CA2391084A1 - Structures moleculaires a base d'acide nucleique d'ordre eleve - Google Patents

Structures moleculaires a base d'acide nucleique d'ordre eleve Download PDF

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Publication number
CA2391084A1
CA2391084A1 CA002391084A CA2391084A CA2391084A1 CA 2391084 A1 CA2391084 A1 CA 2391084A1 CA 002391084 A CA002391084 A CA 002391084A CA 2391084 A CA2391084 A CA 2391084A CA 2391084 A1 CA2391084 A1 CA 2391084A1
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CA
Canada
Prior art keywords
nucleic acid
poly
molecules
structure according
molecule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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CA002391084A
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English (en)
Inventor
Frank J. Carr
Graham Carter
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Merck Patent GmbH
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9926810.4A external-priority patent/GB9926810D0/en
Priority claimed from GB0011126A external-priority patent/GB0011126D0/en
Application filed by Individual filed Critical Individual
Publication of CA2391084A1 publication Critical patent/CA2391084A1/fr
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/15—Nucleic acids forming more than 2 strands, e.g. TFOs
    • C12N2310/151—Nucleic acids forming more than 2 strands, e.g. TFOs more than 3 strands, e.g. tetrads, H-DNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/52—Physical structure branched

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des structures moléculaires à base d'acide nucléique se liant à d'autres entités moléculaires, en particulier à des entités autres que les acides nucléiques eux-mêmes. L'invention concerne, en particulier, des structures moléculaires à base d'acide nucléique possédant une activité pharmaceutique par l'intermédiaire d'une liaison avec des cibles moléculaires spécifiques, ce qui influe sur des états pathologiques. L'invention concerne enfin des structures moléculaires à base d'acide nucléique à utilité diagnostique.
CA002391084A 1999-11-13 2000-11-13 Structures moleculaires a base d'acide nucleique d'ordre eleve Abandoned CA2391084A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9926810.4 1999-11-13
GBGB9926810.4A GB9926810D0 (en) 1999-11-13 1999-11-13 High order nucleic acid-based structures
GB0011126.0 2000-05-10
GB0011126A GB0011126D0 (en) 2000-05-10 2000-05-10 High order nucleic acid-based structures
PCT/EP2000/011197 WO2001036624A1 (fr) 1999-11-13 2000-11-13 Structures moleculaires a base d'acide nucleique d'ordre eleve

Publications (1)

Publication Number Publication Date
CA2391084A1 true CA2391084A1 (fr) 2001-05-25

Family

ID=26244234

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002391084A Abandoned CA2391084A1 (fr) 1999-11-13 2000-11-13 Structures moleculaires a base d'acide nucleique d'ordre eleve

Country Status (16)

Country Link
EP (1) EP1228201A1 (fr)
JP (1) JP2003522524A (fr)
KR (1) KR20020059727A (fr)
CN (1) CN1390253A (fr)
AU (1) AU782880B2 (fr)
BR (1) BR0015484A (fr)
CA (1) CA2391084A1 (fr)
CZ (1) CZ20021472A3 (fr)
HK (1) HK1052529A1 (fr)
HU (1) HUP0203914A2 (fr)
MX (1) MXPA02004727A (fr)
NO (1) NO20022231L (fr)
PL (1) PL358811A1 (fr)
RU (1) RU2002113755A (fr)
SK (1) SK6042002A3 (fr)
WO (1) WO2001036624A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003523721A (ja) 1998-12-31 2003-08-12 カイロン コーポレイション 抗原性ｈｉｖｃ型ポリペプチドをコードするポリヌクレオチド、ポリペプチド、およびそれらの使用
US7211659B2 (en) 2001-07-05 2007-05-01 Chiron Corporation Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof
US9796749B2 (en) 2011-08-05 2017-10-24 President And Fellows Of Harvard College Compositions and methods relating to nucleic acid nano- and micro-technology
US10604543B2 (en) 2012-07-24 2020-03-31 President And Fellows Of Harvard College Self-assembly of nucleic acid nanostructures
WO2014074597A1 (fr) 2012-11-06 2014-05-15 President And Fellows Of Harvard College Compositions et procédés se rapportant à des nanostructures d'acides nucléiques complexes
WO2015070080A2 (fr) * 2013-11-08 2015-05-14 Dana-Farber Cancer Institute, Inc. Nanostructures d'acides nucléiques pour l'administration d'agents in vivo
CN106488883A (zh) 2014-05-22 2017-03-08 哈佛学院院长及董事 可扩展的基于核酸的纳米制造
WO2017156264A1 (fr) 2016-03-11 2017-09-14 Children's Medical Center Corporation Caténanes de nanocommutateurs d'acide nucléique
EP4071159B1 (fr) 2016-08-02 2023-12-13 President and Fellows of Harvard College Auto-assemblage coopératif croisé
WO2020011248A1 (fr) * 2018-07-12 2020-01-16 百药智达（北京）纳米生物技术有限公司 Nanoparticules d'acides nucléiques, composition pharmaceutique les comprenant , médicament comprenant de la doxorubicine, et procédé de préparation associé
CN110711254B (zh) * 2018-07-12 2022-07-26 百药智达（北京）纳米生物技术有限公司 核酸纳米颗粒及包含其的药物组合物
CN110960542B (zh) * 2018-09-30 2022-07-26 百药智达（北京）纳米生物技术有限公司 含吡柔比星的药物、其制备方法、药物组合物及其应用
CN110960534B (zh) * 2018-09-30 2022-07-26 百药智达（北京）纳米生物技术有限公司 含五氟尿嘧啶的药物、其制备方法、药物组合物及其应用
CN110960530B (zh) * 2018-09-30 2022-07-22 百药智达（北京）纳米生物技术有限公司 含他克林的药物、其制备方法、药物组合物及其应用
CN110960536B (zh) * 2018-09-30 2022-07-26 百药智达（北京）纳米生物技术有限公司 含阿司匹林的药物、其制备方法、药物组合物及应用
CN110960690B (zh) * 2018-09-30 2022-07-22 百药智达（北京）纳米生物技术有限公司 含表柔比星的药物、其制备方法、药物组合物及其应用
CN111053765B (zh) * 2018-10-16 2022-07-26 百药智达（北京）纳米生物技术有限公司 含紫杉醇的药物、其制备方法、药物组合物及应用
CN111068065B (zh) * 2018-10-22 2022-07-26 百药智达（北京）纳米生物技术有限公司 含奥沙利铂的药物、其制备方法、药物组合物及其应用
CN111084887B (zh) * 2018-10-23 2022-07-22 百药智达（北京）纳米生物技术有限公司 含黄酮的药物、其制备方法、药物组合物及应用
CN111096965B (zh) * 2018-10-29 2022-07-26 百药智达（北京）纳米生物技术有限公司 含双氢青蒿素的药物、其制备方法、药物组合物及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985000813A1 (fr) * 1983-08-03 1985-02-28 The Research Foundation Of State University Of New Jonctions ramifiees d'acide nucleique ayant une mobilite de migration definie de maniere precise
US5386020A (en) * 1991-01-10 1995-01-31 New York University Multiply connected, three-dimensional nucleic acid structures
US5278051A (en) * 1991-12-12 1994-01-11 New York University Construction of geometrical objects from polynucleotides
US6072044A (en) * 1996-04-26 2000-06-06 New York University Nanoconstructions of geometrical objects and lattices from antiparallel nucleic acid double crossover molecules

Also Published As

Publication number Publication date
PL358811A1 (en) 2004-08-23
AU782880B2 (en) 2005-09-08
AU2000101A (en) 2001-05-30
CZ20021472A3 (cs) 2002-07-17
WO2001036624A1 (fr) 2001-05-25
MXPA02004727A (es) 2002-08-30
JP2003522524A (ja) 2003-07-29
SK6042002A3 (en) 2002-12-03
EP1228201A1 (fr) 2002-08-07
HUP0203914A2 (en) 2003-03-28
CN1390253A (zh) 2003-01-08
HK1052529A1 (zh) 2003-09-19
RU2002113755A (ru) 2004-01-10
NO20022231D0 (no) 2002-05-10
KR20020059727A (ko) 2002-07-13
NO20022231L (no) 2002-05-10
BR0015484A (pt) 2002-07-02

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Legal Events

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FZDE Discontinued