CA2401327C - Nucleic acid formulations comprising poly-amino acids for gene delivery and methods of use - Google Patents
Nucleic acid formulations comprising poly-amino acids for gene delivery and methods of use Download PDFInfo
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- CA2401327C CA2401327C CA2401327A CA2401327A CA2401327C CA 2401327 C CA2401327 C CA 2401327C CA 2401327 A CA2401327 A CA 2401327A CA 2401327 A CA2401327 A CA 2401327A CA 2401327 C CA2401327 C CA 2401327C
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- CA
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- Prior art keywords
- poly
- formulation
- nucleic acid
- anionic polymer
- glutamic acid
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- Expired - Lifetime
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
Landscapes
- Health & Medical Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
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| US18723600P | 2000-03-03 | 2000-03-03 | |
| US60/187,236 | 2000-03-03 | ||
| US26175101P | 2001-01-16 | 2001-01-16 | |
| US60/261,751 | 2001-01-16 | ||
| PCT/US2001/006953 WO2001066149A2 (en) | 2000-03-03 | 2001-03-02 | Nucleic acid formulations for gene delivery and methods of use |
Publications (2)
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| CA2401327A1 CA2401327A1 (en) | 2001-09-13 |
| CA2401327C true CA2401327C (en) | 2014-05-06 |
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|---|---|---|---|
| CA2401327A Expired - Lifetime CA2401327C (en) | 2000-03-03 | 2001-03-02 | Nucleic acid formulations comprising poly-amino acids for gene delivery and methods of use |
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| WO (1) | WO2001066149A2 (cg-RX-API-DMAC10.html) |
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| US20040192593A1 (en) * | 1999-07-26 | 2004-09-30 | Baylor College Of Medicine | Protease resistant ti-growth hormone releasing hormone |
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| AU2001296354A1 (en) * | 2000-09-25 | 2002-04-02 | Baylor College Of Medicine | Improved system for regulation of transgene expression |
| AU2002348417B9 (en) * | 2001-10-26 | 2010-02-04 | Baylor College Of Medicine | A composition and method to alter lean body mass and bone properties in a subject |
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| WO2025046513A1 (en) | 2023-08-29 | 2025-03-06 | Inceptor Bio, Llc | Methods of manufacturing myeloid-derived cells from hematopoietic stem cells and compositions and uses thereof |
| WO2026047626A1 (en) | 2024-08-30 | 2026-03-05 | Inceptor Bio, Llc | Compositions and methods involving immune cells engineered for binding bispecific antibodies for use in cell therapy |
| CN119925619B (zh) * | 2024-12-31 | 2026-07-14 | 首都医科大学 | 一种递送外源质粒dna的赋形剂及其制备和应用 |
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| US4543252A (en) * | 1982-01-21 | 1985-09-24 | The Regents Of The University Of California | Cationic oligopeptides having microbicidal activity |
| JPS60501759A (ja) | 1983-07-01 | 1985-10-17 | バテル メモリアル インステイチユ−ト | 生物分解性ポリペプチド及び薬剤の緩慢な放出のためのその使用 |
| DE3581471D1 (de) | 1984-10-19 | 1991-02-28 | Battelle Memorial Institute | Durch mikroorganismen abbaubares polypeptid und seine verwendung fuer die fortschreitende abgabe von medikamenten. |
| US5749847A (en) * | 1988-01-21 | 1998-05-12 | Massachusetts Institute Of Technology | Delivery of nucleotides into organisms by electroporation |
| JP3368603B2 (ja) | 1992-02-28 | 2003-01-20 | オリンパス光学工業株式会社 | 遺伝子治療用処置具 |
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| US5679647A (en) * | 1993-08-26 | 1997-10-21 | The Regents Of The University Of California | Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides |
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-
2001
- 2001-03-02 WO PCT/US2001/006953 patent/WO2001066149A2/en not_active Ceased
- 2001-03-02 AT AT01918339T patent/ATE511400T1/de not_active IP Right Cessation
- 2001-03-02 EP EP01918339A patent/EP1259265B1/en not_active Expired - Lifetime
- 2001-03-02 CA CA2401327A patent/CA2401327C/en not_active Expired - Lifetime
- 2001-03-02 AU AU2001245427A patent/AU2001245427A1/en not_active Abandoned
- 2001-03-02 BR BR0108962-5A patent/BR0108962A/pt not_active IP Right Cessation
- 2001-03-02 DK DK01918339.1T patent/DK1259265T3/da active
- 2001-03-02 JP JP2001564801A patent/JP4987205B2/ja not_active Expired - Lifetime
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2002
- 2002-09-03 US US10/234,406 patent/US7173116B2/en not_active Expired - Lifetime
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2006
- 2006-11-20 US US11/561,847 patent/US7491537B2/en not_active Expired - Lifetime
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| WO2001066149A3 (en) | 2002-03-14 |
| WO2001066149A2 (en) | 2001-09-13 |
| AU2001245427A1 (en) | 2001-09-17 |
| US20030109478A1 (en) | 2003-06-12 |
| EP1259265B1 (en) | 2011-06-01 |
| JP4987205B2 (ja) | 2012-07-25 |
| JP2003525912A (ja) | 2003-09-02 |
| ATE511400T1 (de) | 2011-06-15 |
| US20070213287A1 (en) | 2007-09-13 |
| EP1259265A2 (en) | 2002-11-27 |
| CA2401327A1 (en) | 2001-09-13 |
| US7491537B2 (en) | 2009-02-17 |
| BR0108962A (pt) | 2002-12-24 |
| DK1259265T3 (da) | 2011-07-11 |
| US7173116B2 (en) | 2007-02-06 |
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