU2002127733/15A patent/RU2002127733A/ru unknown
- 2001-03-15 BR BR0109192-1A patent/BR0109192A/pt not_active Application Discontinuation
- 2001-03-15 KR KR1020087002403A patent/KR20080012407A/ko not_active Ceased
- 2001-03-15 AU AU2001241143A patent/AU2001241143B2/en not_active Ceased
- 2001-03-15 CN CNB018093396A patent/CN100506232C/zh not_active Expired - Fee Related
- 2001-03-15 CZ CZ20023092A patent/CZ20023092A3/cs unknown
- 2001-03-15 IL IL15168301A patent/IL151683A0/xx not_active IP Right Cessation
- 2001-03-15 HU HU0300391A patent/HUP0300391A3/hu unknown
- 2001-03-16 TW TW090106162A patent/TWI286932B/zh not_active IP Right Cessation
- 2001-03-16 AR ARP010101231A patent/AR029818A1/es unknown
- 2001-03-27 US US09/817,046 patent/US20010056104A1/en not_active Abandoned
-
2002
- 2002-09-13 NO NO20024381A patent/NO20024381L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003526660A (ja) | 2003-09-09 |
| NZ521325A (en) | 2004-05-28 |
| AR029818A1 (es) | 2003-07-16 |
| AU2001241143B2 (en) | 2005-08-25 |
| WO2001068072A2 (en) | 2001-09-20 |
| MXPA02008967A (es) | 2003-02-12 |
| AU4114301A (en) | 2001-09-24 |
| CA2402597A1 (en) | 2001-09-20 |
| WO2001068072A3 (en) | 2002-06-06 |
| CZ20023092A3 (cs) | 2003-05-14 |
| NO20024381L (no) | 2002-11-15 |
| HUP0300391A3 (en) | 2008-05-28 |
| EP1272194A2 (en) | 2003-01-08 |
| CN1429112A (zh) | 2003-07-09 |
| RU2002127733A (ru) | 2004-03-27 |
| HUP0300391A2 (hu) | 2003-06-28 |
| IL151683A0 (en) | 2003-04-10 |
| NO20024381D0 (no) | 2002-09-13 |
| TWI286932B (en) | 2007-09-21 |
| CN100506232C (zh) | 2009-07-01 |
| BR0109192A (pt) | 2003-05-27 |
| KR20080012407A (ko) | 2008-02-11 |
| US20010056104A1 (en) | 2001-12-27 |
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