CA2391084A1 - High order nucleic acid based structures - Google Patents
High order nucleic acid based structures Download PDFInfo
- Publication number
- CA2391084A1 CA2391084A1 CA002391084A CA2391084A CA2391084A1 CA 2391084 A1 CA2391084 A1 CA 2391084A1 CA 002391084 A CA002391084 A CA 002391084A CA 2391084 A CA2391084 A CA 2391084A CA 2391084 A1 CA2391084 A1 CA 2391084A1
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- Prior art keywords
- nucleic acid
- poly
- molecules
- structure according
- molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- PIEPQKCYPFFYMG-UHFFFAOYSA-N tris acetate Chemical compound CC(O)=O.OCC(N)(CO)CO PIEPQKCYPFFYMG-UHFFFAOYSA-N 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/15—Nucleic acids forming more than 2 strands, e.g. TFOs
- C12N2310/151—Nucleic acids forming more than 2 strands, e.g. TFOs more than 3 strands, e.g. tetrads, H-DNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/52—Physical structure branched
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Crystallography & Structural Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9926810.4A GB9926810D0 (en) | 1999-11-13 | 1999-11-13 | High order nucleic acid-based structures |
| GB9926810.4 | 1999-11-13 | ||
| GB0011126.0 | 2000-05-10 | ||
| GB0011126A GB0011126D0 (en) | 2000-05-10 | 2000-05-10 | High order nucleic acid-based structures |
| PCT/EP2000/011197 WO2001036624A1 (en) | 1999-11-13 | 2000-11-13 | High order nucleic acid based structures |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2391084A1 true CA2391084A1 (en) | 2001-05-25 |
Family
ID=26244234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002391084A Abandoned CA2391084A1 (en) | 1999-11-13 | 2000-11-13 | High order nucleic acid based structures |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1228201A1 (pl) |
| JP (1) | JP2003522524A (pl) |
| KR (1) | KR20020059727A (pl) |
| CN (1) | CN1390253A (pl) |
| AU (1) | AU782880B2 (pl) |
| BR (1) | BR0015484A (pl) |
| CA (1) | CA2391084A1 (pl) |
| CZ (1) | CZ20021472A3 (pl) |
| HK (1) | HK1052529A1 (pl) |
| HU (1) | HUP0203914A2 (pl) |
| MX (1) | MXPA02004727A (pl) |
| NO (1) | NO20022231L (pl) |
| PL (1) | PL358811A1 (pl) |
| RU (1) | RU2002113755A (pl) |
| SK (1) | SK6042002A3 (pl) |
| WO (1) | WO2001036624A1 (pl) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000039304A2 (en) | 1998-12-31 | 2000-07-06 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
| EP2412242A3 (en) | 2001-07-05 | 2012-06-13 | Novartis Vaccines and Diagnostics, Inc. | Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof |
| AU2012294724B2 (en) * | 2011-08-05 | 2017-05-04 | President And Fellows Of Harvard College | Compositions and methods relating to nucleic acid nano-and micro-technology |
| JP6596336B2 (ja) | 2012-07-24 | 2019-10-23 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 核酸ナノ構造の自己集合 |
| US9975916B2 (en) | 2012-11-06 | 2018-05-22 | President And Fellows Of Harvard College | Compositions and methods relating to complex nucleic acid nanostructures |
| EP3065722A4 (en) * | 2013-11-08 | 2017-11-15 | Dana-Farber Cancer Institute, Inc. | Nucleic acid nanostructures for in vivo agent delivery |
| US10099920B2 (en) | 2014-05-22 | 2018-10-16 | President And Fellows Of Harvard College | Scalable nucleic acid-based nanofabrication |
| WO2017156264A1 (en) | 2016-03-11 | 2017-09-14 | Children's Medical Center Corporation | Nucleic acid nanoswitch catenanes |
| CN109790199B (zh) | 2016-08-02 | 2022-10-18 | 哈佛学院院长及董事 | 交叉协同自组装体 |
| KR102656600B1 (ko) * | 2018-07-12 | 2024-04-15 | 바이 야오 쥐 다 (베이징) 나노바이오 테크놀로지 컴퍼니 리미티드 | 핵산 나노입자, 이를 포함하는 약물 조성물, 독소루비신 함유 약물 및 그 제조 방법 |
| CN110711254B (zh) * | 2018-07-12 | 2022-07-26 | 百药智达（北京）纳米生物技术有限公司 | 核酸纳米颗粒及包含其的药物组合物 |
| CN110960536B (zh) * | 2018-09-30 | 2022-07-26 | 百药智达（北京）纳米生物技术有限公司 | 含阿司匹林的药物、其制备方法、药物组合物及应用 |
| CN110960542B (zh) * | 2018-09-30 | 2022-07-26 | 百药智达（北京）纳米生物技术有限公司 | 含吡柔比星的药物、其制备方法、药物组合物及其应用 |
| CN110960530B (zh) * | 2018-09-30 | 2022-07-22 | 百药智达（北京）纳米生物技术有限公司 | 含他克林的药物、其制备方法、药物组合物及其应用 |
| CN110960690B (zh) * | 2018-09-30 | 2022-07-22 | 百药智达（北京）纳米生物技术有限公司 | 含表柔比星的药物、其制备方法、药物组合物及其应用 |
| CN110960534B (zh) * | 2018-09-30 | 2022-07-26 | 百药智达（北京）纳米生物技术有限公司 | 含五氟尿嘧啶的药物、其制备方法、药物组合物及其应用 |
| CN111053765B (zh) * | 2018-10-16 | 2022-07-26 | 百药智达（北京）纳米生物技术有限公司 | 含紫杉醇的药物、其制备方法、药物组合物及应用 |
| CN111068065B (zh) * | 2018-10-22 | 2022-07-26 | 百药智达（北京）纳米生物技术有限公司 | 含奥沙利铂的药物、其制备方法、药物组合物及其应用 |
| CN111084887B (zh) * | 2018-10-23 | 2022-07-22 | 百药智达（北京）纳米生物技术有限公司 | 含黄酮的药物、其制备方法、药物组合物及应用 |
| CN111096965B (zh) * | 2018-10-29 | 2022-07-26 | 百药智达（北京）纳米生物技术有限公司 | 含双氢青蒿素的药物、其制备方法、药物组合物及其应用 |
| WO2020210468A1 (en) | 2019-04-10 | 2020-10-15 | President And Fellows Of Harvard College | Nucleic acid nanostructures crosslinked with oligolysine |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0151631A1 (en) * | 1983-08-03 | 1985-08-21 | The Research Foundation Of State University Of New York | Nucleic acid branched junctions with precisely defined migrational mobility |
| US5386020A (en) * | 1991-01-10 | 1995-01-31 | New York University | Multiply connected, three-dimensional nucleic acid structures |
| US5278051A (en) * | 1991-12-12 | 1994-01-11 | New York University | Construction of geometrical objects from polynucleotides |
| US6072044A (en) * | 1996-04-26 | 2000-06-06 | New York University | Nanoconstructions of geometrical objects and lattices from antiparallel nucleic acid double crossover molecules |
-
2000
- 2000-11-13 RU RU2002113755/04A patent/RU2002113755A/ru unknown
- 2000-11-13 AU AU20001/01A patent/AU782880B2/en not_active Ceased
- 2000-11-13 HU HU0203914A patent/HUP0203914A2/hu unknown
- 2000-11-13 EP EP00983130A patent/EP1228201A1/en not_active Withdrawn
- 2000-11-13 WO PCT/EP2000/011197 patent/WO2001036624A1/en not_active Ceased
- 2000-11-13 SK SK604-2002A patent/SK6042002A3/sk not_active Application Discontinuation
- 2000-11-13 KR KR1020027006140A patent/KR20020059727A/ko not_active Withdrawn
- 2000-11-13 PL PL00358811A patent/PL358811A1/pl unknown
- 2000-11-13 CN CN00815433A patent/CN1390253A/zh active Pending
- 2000-11-13 BR BR0015484-9A patent/BR0015484A/pt not_active IP Right Cessation
- 2000-11-13 MX MXPA02004727A patent/MXPA02004727A/es unknown
- 2000-11-13 CZ CZ20021472A patent/CZ20021472A3/cs unknown
- 2000-11-13 CA CA002391084A patent/CA2391084A1/en not_active Abandoned
- 2000-11-13 JP JP2001538503A patent/JP2003522524A/ja active Pending
- 2000-11-13 HK HK03104743.9A patent/HK1052529A1/zh unknown
-
2002
- 2002-05-10 NO NO20022231A patent/NO20022231L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL358811A1 (pl) | 2004-08-23 |
| HK1052529A1 (zh) | 2003-09-19 |
| SK6042002A3 (en) | 2002-12-03 |
| NO20022231D0 (no) | 2002-05-10 |
| MXPA02004727A (es) | 2002-08-30 |
| RU2002113755A (ru) | 2004-01-10 |
| NO20022231L (no) | 2002-05-10 |
| CZ20021472A3 (cs) | 2002-07-17 |
| JP2003522524A (ja) | 2003-07-29 |
| WO2001036624A1 (en) | 2001-05-25 |
| HUP0203914A2 (en) | 2003-03-28 |
| KR20020059727A (ko) | 2002-07-13 |
| AU2000101A (en) | 2001-05-30 |
| BR0015484A (pt) | 2002-07-02 |
| EP1228201A1 (en) | 2002-08-07 |
| AU782880B2 (en) | 2005-09-08 |
| CN1390253A (zh) | 2003-01-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |