CA2391087A1 - Imidazole compounds as phosphodiesterase vii inhibitors - Google Patents
Imidazole compounds as phosphodiesterase vii inhibitors Download PDFInfo
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- CA2391087A1 CA2391087A1 CA002391087A CA2391087A CA2391087A1 CA 2391087 A1 CA2391087 A1 CA 2391087A1 CA 002391087 A CA002391087 A CA 002391087A CA 2391087 A CA2391087 A CA 2391087A CA 2391087 A1 CA2391087 A1 CA 2391087A1
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- denotes
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- 150000002460 imidazoles Chemical class 0.000 title claims abstract description 8
- 239000002606 phosphodiesterase VII inhibitor Substances 0.000 title abstract description 15
- 239000003814 drug Substances 0.000 claims abstract description 19
- 150000003839 salts Chemical class 0.000 claims abstract description 19
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 12
- 239000012453 solvate Substances 0.000 claims abstract description 8
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 6
- 125000003342 alkenyl group Chemical group 0.000 claims abstract description 4
- 229910052801 chlorine Inorganic materials 0.000 claims abstract description 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 4
- 229910052731 fluorine Inorganic materials 0.000 claims abstract description 4
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 3
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 3
- 150000001875 compounds Chemical class 0.000 claims description 31
- 238000006243 chemical reaction Methods 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 11
- 239000004480 active ingredient Substances 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 9
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Classifications
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- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
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Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19954707A DE19954707A1 (de) | 1999-11-13 | 1999-11-13 | Imidazolverbindungen als Phosphodiesterase VII-Hemmer |
| DE19954707.6 | 1999-11-13 | ||
| PCT/EP2000/010765 WO2001036425A2 (de) | 1999-11-13 | 2000-10-31 | Imidazolverbindungen als phosphodiesterase vii-hemmer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2391087A1 true CA2391087A1 (en) | 2001-05-25 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002391087A Abandoned CA2391087A1 (en) | 1999-11-13 | 2000-10-31 | Imidazole compounds as phosphodiesterase vii inhibitors |
Country Status (23)
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|---|---|
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| EP (1) | EP1228073B1 (enExample) |
| JP (1) | JP4819272B2 (enExample) |
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| BR (1) | BR0015487A (enExample) |
| CA (1) | CA2391087A1 (enExample) |
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| MX (1) | MXPA02004728A (enExample) |
| NO (1) | NO20022232D0 (enExample) |
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| ES2217956B1 (es) * | 2003-01-23 | 2006-04-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de 4-aminotieno(2,3-d)pirimidin-6-carbonitrilo. |
| EP2258357A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| EP2275096A3 (en) | 2005-08-26 | 2011-07-13 | Braincells, Inc. | Neurogenesis via modulation of the muscarinic receptors |
| WO2007047978A2 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| EP2314289A1 (en) | 2005-10-31 | 2011-04-27 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| US7678808B2 (en) | 2006-05-09 | 2010-03-16 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
| EP2021000A2 (en) | 2006-05-09 | 2009-02-11 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| WO2008030651A1 (en) | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| US8637528B2 (en) | 2007-03-27 | 2014-01-28 | Omeros Corporation | Use of PDE7 inhibitors for the treatment of movement disorders |
| MX2009010450A (es) * | 2007-03-27 | 2009-11-23 | Omeros Corp | El uso de inhibidores de la fosfodiesterasa 7 para el tratamiento transtornos del movimiento. |
| DE102007047738A1 (de) * | 2007-10-05 | 2009-04-09 | Merck Patent Gmbh | Imidazolderivate |
| US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| US9220715B2 (en) | 2010-11-08 | 2015-12-29 | Omeros Corporation | Treatment of addiction and impulse-control disorders using PDE7 inhibitors |
| KR102385359B1 (ko) | 2010-11-08 | 2022-04-11 | 오메로스 코포레이션 | Pde7 억제제를 사용한 중독 및 충동-조절 장애의 치료 |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| US11685745B2 (en) | 2017-07-12 | 2023-06-27 | Dart Neuroscience, Llc | Substituted benzoxazole and benzofuran compounds as PDE7 inhibitors |
| CA3264513A1 (en) | 2022-08-18 | 2024-02-22 | Mitodicure Gmbh | USE OF SUBSTITUTED BENZOFURAN AND BENZOXAZOLE COMPOUNDS FOR THE TREATMENT AND PREVENTION OF DISEASES ASSOCIATED WITH CHRONIC FATIGUE, EXHAUSTION AND/OR EXERCISE INTOLERANCE |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2919271A (en) * | 1957-12-05 | 1959-12-29 | Smith Kline French Lab | 3-amino-1, 2-dihydro-3h-pyrido [3, 2, 1-kl]-phenothiazines |
| EP0480939B1 (en) * | 1989-06-09 | 1995-01-25 | The Upjohn Company | Heterocyclic amines having central nervous system activity |
| US5318965A (en) * | 1990-08-24 | 1994-06-07 | Abbott Laboratories | Quinobenzoxazine, antineoplastic agents |
| ZA9810766B (en) * | 1997-11-28 | 1999-05-25 | Mochida Pharm Co Ltd | Novel compounds having cgmp-pde inhibitory activity |
-
1999
- 1999-11-13 DE DE19954707A patent/DE19954707A1/de not_active Withdrawn
-
2000
- 2000-10-31 PT PT00975978T patent/PT1228073E/pt unknown
- 2000-10-31 US US10/129,629 patent/US6884800B1/en not_active Expired - Fee Related
- 2000-10-31 CZ CZ20021474A patent/CZ20021474A3/cs unknown
- 2000-10-31 EP EP00975978A patent/EP1228073B1/de not_active Expired - Lifetime
- 2000-10-31 RU RU2002113759/04A patent/RU2002113759A/ru unknown
- 2000-10-31 JP JP2001538914A patent/JP4819272B2/ja not_active Expired - Fee Related
- 2000-10-31 CN CN00815534A patent/CN1390222A/zh active Pending
- 2000-10-31 HU HU0203422A patent/HUP0203422A3/hu unknown
- 2000-10-31 CA CA002391087A patent/CA2391087A1/en not_active Abandoned
- 2000-10-31 AU AU13907/01A patent/AU775886B2/en not_active Ceased
- 2000-10-31 BR BR0015487-3A patent/BR0015487A/pt not_active Application Discontinuation
- 2000-10-31 DK DK00975978T patent/DK1228073T3/da active
- 2000-10-31 AT AT00975978T patent/ATE245653T1/de not_active IP Right Cessation
- 2000-10-31 SK SK601-2002A patent/SK6012002A3/sk unknown
- 2000-10-31 KR KR1020027006131A patent/KR20020049051A/ko not_active Withdrawn
- 2000-10-31 MX MXPA02004728A patent/MXPA02004728A/es not_active Application Discontinuation
- 2000-10-31 PL PL00355098A patent/PL355098A1/xx unknown
- 2000-10-31 ES ES00975978T patent/ES2200968T3/es not_active Expired - Lifetime
- 2000-10-31 DE DE50003036T patent/DE50003036D1/de not_active Expired - Lifetime
- 2000-10-31 WO PCT/EP2000/010765 patent/WO2001036425A2/de not_active Ceased
- 2000-11-10 AR ARP000105929A patent/AR026421A1/es unknown
-
2002
- 2002-05-10 NO NO20022232A patent/NO20022232D0/no not_active Application Discontinuation
- 2002-06-12 ZA ZA200204729A patent/ZA200204729B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU1390701A (en) | 2001-05-30 |
| EP1228073A2 (de) | 2002-08-07 |
| AU775886B2 (en) | 2004-08-19 |
| BR0015487A (pt) | 2002-07-02 |
| DE50003036D1 (de) | 2003-08-28 |
| AR026421A1 (es) | 2003-02-12 |
| HUP0203422A3 (en) | 2004-12-28 |
| WO2001036425A2 (de) | 2001-05-25 |
| ES2200968T3 (es) | 2004-03-16 |
| US6884800B1 (en) | 2005-04-26 |
| MXPA02004728A (es) | 2002-08-30 |
| PT1228073E (pt) | 2003-12-31 |
| NO20022232L (no) | 2002-05-10 |
| RU2002113759A (ru) | 2004-01-10 |
| KR20020049051A (ko) | 2002-06-24 |
| ATE245653T1 (de) | 2003-08-15 |
| PL355098A1 (en) | 2004-04-05 |
| DE19954707A1 (de) | 2001-05-17 |
| JP4819272B2 (ja) | 2011-11-24 |
| DK1228073T3 (da) | 2003-11-03 |
| WO2001036425A3 (de) | 2002-01-10 |
| CZ20021474A3 (cs) | 2002-07-17 |
| EP1228073B1 (de) | 2003-07-23 |
| HUP0203422A2 (hu) | 2003-02-28 |
| NO20022232D0 (no) | 2002-05-10 |
| ZA200204729B (en) | 2003-11-26 |
| SK6012002A3 (en) | 2002-09-10 |
| CN1390222A (zh) | 2003-01-08 |
| JP2003514821A (ja) | 2003-04-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20131031 |