CA2386865A1 - Diagnostic et traitement du cancer utilisant des molecules liees au sgp-28 - Google Patents
Diagnostic et traitement du cancer utilisant des molecules liees au sgp-28 Download PDFInfo
- Publication number
- CA2386865A1 CA2386865A1 CA002386865A CA2386865A CA2386865A1 CA 2386865 A1 CA2386865 A1 CA 2386865A1 CA 002386865 A CA002386865 A CA 002386865A CA 2386865 A CA2386865 A CA 2386865A CA 2386865 A1 CA2386865 A1 CA 2386865A1
- Authority
- CA
- Canada
- Prior art keywords
- seq
- sgp28
- amino acids
- antibody
- polynucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010028980 Neoplasm Diseases 0.000 title claims 15
- 201000011510 cancer Diseases 0.000 title claims 15
- 238000003745 diagnosis Methods 0.000 title abstract 2
- 238000002560 therapeutic procedure Methods 0.000 title abstract 2
- 101000726258 Homo sapiens Cysteine-rich secretory protein 3 Proteins 0.000 claims abstract 47
- 102100027367 Cysteine-rich secretory protein 3 Human genes 0.000 claims abstract 37
- 238000000034 method Methods 0.000 claims abstract 18
- 108091033319 polynucleotide Proteins 0.000 claims abstract 18
- 239000002157 polynucleotide Substances 0.000 claims abstract 18
- 102000040430 polynucleotide Human genes 0.000 claims abstract 18
- 239000012634 fragment Substances 0.000 claims abstract 8
- 239000000203 mixture Substances 0.000 claims abstract 8
- 206010060862 Prostate cancer Diseases 0.000 claims abstract 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims abstract 2
- 150000001413 amino acids Chemical class 0.000 claims 31
- 239000000523 sample Substances 0.000 claims 19
- 239000008194 pharmaceutical composition Substances 0.000 claims 16
- 210000001519 tissue Anatomy 0.000 claims 8
- 229960005486 vaccine Drugs 0.000 claims 7
- 239000012472 biological sample Substances 0.000 claims 5
- 230000002163 immunogen Effects 0.000 claims 4
- 108020004999 messenger RNA Proteins 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 230000010261 cell growth Effects 0.000 claims 3
- 239000003550 marker Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 230000004075 alteration Effects 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 210000002307 prostate Anatomy 0.000 claims 2
- 108091026890 Coding region Proteins 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- URINYHFMLIGJCL-UHFFFAOYSA-N NCSN Chemical compound NCSN URINYHFMLIGJCL-UHFFFAOYSA-N 0.000 claims 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 210000003563 lymphoid tissue Anatomy 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 210000000582 semen Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57434—Specifically defined cancers of prostate
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4721—Cationic antimicrobial peptides, e.g. defensins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- Transplantation (AREA)
- Pregnancy & Childbirth (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Physics & Mathematics (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Food Science & Technology (AREA)
Abstract
La présente invention concerne des procédés et compositions destinés au diagnostic et au traitement du cancer de la prostate. On utilise à cet effet des polynucléotides correspondant au gène SGP-28 humain, des protéines codées par le gène SGP-28 ou certains de leurs fragments, et des anticorps spécifiquement capables de reconnaître des protéines du SGP-28 ou de s'y lier.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16261099P | 1999-10-28 | 1999-10-28 | |
US60/162,610 | 1999-10-28 | ||
PCT/US2000/029607 WO2001031343A2 (fr) | 1999-10-28 | 2000-10-27 | Diagnostic et traitement du cancer utilisant des molecules liees au sgp-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2386865A1 true CA2386865A1 (fr) | 2001-05-03 |
CA2386865C CA2386865C (fr) | 2012-05-22 |
Family
ID=22586387
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2386865A Expired - Fee Related CA2386865C (fr) | 1999-10-28 | 2000-10-27 | Diagnostic et traitement du cancer utilisant des molecules liees au sgp-28 |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1228373B1 (fr) |
JP (2) | JP3779926B2 (fr) |
AT (1) | ATE291738T1 (fr) |
AU (1) | AU781223B2 (fr) |
CA (1) | CA2386865C (fr) |
DE (1) | DE60018964T2 (fr) |
ES (1) | ES2240192T3 (fr) |
IL (3) | IL149045A0 (fr) |
WO (1) | WO2001031343A2 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008110006A1 (fr) * | 2007-03-12 | 2008-09-18 | Miraculins Inc. | Biomarqueurs du cancer de la prostate et utilisations de ceux-ci |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6835822B1 (en) | 1999-10-28 | 2004-12-28 | Agensys, Inc. | Diagnosis and therapy of cancer using SGP28-related molecules |
EP1513865A4 (fr) * | 2002-05-28 | 2006-05-03 | Univ Minnesota | Utilisation de polyppetides crisp comme contaceptifs et inhibiteurs de capacitation du sperme |
US20110144673A1 (en) | 2009-12-11 | 2011-06-16 | Fox Hollow Technologies, Inc. | Material removal device having improved material capture efficiency and methods of use |
CN102914658A (zh) * | 2012-10-24 | 2013-02-06 | 高维强 | Crisp3蛋白在前列腺癌诊断和治疗中的应用 |
-
2000
- 2000-10-27 JP JP2001533429A patent/JP3779926B2/ja not_active Expired - Fee Related
- 2000-10-27 AU AU12372/01A patent/AU781223B2/en not_active Ceased
- 2000-10-27 IL IL14904500A patent/IL149045A0/xx unknown
- 2000-10-27 ES ES00973927T patent/ES2240192T3/es not_active Expired - Lifetime
- 2000-10-27 CA CA2386865A patent/CA2386865C/fr not_active Expired - Fee Related
- 2000-10-27 AT AT00973927T patent/ATE291738T1/de not_active IP Right Cessation
- 2000-10-27 EP EP00973927A patent/EP1228373B1/fr not_active Expired - Lifetime
- 2000-10-27 DE DE60018964T patent/DE60018964T2/de not_active Expired - Lifetime
- 2000-10-27 WO PCT/US2000/029607 patent/WO2001031343A2/fr active Application Filing
-
2002
- 2002-04-09 IL IL149045A patent/IL149045A/en not_active IP Right Cessation
-
2006
- 2006-01-27 JP JP2006019870A patent/JP4325943B2/ja not_active Expired - Fee Related
-
2010
- 2010-07-15 IL IL207012A patent/IL207012A/en not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008110006A1 (fr) * | 2007-03-12 | 2008-09-18 | Miraculins Inc. | Biomarqueurs du cancer de la prostate et utilisations de ceux-ci |
Also Published As
Publication number | Publication date |
---|---|
WO2001031343A2 (fr) | 2001-05-03 |
AU781223B2 (en) | 2005-05-12 |
DE60018964D1 (de) | 2005-04-28 |
JP2006187290A (ja) | 2006-07-20 |
CA2386865C (fr) | 2012-05-22 |
AU1237201A (en) | 2001-05-08 |
WO2001031343A3 (fr) | 2002-01-31 |
IL207012A (en) | 2013-05-30 |
DE60018964T2 (de) | 2006-01-12 |
JP4325943B2 (ja) | 2009-09-02 |
ES2240192T3 (es) | 2005-10-16 |
EP1228373B1 (fr) | 2005-03-23 |
ATE291738T1 (de) | 2005-04-15 |
JP3779926B2 (ja) | 2006-05-31 |
IL149045A0 (en) | 2002-11-10 |
JP2003512825A (ja) | 2003-04-08 |
IL149045A (en) | 2010-11-30 |
IL207012A0 (en) | 2011-08-01 |
EP1228373A2 (fr) | 2002-08-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20151027 |