CA2387666A1 - Proteine du virus de l'hepatite c (hcv) a oxydoreduction reversible a conformation de type endogene - Google Patents
Proteine du virus de l'hepatite c (hcv) a oxydoreduction reversible a conformation de type endogene Download PDFInfo
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- CA2387666A1 CA2387666A1 CA002387666A CA2387666A CA2387666A1 CA 2387666 A1 CA2387666 A1 CA 2387666A1 CA 002387666 A CA002387666 A CA 002387666A CA 2387666 A CA2387666 A CA 2387666A CA 2387666 A1 CA2387666 A1 CA 2387666A1
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- hcv
- protein
- amino acid
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- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
- C07K16/109—Hepatitis C virus; Hepatitis G virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La présente invention concerne des protéines HCV dans lesquelles les résidus de cystéine sont protégés de façon réversible durant la purification. Cette procédure de purification donne finalement des protéines HCV qui présentent une activité biologique, une conformation protéinique de type endogène et des épitopes correspondants. Cette invention concerne aussi des techniques de recherche de médicament utilisant ces protéines HCV, et des applications diagnostiques et thérapeutiques, telles que des vaccins et des médicaments.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99870225 | 1999-10-27 | ||
| EP99870225.2 | 1999-10-27 | ||
| US16928899P | 1999-12-07 | 1999-12-07 | |
| US60/169,288 | 1999-12-07 | ||
| PCT/EP2000/010499 WO2001030815A1 (fr) | 1999-10-27 | 2000-10-25 | Proteine du virus de l'hepatite c (hcv) a oxydoreduction reversible a conformation de type endogene |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2387666A1 true CA2387666A1 (fr) | 2001-05-03 |
Family
ID=30129297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002387666A Abandoned CA2387666A1 (fr) | 1999-10-27 | 2000-10-25 | Proteine du virus de l'hepatite c (hcv) a oxydoreduction reversible a conformation de type endogene |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1224214A1 (fr) |
| JP (1) | JP2003513022A (fr) |
| CN (1) | CN1384839A (fr) |
| AU (1) | AU1144501A (fr) |
| BR (1) | BR0015170A (fr) |
| CA (1) | CA2387666A1 (fr) |
| CZ (1) | CZ20021819A3 (fr) |
| HU (1) | HUP0203195A3 (fr) |
| MX (1) | MXPA02004052A (fr) |
| NZ (1) | NZ518095A (fr) |
| PL (1) | PL354990A1 (fr) |
| RU (1) | RU2002109480A (fr) |
| WO (1) | WO2001030815A1 (fr) |
| ZA (1) | ZA200203169B (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020064835A1 (en) * | 2000-07-10 | 2002-05-30 | Diosynth Rtp, Inc. | Purification of human troponin I |
| US7238356B2 (en) | 2001-04-24 | 2007-07-03 | Innogenetics N.V. | Core-glycosylated HCV envelope proteins |
| EP1481984A1 (fr) * | 2003-05-28 | 2004-12-01 | Innogenetics N.V. | Ns5 du virus l'hepatite c (vhc) modifie |
| CA2906407A1 (fr) * | 2013-03-14 | 2014-09-18 | Abbott Laboratories | Antigenes recombinants ns3 de vhc et leurs mutants pour la detection d'anticorps amelioree |
| EP3756648A1 (fr) * | 2019-06-27 | 2020-12-30 | Imnate Sarl | Formulations de vaccin améliorées |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4734362A (en) * | 1986-02-03 | 1988-03-29 | Cambridge Bioscience Corporation | Process for purifying recombinant proteins, and products thereof |
| ATE162799T1 (de) * | 1989-06-02 | 1998-02-15 | Genetic Systems Corp | Peptide mit thiolgeschütztem cystein zur verwendung in immuntests |
| EP1845108A3 (fr) * | 1994-07-29 | 2007-10-24 | Innogenetics N.V. | Anticorps monoclonaux de protéines d'enveloppe de virus de l'hépatite C purifiée pour l'utilisation de diagnostic et thérapeutique |
| GB9703406D0 (en) * | 1997-02-19 | 1997-04-09 | Chiron Spa | Expression of heterologous proteins |
| EP0947525A1 (fr) * | 1998-03-27 | 1999-10-06 | Innogenetics N.V. | Epitopes de protéines d'enveloppe virale et anticorps spécifiques pour cet epitope: usage pour le diagnostic de l'antigène de virus HCV dans le tissu hÔte |
-
2000
- 2000-10-25 NZ NZ518095A patent/NZ518095A/en unknown
- 2000-10-25 RU RU2002109480/13A patent/RU2002109480A/ru not_active Application Discontinuation
- 2000-10-25 JP JP2001533812A patent/JP2003513022A/ja active Pending
- 2000-10-25 MX MXPA02004052A patent/MXPA02004052A/es unknown
- 2000-10-25 HU HU0203195A patent/HUP0203195A3/hu unknown
- 2000-10-25 BR BR0015170-0A patent/BR0015170A/pt not_active IP Right Cessation
- 2000-10-25 PL PL00354990A patent/PL354990A1/xx not_active Application Discontinuation
- 2000-10-25 CA CA002387666A patent/CA2387666A1/fr not_active Abandoned
- 2000-10-25 WO PCT/EP2000/010499 patent/WO2001030815A1/fr active Search and Examination
- 2000-10-25 CN CN00814993A patent/CN1384839A/zh active Pending
- 2000-10-25 EP EP00972863A patent/EP1224214A1/fr not_active Withdrawn
- 2000-10-25 AU AU11445/01A patent/AU1144501A/en not_active Abandoned
- 2000-10-25 CZ CZ20021819A patent/CZ20021819A3/cs unknown
-
2002
- 2002-04-22 ZA ZA200203169A patent/ZA200203169B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ518095A (en) | 2003-09-26 |
| PL354990A1 (en) | 2004-03-22 |
| WO2001030815A1 (fr) | 2001-05-03 |
| BR0015170A (pt) | 2002-06-25 |
| ZA200203169B (en) | 2003-09-23 |
| AU1144501A (en) | 2001-05-08 |
| CZ20021819A3 (cs) | 2003-06-18 |
| JP2003513022A (ja) | 2003-04-08 |
| RU2002109480A (ru) | 2004-03-10 |
| CN1384839A (zh) | 2002-12-11 |
| HUP0203195A3 (en) | 2004-07-28 |
| HUP0203195A2 (hu) | 2002-12-28 |
| MXPA02004052A (es) | 2002-11-07 |
| EP1224214A1 (fr) | 2002-07-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |