CA2396157A1 - Use of exendins and agonists thereof for modulation of triglyceride levels and treatment of dyslipidemia - Google Patents
Use of exendins and agonists thereof for modulation of triglyceride levels and treatment of dyslipidemia Download PDFInfo
- Publication number
- CA2396157A1 CA2396157A1 CA002396157A CA2396157A CA2396157A1 CA 2396157 A1 CA2396157 A1 CA 2396157A1 CA 002396157 A CA002396157 A CA 002396157A CA 2396157 A CA2396157 A CA 2396157A CA 2396157 A1 CA2396157 A1 CA 2396157A1
- Authority
- CA
- Canada
- Prior art keywords
- solvent
- peptide
- exendin
- tfa
- gly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Endocrinology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17536500P | 2000-01-10 | 2000-01-10 | |
| US60/175,365 | 2000-01-10 | ||
| PCT/US2001/000719 WO2001051078A1 (en) | 2000-01-10 | 2001-01-09 | Use of exendins and agonists thereof for modulation of triglyceride levels and treatment of dyslipidemia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2396157A1 true CA2396157A1 (en) | 2001-07-19 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002396157A Abandoned CA2396157A1 (en) | 2000-01-10 | 2001-01-09 | Use of exendins and agonists thereof for modulation of triglyceride levels and treatment of dyslipidemia |
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| Country | Link |
|---|---|
| US (1) | US20030036504A1 (enExample) |
| EP (1) | EP1246638B2 (enExample) |
| JP (1) | JP2003519667A (enExample) |
| AT (1) | ATE275967T1 (enExample) |
| AU (1) | AU2006202247A1 (enExample) |
| CA (1) | CA2396157A1 (enExample) |
| DE (1) | DE60105547T3 (enExample) |
| DK (1) | DK1246638T4 (enExample) |
| ES (1) | ES2227115T5 (enExample) |
| PT (1) | PT1246638E (enExample) |
| WO (1) | WO2001051078A1 (enExample) |
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| US7048906B2 (en) | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
| WO1998030231A1 (en) * | 1997-01-07 | 1998-07-16 | Amylin Pharmaceuticals, Inc. | Use of exendins and agonists thereof for the reduction of food intake |
| US20030040469A1 (en) * | 2000-03-08 | 2003-02-27 | Knudsen Liselotte Bjerre | Lowering serum lipids |
| EP1263458B1 (en) * | 2000-03-08 | 2005-11-16 | Novo Nordisk A/S | Lowering serum cholesterol |
| EP2022505B1 (en) | 2001-07-31 | 2011-12-14 | The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services | GLP-1, exendin-4, peptide analogs and uses thereof |
| CN100350968C (zh) | 2001-09-24 | 2007-11-28 | 皇家创新有限公司 | 饮食行为的改进 |
| JP4733922B2 (ja) | 2002-01-10 | 2011-07-27 | インペリアル・イノベ−ションズ・リミテッド | 摂食行動の修正 |
| US8076288B2 (en) | 2004-02-11 | 2011-12-13 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides having glucose lowering activity |
| WO2005077094A2 (en) | 2004-02-11 | 2005-08-25 | Amylin Pharmaceuticals, Inc. | Pancreatic polypeptide family motifs and polypeptides comprising the same |
| DE102004043153B4 (de) * | 2004-09-03 | 2013-11-21 | Philipps-Universität Marburg | Erfindung betreffend GLP-1 und Exendin |
| US8263545B2 (en) | 2005-02-11 | 2012-09-11 | Amylin Pharmaceuticals, Inc. | GIP analog and hybrid polypeptides with selectable properties |
| EP2390264A1 (en) | 2005-02-11 | 2011-11-30 | Amylin Pharmaceuticals Inc. | GIP analog and hybrid polypeptides with selectable propperties |
| US20060190425A1 (en) * | 2005-02-24 | 2006-08-24 | Yuan-Chi Chang | Method for merging multiple ranked lists with bounded memory |
| CN101193626A (zh) * | 2005-03-11 | 2008-06-04 | 益德威士医药股份有限公司 | 奥曲肽的受控释放制剂 |
| US7759312B2 (en) * | 2005-03-11 | 2010-07-20 | Endo Pharmaceuticals Solutions Inc. | Delivery of dry formulations of octreotide |
| TWI364292B (en) | 2005-06-30 | 2012-05-21 | Ipsen Pharma Sas | Glp-1 pharmaceutical compositions |
| MX2008002028A (es) * | 2005-08-11 | 2008-03-27 | Amylin Pharmaceuticals Inc | Polipeptidos hibridos con propiedades de seleccion. |
| EP2330124B1 (en) * | 2005-08-11 | 2015-02-25 | Amylin Pharmaceuticals, LLC | Hybrid polypeptides with selectable properties |
| WO2007024700A2 (en) | 2005-08-19 | 2007-03-01 | Amylin Pharmaceuticals, Inc. | Exendin for treating diabetes and reducing body weight |
| US8497240B2 (en) | 2006-08-17 | 2013-07-30 | Amylin Pharmaceuticals, Llc | DPP-IV resistant GIP hybrid polypeptides with selectable properties |
| TWI428346B (zh) | 2006-12-13 | 2014-03-01 | Imp Innovations Ltd | 新穎化合物及其等對進食行為影響 |
| RU2413528C2 (ru) | 2007-01-18 | 2011-03-10 | Открытое Акционерное Общество "Валента Фармацевтика" | Лекарственный препарат для лечения сахарного диабета на основе экзенатида и даларгина, применение и способ лечения |
| KR100805208B1 (ko) * | 2007-03-27 | 2008-02-21 | 주식회사 펩트론 | 엑센딘 함유 서방성 제제 조성물, 엑센딘 함유 서방성미립구 및 이의 제조 방법 |
| AU2008297954A1 (en) * | 2007-09-11 | 2009-03-19 | Mondobiotech Laboratories Ag | Minigastrin as a therapeutic agent |
| AU2008306141A1 (en) * | 2007-09-11 | 2009-04-09 | Mondobiotech Laboratories Ag | Thyrotropin releasing hormone for therapeutic applications |
| US20110263496A1 (en) * | 2008-05-21 | 2011-10-27 | Amylin Pharmaceuticals, Inc. | Exendins to lower cholesterol and triglycerides |
| UA104866C2 (uk) * | 2008-06-25 | 2014-03-25 | Ендо Фармас'Ютікалз Солюшнз Інк. | Імплантат октреотиду, який містить вивільняючу речовину |
| WO2009158412A2 (en) * | 2008-06-25 | 2009-12-30 | Endo Pharmaceuticals Solutions Inc. | Sustained delivery of exenatide and other polypeptides |
| EP2216042A1 (en) | 2009-02-09 | 2010-08-11 | Ipsen Pharma S.A.S. | GLP-1 analogues pharmaceutical compositions |
| EP2435061A4 (en) | 2009-05-28 | 2013-03-27 | Amylin Pharmaceuticals Inc | DAMPING GLP-1 RECEPTOR AGONIST COMPOUNDS |
| CA2803646A1 (en) | 2010-07-02 | 2012-01-05 | Angiochem Inc. | Short and d-amino acid-containing polypeptides for therapeutic conjugates and uses thereof |
| US9161953B2 (en) | 2010-12-22 | 2015-10-20 | Amylin Pharmaceuticals, Llc | GLP-1 receptor agonists for islet cell transplantation |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| MX362190B (es) | 2012-12-21 | 2019-01-08 | Sanofi Sa | Agonistas duales de glp1/gip o trigonales de glp1/gip/glucagon. |
| TW201609796A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 非醯化之艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物 |
| WO2015086728A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
| WO2015086729A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/gip receptor agonists |
| WO2015086733A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/glucagon receptor agonists |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑 |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物 |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| RU2573933C1 (ru) | 2014-08-21 | 2016-01-27 | Дафот Энтерпрайсис Лимитед | Пептид для лечения сахарного диабета 2-го типа и его осложнений |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| TW201706291A (zh) | 2015-07-10 | 2017-02-16 | 賽諾菲公司 | 作為選擇性肽雙重ｇｌｐ－１／升糖素受體促效劑之新毒蜥外泌肽（ｅｘｅｎｄｉｎ－４）衍生物 |
| MY197023A (en) | 2015-12-23 | 2023-05-22 | Amgen Inc | Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (gipr) in combination with glp-1 agonists |
| WO2018071528A1 (en) * | 2016-10-11 | 2018-04-19 | University Of Georgia Research Foundation, Inc. | Proteins and method for treating obesity and associated comorbidities |
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| JP7309606B2 (ja) * | 2016-12-22 | 2023-07-18 | サノフイ | 活性比が最適化されたｆｇｆ２１化合物／ｇｌｐ－１ｒアゴニスト組合せ物 |
| JOP20190177A1 (ar) | 2017-01-17 | 2019-07-16 | Amgen Inc | طريقة لعلاج أو تحسين اضطرابات أيضية باستخدام مساعدات مستقبل glp-1 مقترنة بمناهضات لمستقبل ببتيد مثبط معوي (gipr) |
| MX2019013919A (es) | 2017-06-20 | 2020-01-21 | Amgen Inc | Metodo para tratar o mejorar trastornos metabolicos con proteinas de union para el receptor peptidico inhibidor gastrico (gipr) en combinacion con agonistas de glp-1. |
| EP3642238A1 (en) | 2017-06-21 | 2020-04-29 | Amgen Inc. | Method of treating or ameliorating metabolic disorders using antagonistic binding proteins for gastric inhibitory peptide receptor (gipr)/glp-1 receptor agonist fusion proteins |
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| WO2024123812A1 (en) | 2022-12-05 | 2024-06-13 | Shattuck Labs, Inc. | Fusion proteins for the treatment of cardiometabolic diseases |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4050797A (en) * | 1996-08-02 | 1998-02-25 | Ligand Pharmaceuticals Incorporated | Prevention or treatment of type 2 diabetes or cardiovascular disease with ppar modulators |
| WO1998030231A1 (en) * | 1997-01-07 | 1998-07-16 | Amylin Pharmaceuticals, Inc. | Use of exendins and agonists thereof for the reduction of food intake |
| KR20010033017A (ko) * | 1997-12-12 | 2001-04-25 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | 과지질혈증 치료제인 스타틴-ＬＰ(ａ) 억제제의 병용 제제 |
| SE9801992D0 (sv) * | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl-2-hydroxypropionic acid derivative I |
| CA2372214A1 (en) * | 1999-04-30 | 2000-11-09 | Amylin Pharmaceuticals, Inc. | Modified exendins and exendin agonists |
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2001
- 2001-01-09 CA CA002396157A patent/CA2396157A1/en not_active Abandoned
- 2001-01-09 DK DK01900978.6T patent/DK1246638T4/da active
- 2001-01-09 WO PCT/US2001/000719 patent/WO2001051078A1/en not_active Ceased
- 2001-01-09 US US09/756,690 patent/US20030036504A1/en not_active Abandoned
- 2001-01-09 EP EP01900978.6A patent/EP1246638B2/en not_active Expired - Lifetime
- 2001-01-09 ES ES01900978.6T patent/ES2227115T5/es not_active Expired - Lifetime
- 2001-01-09 JP JP2001551501A patent/JP2003519667A/ja active Pending
- 2001-01-09 PT PT01900978T patent/PT1246638E/pt unknown
- 2001-01-09 AT AT01900978T patent/ATE275967T1/de active
- 2001-01-09 DE DE60105547.0T patent/DE60105547T3/de not_active Expired - Lifetime
-
2006
- 2006-05-26 AU AU2006202247A patent/AU2006202247A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| HK1050477A1 (en) | 2003-06-27 |
| ES2227115T5 (es) | 2014-10-30 |
| AU784488B2 (en) | 2006-04-13 |
| DE60105547T3 (de) | 2014-12-31 |
| DK1246638T3 (da) | 2005-01-10 |
| DE60105547T2 (de) | 2005-10-13 |
| PT1246638E (pt) | 2004-12-31 |
| AU2638001A (en) | 2001-07-24 |
| EP1246638A1 (en) | 2002-10-09 |
| US20030036504A1 (en) | 2003-02-20 |
| AU2006202247A1 (en) | 2006-06-22 |
| EP1246638B2 (en) | 2014-07-30 |
| ES2227115T3 (es) | 2005-04-01 |
| DK1246638T4 (da) | 2014-09-22 |
| ATE275967T1 (de) | 2004-10-15 |
| JP2003519667A (ja) | 2003-06-24 |
| EP1246638B1 (en) | 2004-09-15 |
| DE60105547D1 (de) | 2004-10-21 |
| WO2001051078A1 (en) | 2001-07-19 |
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